Edward C. Giardino

ScholarGPS® ID: 37671300405636

Affiliation

Johnson & Johnson, New Brunswick, New Jersey, United States

Affiliation History

Field

Physical Sciences and Mathematics

Discipline

Chemistry

Top Specialties

Medicinal Chemistry | Potassium Channel | Chemical Synthesis

Metrics Summary

Publication Count

Predicted Citations

792

Predicted h-index

Ranking

Publications and Citation History

Publications based on Top Specialties

Types of Publication

Publications
Books
Patents
NIH/NSF

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Animal model for evaluating vasomotor response in vivo (patent) Parry, Tom Jay \| Damiano, Bruce P. \| Giardino, Edward C. \| Connelly, Margery A. Patent Number: 8852556 (2014) Cite \| Source
High-content assays for evaluating cellular and hepatic diacylglycerol acyltransferase activity (journal article) Qi, Jenson \| Lang, Wensheng \| Giardino, Edward \| Caldwell, Gary W. \| Smith, Charles \| Minor, Lisa K. \| Darrow, Andrew L. \| Willemsens, Gustaaf \| DeWaepenaert, Katharina \| Roevens, Peter \| ... \| Connelly, Margery A. Journal of Lipid Research, volume 51, issue 12, pages 3559-3567 (2010). 10.1194/jlr.D008029 Cited by (21) \| Cite \| Source \| Open Access
Discovery and Clinical Evaluation of 1-{ N -[2-(Amidinoaminooxy)ethyl]amino}carbonylmethyl-6-methyl-3-[2,2-difluoro-2-phenylethylamino]pyrazinone (RWJ-671818), a Thrombin Inhibitor with an Oxyguanidine P1 Motif (journal article) Lu, Tianbao \| Markotan, Thomas \| Ballentine, Shelley K. \| Giardino, Edward C. \| Spurlino, John \| Brown, Kathryn \| Maryanoff, Bruce E. \| Tomczuk, Bruce E. \| Damiano, Bruce P. \| Shukla, Umesh \| ... \| Player, Mark R. Journal of Medicinal Chemistry, volume 53, issue 4, pages 1843-1856 (2010). 10.1021/jm901802n Cited by (30) \| Cite \| Source
Cooperative antithrombotic effect from the simultaneous inhibition of thrombin and factor Xa (journal article) Giardino, Edward C \| Haertlein, Barbara J \| de Garavilla, Lawrence \| Costanzo, Michael J \| Damiano, Bruce P \| Andrade-Gordon, Patricia \| Maryanoff, Bruce E Blood Coagulation & Fibrinolysis, volume 21, issue 2, pages 128-134 (2010). 10.1097/MBC.0b013e3283358100 Cited by (24) \| Cite \| Source
Torcetrapib Produces Endothelial Dysfunction Independent of Cholesteryl Ester Transfer Protein Inhibition (journal article) Connelly, Margery A \| Parry, Tom J \| Giardino, Edward C \| Huang, Zhihong \| Cheung, Wai-man \| Chen, Cailin \| Cools, Frank \| Van der Linde, Henk \| Gallacher, David J \| Kuo, Gee-Hong \| ... \| Damiano, Bruce P Journal of Cardiovascular Pharmacology, volume 55, issue 5, pages 459-468 (2010). 10.1097/FJC.0b013e3181cf03cb Cited by (42) \| Cite \| Source
Orally efficacious thrombin inhibitors with cyanofluorophenylacetamide as the P2 motif (journal article) Kreutter, Kevin D. \| Lu, Tianbao \| Lee, Lily \| Giardino, Edward C. \| Patel, Sharmila \| Huang, Hui \| Xu, Guozhang \| Fitzgerald, Mark \| Haertlein, Barbara J. \| Mohan, Venkatraman \| ... \| Player, Mark R. Bioorganic & Medicinal Chemistry Letters, volume 18, issue 9, pages 2865-2870 (2008). 10.1016/j.bmcl.2008.03.087 Cited by (29) \| Cite \| Source
