Irene Tom

ScholarGPS® ID: 32162795155309

Affiliation

Genentech, Inc., South San Francisco, United States

Affiliation History

Field

Physical Sciences and Mathematics

Discipline

Chemistry

Top Specialties

Protein Microarray | Antibody | Cancer

Metrics Summary

Publication Count

Predicted Citations

3,177

Predicted h-index

Ranking

Publications and Citation History

Publications based on Top Specialties

Types of Publication

Publications
Books
Patents
NIH/NSF

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Allosteric inhibition of HTRA1 activity by a conformational lock mechanism to treat age-related macular degeneration (journal article) Gerhardy, Stefan \| Ultsch, Mark \| Tang, Wanjian \| Green, Evan \| Holden, Jeffrey K. \| Li, Wei \| Estevez, Alberto \| Arthur, Chris \| Tom, Irene \| Rohou, Alexis \| Kirchhofer, Daniel Nature Communications, volume 13, issue 1 (2022). 10.1038/s41467-022-32760-9 Cited by (6) \| Cite \| Source
Phase 1 Study of the Anti-HtrA1 Antibody-binding Fragment FHTR2163 in Geographic Atrophy Secondary to Age-related Macular Degeneration (journal article) Khanani, Arshad M. \| Hershberger, Vrinda S. \| Pieramici, Dante J. \| Khurana, Rahul N. \| Brunstein, Flavia \| Ma, Ling \| Maass, Katie F. \| Honigberg, Lee A. \| Tom, Irene \| Chen, Hao \| ... \| Lai, Phillip American Journal of Ophthalmology, volume 232 (2021). 10.1016/j.ajo.2021.06.017 Cited by (22) \| Cite \| Source
PCDH7 interacts with GluN1 and regulates dendritic spine morphology and synaptic function (journal article) Wang, Yuanyuan \| Kerrisk Campbell, Meghan \| Tom, Irene \| Foreman, Oded \| Hanson, Jesse E. \| Sheng, Morgan Scientific Reports, volume 10, issue 1 (2020). 10.1038/s41598-020-67831-8 Cited by (16) \| Cite \| Source
Development of a therapeutic anti-HtrA1 antibody and the identification of DKK3 as a pharmacodynamic biomarker in geographic atrophy (journal article) Tom, Irene \| Pham, Victoria C. \| Katschke, Kenneth J. \| Li, Wei \| Liang, Wei-Ching \| Gutierrez, Johnny \| Ah Young, Andrew \| Figueroa, Isabel \| Eshghi, Shadi Toghi \| Lee, ChingWei V. \| ... \| Lill, Jennie R. Proceedings of the National Academy of Sciences, volume 117, issue 18, pages 9952-9963 (2020). 10.1073/pnas.1917608117 Cited by (36) \| Cite \| Source
TREM2 Binds to Apolipoproteins, Including APOE and CLU/APOJ, and Thereby Facilitates Uptake of Amyloid-Beta by Microglia (journal article) Yeh, Felix L. \| Wang, Yuanyuan \| Tom, Irene \| Gonzalez, Lino C. \| Sheng, Morgan Neuron, volume 91, issue 2, pages 328-340 (2016). 10.1016/j.neuron.2016.06.015 Cited by (589) \| Cite \| Source \| Open Access
The extracellular interactome of the human adenovirus family reveals diverse strategies for immunomodulation (journal article) Martinez-Martin, Nadia \| Ramani, Sree R. \| Hackney, Jason A. \| Tom, Irene \| Wranik, Bernd J. \| Chan, Michelle \| Wu, Johnny \| Paluch, Maciej T. \| Takeda, Kentaro \| Hass, Philip E. \| ... \| Gonzalez, Lino C. Nature Communications, volume 7, issue 1 (2016). 10.1038/ncomms11473 Cited by (36) \| Cite \| Source \| Open Access
Operational redundancy in axon guidance through the multifunctional receptor Robo3 and its ligand NELL2 (journal article) Jaworski, Alexander \| Tom, Irene \| Tong, Raymond K. \| Gildea, Holly K. \| Koch, Alexander W. \| Gonzalez, Lino C. \| Tessier-Lavigne, Marc Science, volume 350, issue 6263, pages 961-965 (2015). 10.1126/science.aad2615 Cited by (79) \| Cite \| Source
Baculovirus display for discovery of low-affinity extracellular receptor–ligand interactions using protein microarrays (journal article) Tom, Irene \| Estevez, Alberto \| Bowman, Krista \| Gonzalez, Lino C. Analytical Biochemistry, volume 479 (2015). 10.1016/j.ab.2015.03.015 Cited by (2) \| Cite \| Source \| Open Access
Single clone expression cloning and protein microarray platforms for the identification of novel viral immunomodulatory proteins (VIR9P.1157) (journal article) Tom, Irene \| Martin, Nadia \| Ramani, Sree \| Gonzalez, Lino The Journal of Immunology, volume 194, issue 1_Supplement, pages 215.23-215.23 (2015). 10.4049/jimmunol.194.Supp.215.23 Cite \| Source
Baculovirus display for discovery of low‐affinity extracellular receptor‐ligand interactions using protein microarrays (595.2) (journal article) Tom, Irene \| Estevez, Alberto \| Bowman, Krista \| Gonzalez, Lino The FASEB Journal, volume 28, issue S1 (2014). 10.1096/fasebj.28.1_supplement.595.2 Cite \| Source
