Carl Crysler

ScholarGPS® ID: 37356418916024

Affiliation
Johnson & Johnson, New Brunswick, New Jersey, United States
Affiliation History

Field
Physical Sciences and Mathematics
Discipline
Chemistry
Top Specialties
Medicinal Chemistry | Chemical Synthesis | Integrin | Protein Kinase Inhibitor
Metrics Summary
Publication Count
36
Predicted Citations
1,494
Predicted h-index
23
Ranking

Publications and Citation History

Publications based on Top Specialties

Types of Publication

  • Publications
  • Books
  • Patents
  • NIH/NSF
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Methods of treatment using allosteric processing inhibitors for matrix metalloproteinases (patent)
Leonard, Kristi A. | Alexander, Richard Scott | Barbay, Joseph Kent | Bone, Roger F. | Crysler, Carl | Deckman, Ingrid Christa | Jackson, Paul F. | Kuo, Lawrence C. | Lewandowski, Frank A. | Maguire, Diane M. | ... | Wang, Aihua
Patent Number: 8883473 (2014)
Cited by (3) | Cite | Source
Enhancement of kinase selectivity in a potent class of arylamide FMS inhibitors (journal article)
Illig, Carl R. | Manthey, Carl L. | Meegalla, Sanath K. | Wall, Mark J. | Chen, Jinsheng | Wilson, Kenneth J. | DesJarlais, Renee L. | Ballentine, Shelley K. | Schubert, Carsten | Crysler, Carl S. | ... | Tomczuk, Bruce E.
Bioorganic & Medicinal Chemistry Letters, volume 23, issue 23, pages 6363-6369 (2013).
10.1016/j.bmcl.2013.09.061
Cited by (3) | Cite | Source
A novel series of N-(azetidin-3-yl)-2-(heteroarylamino)acetamide CCR2 antagonists (journal article)
Subasinghe, Nalin L. | Lanter, James | Markotan, Thomas | Opas, Evan | McKenney, Sandra | Crysler, Carl | Hou, Cuifen | O’Neill, John | Johnson, Dana | Sui, Zhihua
Bioorganic & Medicinal Chemistry Letters, volume 23, issue 4, pages 1063-1069 (2013).
10.1016/j.bmcl.2012.12.017
Cited by (19) | Cite | Source
Design and synthesis of polyethylene glycol-modified biphenylsulfonyl-thiophene-carboxamidine inhibitors of the complement component C1s (journal article)
Subasinghe, Nalin L. | Khalil, Ehab | Travins, Jeremy M. | Ali, Farah | Ballentine, Shelley K. | Hufnagel, Heather R. | Pan, Wenxi | Leonard, Kristi | Bone, Roger F. | Soll, Richard M. | ... | Gaul, Michael D.
Bioorganic & Medicinal Chemistry Letters, volume 22, issue 16, pages 5303-5307 (2012).
10.1016/j.bmcl.2012.06.030
Cited by (12) | Cite | Source
The discovery of novel cyclohexylamide CCR2 antagonists (journal article)
Lanter, James C. | Markotan, Thomas P. | Zhang, Xuqing | Subasinghe, Nalin | Kang, Fu-An | Hou, Cuifen | Singer, Monica | Opas, Evan | McKenney, Sandra | Crysler, Carl | ... | Sui, Zhihua
Bioorganic & Medicinal Chemistry Letters, volume 21, issue 24, pages 7496-7501 (2011).
10.1016/j.bmcl.2011.09.113
Cited by (9) | Cite | Source
Optimization of a Potent Class of Arylamide Colony-Stimulating Factor-1 Receptor Inhibitors Leading to Anti-inflammatory Clinical Candidate 4-Cyano- N -[2-(1-cyclohexen-1-yl)-4-[1-[(dimethylamino)acetyl]-4-piperidinyl]phenyl]-1 H -imidazole-2-carboxamide (journal article)
Illig, Carl R. | Manthey, Carl L. | Wall, Mark J. | Meegalla, Sanath K. | Chen, Jinsheng | Wilson, Kenneth J. | Ballentine, Shelley K. | DesJarlais, Renee L. | Schubert, Carsten | Crysler, Carl S. | ... | Tomczuk, Bruce E.
