Paul Moran

ScholarGPS® ID: 32077042963355

Affiliation

Genentech, Inc., South San Francisco, United States

Affiliation History

Field

Life Sciences

Discipline

Biochemistry

Top Specialties

Antibody | Growth Factor | Hepatocyte | Hepatocyte Growth Factor

Metrics Summary

Publication Count

Predicted Citations

2,533

Predicted h-index

Ranking

Publications and Citation History

Publications based on Top Specialties

Types of Publication

Publications
Books
Patents
NIH/NSF

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Structures of the ApoL1 and ApoL2 N-terminal domains reveal a non-classical four-helix bundle motif (journal article) Ultsch, Mark \| Holliday, Michael J. \| Gerhardy, Stefan \| Moran, Paul \| Scales, Suzie J. \| Gupta, Nidhi \| Oltrabella, Francesca \| Chiu, Cecilia \| Fairbrother, Wayne \| Eigenbrot, Charles \| Kirchhofer, Daniel Communications Biology, volume 4, issue 1 (2021). 10.1038/s42003-021-02387-5 Cited by (10) \| Cite \| Source
Domain-Specific Antibodies Reveal Differences in the Membrane Topologies of Apolipoprotein L1 in Serum and Podocytes (journal article) Gupta, Nidhi \| Wang, Xinhua \| Wen, Xiaohui \| Moran, Paul \| Paluch, Maciej \| Hass, Philip E. \| Heidersbach, Amy \| Haley, Benjamin \| Kirchhofer, Daniel \| Brezski, Randall J. \| ... \| Scales, Suzie J. Journal of the American Society of Nephrology, volume 31, issue 9, pages 2065-2082 (2020). 10.1681/ASN.2019080830 Cited by (18) \| Cite \| Source
Discovery of a cryptic peptide-binding site on PCSK9 and design of antagonists (journal article) Zhang, Yingnan \| Ultsch, Mark \| Skelton, Nicholas J \| Burdick, Daniel J \| Beresini, Maureen H \| Li, Wei \| Kong-Beltran, Monica \| Peterson, Andrew \| Quinn, John \| Chiu, Cecilia \| ... \| Kirchhofer, Daniel Nature Structural & Molecular Biology, volume 24, issue 10, pages 848-856 (2017). 10.1038/nsmb.3453 Cited by (58) \| Cite \| Source
Anti-HtrA1 antibodies and methods of use (patent) Wu, Yan \| van Lookeren-Campagne, Menno \| Kirchhofer, Daniel \| Lipari, Michael Terry \| Katschke, Jr., Kenneth J. \| Moran, Paul M. \| Stawicki, Scott \| Liang, Wei-Ching Patent Number: 9738727 (2017) Cited by (2) \| Cite \| Source
Anti-PCSK9 antibodies, formulations, dosing, and methods of use (patent) Wu, Yan \| Chiu, Cecilia Pui Chi \| Kirchhofer, Daniel K. \| Peterson, Andrew \| Kolumam, Ganesh A. \| Beltran, Monica Kong \| Moran, Paul \| Li, Wei \| Lam, Xanthe M. \| Luis, Lin \| Hui, Ada Patent Number: 9266961 (2016) Cited by (1) \| Cite \| Source
The trimeric serine protease HtrA1 forms a cage-like inhibition complex with an anti-HtrA1 antibody (journal article) Ciferri, Claudio \| Lipari, Michael T. \| Liang, Wei-Ching \| Estevez, Alberto \| Hang, Julie \| Stawicki, Scott \| Wu, Yan \| Moran, Paul \| Elliott, Mike \| Eigenbrot, Charles \| ... \| Kirchhofer, Daniel Biochemical Journal, volume 472, issue 2, pages 169-181 (2015). 10.1042/BJ20150601 Cited by (19) \| Cite \| Source
Identification of a Small Peptide That Inhibits PCSK9 Protein Binding to the Low Density Lipoprotein Receptor (journal article) Zhang, Yingnan \| Eigenbrot, Charles \| Zhou, Lijuan \| Shia, Steven \| Li, Wei \| Quan, Clifford \| Tom, Jeffrey \| Moran, Paul \| Di Lello, Paola \| Skelton, Nicholas J. \| ... \| Kirchhofer, Daniel Journal of Biological Chemistry, volume 289, issue 2, pages 942-955 (2014). 10.1074/jbc.M113.514067 Cited by (138) \| Cite \| Source \| Open Access
ANTI-PCSK9 ANTIBODIES, FORMULATIONS, DOSING, AND METHODS OF USE (patent) Wu, Yan \| Chiu, Cecilia Pui Chi \| Kirchhofer, Daniel \| Peterson, Andrew S. \| Kolumam, Ganesh \| Beltran, Monica Kong \| Moran, Paul \| Li, Wei \| Lam, Xanthe M. \| Luis, Lin \| Hui, Ada Patent Number: 20130344085 (2013) Cite \| Source
Anti-hepsin antibodies and methods using same (patent) Kirchhofer, Daniel \| Moran, Paul M. \| Ganesan, Rajkumar \| Zhang, Yingnan Patent Number: 8435511 (2013) Cited by (3) \| Cite \| Source
