Robert H. Gruninger

ScholarGPS® ID: 37220033323392

Affiliation
Janssen Pharmaceutica
Affiliation History

Field
Physical Sciences and Mathematics
Discipline
Chemistry
Top Specialties
Medicinal Chemistry | Protein Kinase Inhibitor | Chemical Synthesis
Metrics Summary
Publication Count
22
Predicted Citations
1,290
Predicted h-index
20
Ranking

Publications and Citation History

Publications based on Top Specialties

Types of Publication

  • Publications
  • Books
  • Patents
  • NIH/NSF
You must register and claim your profile to add or remove publications from it.
... publications
FILTER BY:
Year
Type
Specialty
Affiliations
Access
Co-Authors
Add
Delete
1,2,4-triazolylaminoaryl (heteroaryl) sulfonamide derivatives (patent)
Huang, Shenlin | Lin, Ronghui | Connolly, Peter J. | Emanuel, Stuart L. | Middleton, Steven A. | Gruninger, Robert H. | Wetter, Steven K.
Patent Number: 8299082 (2012)
Cite | Source
1,2,4-Triazolylaminoaryl (heteroaryl) sulfonamide derivatives (patent)
Huang, Shenlin | Lin, Ronghui | Connolly, Peter J. | Emanuel, Stuart L. | Middleton, Steven A. | Gruninger, Robert H. | Wetter, Steven K.
Patent Number: 7888380 (2011)
Cited by (2) | Cite | Source
4-Amino-6-arylamino-pyrimidine-5-carbaldehyde hydrazones as potent ErbB-2/EGFR dual kinase inhibitors (journal article)
Xu, Guozhang | Abad, Marta C. | Connolly, Peter J. | Neeper, Michael P. | Struble, Geoffrey T. | Springer, Barry A. | Emanuel, Stuart L. | Pandey, Niranjan | Gruninger, Robert H. | Adams, Mary | ... | Middleton, Steven A.
Bioorganic & Medicinal Chemistry Letters, volume 18, issue 16, pages 4615-4619 (2008).
10.1016/j.bmcl.2008.07.020
Cited by (63) | Cite | Source
Discovery of novel 4-amino-6-arylaminopyrimidine-5-carbaldehyde oximes as dual inhibitors of EGFR and ErbB-2 protein tyrosine kinases (journal article)
Xu, Guozhang | Searle, Lily Lee | Hughes, Terry V. | Beck, Amanda K. | Connolly, Peter J. | Abad, Marta C. | Neeper, Michael P. | Struble, Geoffrey T. | Springer, Barry A. | Emanuel, Stuart L. | ... | Greenberger, Lee M.
Bioorganic & Medicinal Chemistry Letters, volume 18, issue 12, pages 3495-3499 (2008).
10.1016/j.bmcl.2008.05.024
Cited by (43) | Cite | Source
Cellular and in Vivo Activity of JNJ-28871063, A Nonquinazoline Pan-ErbB Kinase Inhibitor That Crosses the Blood-Brain Barrier and Displays Efficacy against Intracranial Tumors (journal article)
Emanuel, S. L. | Hughes, T. V. | Adams, M. | Rugg, C. A. | Fuentes-Pesquera, A. | Connolly, P. J. | Pandey, N. | Moreno-Mazza, S. | Butler, J. | Borowski, V. | ... | Greenberger, L. M.
Molecular Pharmacology, volume 73, issue 2, pages 338-348 (2008).
10.1124/mol.107.041236
Cited by (34) | Cite | Source | Open Access
Substituted triazole diamine derivatives as kinase inhibitors (patent)
Lin, Ronghui | Huang, Shenlin | Wetter, Steven K. | Connolly, Peter J. | Emanuel, Stuart L. | Gruninger, Robert H. | Middleton, Steven A.
Patent Number: 7317031 (2008)
Cited by (17) | Cite | Source
Synthesis and evaluation of pyrazolo[3,4-b]pyridine CDK1 inhibitors as anti-tumor agents (journal article)
