Shelli R. McAlpine

ScholarGPS® ID: 36600667089223

Affiliation
University of New South Wales, Sydney, Australia
Affiliation History

Field
Physical Sciences and Mathematics
Discipline
Chemistry
Top Specialties
Medicinal Chemistry | Heat Shock Protein | Biosynthesis | Cancer | Chemical Synthesis | Peptide | Cancer Cell | Cyclic Peptide | Structure–activity Relationship | DNA
Metrics Summary
Publication Count
91
Predicted Citations
3,076
Predicted h-index
33
Ranking

Publications and Citation History

Publications based on Top Specialties

Types of Publication

  • Publications
  • Books
  • Patents
  • NIH/NSF
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Delivering hydrophilic peptide inhibitors of heat shock protein 70 into cancer cells (journal article)
Han, Zifei | McAlpine, Shelli R. | Chapman, Robert
Bioorganic Chemistry, volume 122 (2022).
10.1016/j.bioorg.2022.105713
Cited by (1) | Cite | Source
Using NMR to identify binding regions for N and C-terminal Hsp90 inhibitors using Hsp90 domains (journal article)
McConnell, Jeanette R. | Dyson, H. Jane | McAlpine, Shelli R.
RSC Medicinal Chemistry, volume 12, issue 3, pages 410-415 (2021).
10.1039/D0MD00387E
Cited by (4) | Cite | Source
Frontispiece: Cyclic Peptides as Drugs for Intracellular Targets: The Next Frontier in Peptide Therapeutic Development (journal article)
Buckton, Laura K. | Rahimi, Marwa N. | McAlpine, Shelli R.
Chemistry – A European Journal, volume 27, issue 5 (2021).
10.1002/chem.202180561
Cite | Source
Cyclic Peptides as Drugs for Intracellular Targets: The Next Frontier in Peptide Therapeutic Development (journal article)
Buckton, Laura K. | Rahimi, Marwa N. | McAlpine, Shelli R.
Chemistry – A European Journal, volume 27, issue 5, pages 1487-1513 (2021).
10.1002/chem.201905385
Cited by (100) | Cite | Source
Real time monitoring of peptide delivery in vitro using high payload pH responsive nanogels (journal article)
Farazi, Shegufta | Chen, Fan | Foster, Henry | Boquiren, Raelene | McAlpine, Shelli R. | Chapman, Robert
Polymer Chemistry, volume 11, issue 2, pages 425-432 (2020).
10.1039/C9PY01120J
Cited by (15) | Cite | Source
Polymer mediated transport of the Hsp90 inhibitor LB76, a polar cyclic peptide, produces an Hsp90 cellular phenotype (journal article)
Rahimi, Marwa N. | Foster, Henry G. | Farazi, Shegufta N. | Chapman, Robert | McAlpine, Shelli R.
Chemical Communications, volume 55, issue 31, pages 4515-4518 (2019).
10.1039/C9CC00890J
Cited by (4) | Cite | Source
Nanoparticles for Bioapplications: Study of the Cytotoxicity of Water Dispersible CdSe(S) and CdSe(S)/ZnO Quantum Dots (journal article)
Mirnajafizadeh, Fatemeh | Ramsey, Deborah | McAlpine, Shelli | Wang, Fan | Stride, John
Nanomaterials, volume 9, issue 3, pages 465- (2019).
10.3390/nano9030465
Cited by (2) | Cite | Source
Designing de Novo Small Molecules That Control Heat Shock Protein 70 (Hsp70) and Heat Shock Organizing Protein (HOP) within the Chaperone Protein-Folding Machinery (journal article)
Zaiter, Samantha S. | Huo, Yuantao | Tiew, Fong Y. | Gestwicki, Jason E. | McAlpine, Shelli R.
Journal of Medicinal Chemistry, volume 62, issue 2, pages 742-761 (2019).
10.1021/acs.jmedchem.8b01436
Cited by (11) | Cite | Source
Protein–protein inhibitor designed de novo to target the MEEVD region on the C-terminus of Hsp90 and block co-chaperone activity (journal article)
Rahimi, Marwa N. | McAlpine, Shelli R.
Chemical Communications, volume 55, issue 6, pages 846-849 (2019).
10.1039/C8CC07576J
Cited by (18) | Cite | Source
Functionalization of Quinazolin‐4‐ones Part 3: Synthesis, Structures Elucidation, DNA‐PK, PI3K, and Cytotoxicity of Novel 8‐Aryl‐2‐morpholino‐quinazolin‐4‐ones (journal article)