Journal of Medicinal Chemistry, volume 54, issue 22, pages 7860-7883 (2011).
10.1021/jm200900q
Cited by (32) | Cite | Source
Design, synthesis and SAR of indazole and benzoisoxazole containing 4-azetidinyl-1-aryl-cyclohexanes as CCR2 antagonists (journal article)
Zhang, Xuqing | Hufnagel, Heather | Hou, Cuifen | Opas, Evan | McKenney, Sandra | Crysler, Carl | O’Neill, John | Johnson, Dana | Sui, Zhihua
Bioorganic & Medicinal Chemistry Letters, volume 21, issue 20, pages 6042-6048 (2011).
10.1016/j.bmcl.2011.08.074
Cited by (12) | Cite | Source
Overcoming hERG activity in the discovery of a series of 4-azetidinyl-1-aryl-cyclohexanes as CCR2 antagonists (journal article)
Zhang, Xuqing | Hufnagel, Heather | Markotan, Thomas | Lanter, James | Cai, Chaozhong | Hou, Cuifen | Singer, Monica | Opas, Evan | McKenney, Sandra | Crysler, Carl | ... | Sui, Zhihua
Bioorganic & Medicinal Chemistry Letters, volume 21, issue 18, pages 5577-5582 (2011).
10.1016/j.bmcl.2011.06.080
Cited by (19) | Cite | Source
Potency variation of small-molecule chymase inhibitors across species (journal article)
Kervinen, Jukka | Crysler, Carl | Bayoumy, Shariff | Abad, Marta C. | Spurlino, John | Deckman, Ingrid | Greco, Michael N. | Maryanoff, Bruce E. | de Garavilla, Lawrence
Biochemical Pharmacology, volume 80, issue 7, pages 1033-1041 (2010).
10.1016/j.bcp.2010.06.014
Cited by (24) | Cite | Source
Reducing ion channel activity in a series of 4-heterocyclic arylamide FMS inhibitors (journal article)
Wilson, Kenneth J. | Illig, Carl R. | Chen, Jinsheng | Wall, Mark J. | Ballentine, Shelley K. | DesJarlais, Renee L. | Chen, Yanmin | Schubert, Carsten | Donatelli, Robert | Petrounia, Ioanna | ... | Meegalla, Sanath K.
Bioorganic & Medicinal Chemistry Letters, volume 20, issue 13, pages 3925-3929 (2010).
10.1016/j.bmcl.2010.05.013
Cited by (11) | Cite | Source
JNJ-28312141, a novel orally active colony-stimulating factor-1 receptor/FMS-related receptor tyrosine kinase-3 receptor tyrosine kinase inhibitor with potential utility in solid tumors, bone metastases, and acute myeloid leukemia (journal article)
Manthey, Carl L. | Johnson, Dana L. | Illig, Carl R. | Tuman, Robert W. | Zhou, Zhao | Baker, Judith F. | Chaikin, Margery A. | Donatelli, Robert R. | Franks, Carol F. | Zeng, Lee | ... | Molloy, Christopher J.
Molecular Cancer Therapeutics, volume 8, issue 11, pages 3151-3161 (2009).
10.1158/1535-7163.MCT-09-0255
Cited by (96) | Cite | Source | Open Access
Pyrido[2,3- d ]pyrimidin-5-ones: A Novel Class of Antiinflammatory Macrophage Colony-Stimulating Factor-1 Receptor Inhibitors (journal article)
Huang, Hui | Hutta, Daniel A. | Rinker, James M. | Hu, Huaping | Parsons, William H. | Schubert, Carsten | DesJarlais, Renee L. | Crysler, Carl S. | Chaikin, Margery A. | Donatelli, Robert R. | ... | Player, Mark R.
Journal of Medicinal Chemistry, volume 52, issue 4, pages 1081-1099 (2009).
10.1021/jm801406h
Cited by (40) | Cite | Source
Structure-based optimization of a potent class of arylamide FMS inhibitors (journal article)
Meegalla, Sanath K. | Wall, Mark J. | Chen, Jinsheng | Wilson, Kenneth J. | Ballentine, Shelley K. | DesJarlais, Renee L. | Schubert, Carsten | Crysler, Carl S. | Chen, Yanmin | Molloy, Christopher J. | ... | Illig, Carl R.