7-Fluoroindazoles as Potent and Selective Inhibitors of Factor Xa (journal article) Lee, Yu-Kai \| Parks, Daniel J. \| Lu, Tianbao \| Thieu, Tho V. \| Markotan, Thomas \| Pan, Wenxi \| McComsey, David F. \| Milkiewicz, Karen L. \| Crysler, Carl S. \| Ninan, Nisha \| ... \| Player, Mark R. Journal of Medicinal Chemistry, volume 51, issue 2, pages 282-297 (2008). 10.1021/jm701217r Cited by (52) \| Cite \| Source
In-Depth Study of Tripeptide-Based α-Ketoheterocycles as Inhibitors of Thrombin. Effective Utilization of the S1 ‘ Subsite and Its Implications to Structure-Based Drug Design. (journal article) Costanzo, Michael J. \| Almond, Harold R. \| Hecker, Leonard R. \| Schott, Mary R. \| Yabut, Stephen C. \| Zhang, Han-Cheng \| Andrade-Gordon, Patricia \| Corcoran, Thomas W. \| Giardino, Edward C. \| Kauffman, Jack A. \| ... \| Maryanoff, Bruce E. Journal of Medicinal Chemistry, volume 50, issue 23, pages 5868-5868 (2007). 10.1021/jm701211q Cited by (1) \| Cite \| Source \| Open Access
Exploration of Potential Prodrugs of RWJ‐445167, an Oxyguanidine‐based Dual Inhibitor of Thrombin and Factor Xa (journal article) Maryanoff, Bruce E. \| McComsey, David F. \| Costanzo, Michael J. \| Yabut, Stephen C. \| Lu, Tianbao \| Player, Mark R. \| Giardino, Edward C. \| Damiano, Bruce P. Chemical Biology & Drug Design, volume 68, issue 1, pages 29-36 (2006). 10.1111/j.1747-0285.2006.00408.x Cited by (22) \| Cite \| Source \| Open Access
A Novel, Potent Dual Inhibitor of the Leukocyte Proteases Cathepsin G and Chymase (journal article) de Garavilla, Lawrence \| Greco, Michael N. \| Sukumar, Narayanasami \| Chen, Zhi-Wei \| Pineda, Agustin O. \| Mathews, F. Scott \| Di Cera, Enrico \| Giardino, Edward C. \| Wells, Grace I. \| Haertlein, Barbara J. \| ... \| Maryanoff, Bruce E. Journal of Biological Chemistry, volume 280, issue 18, pages 18001-18007 (2005). 10.1074/jbc.M501302200 Cited by (77) \| Cite \| Source \| Open Access
In-Depth Study of Tripeptide-Based α-Ketoheterocycles as Inhibitors of Thrombin. Effective Utilization of the S1 ‘ Subsite and Its Implications to Structure-Based Drug Design (journal article) Costanzo, Michael J. \| Almond, Harold R. \| Hecker, Leonard R. \| Schott, Mary R. \| Yabut, Stephen C. \| Zhang, Han-Cheng \| Andrade-Gordon, Patricia \| Corcoran, Thomas W. \| Giardino, Edward C. \| Kauffman, Jack A. \| ... \| Maryanoff, Bruce E. Journal of Medicinal Chemistry, volume 48, issue 6, pages 1984-2008 (2005). 10.1021/jm0303857 Cited by (57) \| Cite \| Source
Oxyguanidines. Part 2: Discovery of a novel orally active thrombin inhibitor through structure-based drug design and parallel synthesis (journal article) Lu, Tianbao \| Markotan, Thomas \| Coppo, Frank \| Tomczuk, Bruce \| Crysler, Carl \| Eisennagel, Stephen \| Spurlino, John \| Gremminger, Lisa \| Soll, Richard M \| Giardino, Edward C \| Bone, Roger Bioorganic & Medicinal Chemistry Letters, volume 14, issue 14, pages 3727-3731 (2004). 10.1016/j.bmcl.2004.05.002 Cited by (21) \| Cite \| Source
