Sylvie Laquerre

ScholarGPS® ID: 37776637878268

Affiliation

Johnson & Johnson, New Brunswick, New Jersey, United States

Affiliation History

Field

Medicine

Discipline

Oncology

Top Specialties

Cancer | Antibody | Bispecific Monoclonal Antibody

Metrics Summary

Publication Count

Predicted Citations

3,372

Predicted h-index

Ranking

Publications and Citation History

Publications based on Top Specialties

Types of Publication

Publications
Books
Patents
NIH/NSF

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Discovery of Orally Bioavailable Ligand Efficient Quinazolindiones as Potent and Selective Tankyrases Inhibitors (journal article) Qin, Donghui \| Lin, Xiaojuan \| Liu, Zhi \| Chen, Yan \| Zhang, Zhiliu \| Wu, Chengde \| Liu, Linlin \| Pan, Yan \| Laquerre, Sylvie \| Emery, John \| ... \| Su, Dai-Shi ACS Medicinal Chemistry Letters, volume 12, issue 6, pages 1005-1010 (2021). 10.1021/acsmedchemlett.1c00160 Cited by (5) \| Cite \| Source
Method of adjuvant cancer treatment (patent) Laquerre, Sylvie \| Lebowitz, Peter F. Patent Number: 10869869 (2020) Cite \| Source
Amivantamab (JNJ-61186372), an Fc Enhanced EGFR/cMet Bispecific Antibody, Induces Receptor Downmodulation and Antitumor Activity by Monocyte/Macrophage Trogocytosis (journal article) Vijayaraghavan, Smruthi \| Lipfert, Lorraine \| Chevalier, Kristen \| Bushey, Barbara S. \| Henley, Benjamin \| Lenhart, Ryan \| Sendecki, Jocelyn \| Beqiri, Marilda \| Millar, Hillary J. \| Packman, Kathryn \| ... \| Moores, Sheri L. Molecular Cancer Therapeutics, volume 19, issue 10, pages 2044-2056 (2020). 10.1158/1535-7163.MCT-20-0071 Cited by (97) \| Cite \| Source
The Combined Effect of FGFR Inhibition and PD-1 Blockade Promotes Tumor-Intrinsic Induction of Antitumor Immunity (journal article) Palakurthi, Sangeetha \| Kuraguchi, Mari \| Zacharek, Sima J. \| Zudaire, Enrique \| Huang, Wei \| Bonal, Dennis M. \| Liu, Jeffrey \| Dhaneshwar, Abha \| DePeaux, Kristin \| Gowaski, Martha R. \| ... \| Lorenzi, Matthew V. Cancer Immunology Research, volume 7, issue 9, pages 1457-1471 (2019). 10.1158/2326-6066.CIR-18-0595 Cited by (102) \| Cite \| Source
OA10.06 A First-in-Human Phase 1 Trial of the EGFR-cMET Bispecific Antibody JNJ-61186372 in Patients with Advanced Non-Small Cell Lung Cancer (NSCLC) (journal article) Park, K. \| Ahn, M. \| Lee, S. \| Kim, H.R. \| Hong, M.H. \| Millington, D. \| Curtis, M. \| Triantos, S. \| Chaplan, S. \| Haddish-Berhane, N. \| ... \| Cho, B.C. Journal of Thoracic Oncology, volume 13, issue 10, pages S344-S345 (2018). 10.1016/j.jtho.2018.08.292 Cited by (8) \| Cite \| Source
Discovery of a First-in-Class Gut-Restricted RET Kinase Inhibitor as a Clinical Candidate for the Treatment of IBS (journal article) Schenck Eidam, Hilary \| Russell, John \| Raha, Kaushik \| DeMartino, Michael \| Qin, Donghui \| Guan, Huiping Amy \| Zhang, Zhiliu \| Zhen, Gong \| Yu, Haiyu \| Wu, Chengde \| ... \| Cheung, Mui ACS Medicinal Chemistry Letters, volume 9, issue 7, pages 623-628 (2018). 10.1021/acsmedchemlett.8b00035 Cited by (25) \| Cite \| Source
