Lori S. Friedman

ScholarGPS® ID: 36941344388760

Affiliation

ORIC Pharmaceuticals, United States

Affiliation History

Field

Medicine

Discipline

Oncology

Top Specialties

Metrics Summary

Publication Count

Predicted Citations

10,128

Predicted h-index

Ranking

Publications and Citation History

Publications based on Top Specialties

Types of Publication

Publications
Books
Patents
NIH/NSF

Add Delete
A Druggable FOXA1-Glucocorticoid Receptor Transcriptional Axis Drives Tumor Growth in a Subset of Non-Small Cell Lung Cancer (journal article) Dorso, M. \| Patel, Payal T. \| Pankov, Aleksandr \| Boyer, Jacob A. \| Soni, Rajesh K. \| Del Priore, Isabella S. \| Hayatt, Omar \| Kulick, Amanda \| Hagen, Connor J. \| de Stanchina, Elisa \| ... \| Chandarlapaty, Sarat Cancer Research Communications, volume 3, issue 9, pages 1788-1799 (2023). 10.1158/2767-9764.CRC-23-0310 Cited by (2) \| Cite \| Source
The oral selective estrogen receptor degrader GDC-0810 (ARN-810) in postmenopausal women with hormone receptor-positive HER2-negative (HR + /HER2 −) advanced/metastatic breast cancer (journal article) Bardia, Aditya \| Mayer, Ingrid \| Winer, Eric \| Linden, Hannah M. \| Ma, Cynthia X. \| Parker, Barbara A. \| Bellet, Meritxell \| Arteaga, Carlos L. \| Cheeti, Sravanthi \| Gates, Mary \| ... \| Jhaveri, Komal Breast Cancer Research and Treatment, volume 197, issue 2, pages 319-331 (2023). 10.1007/s10549-022-06797-9 Cited by (13) \| Cite \| Source
CD73 Inhibition Reverses Immunosuppression and Has Potential As an Immunomodulatory Therapy in Patients with Multiple Myeloma (journal article) Junttila, Melissa R \| Ray, Arghya \| Warne, Robert \| Chen, Xi R \| Du, Ting \| Lui, Fang \| Katewa, Subhash \| Blank, Brian \| Moore, Jared \| Ndubaku, Chudi \| ... \| Friedman, Lori Blood, volume 140, issue Supplement 1, pages 9957-9958 (2022). 10.1182/blood-2022-168275 Cited by (2) \| Cite \| Source
CD73 Inhibition Overcomes Immunosuppression and Triggers Autologous T-Cell Mediated Multiple Myeloma Cell Lysis in the Bone Marrow Milieu (journal article) Ray, Arghya \| Junttila, Melissa R \| DU, Ting \| Sutimantanapi, Dena \| Chen, Xi \| Warne, Bob \| Chang, Jae \| Blank, Brian \| Wu, Kejia \| Moore, Jared \| ... \| Anderson, Kenneth C. Blood, volume 138, issue Supplement 1, pages 2675-2675 (2021). 10.1182/blood-2021-148174 Cited by (1) \| Cite \| Source
Biomarker results supporting selection of RP2D from a phase 1b study of ORIC-101, a glucocorticoid receptor antagonist, in combination with nab-paclitaxel in patients with advanced solid tumors. (journal article) Daemen, Anneleen \| Pankov, Aleksandr \| Barkund, Shravani \| Zhou, Haiying \| Duff, Maureen \| Johnson, Ann \| Xu, Rongda \| Multani, Pratik S. \| Chow Maneval, Edna \| Friedman, Lori Journal of Clinical Oncology, volume 39, issue 15_suppl, pages 3110-3110 (2021). 10.1200/JCO.2021.39.15_suppl.3110 Cited by (1) \| Cite \| Source
