Sylvie G. Bernier

ScholarGPS® ID: 33348516151309

Affiliation

Cyclerion Therapeutics, Inc., United States

Affiliation History

Field

Physical Sciences and Mathematics

Discipline

Chemistry

Top Specialties

Metrics Summary

Publication Count

Predicted Citations

2,670

Predicted h-index

Ranking

Publications and Citation History

Publications based on Top Specialties

Types of Publication

Publications
Books
Patents
NIH/NSF

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The CNS-penetrant soluble guanylate cyclase stimulator CYR119 attenuates markers of inflammation in the central nervous system (journal article) Correia, Susana S. \| Liu, Guang \| Jacobson, Sarah \| Bernier, Sylvie G. \| Tobin, Jenny V. \| Schwartzkopf, Chad D. \| Atwater, Emily \| Lonie, Elisabeth \| Rivers, Sam \| Carvalho, Andrew \| ... \| Jones, Juli E. Journal of Neuroinflammation, volume 18, issue 1 (2021). 10.1186/s12974-021-02275-z Cited by (13) \| Cite \| Source
Olinciguat, a stimulator of soluble guanylyl cyclase, attenuates inflammation, vaso‐occlusion and nephropathy in mouse models of sickle cell disease (journal article) Tchernychev, Boris \| Li, Huihui \| Lee, Sung‐Kyun \| Gao, Xin \| Ramanarasimhaiah, Raghunath \| Liu, Guang \| Hall, Katherine C. \| Bernier, Sylvie G. \| Jones, Juli E. \| Feil, Susanne \| ... \| Masferrer, Jaime L. British Journal of Pharmacology, volume 178, issue 17, pages 3463-3475 (2021). 10.1111/bph.15492 Cited by (13) \| Cite \| Source
The CNS-Penetrant Soluble Guanylate Cyclase Stimulator CY6463 Reveals its Therapeutic Potential in Neurodegenerative Diseases (journal article) Correia, Susana S. \| Iyengar, Rajesh R. \| Germano, Peter \| Tang, Kim \| Bernier, Sylvie G. \| Schwartzkopf, Chad D. \| Tobin, Jenny \| Lee, Thomas W.-H. \| Liu, Guang \| Jacobson, Sarah \| ... \| Currie, Mark G. Frontiers in Pharmacology, volume 12 (2021). 10.3389/fphar.2021.656561 Cited by (20) \| Cite \| Source
Discovery of CYR715: A novel carboxylic acid-containing soluble guanylate cyclase stimulator (journal article) Rennie, Glen R. \| Barden, Timothy C. \| Bernier, Sylvie G. \| Carvalho, Andrew \| Deming, Renee \| Germano, Peter \| Hudson, Colleen \| Im, G-Yoon J. \| Iyengar, Rajesh R. \| Jia, Lei \| ... \| Renhowe, Paul A. Bioorganic & Medicinal Chemistry Letters, volume 40 (2021). 10.1016/j.bmcl.2021.127886 Cited by (4) \| Cite \| Source
Pharmacological Characterization of IW-1973, a Novel Soluble Guanylate Cyclase Stimulator with Extensive Tissue Distribution, Antihypertensive, Anti-Inflammatory, and Antifibrotic Effects in Preclinical Models of Disease (journal article) Tobin, Jenny V. \| Zimmer, Daniel P. \| Shea, Courtney \| Germano, Peter \| Bernier, Sylvie G. \| Liu, Guang \| Long, Kim \| Miyashiro, Joy \| Ranganath, Sheila \| Jacobson, Sarah \| ... \| Masferrer, Jaime L. Journal of Pharmacology and Experimental Therapeutics, volume 365, issue 3, pages 664-675 (2018). 10.1124/jpet.117.247429 Cited by (46) \| Cite \| Source \| Open Access