Lin, Ronghui | Connolly, Peter J. | Lu, Yanhua | Chiu, George | Li, Shengjian | Yu, Yang | Huang, Shenlin | Li, Xun | Emanuel, Stuart L. | Middleton, Steven A. | ... | Greenberger, Lee M.
Bioorganic & Medicinal Chemistry Letters, volume 17, issue 15, pages 4297-4302 (2007).
10.1016/j.bmcl.2007.05.029
Cited by (133) | Cite | Source
4-Aryl-5-cyano-2-aminopyrimidines as VEGF-R2 inhibitors: Synthesis and biological evaluation (journal article)
Hughes, Terry V. | Emanuel, Stuart L. | Beck, Amanda K. | Wetter, Steven K. | Connolly, Peter J. | Karnachi, Prabha | Reuman, Michael | Seraj, Jabed | Fuentes-Pesquera, Angel R. | Gruninger, Robert H. | ... | Moffat, David F.C.
Bioorganic & Medicinal Chemistry Letters, volume 17, issue 12, pages 3266-3270 (2007).
10.1016/j.bmcl.2007.04.021
Cited by (42) | Cite | Source
Synthesis and biological study of 2-amino-4-aryl-5-chloropyrimidine analogues as inhibitors of VEGFR-2 and cyclin dependent kinase 1 (CDK1) (journal article)
Huang, Shenlin | Li, Ronghua | Connolly, Peter J. | Emanuel, Stuart | Fuentes-Pesquera, Angel | Adams, Mary | Gruninger, Robert H. | Seraj, Jabed | Middleton, Steven A. | Davis, Jeremy M. | Moffat, David F.C.
Bioorganic & Medicinal Chemistry Letters, volume 17, issue 8, pages 2179-2183 (2007).
10.1016/j.bmcl.2007.01.086
Cited by (13) | Cite | Source
Amino substituted pyridinyl methanone compounds useful in treating kinase disorders (patent)
Lin, Ronghui | Wetter, Steven K. | Lu, Yanhua | Connolly, Peter J. | Emanuel, Stuart | Gruninger, Robert H. | Middleton, Steven A.
Patent Number: 7109220 (2006)
Cite | Source
(6,7-Dimethoxy-2,4-dihydroindeno[1,2- c ]pyrazol-3-yl)phenylamines: Platelet-Derived Growth Factor Receptor Tyrosine Kinase Inhibitors with Broad Antiproliferative Activity against Tumor Cells (journal article)
Ho, Chih Y. | Ludovici, Donald W. | Maharoof, Umar S. M. | Mei, Jay | Sechler, Jan L. | Tuman, Robert W. | Strobel, Eric D. | Andraka, Laura | Yen, Hwa-Kwo | Leo, Gregory | ... | Galemmo, Robert A.
Journal of Medicinal Chemistry, volume 48, issue 26, pages 8163-8173 (2005).
10.1021/jm050680m
Cited by (34) | Cite | Source
The In vitro and In vivo Effects of JNJ-7706621: A Dual Inhibitor of Cyclin-Dependent Kinases and Aurora Kinases (journal article)
Emanuel, Stuart | Rugg, Catherine A. | Gruninger, Robert H. | Lin, Ronghui | Fuentes-Pesquera, Angel | Connolly, Peter J. | Wetter, Steven K. | Hollister, Beth | Kruger, Walter W. | Napier, Cheryl | ... | Middleton, Steven A.
Cancer Research, volume 65, issue 19, pages 9038-9046 (2005).
10.1158/0008-5472.CAN-05-0882
Cited by (103) | Cite | Source | Open Access
Substituted triazole diamine derivatives as kinase inhibitors (patent)
Lin, Ronghui | Connolly, Peter J. | Wetter, Steven K. | Huang, Shenlin | Emanuel, Stuart L. | Gruninger, Robert H. | Middleton, Steven A.
Patent Number: 6924302 (2005)
Cited by (9) | Cite | Source
Synthesis and Structure−Activity Relationships of Pyrazine-Pyridine Biheteroaryls as Novel, Potent, and Selective Vascular Endothelial Growth Factor Receptor-2 Inhibitors (journal article)
