Whitney Shatz

ScholarGPS® ID: 37616713345050

Affiliation

Genentech, Inc., South San Francisco, United States

Affiliation History

Field

Physical Sciences and Mathematics

Discipline

Chemistry

Top Specialties

Antibody | Bispecific Monoclonal Antibody

Metrics Summary

Publication Count

Predicted Citations

924

Predicted h-index

Ranking

Publications and Citation History

Publications based on Top Specialties

Types of Publication

Publications
Books
Patents
NIH/NSF

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Nanolipoprotein particles for co-delivery of cystine-knot peptides and Fab–based therapeutics (journal article) Darwish, Martine \| Gao, Xinxin \| Shatz, Whitney \| Li, Hong \| Lin, May \| Franke, Yvonne \| Tam, Christine \| Mortara, Kyle \| Zilberleyb, Inna \| Hannoush, Rami N. \| Blanchette, Craig Nanoscale Advances, volume 3, issue 13, pages 3929-3941 (2021). 10.1039/D1NA00218J Cite \| Source
Fab-Nanolipoprotein Conjugate Causes Vitreous Opacity and Cataracts Following a Single Intravitreal Administration in New Zealand White Rabbits (journal article) Tassew, Nardos G. \| Laing, Steven T. \| Shatz, Whitney \| Crowell, Susan R. \| Loyet, Kelly M. \| Schuetz, Chris \| Blanchette, Craig Toxicologic Pathology, volume 49, issue 3, pages 647-655 (2021). 10.1177/0192623320969671 Cite \| Source
Nanolipoprotein Particles as a Delivery Platform for Fab Based Therapeutics (journal article) Darwish, Martine \| Shatz, Whitney \| Leonard, Brandon \| Loyet, Kelly \| Barrett, Kathy \| Wong, Janice L. \| Li, Hong \| Abraham, Ryan \| Lin, May \| Franke, Yvonne \| ... \| Blanchette, Craig Bioconjugate Chemistry, volume 31, issue 8, pages 1995-2007 (2020). 10.1021/acs.bioconjchem.0c00349 Cited by (12) \| Cite \| Source
Data on charge separation of bispecific and mispaired IgGs using native charge-variant mass spectrometry (journal article) Phung, Wilson \| Han, Guanghui \| Polderdijk, Stéphanie G.I. \| Dillon, Michael \| Shatz, Whitney \| Liu, Peter \| Wei, Bingchuan \| Suresh, Pawankumar \| Fischer, David \| Spiess, Christoph \| ... \| Sandoval, Wendy Data in Brief, volume 30 (2020). 10.1016/j.dib.2020.105435 Cited by (6) \| Cite \| Source
Anti-factor D antibody variant conjugates and uses thereof (patent) Hass, Philip E. \| Kelley, Robert F. \| Scheer, Justin M. \| Shatz, Whitney \| Tesar, Devin \| van Lookeren Campagne, Menno Patent Number: 10654932 (2020) Cite \| Source
Characterization of bispecific and mispaired IgGs by native charge-variant mass spectrometry (journal article) Phung, Wilson \| Han, Guanghui \| Polderdijk, Stéphanie G.I. \| Dillon, Michael \| Shatz, Whitney \| Liu, Peter \| Wei, Bingchuan \| Suresh, Pawankumar \| Fischer, David \| Spiess, Christoph \| ... \| Sandoval, Wendy International Journal of Mass Spectrometry, volume 446 (2019). 10.1016/j.ijms.2019.116229 Cited by (12) \| Cite \| Source
Influence of Charge, Hydrophobicity, and Size on Vitreous Pharmacokinetics of Large Molecules (journal article) Crowell, Susan R. \| Wang, Kathryn \| Famili, Amin \| Shatz, Whitney \| Loyet, Kelly M. \| Chang, Vincent \| Liu, Yanqiu \| Prabhu, Saileta \| Kamath, Amrita V. \| Kelley, Robert F. Translational Vision Science & Technology, volume 8, issue 6, pages 1- (2019). 10.1167/tvst.8.6.1 Cited by (42) \| Cite \| Source
Anti-factor D antibodies and conjugates (patent) Kelley, Robert F. \| Shatz, Whitney \| Tesar, Devin \| Scheer, Justin M. \| Dion, Michelle Patent Number: 10407510 (2019) Cite \| Source
Identification and characterization of an octameric PEG-protein conjugate system for intravitreal long-acting delivery to the back of the eye (journal article) Shatz, Whitney \| Hass, Philip E. \| Peer, Nikhil \| Paluch, Maciej T. \| Blanchette, Craig \| Han, Guanghui \| Sandoval, Wendy \| Morando, Ashley \| Loyet, Kelly M. \| Bantseev, Vladimir \| ... \| Kelley, Robert F. PLOS ONE, volume 14, issue 6, pages e0218613- (2019). 10.1371/journal.pone.0218613 Cited by (20) \| Cite \| Source
In Vivo Stability Profiles of Anti-factor D Molecules Support Long-Acting Delivery Approaches (journal article) Loyet, Kelly M. \| Hass, Philip E. \| Sandoval, Wendy N. \| Morando, Ashley \| Liu, Peter \| Shatz, Whitney \| Dickmann, Leslie \| Kenrick, Margaret \| Good, Jeremy \| Davancaze, Teresa \| ... \| Scheer, Justin M. Molecular Pharmaceutics, volume 16, issue 1, pages 86-95 (2019). 10.1021/acs.molpharmaceut.8b00871 Cited by (6) \| Cite \| Source