Furin-cleaved Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) Is Active and Modulates Low Density Lipoprotein Receptor and Serum Cholesterol Levels (journal article) Lipari, Michael T. \| Li, Wei \| Moran, Paul \| Kong-Beltran, Monica \| Sai, Tao \| Lai, Joyce \| Lin, S. Jack \| Kolumam, Ganesh \| Zavala-Solorio, Jose \| Izrael-Tomasevic, Anita \| ... \| Kirchhofer, Daniel Journal of Biological Chemistry, volume 287, issue 52, pages 43482-43491 (2012). 10.1074/jbc.M112.380618 Cited by (105) \| Cite \| Source \| Open Access
Calcium-Independent Inhibition of PCSK9 by Affinity-Improved Variants of the LDL Receptor EGF(A) Domain (journal article) Zhang, Yingnan \| Zhou, Lijuan \| Kong-Beltran, Monica \| Li, Wei \| Moran, Paul \| Wang, Jianyong \| Quan, Clifford \| Tom, Jeffrey \| Kolumam, Ganesh \| Elliott, J. Michael \| ... \| Kirchhofer, Daniel Journal of Molecular Biology, volume 422, issue 5, pages 685-696 (2012). 10.1016/j.jmb.2012.06.018 Cited by (34) \| Cite \| Source
Structural and Functional Analysis of HtrA1 and Its Subdomains (journal article) Eigenbrot, Charles \| Ultsch, Mark \| Lipari, Michael T. \| Moran, Paul \| Lin, S. Jack \| Ganesan, Rajkumar \| Quan, Clifford \| Tom, Jeffrey \| Sandoval, Wendy \| van Lookeren Campagne, Menno \| Kirchhofer, Daniel Structure, volume 20, issue 6, pages 1040-1050 (2012). 10.1016/j.str.2012.03.021 Cited by (85) \| Cite \| Source \| Open Access
An allosteric anti-hepsin antibody derived from a constrained phage display library (journal article) Ganesan, R. \| Zhang, Y. \| Landgraf, K. E. \| Lin, S. J. \| Moran, P. \| Kirchhofer, D. Protein Engineering Design and Selection, volume 25, issue 3, pages 127-133 (2012). 10.1093/protein/gzr067 Cited by (20) \| Cite \| Source \| Open Access
Pegylated Kunitz Domain Inhibitor Suppresses Hepsin-Mediated Invasive Tumor Growth and Metastasis (journal article) Li, Wei \| Wang, Bu-Er \| Moran, Paul \| Lipari, Terry \| Ganesan, Rajkumar \| Corpuz, Racquel \| Ludlam, Mary J.C. \| Gogineni, Alvin \| Koeppen, Hartmut \| Bunting, Stuart \| ... \| Kirchhofer, Daniel Cancer Research, volume 69, issue 21, pages 8395-8402 (2009). 10.1158/0008-5472.CAN-09-1995 Cited by (49) \| Cite \| Source
Methods and compositions for modulating hepatocyte growth factor activation (patent) Kirchhofer, Daniel K. \| Moran, Paul M. \| Peek, Mark D. Patent Number: 7432044 (2008) Cited by (5) \| Cite \| Source
Development of Neurotrophic Factor Therapy for Alzheimer's Disease (book chapter) In Ciba Foundation Symposium 196 ‐ Growth Factors as Drugs for Neurological and Sensory Disorders Hefti, Franz \| Armanini, Mark P. \| Beck, Klaus D. \| Caras, Ingrid W. \| Chen, Karen S. \| Godowski, Paul J. \| Goodman, Laurie J. \| Hammonds, R. Glenn \| Mark, Melanie R. \| Moran, Paul \| ... \| Winslow, John W. Wiley (2007) 10.1002/9780470514863.ch5 Cited by (4) \| Cite \| Source
Methods and compositions for modulating hepsin activation of urokinase-type plasminogen activator (patent) Kirchhofer, Daniel \| Moran, Paul Patent Number: 20130022611 (2007) Cited by (4) \| Cite \| Source
Utilizing the activation mechanism of serine proteases to engineer hepatocyte growth factor into a Met antagonist (journal article) Kirchhofer, Daniel \| Lipari, Michael T. \| Santell, Lydia \| Billeci, Karen L. \| Maun, Henry R. \| Sandoval, Wendy N. \| Moran, Paul \| Ridgway, John \| Eigenbrot, Charles \| Lazarus, Robert A. Proceedings of the National Academy of Sciences, volume 104, issue 13, pages 5306-5311 (2007). 10.1073/pnas.0700184104 Cited by (43) \| Cite \| Source \| Open Access
Pro-urokinase-type Plasminogen Activator Is a Substrate for Hepsin (journal article) Moran, Paul \| Li, Wei \| Fan, Bin \| Vij, Rajesh \| Eigenbrot, Charles \| Kirchhofer, Daniel Journal of Biological Chemistry, volume 281, issue 41, pages 30439-30446 (2006). 10.1074/jbc.M605440200 Cited by (74) \| Cite \| Source \| Open Access
Methods and compositions for modulating hepatocyte growth factor activation (patent) Kirchhofer, Daniel \| Moran, Paul \| Peek, Mark Patent Number: 20100209956 (2005) Cite \| Source