Erratum to: Genome co-amplification upregulates a mitotic gene network activity that predicts outcome and response to mitotic protein inhibitors in breast cancer (journal article) Hu, Zhi \| Mao, Jian-Hua \| Curtis, Christina \| Huang, Ge \| Gu, Shenda \| Heiser, Laura \| Lenburg, Marc E. \| Korkola, James E. \| Bayani, Nora \| Samarajiwa, Shamith \| ... \| Gray, Joe W. Breast Cancer Research, volume 19, issue 1 (2017). 10.1186/s13058-017-0809-6 Cited by (1) \| Cite \| Source \| Open Access
Characterization of In Vivo Resistance to Osimertinib and JNJ-61186372, an EGFR/Met Bispecific Antibody, Reveals Unique and Consensus Mechanisms of Resistance (journal article) Emdal, Kristina B. \| Dittmann, Antje \| Reddy, Raven J. \| Lescarbeau, Rebecca S. \| Moores, Sheri L. \| Laquerre, Sylvie \| White, Forest M. Molecular Cancer Therapeutics, volume 16, issue 11, pages 2572-2585 (2017). 10.1158/1535-7163.MCT-17-0413 Cited by (24) \| Cite \| Source
Discovery and Pharmacological Characterization of JNJ-42756493 (Erdafitinib), a Functionally Selective Small-Molecule FGFR Family Inhibitor (journal article) Perera, Timothy P.S. \| Jovcheva, Eleonora \| Mevellec, Laurence \| Vialard, Jorge \| De Lange, Desiree \| Verhulst, Tinne \| Paulussen, Caroline \| Van De Ven, Kelly \| King, Peter \| Freyne, Eddy \| ... \| Lorenzi, Matthew V. Molecular Cancer Therapeutics, volume 16, issue 6, pages 1010-1020 (2017). 10.1158/1535-7163.MCT-16-0589 Cited by (242) \| Cite \| Source \| Open Access
Fc-mediated activity of EGFR x c-Met bispecific antibody JNJ-61186372 enhanced killing of lung cancer cells (journal article) Grugan, Katharine D. \| Dorn, Keri \| Jarantow, Stephen W. \| Bushey, Barbara S. \| Pardinas, Jose R. \| Laquerre, Sylvie \| Moores, Sheri L. \| Chiu, Mark L. mAbs, volume 9, issue 1, pages 114-126 (2017). 10.1080/19420862.2016.1249079 Cited by (62) \| Cite \| Source \| Open Access
Genome co-amplification upregulates a mitotic gene network activity that predicts outcome and response to mitotic protein inhibitors in breast cancer (journal article) Hu, Zhi \| Mao, Jian-Hua \| Curtis, Christina \| Huang, Ge \| Gu, Shenda \| Heiser, Laura \| Lenburg, Marc E. \| Korkola, James E. \| Bayani, Nora \| Samarajiwa, Shamith \| ... \| Gray, Joe W. Breast Cancer Research, volume 18, issue 1 (2016). 10.1186/s13058-016-0728-y Cited by (11) \| Cite \| Source \| Open Access
Combination of inhibitor of B-Raf and inhibitor of AKT in the treatment of cancer (patent) Dumble, Melissa \| Gilmer, Tona \| Kumar, Rakesh \| Laquerre, Sylvie \| Lebowitz, Peter F. \| Morris, Shannon Renae Patent Number: 9402846 (2016) Cite \| Source