Bioorganic & Medicinal Chemistry Letters, volume 18, issue 12, pages 3632-3637 (2008).
10.1016/j.bmcl.2008.04.059
Cited by (30) | Cite | Source
Orally efficacious thrombin inhibitors with cyanofluorophenylacetamide as the P2 motif (journal article)
Kreutter, Kevin D. | Lu, Tianbao | Lee, Lily | Giardino, Edward C. | Patel, Sharmila | Huang, Hui | Xu, Guozhang | Fitzgerald, Mark | Haertlein, Barbara J. | Mohan, Venkatraman | ... | Player, Mark R.
Bioorganic & Medicinal Chemistry Letters, volume 18, issue 9, pages 2865-2870 (2008).
10.1016/j.bmcl.2008.03.087
Cited by (29) | Cite | Source
Carboxylic acid bioisosteres acylsulfonamides, acylsulfamides, and sulfonylureas as novel antagonists of the CXCR2 receptor (journal article)
Winters, Michael P. | Crysler, Carl | Subasinghe, Nalin | Ryan, Declan | Leong, Lynette | Zhao, Shuyuan | Donatelli, Robert | Yurkow, Edward | Mazzulla, Marie | Boczon, Lisa | ... | Tomczuk, Bruce
Bioorganic & Medicinal Chemistry Letters, volume 18, issue 6, pages 1926-1930 (2008).
10.1016/j.bmcl.2008.01.127
Cited by (27) | Cite | Source
Synthesis and evaluation of novel 3,4,6-substituted 2-quinolones as FMS kinase inhibitors (journal article)
Wall, Mark J. | Chen, Jinsheng | Meegalla, Sanath | Ballentine, Shelley K. | Wilson, Kenneth J. | DesJarlais, Renee L. | Schubert, Carsten | Chaikin, Margery A. | Crysler, Carl | Petrounia, Ioanna P. | ... | Illig, Carl R.
Bioorganic & Medicinal Chemistry Letters, volume 18, issue 6, pages 2097-2102 (2008).
10.1016/j.bmcl.2008.01.088
Cited by (47) | Cite | Source
Biphenylsulfonyl-thiophene-carboxamidine inhibitors of the complement component C1s (journal article)
Travins, Jeremy M. | Ali, Farah | Huang, Hui | Ballentine, Shelley K. | Khalil, Ehab | Hufnagel, Heather R. | Pan, Wenxi | Gushue, Joan | Leonard, Kristi | Bone, Roger F. | ... | Subasinghe, Nalin L.
Bioorganic & Medicinal Chemistry Letters, volume 18, issue 5, pages 1603-1606 (2008).
10.1016/j.bmcl.2008.01.064
Cited by (16) | Cite | Source
Discovery of novel FMS kinase inhibitors as anti-inflammatory agents (journal article)
Illig, Carl R. | Chen, Jinsheng | Wall, Mark J. | Wilson, Kenneth J. | Ballentine, Shelley K. | Rudolph, M. Jonathan | DesJarlais, Renee L. | Chen, Yanmin | Schubert, Carsten | Petrounia, Ioanna | ... | Meegalla, Sanath K.
Bioorganic & Medicinal Chemistry Letters, volume 18, issue 5, pages 1642-1648 (2008).
10.1016/j.bmcl.2008.01.059
Cited by (44) | Cite | Source
7-Fluoroindazoles as Potent and Selective Inhibitors of Factor Xa (journal article)
Lee, Yu-Kai | Parks, Daniel J. | Lu, Tianbao | Thieu, Tho V. | Markotan, Thomas | Pan, Wenxi | McComsey, David F. | Milkiewicz, Karen L. | Crysler, Carl S. | Ninan, Nisha | ... | Player, Mark R.
Journal of Medicinal Chemistry, volume 51, issue 2, pages 282-297 (2008).
10.1021/jm701217r
Cited by (52) | Cite | Source
Structural Basis for Elastolytic Substrate Specificity in Rodent α-Chymases (journal article)
Kervinen, Jukka | Abad, Marta | Crysler, Carl | Kolpak, Michael | Mahan, Andrew D. | Masucci, John A. | Bayoumy, Shariff | Cummings, Maxwell D. | Yao, Xiang | Olson, Matthew | ... | Spurlino, John
Journal of Biological Chemistry, volume 283, issue 1, pages 427-436 (2008).
10.1074/jbc.M707157200
Cited by (16) | Cite | Source | Open Access