Strategies for modifying drug residence time and ocular bioavailability to decrease treatment frequency for back of the eye diseases (journal article) Shatz, Whitney \| Aaronson, Jeffrey \| Yohe, Stefan \| Kelley, Robert F. \| Kalia, Yogeshvar N. Expert Opinion on Drug Delivery, volume 16, issue 1, pages 43-57 (2019). 10.1080/17425247.2019.1553953 Cited by (21) \| Cite \| Source
Impact of polymer geometry on the interactions of protein-PEG conjugates (journal article) Zarzar, Jonathan \| Shatz, Whitney \| Peer, Nikhil \| Taing, Rosalynn \| McGarry, Brian \| Liu, Yun \| Greene, Daniel G. \| Zarraga, Isidro E. Biophysical Chemistry, volume 236 (2018). 10.1016/j.bpc.2017.10.003 Cited by (14) \| Cite \| Source
Protein engineering to increase the potential of a therapeutic antibody Fab for long-acting delivery to the eye (journal article) Tesar, Devin \| Luoma, Jacob \| Wyatt, Emily A. \| Shi, Catherine \| Shatz, Whitney \| Hass, Philip E. \| Mathieu, Mary \| Yi, Li \| Corn, Jacob E. \| Maass, Katie F. \| ... \| Kelley, Robert F. mAbs, volume 9, issue 8, pages 1297-1305 (2017). 10.1080/19420862.2017.1372078 Cited by (17) \| Cite \| Source \| Open Access
An efficient route to bispecific antibody production using single-reactor mammalian co-culture (journal article) Shatz, Whitney \| Ng, Domingos \| Dutina, George \| Wong, Athena W. \| Dunshee, Diana Ronai \| Sonoda, Junichiro \| Shen, Amy \| Scheer, Justin M. mAbs, volume 8, issue 8, pages 1487-1497 (2016). 10.1080/19420862.2016.1234569 Cited by (16) \| Cite \| Source \| Open Access
Contribution of Antibody Hydrodynamic Size to Vitreal Clearance Revealed through Rabbit Studies Using a Species-Matched Fab (journal article) Shatz, Whitney \| Hass, Philip E. \| Mathieu, Mary \| Kim, Hok Seon \| Leach, Kim \| Zhou, Michelle \| Crawford, Yongping \| Shen, Amy \| Wang, Kathryn \| Chang, Debby P. \| ... \| Kelley, Robert F. Molecular Pharmaceutics, volume 13, issue 9, pages 2996-3003 (2016). 10.1021/acs.molpharmaceut.6b00345 Cited by (63) \| Cite \| Source
Design and Pharmacokinetic Characterization of Novel Antibody Formats for Ocular Therapeutics (journal article) Gadkar, Kapil \| Pastuskovas, Cinthia V. \| Le Couter, Jennifer E. \| Elliott, J. Michael \| Zhang, Jianhuan \| Lee, Chingwei V. \| Sanowar, Sarah \| Fuh, Germaine \| Kim, Hok Seon \| Lombana, T. Noelle \| ... \| Scheer, Justin M. Investigative Opthalmology & Visual Science, volume 56, issue 9, pages 5390- (2015). 10.1167/iovs.15-17108 Cited by (59) \| Cite \| Source \| Open Access
Knobs-into-holes antibody production in mammalian cell lines reveals that asymmetric afucosylation is sufficient for full antibody-dependent cellular cytotoxicity (journal article) Shatz, Whitney \| Chung, Shan \| Li, Bing \| Marshall, Brett \| Tejada, Max \| Phung, Wilson \| Sandoval, Wendy \| Kelley, Robert F \| Scheer, Justin M mAbs, volume 5, issue 6, pages 872-881 (2013). 10.4161/mabs.26307 Cited by (68) \| Cite \| Source \| Open Access
Development of a Human IgG4 Bispecific Antibody for Dual Targeting of Interleukin-4 (IL-4) and Interleukin-13 (IL-13) Cytokines (journal article) Spiess, Christoph \| Bevers, Jack \| Jackman, Janet \| Chiang, Nancy \| Nakamura, Gerald \| Dillon, Michael \| Liu, Hongbin \| Molina, Patricia \| Elliott, J. Michael \| Shatz, Whitney \| ... \| Wu, Lawren C. Journal of Biological Chemistry, volume 288, issue 37, pages 26583-26593 (2013). 10.1074/jbc.M113.480483 Cited by (60) \| Cite \| Source \| Open Access
Bispecific antibodies with natural architecture produced by co-culture of bacteria expressing two distinct half-antibodies (journal article) Spiess, Christoph \| Merchant, Mark \| Huang, Arthur \| Zheng, Zhong \| Yang, Nai-Ying \| Peng, Jing \| Ellerman, Diego \| Shatz, Whitney \| Reilly, Dorothea \| Yansura, Daniel G \| Scheer, Justin M Nature Biotechnology, volume 31, issue 8, pages 753-758 (2013). 10.1038/nbt.2621 Cited by (232) \| Cite \| Source
Long-Range Structural and Dynamical Changes Induced by Cofactor Binding in DNA Methyltransferase M.HhaI (journal article) Zhou, Hongjun \| Shatz, Whitney \| Purdy, Matthew M. \| Fera, Nick \| Dahlquist, Frederick W. \| Reich, Norbert O. Biochemistry, volume 46, issue 24, pages 7261-7268 (2007). 10.1021/bi602662e Cited by (13) \| Cite \| Source