Klaus Klumpp

ScholarGPS® ID: 35179122085683

Affiliation
Roche Holding AG, Basel, Switzerland
Affiliation History

Field
Life Sciences
Discipline
Virology
Top Specialties
Virus | Nucleoside | Hepatitis | RNA | Medicinal Chemistry | Antiviral Drug | Influenza | HIV | Nucleoside Analogue | Reverse Transcriptase
Metrics Summary
Publication Count
100
Predicted Citations
6,061
Predicted h-index
50
Ranking

Publications and Citation History

Publications based on Top Specialties

Types of Publication

  • Publications
  • Books
  • Patents
  • NIH/NSF
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Oxadiazepinone HBV capsid assembly modulators (journal article)
Kuduk, Scott D. | Stoops, Bart | Lam, Angela M. | Espiritu, Christine | Vogel, Robert | Lau, Vincent | Klumpp, Klaus | Flores, Osvaldo A. | Hartman, George D.
Bioorganic & Medicinal Chemistry Letters, volume 52 (2021).
10.1016/j.bmcl.2021.128353
Cited by (8) | Cite | Source
Identification of a new class of HBV capsid assembly modulator (journal article)
Kuduk, Scott D. | Stoops, Bart | Alexander, Richard | Lam, Angela M. | Espiritu, Christine | Vogel, Robert | Lau, Vincent | Klumpp, Klaus | Flores, Osvaldo A. | Hartman, George D.
Bioorganic & Medicinal Chemistry Letters, volume 39 (2021).
10.1016/j.bmcl.2021.127848
Cited by (11) | Cite | Source
4′-fluoro-2′-methyl substituted nucleoside derivatives as inhibitors of HCV RNA replication (patent)
Smith, Mark | Klumpp, Klaus G.
Patent Number: 10682369 (2020)
Cite | Source
Hepatitis B virus-induced modulation of liver macrophage function promotes hepatocyte infection (journal article)
Faure-Dupuy, Suzanne | Delphin, Marion | Aillot, Ludovic | Dimier, Laura | Lebossé, Fanny | Fresquet, Judith | Parent, Romain | Matter, Matthias Sebastian | Rivoire, Michel | Bendriss-Vermare, Nathalie | ... | Lucifora, Julie
Journal of Hepatology, volume 71, issue 6, pages 1086-1098 (2019).
10.1016/j.jhep.2019.06.032
Cited by (69) | Cite | Source
Combinations and methods comprising a capsid assembly inhibitor (patent)
Hartman, George | Flores, Osvaldo | Klumpp, Klaus | Lam, Man Iu | Berke, Jan Martin
Patent Number: 10441589 (2019)
Cite | Source
SAR studies in the sulfonyl carboxamide class of HBV capsid assembly modulators (journal article)
Kuduk, Scott D. | Lam, Angela M. | Espiritu, Christine | Vogel, Robert | Lau, Vincent | Klumpp, Klaus | Flores, Osvaldo A. | Hartman, George D.
Bioorganic & Medicinal Chemistry Letters, volume 29, issue 16, pages 2405-2409 (2019).
10.1016/j.bmcl.2019.05.029
Cited by (13) | Cite | Source
4′-vinyl substituted nucleoside derivatives as inhibitors of respiratory syncytial virus RNA replication (patent)
Smith, Mark | Klumpp, Klaus G.
Patent Number: 10358458 (2019)
Cite | Source
Preclinical Characterization of NVR 3-778, a First-in-Class Capsid Assembly Modulator against Hepatitis B Virus (journal article)
Lam, Angela M. | Espiritu, Christine | Vogel, Robert | Ren, Suping | Lau, Vincent | Kelly, Mollie | Kuduk, Scott D. | Hartman, George D. | Flores, Osvaldo A. | Klumpp, Klaus
Antimicrobial Agents and Chemotherapy, volume 63, issue 1 (2019).
10.1128/AAC.01734-18
Cited by (45) | Cite | Source
4′-difluoromethyl substituted nucleoside derivatives as inhibitors of influenza RNA replication (patent)
Smith, Mark | Klumpp, Klaus G.
Patent Number: 10092649 (2018)
Cited by (2) | Cite | Source
Structure-Guided Combinatorial Engineering Facilitates Affinity and Specificity Optimization of Anti-CD81 Antibodies. (journal article)