The soluble guanylate cyclase stimulator IWP‐550 inhibits neuroinflammation in vitro and in vivo (journal article) Liu, Guang \| Correia, Susana S. \| Bernier, Sylvie G. \| Tang, Kim \| Jacobson, Sarah \| Sarno, Renee \| Catanzano, Victoria \| Nguyen, Brandon \| Atwater, Emily \| Lee, Thomas W. \| ... \| Hadcock, John R. The FASEB Journal, volume 32, issue S1 (2018). 10.1096/fasebj.2018.32.1_supplement.823.3 Cite \| Source
Discovery of stimulator binding to a conserved pocket in the heme domain of soluble guanylyl cyclase (journal article) Wales, Jessica A. \| Chen, Cheng-Yu \| Breci, Linda \| Weichsel, Andrzej \| Bernier, Sylvie G. \| Sheppeck, James E. \| Solinga, Robert \| Nakai, Takashi \| Renhowe, Paul A. \| Jung, Joon \| Montfort, William R. Journal of Biological Chemistry, volume 293, issue 5, pages 1850-1864 (2018). 10.1074/jbc.RA117.000457 Cited by (30) \| Cite \| Source \| Open Access
The Soluble Guanylate Cyclase Stimulator IWP-953 Increases Conventional Outflow Facility in Mouse Eyes (journal article) Ge, Pei \| Navarro, Iris D. \| Kessler, Marco M. \| Bernier, Sylvie G. \| Perl, Nicholas R. \| Sarno, Renee \| Masferrer, Jaime \| Hannig, Gerhard \| Stamer, W. Daniel Investigative Opthalmology & Visual Science, volume 57, issue 3, pages 1317- (2016). 10.1167/iovs.15-18958 Cited by (25) \| Cite \| Source \| Open Access
Discovery of Clinical Candidate GSK1842799 As a Selective S1P1 Receptor Agonist (Prodrug) for Multiple Sclerosis (journal article) Deng, Hongfeng \| Bernier, Sylvie G. \| Doyle, Elisabeth \| Lorusso, Jeanine \| Morgan, Barry A. \| Westlin, William F. \| Evindar, Ghotas ACS Medicinal Chemistry Letters, volume 4, issue 10, pages 942-947 (2013). 10.1021/ml400194r Cited by (18) \| Cite \| Source \| Open Access
Exploring amino acids derivatives as potent, selective, and direct agonists of sphingosine-1-phosphate receptor subtype-1 (journal article) Evindar, Ghotas \| Deng, Hongfeng \| Bernier, Sylvie G. \| Doyle, Elisabeth \| Lorusso, Jeanine \| Morgan, Barry A. \| Westlin, William F. Bioorganic & Medicinal Chemistry Letters, volume 23, issue 2, pages 472-475 (2013). 10.1016/j.bmcl.2012.11.053 Cited by (2) \| Cite \| Source
Gastrointestinal pain: Unraveling a novel endogenous pathway through uroguanylin/guanylate cyclase-C/cGMP activation (journal article) Silos-Santiago, Inmaculada \| Hannig, Gerhard \| Eutamene, Helene \| Ustinova, Elena E. \| Bernier, Sylvie G. \| Ge, Pei \| Graul, Christopher \| Jacobson, Sarah \| Jin, Hong \| Liong, Elaine \| ... \| Currie, Mark G. Pain, volume 154, issue 9, pages 1820-1830 (2013). 10.1016/j.pain.2013.05.044 Cited by (59) \| Cite \| Source
Exploration of amino alcohol derivatives as novel, potent, and highly selective sphingosine-1-phosphate receptor subtype-1 agonists (journal article) Evindar, Ghotas \| Bernier, Sylvie G. \| Doyle, Elisabeth \| Kavarana, Malcolm J. \| Satz, Alexander L. \| Lorusso, Jeanine \| Blanchette, Heather S. \| Saha, Ashis K. \| Hannig, Gerhard \| Morgan, Barry A. \| Westlin, William F. Bioorganic & Medicinal Chemistry Letters, volume 20, issue 8, pages 2520-2524 (2010). 10.1016/j.bmcl.2010.02.098 Cited by (7) \| Cite \| Source