Kuo, Gee-Hong | Prouty, Catherine | Wang, Aihua | Emanuel, Stuart | DeAngelis, Alan | Zhang, Yan | Song, Fengbin | Beall, Lawrence | Connolly, Peter J. | Karnachi, Prahba | ... | Murray, William V.
Journal of Medicinal Chemistry, volume 48, issue 15, pages 4892-4909 (2005).
10.1021/jm058205b
Cited by (31) | Cite | Source
Synthesis and Identification of [1,3,5]Triazine-pyridine Biheteroaryl as a Novel Series of Potent Cyclin-Dependent Kinase Inhibitors (journal article)
Kuo, Gee-Hong | DeAngelis, Alan | Emanuel, Stuart | Wang, Aihua | Zhang, Yan | Connolly, Peter J. | Chen, Xin | Gruninger, Robert H. | Rugg, Catherine | Fuentes-Pesquera, Angel | ... | Murray, William V.
Journal of Medicinal Chemistry, volume 48, issue 14, pages 4535-4546 (2005).
10.1021/jm040214h
Cited by (81) | Cite | Source
1-Acyl-1 H -[1,2,4]triazole-3,5-diamine Analogues as Novel and Potent Anticancer Cyclin-Dependent Kinase Inhibitors:  Synthesis and Evaluation of Biological Activities (journal article)
Lin, Ronghui | Connolly, Peter J. | Huang, Shenlin | Wetter, Steven K. | Lu, Yanhua | Murray, William V. | Emanuel, Stuart L. | Gruninger, Robert H. | Fuentes-Pesquera, Angel R. | Rugg, Catherine A. | ... | Jolliffe, Linda K.
Journal of Medicinal Chemistry, volume 48, issue 13, pages 4208-4211 (2005).
10.1021/jm050267e
Cited by (109) | Cite | Source
3-Acyl-2,6-diaminopyridines as cyclin-dependent kinase inhibitors: synthesis and biological evaluation (journal article)
Lin, Ronghui | Lu, Yanhua | Wetter, Steven K. | Connolly, Peter J. | Turchi, Ignatius J. | Murray, William V. | Emanuel, Stuart L. | Gruninger, Robert H. | Fuentes-Pesquera, Angel R. | Adams, Mary | ... | Jolliffe, Linda K.
Bioorganic & Medicinal Chemistry Letters, volume 15, issue 9, pages 2221-2224 (2005).
10.1016/j.bmcl.2005.03.024
Cited by (22) | Cite | Source
Synthesis and Discovery of Pyrazine−Pyridine Biheteroaryl as a Novel Series of Potent Vascular Endothelial Growth Factor Receptor-2 Inhibitors (journal article)
Kuo, Gee-Hong | Wang, Aihua | Emanuel, Stuart | DeAngelis, Alan | Zhang, Rui | Connolly, Peter J. | Murray, William V. | Gruninger, Robert H. | Sechler, Jan | Fuentes-Pesquera, Angel | ... | Chen, Xin
Journal of Medicinal Chemistry, volume 48, issue 6, pages 1886-1900 (2005).
10.1021/jm040099a
Cited by (27) | Cite | Source
Amino substituted pyridinyl methanone compounds useful in treating kinase disorders (patent)
Lin, Ronghui | Wetter, Steven K. | Lu, Yanhua | Connolly, Peter J. | Emanuel, Stuart | Gruninger, Robert H. | Middleton, Steven A.
Patent Number: 20050124610 (2004)
Cited by (1) | Cite | Source
A Vascular Endothelial Growth Factor Receptor-2 Kinase Inhibitor Potentiates the Activity of the Conventional Chemotherapeutic Agents Paclitaxel and Doxorubicin in Tumor Xenograft Models (journal article)
Emanuel, Stuart | Gruninger, Robert H. | Fuentes-Pesquera, Angel | Connolly, Peter J. | Seamon, Jennifer A. | Hazel, Susan | Tominovich, Rose | Hollister, Beth | Napier, Cheryl | D'Andrea, Michael R. | ... | Middleton, Steven A.
Molecular Pharmacology, volume 66, issue 3, pages 635-647 (2004).
10.1124/mol.104.000638
Cited by (48) | Cite | Source | Open Access