Christopher M. Flores

ScholarGPS® ID: 34472128124907

Affiliation
Johnson & Johnson, New Brunswick, New Jersey, United States
Affiliation History

Field
Pharmacy and Pharmaceutical Sciences
Discipline
Pharmacology and Toxicology
Top Specialties
Medicinal Chemistry | Calcium Channel | Neuron | Calcium Channel Blocker | Transient Receptor Potential Channel | Channel Blocker | Nicotine | Nicotinic Acetylcholine Receptor | Drug Development | Sensory Neuron | Analgesic | Receptor Antagonist
Metrics Summary
Publication Count
114
Predicted Citations
6,099
Predicted h-index
40
Ranking

Publications and Citation History

Publications based on Top Specialties

Types of Publication

  • Publications
  • Books
  • Patents
  • NIH/NSF
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JNJ-10450232 (NTM-006), A novel non-opioid with structural similarities to acetaminophen, produces relatively long-lasting analgesia after a single dose in patients undergoing 3rd molar extraction (journal article)
Gelotte, Cathy K. | Vakil, Amy M. | Zimmerman, Brenda A. | Zannikos, Peter | Mishra, Rajesh | Eichenbaum, Gary | Kuffner, Edwin K. | Flores, Christopher M.
Regulatory Toxicology and Pharmacology (2023).
10.1016/j.yrtph.2023.105480
Cited by (2) | Cite | Source
Metabolism and disposition of JNJ-10450232 (NTM-006) in rats, dogs, monkeys and humans (journal article)
Lim, Heng-Keang | Chen, Jie | Lam, Wing | Gong, Yong | Leclercq, Laurent | Silva, Jose | Salter, Rhys | Berwaerts, Joris | Gelotte, Cathy K. | Vakil, Amy M. | ... | Flores, Christopher M.
Regulatory Toxicology and Pharmacology (2023).
10.1016/j.yrtph.2023.105379
Cited by (4) | Cite | Source
Preclinical safety assessment of JNJ-10450232 (NTM-006), a structural analog of acetaminophen, that does not cause hepatotoxicity at supratherapeutic doses (journal article)
Zhou, Junguo | De Jonghe, Sandra | Codd, Ellen E. | Weiner, Sandy | Gallacher, David | Stahle, Paul | Kelley, Michael F. | Kuffner, Edwin K. | Flores, Christopher M. | Eichenbaum, Gary E.
Regulatory Toxicology and Pharmacology (2023).
10.1016/j.yrtph.2023.105334
Cited by (2) | Cite | Source
First-in-human study to evaluate the safety, tolerability and pharmacokinetics of a novel analgesic and antipyretic drug with structural similarity to acetaminophen (journal article)
Gelotte, Cathy K. | Vakil, Amy M. | Berwaerts, Joris | Zimmerman, Brenda A. | Eichenbaum, Gary E. | Flores, Christopher M. | Kuffner, Edwin K.
Regulatory Toxicology and Pharmacology, volume 134 (2022).
10.1016/j.yrtph.2022.105236
Cited by (3) | Cite | Source
Revealing Unknown Benefits of Existing Medications to Aid the Discovery of New Treatments for Post‐Traumatic Stress Disorder (journal article)
Kern, David M. | Teneralli, Rachel E. | Flores, Christopher M. | Wittenberg, Gayle M. | Gilbert, James P. | Cepeda, M. Soledad
Psychiatric Research and Clinical Practice, volume 4, issue 1, pages 12-20 (2022).
10.1176/appi.prcp.20210019
Cite | Source
The discovery of azetidine-piperazine di-amides as potent, selective and reversible monoacylglycerol lipase (MAGL) inhibitors (journal article)
Zhu, Bin | Connolly, Peter J. | Zhang, Yue-Mei | McDonnell, Mark E. | Bian, Haiyan | Lin, Shu-Chen | Liu, Li | Zhang, Sui-Po | Chevalier, Kristen M. | Brandt, Michael R. | ... | Macielag, Mark J.
Bioorganic & Medicinal Chemistry Letters, volume 30, issue 14, pages 127243- (2020).
10.1016/j.bmcl.2020.127243
Cited by (12) | Cite | Source
The discovery of diazetidinyl diamides as potent and reversible inhibitors of monoacylglycerol lipase (MAGL) (journal article)
Zhu, Bin | Connolly, Peter J. | Zhang, Sui-Po | Chevalier, Kristen M. | Milligan, Cynthia M. | Flores, Christopher M. | Macielag, Mark J.
Bioorganic & Medicinal Chemistry Letters, volume 30, issue 12, pages 127198- (2020).
10.1016/j.bmcl.2020.127198
Cited by (7) | Cite | Source
Substituted imidazoles as N-type calcium channel blockers (patent)
Ahmad, Ishtiyaque | Bakthavatchalam, Rajagopal | Battula, Sivaramakrishna | Gijsen, Henricus Jacobus Maria | Vadivelu, Saravanan | Wall, Mark | Flores, Christopher
Patent Number: 10653673 (2020)
Cite | Source
Pharmacologic Characterization of JNJ-42226314, [1-(4-Fluorophenyl)indol-5-yl]-[3-[4-(thiazole-2-carbonyl)piperazin-1-yl]azetidin-1-yl]methanone, a Reversible, Selective, and Potent Monoacylglycerol Lipase Inhibitor (journal article)