Synthesis and evaluation of arylalkoxy- and biarylalkoxy-phenylamide and phenylimidazoles as potent and selective sphingosine-1-phosphate receptor subtype-1 agonists (journal article) Evindar, Ghotas \| Satz, Alexander L. \| Bernier, Sylvie G. \| Kavarana, Malcolm J. \| Doyle, Elisabeth \| Lorusso, Jeanine \| Taghizadeh, Nazbeh \| Halley, Keith \| Hutchings, Amy \| Kelley, Michael S. \| ... \| Westlin, William F. Bioorganic & Medicinal Chemistry Letters, volume 19, issue 8, pages 2315-2319 (2009). 10.1016/j.bmcl.2009.02.073 Cited by (7) \| Cite \| Source
Synthesis and evaluation of alkoxy-phenylamides and alkoxy-phenylimidazoles as potent sphingosine-1-phosphate receptor subtype-1 agonists (journal article) Evindar, Ghotas \| Bernier, Sylvie G. \| Kavarana, Malcolm J. \| Doyle, Elisabeth \| Lorusso, Jeanine \| Kelley, Michael S. \| Halley, Keith \| Hutchings, Amy \| Wright, Albion D. \| Saha, Ashis K. \| ... \| Westlin, William F. Bioorganic & Medicinal Chemistry Letters, volume 19, issue 2, pages 369-372 (2009). 10.1016/j.bmcl.2008.11.072 Cited by (13) \| Cite \| Source
An inhibitor of methionine aminopeptidase type-2, PPI-2458, ameliorates the pathophysiological disease processes of rheumatoid arthritis (journal article) Lazarus, D. D. \| Doyle, E. G. \| Bernier, S. G. \| Rogers, A. B. \| Labenski, M. T. \| Wakefield, J. D. \| Karp, R. M. \| Clark, E. J. \| Lorusso, J. \| Hoyt, J. G. \| ... \| Westlin, W. F. Inflammation Research, volume 57, issue 1, pages 18-27 (2008). 10.1007/s00011-007-7075-5 Cited by (13) \| Cite \| Source
Agonists of the sphingosine- 1- phosphate receptor (slp) (patent) Deng, Hongfeng \| Evindar, Ghotas \| Bernier, Sylvie G. \| Yao, Gang \| Coffin, Aaron \| Yang, Hongfang \| Acharya, Raksha A. Patent Number: 20100016260 (2007) Cite \| Source
349 POSTER Effects of PPI-2458, an inhibitor of methionine aminopeptidase type-2, on growth of melanoma and expression of MITF (journal article) Hannig, G. \| Bernier, S.G. \| Karp, R.M. \| Clark, E. \| Doyle, B. \| Lorusso, J. \| Westlin, W.F. European Journal of Cancer Supplements, volume 4, issue 12, pages 109- (2006). 10.1016/S1359-6349(06)70354-8 Cite \| Source
Inhibition of melanoma tumor growth by a pharmacological inhibitor of MetAP-2, PPI-2458 (journal article) Hannig, Gerhard \| Lazarus, Douglas \| Bernier, Sylvie \| Karp, Russell \| Lorusso, Jeanine \| Qiu, Daniel \| Labenski, Matthew \| Wakefield, Jim \| Thompson, Charles \| Westlin, William International Journal of Oncology (2006). 10.3892/ijo.28.4.955 Cited by (12) \| Cite \| Source \| Open Access
Methionine aminopeptidases type I and type II are essential to control cell proliferation (journal article) Bernier, Sylvie G. \| Taghizadeh, Nazbeh \| Thompson, Charles D. \| Westlin, William F. \| Hannig, Gerhard Journal of Cellular Biochemistry, volume 95, issue 6, pages 1191-1203 (2005). 10.1002/jcb.20493 Cited by (59) \| Cite \| Source
Fumagillin class inhibitors of methionine aminopeptidase-2 (journal article) Bernier, S.G. \| Westlin, W.F. \| Hannig, G. Drugs of the Future , volume 30, issue 5, pages 0497- (2005). 10.1358/dof.2005.030.05.895807 Cited by (64) \| Cite \| Source