Enhanced antitumor immunity through sequential targeting of PI3Kδ and LAG3 (journal article) Lauder, Sarah Nicol \| Smart, Kathryn \| Kersemans, Veerle \| Allen, Danny \| Scott, Jake \| Pires, Ana \| Milutinovic, Stefan \| Somerville, Michelle \| Smart, Sean \| Kinchesh, Paul \| ... \| Gallimore, Awen Journal for ImmunoTherapy of Cancer, volume 8, issue 2, pages e000693- (2020). 10.1136/jitc-2020-000693 Cited by (23) \| Cite \| Source
Predictive and Pharmacodynamic Biomarkers of Response to the Phosphatidylinositol 3-Kinase Inhibitor Taselisib in Breast Cancer Preclinical Models (journal article) Moore, Heather M. \| Savage, Heidi M. \| O'Brien, Carol \| Zhou, Wei \| Sokol, Ethan S. \| Goldberg, Michael E. \| Metcalfe, Ciara \| Friedman, Lori S. \| Lackner, Mark R. \| Wilson, Timothy R. Molecular Cancer Therapeutics, volume 19, issue 1, pages 292-303 (2020). 10.1158/1535-7163.MCT-19-0284 Cited by (9) \| Cite \| Source
Preclinical development of the PI3K Alpha selective and PIK3CA Mutant selective inhibitor GDC-0077 and prediction of its human pharmacokinetics (journal article) Pang, Jodie \| Baumgardner, Matthew \| Braun, Marie-Gabrielle \| Cheong, Jonathan \| Edgar, Kyle \| Friedman, Lori \| Hanan, Emily \| Jaochico, Allan \| Ma, Shuguang \| Plise, Emile \| ... \| Salphati, Laurent Drug Metabolism and Pharmacokinetics, volume 34, issue 1, pages S37- (2019). 10.1016/j.dmpk.2018.09.137 Cite \| Source
Methods of treating PR-positive, luminal A breast cancer with PI3K inhibitor, pictilisib (patent) Derynck, Mika K. \| Friedman, Lori \| Gendreau, Steven Brian \| Milan, Sandra Patent Number: 10004748 (2018) Cite \| Source
Hormone-Targeted Therapy and Resistance (journal article) Metcalfe, Ciara \| Friedman, Lori S. \| Hager, Jeffrey H. Annual Review of Cancer Biology, volume 2, issue 1, pages 291-312 (2018). 10.1146/annurev-cancerbio-030617-050512 Cited by (12) \| Cite \| Source
Abstract PD4-14: GDC-0077 is a selective PI3Kalpha inhibitor that demonstrates robust efficacy in PIK3CA mutant breast cancer models as a single agent and in combination with standard of care therapies (journal article) Hong, R \| Edgar, K \| Song, K \| Steven, S \| Young, A \| Hamilton, P \| Arrazate, A \| De La Cruz, C \| Chan, C \| Pang, J \| ... \| Sampath, D Cancer Research, volume 78, issue 4_Supplement, pages PD4-14-PD4-14 (2018). 10.1158/1538-7445.SABCS17-PD4-14 Cited by (20) \| Cite \| Source
Methods and compositions for modulating estrogen receptor mutants (patent) Hager, Jeffrey J. \| Joseph, James D. \| Qian, Jing \| Smith, Nicholas D. \| Chow Maneval, Edna \| Roychowdhury, Debasish F. \| Friedman, Lori \| Sampath, Deepak Patent Number: 9855270 (2018) Cited by (2) \| Cite \| Source
Inhibition of p110δ PI3K prevents inflammatory response and restenosis after artery injury (journal article) Bilancio, Antonio \| Rinaldi, Barbara \| Oliviero, Maria Antonietta \| Donniacuo, Maria \| Monti, Maria Gaia \| Boscaino, Amedeo \| Marino, Irene \| Friedman, Lori \| Rossi, Francesco \| Vanhaesebroeck, Bart \| Migliaccio, Antimo Bioscience Reports, volume 37, issue 5 (2017). 10.1042/BSR20171112 Cited by (23) \| Cite \| Source \| Open Access