Nelson, Bryce | Adams, Jarrett J. | Kuglstatter, Andreas | Li, Zhijian | Harris, Seth F. | Liu, Yang | Bohini, Sandya | Ma, Han | Klumpp, Klaus | Gao, Junjun | Sidhu, Sachdev S.
Journal of Molecular Biology, volume 430, issue 14, pages 2139-2152 (2018).
10.2210/pdb6ejm/pdb
Cite | Source
Structure-Guided Combinatorial Engineering Facilitates Affinity and Specificity Optimization of Anti-CD81 Antibodies (journal article)
Nelson, Bryce | Adams, Jarrett | Kuglstatter, Andreas | Li, Zhijian | Harris, Seth F. | Liu, Yang | Bohini, Sandya | Ma, Han | Klumpp, Klaus | Gao, Junjun | Sidhu, Sachdev S.
Journal of Molecular Biology, volume 430, issue 14, pages 2139-2152 (2018).
10.1016/j.jmb.2018.05.018
Cited by (11) | Cite | Source
4′-fluoro-2′-methyl substituted nucleoside derivatives as inhibitors of HCV RNA replication (patent)
Smith, Mark | Klumpp, Klaus G.
Patent Number: 9895442 (2018)
Cited by (1) | Cite | Source
4′-azido, 3′-deoxy-3′-fluoro substituted nucleoside derivatives as inhibitors of HCV RNA replication (patent)
Smith, Mark | Klumpp, Klaus G.
Patent Number: 9694028 (2017)
Cite | Source
Reconstitution and Functional Analysis of a Full-Length Hepatitis C Virus NS5B Polymerase on a Supported Lipid Bilayer (journal article)
Cho, Nam-Joon | Pham, Edward A. | Hagey, Rachel J. | Lévêque, Vincent J. | Ma, Han | Klumpp, Klaus | Glenn, Jeffrey S.
ACS Central Science, volume 2, issue 7, pages 456-466 (2016).
10.1021/acscentsci.6b00112
Cited by (7) | Cite | Source | Open Access
4′-difluoromethyl substituted nucleoside derivatives as inhibitors of influenza RNA replication (patent)
Smith, Mark | Klumpp, Klaus G.
Patent Number: 9370569 (2016)
Cited by (3) | Cite | Source
4′-azido, 3′-deoxy-3′-fluoro substituted nucleoside derivatives as inhibitors of HCV RNA replication (patent)
Smith, Mark | Klumpp, Klaus G.
Patent Number: 9249176 (2016)
Cited by (1) | Cite | Source
P0640 : Effect of the combination of the HBV core inhibitor NVR 3-778 with nucleoside analogs or other HBV core inhibitors on the inhibition of HBV DNA replication in HepG2.2.15 cells (journal article)
Lam, A. | Espiritu, C. | Flores, O. | Hartman, G. | Klumpp, K.
Journal of Hepatology, volume 62 (2015).
10.1016/S0168-8278(15)30845-X
Cited by (11) | Cite | Source
Prevention of hepatitis C virus infection and spread in human liver chimeric mice by an anti‐CD81 monoclonal antibody (journal article)
Ji, Changhua | Liu, Yang | Pamulapati, Chandra | Bohini, Sandhya | Fertig, Georg | Schraeml, Michael | Rubas, Werner | Brandt, Michael | Ries, Stefan | Ma, Han | Klumpp, Klaus
Hepatology, volume 61, issue 4, pages 1136-1144 (2015).
10.1002/hep.27603
Cited by (28) | Cite | Source | Open Access
A Novel Immuno-Competitive Capture Mass Spectrometry Strategy for Protein–Protein Interaction Profiling Reveals That LATS Kinases Regulate HCV Replication Through NS5A Phosphorylation* (journal article)
Meistermann, Hélène | Gao, Junjun | Golling, Sabrina | Lamerz, Jens | Le Pogam, Sophie | Tzouros, Manuel | Sankabathula, Sailaja | Gruenbaum, Lore | Nájera, Isabel | Langen, Hanno | ... | Augustin, Angélique
Molecular & Cellular Proteomics, volume 13, issue 11, pages 3040-3048 (2014).
10.1074/mcp.M113.028977
Cited by (14) | Cite | Source | Open Access
Inhibition of Hepatitis C Virus in Chimeric Mice by Short Synthetic Hairpin RNAs: Sequence Analysis of Surviving Virus Shows Added Selective Pressure of Combination Therapy (journal article)
Dallas, Anne | Ilves, Heini | Ma, Han | Chin, Daniel J. | MacLachlan, Ian | Klumpp, Klaus | Johnston, Brian H.
Journal of Virology, volume 88, issue 9, pages 4647-4656 (2014).
10.1128/JVI.00105-14
Cited by (14) | Cite | Source | Open Access