Wyatt, Ryan M. | Fraser, Ian | Welty, Natalie | Lord, Brian | Wennerholm, Michelle | Sutton, Steven | Ameriks, Michael K. | Dugovic, Christine | Yun, Sujin | White, Allison | ... | Bonaventure, Pascal
Journal of Pharmacology and Experimental Therapeutics, volume 372, issue 3, pages 339-353 (2020).
10.1124/jpet.119.262139
Cited by (15) | Cite | Source
Discovery and optimization of a novel series of pyrazolyltetrahydropyran N-type calcium channel (Cav 2.2) blockers for the treatment of pain (journal article)
Wall, Mark J. | Subasinghe, Nalin L. | Winters, Michael P. | Lubin, Mary Lou | Finley, Michael F.A. | Qin, Ning | Brandt, Michael R. | Neeper, Michael P. | Schneider, Craig R. | Colburn, Raymond W. | ... | Sui, Zhihua
Bioorganic & Medicinal Chemistry Letters, volume 28, issue 23-24, pages 3780-3783 (2018).
10.1016/j.bmcl.2018.10.007
Cited by (4) | Cite | Source
Characterization of the trigeminovascular actions of several adenosine A2A receptor antagonists in an in vivo rat model of migraine (journal article)
Haanes, Kristian A. | Labastida-Ramírez, Alejandro | Chan, Kayi Y. | de Vries, René | Shook, Brian | Jackson, Paul | Zhang, Jimmy | Flores, Christopher M. | Danser, Alexander H. J. | Villalón, Carlos M. | MaassenVanDenBrink, Antoinette
The Journal of Headache and Pain, volume 19, issue 1 (2018).
10.1186/s10194-018-0867-x
Cited by (20) | Cite | Source | Open Access
Substituted imidazoles as N-type calcium channel blockers (patent)
Ahmad, Ishtiyaque | Bakthavatchalam, Rajagopal | Battula, Sivaramakrishna | Gijsen, Henricus Jacobus Maria | Vadivelu, Saravanan | Wall, Mark | Flores, Christopher
Patent Number: 9974775 (2018)
Cite | Source
A multiple-dose double-blind randomized study to evaluate the safety, pharmacokinetics, pharmacodynamics and analgesic efficacy of the TRPV1 antagonist JNJ-39439335 (mavatrep) (journal article)
Manitpisitkul, Prasarn | Flores, Christopher M. | Moyer, John A. | Romano, Gary | Shalayda, Kevin | Tatikola, Kanaka | Hutchison, James S. | Mayorga, Arthur J.
Scandinavian Journal of Pain, volume 18, issue 2, pages 151-164 (2018).
10.1515/sjpain-2017-0184
Cited by (32) | Cite | Source
A randomized study to evaluate the analgesic efficacy of a single dose of the TRPV1 antagonist mavatrep in patients with osteoarthritis (journal article)
Mayorga, Arthur J. | Flores, Christopher M. | Trudeau, Jeremiah J. | Moyer, John A. | Shalayda, Kevin | Dale, Mark | Frustaci, Mary Ellen | Katz, Nathaniel | Manitpisitkul, Prasarn | Treister, Roi | ... | Romano, Gary
Scandinavian Journal of Pain, volume 17, issue 1, pages 134-143 (2017).
10.1016/j.sjpain.2017.07.021
Cited by (32) | Cite | Source
Jeffrey Scott Nye (journal article)
Manji, Husseini K | Flores, Christopher M
Neuropsychopharmacology, volume 42, issue 8, pages 1748-1748 (2017).
10.1038/npp.2017.62
Cite | Source | Open Access
Substituted pyrazoles as N-type calcium channel blockers (patent)
Wall, Mark | Subasinghe, Nalin | Sui, Zhihua | Flores, Christopher
Patent Number: 9434693 (2016)
Cited by (15) | Cite | Source
Sulfonamides as TRPM8 modulators (patent)
Branum, Shawn T | Colburn, Raymond W | Dax, Scott L | Flores, Christopher M | Jetter, Michele C | Liu, Yi | Ludovici, Donald | Macielag, Mark J | Matthews, Jay M | McNally, James J | ... | Youngman, Mark A
Patent Number: 9434711 (2016)
Cite | Source
Monoacylglycerol lipase inhibitors for the treatment of metabolic diseases and related disorders (patent)
Connelly, Margery | Flores, Christopher M. | Macielag, Mark J.
Patent Number: 9375430 (2016)
Cite | Source
TRPV1 antagonist JNJ-39439335 (mavatrep) demonstrates proof of pharmacology in healthy men: a first-in-human, double-blind, placebo-controlled, randomized, sequential group study (journal article)
Manitpisitkul, Prasarn | Brandt, Michael | Flores, Christopher M. | Kenigs, Velga | Moyer, John A. | Romano, Gary | Shalayda, Kevin | Mayorga, Arthur J.
PAIN Reports, volume 1, issue 4, pages e576- (2016).
10.1097/PR9.0000000000000576
Cited by (20) | Cite | Source | Open Access
Global deletion of MGL in mice delays lipid absorption and alters energy homeostasis and diet-induced obesity (journal article)
Douglass, John D. | Zhou, Yin Xiu | Wu, Amy | Zadrogra, John A. | Gajda, Angela M. | Lackey, Atreju I. | Lang, Wensheng | Chevalier, Kristen M. | Sutton, Steven W. | Zhang, Sui-Po | ... | Storch, Judith
Journal of Lipid Research, volume 56, issue 6, pages 1153-1171 (2015).
10.1194/jlr.M058586
Cited by (47) | Cite | Source | Open Access