Antiplatelet and Antithrombotic Activity of RWJ-53308, A Novel Orally Active Glycoprotein IIb/IIIa Antagonist (journal article) Damiano, Bruce P \| Mitchell, John A \| Giardino, Edward \| Corcoran, Thomas \| Haertlein, Barbara J \| de Garavilla, Lawrence \| Kauffman, Jack A \| Hoekstra, William J \| Maryanoff, Bruce E \| Andrade-Gordon, Patricia Thrombosis Research, volume 104, issue 2, pages 113-126 (2001). 10.1016/S0049-3848(01)00353-X Cited by (29) \| Cite \| Source
Administration of a potent antagonist of protease-activated receptor-1 (PAR-1) attenuates vascular restenosis following balloon angioplasty in rats. (journal article) Andrade-Gordon, P \| Derian, C K \| Maryanoff, B E \| Zhang, H C \| Addo, M F \| Damiano, B P \| D'Andrea, M R \| Darrow, A L \| de Garavilla, L \| Eckardt, A J \| ... \| McComsey, D F The Journal of pharmacology and experimental therapeutics, volume 298, issue 1 (2001). Cited by (40) \| Cite
Antithrombotic Properties of RWJ-50353, a Potent and Novel Thrombin Inhibitor* (journal article) Giardino, Edward C. \| Costanzo, Michael J. \| Kauffman, Jack A. \| Li, Quan Sheng \| Maryanoff, Bruce E. \| Andrade-Gordon, Patricia Thrombosis Research, volume 98, issue 1, pages 83-93 (2000). 10.1016/S0049-3848(99)00219-4 Cited by (17) \| Cite \| Source
Cardiovascular Profile of RWJ 29009, a New Potassium Channel Activator, in Anesthetized and Conscious Dogs (journal article) Damiano, Bruce P. \| Giardino, Edward C. \| Haertlein, Barbara J. \| Stump, Gary L. \| Mitchell, John A. \| Falotico, Robert Journal of Cardiovascular Pharmacology, volume 2, issue 2, pages 300-310 (1994). 10.1097/00005344-199411000-00018 Cite \| Source
Cardiovascular Profile of RWJ 29009, a New Potassium Channel Activator, in Anesthetized and Conscious Dogs (journal article) Damiano, Bruce P. \| Giardino, Edward C. \| Haertlein, Barbara J. \| Stump, Gary L. \| Mitchell, John A. \| Falotico, Robert Journal of Cardiovascular Pharmacology, volume 23, issue 2, pages 300-310 (1994). 10.1097/00005344-199402000-00018 Cited by (7) \| Cite \| Source \| Open Access
Novel thieno[2,3-b]- and [3,4-b]pyrans as potassium channel openers. Thiophene systems—XVII (journal article) Press, Jeffery B. \| McNally, James J. \| Sanfilippo, Pauline J. \| Addo, Michael F. \| Loughney, Deborah \| Giardino, Edward \| Katz, Laurence B. \| Falotico, Robert \| Haertlein, Barbara J. Bioorganic & Medicinal Chemistry, volume 1, issue 6, pages 423-435 (1993). 10.1016/S0968-0896(00)82153-7 Cited by (5) \| Cite \| Source
Thiopene systems. 15. Synthesis and antihypertensive activity of 7- (subsituted benzamido)-6-hydroxythieno[3,2,-b]pyrans as nwe potassium channel activitors (journal article) Sanfilippo, Pauline J. \| McNally, James J. \| Press, Jeffery B. \| Falotico, Robert \| Giardino, Edward \| Katz, Lawrence B. Bioorganic & Medicinal Chemistry Letters, volume 3, issue 6, pages 1385-1388 (1993). 10.1016/S0960-894X(00)80354-6 Cited by (8) \| Cite \| Source
RWJ 26629, a new potassium channel opener and vascular smooth muscle relaxant: a potential antihypertensive and antianginal agent. (journal article) Katz, L B \| Giardino, E C \| Salata, J J \| Moore, J B \| Falotico, R The Journal of pharmacology and experimental therapeutics, volume 267, issue 2 (1993). Cited by (1) \| Cite