Defining the Ligand Specificity of the Deleted in Colorectal Cancer (DCC) Receptor (journal article) Haddick, Patrick C. G. \| Tom, Irene \| Luis, Elizabeth \| Quiñones, Gabriel \| Wranik, Bernd J. \| Ramani, Sree R. \| Stephan, Jean-Philippe \| Tessier-Lavigne, Marc \| Gonzalez, Lino C. PLoS ONE, volume 9, issue 1, pages e84823- (2014). 10.1371/journal.pone.0084823 Cited by (45) \| Cite \| Source \| Open Access
Protein Microarrays for Identification of Novel Extracellular Protein‐Protein Interactions (journal article) Tom, Irene \| Lewin‐Koh, Nicholas \| Ramani, Sree R. \| Gonzalez, Lino C. Current Protocols in Protein Science, volume 72, issue 1 (2013). 10.1002/0471140864.ps2703s72 Cited by (9) \| Cite \| Source
Single clone expression cloning and protein microarray platforms for novel extracellular receptor‐ligand identification (journal article) Tom, Irene \| Quinones, Gabriel \| Estevez, Alberto \| Paluch, Maciej \| Bowman, Krista \| Franke, Yvonne \| Billeci, Karen \| Hass, Phil \| Tang, Jerry \| Lewin‐Koh, Nicholas \| ... \| Gonzalez, Lino The FASEB Journal, volume 27, issue S1 (2013). 10.1096/fasebj.27.1_supplement.803.5 Cite \| Source
Evolutionarily Conserved Paired Immunoglobulin-like Receptor α (PILRα) Domain Mediates Its Interaction with Diverse Sialylated Ligands (journal article) Sun, Yonglian \| Senger, Kate \| Baginski, Tomasz K. \| Mazloom, Anita \| Chinn, Yvonne \| Pantua, Homer \| Hamidzadeh, Kajal \| Ramani, Sree Ranjani \| Luis, Elizabeth \| Tom, Irene \| ... \| Zarrin, Ali A. Journal of Biological Chemistry, volume 287, issue 19, pages 15837-15850 (2012). 10.1074/jbc.M111.286633 Cited by (36) \| Cite \| Source \| Open Access
A secreted protein microarray platform for extracellular protein interaction discovery (journal article) Ramani, Sree R. \| Tom, Irene \| Lewin-Koh, Nicholas \| Wranik, Bernd \| DePalatis, Laura \| Zhang, Jianjun \| Eaton, Dan \| Gonzalez, Lino C. Analytical Biochemistry, volume 420, issue 2, pages 127-138 (2012). 10.1016/j.ab.2011.09.017 Cited by (46) \| Cite \| Source \| Open Access
Murine Insulin Growth Factor-like (IGFL) and Human IGFL1 Proteins Are Induced in Inflammatory Skin Conditions and Bind to a Novel Tumor Necrosis Factor Receptor Family Member, IGFLR1 (journal article) Lobito, Adrian A. \| Ramani, Sree R. \| Tom, Irene \| Bazan, J. Fernando \| Luis, Elizabeth \| Fairbrother, Wayne J. \| Ouyang, Wenjun \| Gonzalez, Lino C. Journal of Biological Chemistry, volume 286, issue 21, pages 18969-18981 (2011). 10.1074/jbc.M111.224626 Cited by (36) \| Cite \| Source \| Open Access
The surface protein TIGIT suppresses T cell activation by promoting the generation of mature immunoregulatory dendritic cells (journal article) Yu, Xin \| Harden, Kristin \| C Gonzalez, Lino \| Francesco, Michelle \| Chiang, Eugene \| Irving, Bryan \| Tom, Irene \| Ivelja, Sinisa \| Refino, Canio J \| Clark, Hilary \| ... \| Grogan, Jane L Nature Immunology, volume 10, issue 1, pages 48-57 (2009). 10.1038/ni.1674 Cited by (1,078) \| Cite \| Source
Generation of PEGylated VPAC1-selective antagonists that inhibit proliferation of a lung cancer cell line (journal article) Pan, Clark Q. \| Hamren, Sarah \| Roczniak, Steve \| Tom, Irene \| DeRome, Mary Peptides, volume 29, issue 3, pages 479-486 (2008). 10.1016/j.peptides.2007.09.003 Cited by (6) \| Cite \| Source
Reproductible production of a PEGylated dual-acting peptide for diabetes (journal article) Tom, Irene \| Lee, Vivian \| Dumas, Michael \| Madanat, Melanie \| Ouyang, Jun \| Severs, Joanne \| Andersen, John \| Buxton, Joane M. \| Whelan, James P. \| Pan, Clark Q. The AAPS Journal, volume 9, issue 2, pages E227-E234 (2007). 10.1208/aapsj0902025 Cited by (13) \| Cite \| Source \| Open Access
Engineering Novel VPAC2-Selective Agonists with Improved Stability and Glucose-Lowering Activity in Vivo (journal article) Pan, Clark Q. \| Li, Fugang \| Tom, Irene \| Wang, Wei \| Dumas, Michael \| Froland, Wayne \| Yung, Stephanie L. \| Li, Yaxin \| Roczniak, Steve \| Claus, Thomas H. \| ... \| Whelan, James P. Journal of Pharmacology and Experimental Therapeutics, volume 320, issue 2, pages 900-906 (2007). 10.1124/jpet.106.112276 Cited by (23) \| Cite \| Source \| Open Access