A Novel Bispecific Antibody Targeting EGFR and cMet Is Effective against EGFR Inhibitor–Resistant Lung Tumors (journal article) Moores, Sheri L. \| Chiu, Mark L. \| Bushey, Barbara S. \| Chevalier, Kristen \| Luistro, Leopoldo \| Dorn, Keri \| Brezski, Randall J. \| Haytko, Peter \| Kelly, Thomas \| Wu, Sheng-Jiun \| ... \| Anderson, G. Mark Cancer Research, volume 76, issue 13, pages 3942-3953 (2016). 10.1158/0008-5472.CAN-15-2833 Cited by (173) \| Cite \| Source \| Open Access
Pharmaceutical combination of MEK inhibitor and B-Raf inhibitors (patent) Dumble, Melissa \| Kumar, Rakesh \| Laquerre, Sylvie \| Lebowitz, Peter Patent Number: 8952018 (2015) Cited by (1) \| Cite \| Source
Combination of inhibitor of B-Raf and an inhibitor of Akt in the treatment of cancer (patent) Dumble, Melissa \| Gilmer, Tona \| Kumar, Rakesh \| Lebowitz, Peter F. \| Morris, Shannon Renae \| Laquerre, Sylvie Patent Number: 8835450 (2014) Cited by (1) \| Cite \| Source
Combination of a B-Raf inhibitor: N-{3-[5-(2-Amino-4-pyrimidinyl)-2-(1,1- dimethylethyl)-1,3-thiazol-4-yl]-2-fluorophenyl}-2,6-difluorobenzenesulfonamide and the Akt inhibitor: N-{ (1S)-2-amino-1-[(3- (patent) Dumble, Melissa \| Gilmer, Tona \| Kumar, Rakesh \| Lebowitz, Peter F. \| Morris, Shannon Renae \| Laquerre, Sylvie Patent Number: 8796298 (2014) Cited by (1) \| Cite \| Source
Pharmaceutical combination of MEK inhibitor and B-RAF inhibitors (patent) Dumble, Melissa \| Kumar, Rakesh \| Laquerre, Sylvie \| Lebowitz, Peter Patent Number: 8703781 (2014) Cite \| Source
Dabrafenib; Preclinical Characterization, Increased Efficacy when Combined with Trametinib, while BRAF/MEK Tool Combination Reduced Skin Lesions (journal article) King, Alastair J. \| Arnone, Marc R. \| Bleam, Maureen R. \| Moss, Katherine G. \| Yang, Jingsong \| Fedorowicz, Kelly E. \| Smitheman, Kimberly N. \| Erhardt, Joseph A. \| Hughes-Earle, Angela \| Kane-Carson, Laurie S. \| ... \| Laquerre, Sylvie G. PLoS ONE, volume 8, issue 7, pages e67583- (2013). 10.1371/journal.pone.0067583 Cited by (172) \| Cite \| Source \| Open Access
Discovery of Dabrafenib: A Selective Inhibitor of Raf Kinases with Antitumor Activity against B-Raf-Driven Tumors (journal article) Rheault, Tara R. \| Stellwagen, John C. \| Adjabeng, George M. \| Hornberger, Keith R. \| Petrov, Kimberly G. \| Waterson, Alex G. \| Dickerson, Scott H. \| Mook, Robert A. \| Laquerre, Sylvie G. \| King, Alastair J. \| ... \| Uehling, David E. ACS Medicinal Chemistry Letters, volume 4, issue 3, pages 358-362 (2013). 10.1021/ml4000063 Cited by (196) \| Cite \| Source \| Open Access
Combinations of BRAF, MEK, and PI3K/mTOR Inhibitors Overcome Acquired Resistance to the BRAF Inhibitor GSK2118436 Dabrafenib, Mediated by NRAS or MEK Mutations (journal article) Greger, James G. \| Eastman, Stephen D. \| Zhang, Vivian \| Bleam, Maureen R. \| Hughes, Ashley M. \| Smitheman, Kimberly N. \| Dickerson, Scott H. \| Laquerre, Sylvie G. \| Liu, Li \| Gilmer, Tona M. Molecular Cancer Therapeutics, volume 11, issue 4, pages 909-920 (2012). 10.1158/1535-7163.MCT-11-0989 Cited by (308) \| Cite \| Source \| Open Access