Heppell, Jacob T. | Islam, Md. Amirul | McAlpine, Shelli R. | Al‐Rawi, Jasim M. A.
Journal of Heterocyclic Chemistry, volume 56, issue 1, pages 124-141 (2019).
10.1002/jhet.3385
Cited by (2) | Cite | Source
Delivering bioactive cyclic peptides that target Hsp90 as prodrugs (journal article)
Huo, Yuantao | Buckton, Laura K. | Bennett, Jack L. | Smith, Eloise C. | Byrne, Frances L. | Hoehn, Kyle L. | Rahimi, Marwa N. | McAlpine, Shelli R.
Journal of Enzyme Inhibition and Medicinal Chemistry, volume 34, issue 1, pages 728-739 (2019).
10.1080/14756366.2019.1580276
Cited by (3) | Cite | Source
Hsp90 Mediates Membrane Deformation and Exosome Release (journal article)
Lauwers, Elsa | Wang, Yu-Chun | Gallardo, Rodrigo | Van der Kant, Rob | Michiels, Emiel | Swerts, Jef | Baatsen, Pieter | Zaiter, Samantha S. | McAlpine, Shelli R. | Gounko, Natalia V. | ... | Verstreken, Patrik
Molecular Cell, volume 71, issue 5, pages 689-702.e9 (2018).
10.1016/j.molcel.2018.07.016
Cited by (102) | Cite | Source
Converting polar cyclic peptides into membrane permeable molecules using N ‐methylation (journal article)
Lee, Leo L. H. | Buckton, Laura K. | McAlpine, Shelli R.
Peptide Science, volume 110, issue 3 (2018).
10.1002/pep2.24063
Cited by (6) | Cite | Source
Synthesis and Structure–Activity Relationships of Inhibitors That Target the C-Terminal MEEVD on Heat Shock Protein 90 (journal article)
Rahimi, Marwa N. | Buckton, Laura K. | Zaiter, Samantha S. | Kho, Jessica | Chan, Vickie | Guo, Aldwin | Konesan, Jenane | Kwon, SuHyeon | Lam, Lok K. O. | Lawler, Michael F. | ... | McAlpine, Shelli R.
ACS Medicinal Chemistry Letters, volume 9, issue 2, pages 73-77 (2018).
10.1021/acsmedchemlett.7b00310
Cited by (21) | Cite | Source
Improving the Cell Permeability of Polar Cyclic Peptides by Replacing Residues with Alkylated Amino Acids, Asparagines, and d -Amino Acids (journal article)
Buckton, Laura K. | McAlpine, Shelli R.
Organic Letters, volume 20, issue 3, pages 506-509 (2018).
10.1021/acs.orglett.7b03363
Cited by (31) | Cite | Source
RITA Mimics: Synthesis and Mechanistic Evaluation of Asymmetric Linked Trithiazoles (journal article)
Pietkiewicz, Adrian L. | Zhang, Yuqi | Rahimi, Marwa N. | Stramandinoli, Michael | Teusner, Matthew | McAlpine, Shelli R.
ACS Medicinal Chemistry Letters, volume 8, issue 4, pages 401-406 (2017).
10.1021/acsmedchemlett.6b00488
Cited by (8) | Cite | Source | Open Access
How Selective are Hsp90 Inhibitors for Cancer Cells over Normal Cells? (journal article)
Wang, Yao | Koay, Yen Chin | McAlpine, Shelli R.
ChemMedChem, volume 12, issue 5, pages 353-357 (2017).
10.1002/cmdc.201600595
Cited by (16) | Cite | Source
Redefining the Phenotype of Heat Shock Protein 90 (Hsp90) Inhibitors (journal article)
Wang, Yao | Koay, Yen Chin | McAlpine, Shelli R.
Chemistry – A European Journal, volume 23, issue 9, pages 2010-2013 (2017).
10.1002/chem.201604807
Cited by (19) | Cite | Source
Reinventing Hsp90 Inhibitors: Blocking C‐Terminal Binding Events to Hsp90 by Using Dimerized Inhibitors (journal article)
Koay, Yen Chin | Wahyudi, Hendra | McAlpine, Shelli R.
Chemistry – A European Journal, volume 22, issue 51, pages 18572-18582 (2016).
10.1002/chem.201603464
Cited by (9) | Cite | Source
A Novel Class of Hsp90 C-Terminal Modulators Have Pre-Clinical Efficacy in Prostate Tumor Cells Without Induction of a Heat Shock Response (journal article)
Armstrong, Heather K. | Koay, Yen Chin | Irani, Swati | Das, Rajdeep | Nassar, Zeyad D. | Selth, Luke A. | Centenera, Margaret M. | McAlpine, Shelli R. | Butler, Lisa M.
The Prostate, volume 76, issue 16, pages 1546-1559 (2016).
10.1002/pros.23239
Cited by (20) | Cite | Source