Role of the E3 ubiquitin ligase RNF157 as a novel downstream effector linking PI3K and MAPK signaling pathways to the cell cycle (journal article) Dogan, Taner \| Gnad, Florian \| Chan, Jocelyn \| Phu, Lilian \| Young, Amy \| Chen, Mark J. \| Doll, Sophia \| Stokes, Matthew P. \| Belvin, Marcia \| Friedman, Lori S. \| ... \| Hatzivassiliou, Georgia Journal of Biological Chemistry, volume 292, issue 35, pages 14311-14324 (2017). 10.1074/jbc.M117.792754 Cited by (11) \| Cite \| Source \| Open Access
Abstract P6-03-01: A combination of dual inhibition in HER2-network by T-DM1 and GDC-0980 provides maximal antitumor efficacy in preclinical model of HER2+ breast cancer (journal article) De, PK \| Carlson, JH \| Sun, Y \| Lin, X \| Friedman, L \| Dey, N \| Leyland-Jones, B Cancer Research, volume 77, issue 4_Supplement, pages P6-03-01-P6-03-01 (2017). 10.1158/1538-7445.SABCS16-P6-03-01 Cite \| Source
Abstract P4-06-05: Treatment of ESR1 mutant and PIK3CA mutant patient-derived breast cancer xenograft models reveals differential anti-tumor responses to estrogen receptor degraders and PI3K inhibitors in vivo (journal article) Young, A \| Crocker, L \| Cheng, E \| Lacap, J \| Hamilton, P \| Oeh, J \| Ingalla, E \| Arrazate, A \| Hager, J \| Nannini, M \| ... \| Sampath, D Cancer Research, volume 77, issue 4_Supplement, pages P4-06-05-P4-06-05 (2017). 10.1158/1538-7445.SABCS16-P4-06-05 Cite \| Source
Phosphoproteome analysis of the MAPK pathway reveals previously undetected feedback mechanisms (journal article) Gnad, Florian \| Doll, Sophia \| Song, Kyung \| Stokes, Matthew P. \| Moffat, John \| Liu, Bonnie \| Arnott, David \| Wallin, Jeffrey \| Friedman, Lori S. \| Hatzivassiliou, Georgia \| Belvin, Marcia PROTEOMICS, volume 16, issue 14, pages 1998-2004 (2016). 10.1002/pmic.201600119 Cited by (6) \| Cite \| Source
Quantitative phosphoproteomic analysis of the PI3K-regulated signaling network (journal article) Gnad, Florian \| Wallin, Jeffrey \| Edgar, Kyle \| Doll, Sophia \| Arnott, David \| Robillard, Liliane \| Kirkpatrick, Donald S. \| Stokes, Matthew P. \| Vijapurkar, Ulka \| Hatzivassiliou, Georgia \| ... \| Belvin, Marcia PROTEOMICS, volume 16, issue 14, pages 1992-1997 (2016). 10.1002/pmic.201600118 Cited by (4) \| Cite \| Source
METHODS OF TREATMENT WITH TASELISIB (patent) Edgar, Kyle A. \| Friedman, Lori S. \| Sampath, Deepak \| Song, Kyung \| Wertz, Ingrid E. \| Wilson, Timothy R. Patent Number: 20160375033 (2016) Cited by (1) \| Cite \| Source
Plasma Metabolomic Changes following PI3K Inhibition as Pharmacodynamic Biomarkers: Preclinical Discovery to Phase I Trial Evaluation (journal article) Ang, Joo Ern \| Pandher, Rupinder \| Ang, Joo Chew \| Asad, Yasmin J. \| Henley, Alan T. \| Valenti, Melanie \| Box, Gary \| de Haven Brandon, Alexis \| Baird, Richard D. \| Friedman, Lori \| ... \| Raynaud, Florence I. Molecular Cancer Therapeutics, volume 15, issue 6, pages 1412-1424 (2016). 10.1158/1535-7163.MCT-15-0815 Cited by (14) \| Cite \| Source \| Open Access