Tom E. Howard

ScholarGPS® ID: 31500136558897

Affiliation
University of Texas Rio Grande Valley, Brownsville, Edinburg, Harlingen, McAllen, Rio Grande City, South Padre Island, United States
Affiliation History

Field
Life Sciences
Discipline
Genetics
Top Specialties
Factor VIII | Angiotensin-converting Enzyme | Enzyme | Thrombosis | Coagulation
Metrics Summary
Publication Count
48
Predicted Citations
1,464
Predicted h-index
18
Ranking

Publications and Citation History

Publications based on Top Specialties

Types of Publication

  • Publications
  • Books
  • Patents
  • NIH/NSF
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Gene-Centric Association Scans of Pleiotropic Immune-Mediated Disease Genes in the PATH Study Identify Novel Determinants of Factor VIII Inhibitor Risk in Hemophilia-A Patients and Confirm Race as an Independent Predictor (journal article)
Bouls, Ruayda | Almeida, Marcio A. | Diego, Vincent P. | Luu, Bernadette W. | Rajalingam, Raja | Ameri, Afshin | Viel, Kevin R. | Chitlur, Meera | Kim, Benjamin | Escobar, Miguel A. | ... | Howard, Tom E.
Blood, volume 142, issue Supplement 1, pages 1246-1246 (2023).
10.1182/blood-2023-190094
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Results from an Association-Scan of the Extended MHC-Class-II Region Using Novel Association-Based Statistical Methods Establish That DQ Allotypes and Race Independently Influence the Risk of Factor VIII Inhibitor Development in Hemophilia-A Patients (journal article)
Ibarra, Paola | Almeida, Marcio A. | Diego, Vincent P. | Luu, Bernadette W. | Viel, Kevin R. | Rajalingam, Raja | Ameri, Afshin | Chitlur, Meera | Kim, Benjamin | Castillo, Grecia | ... | Howard, Tom E.
Blood, volume 142, issue Supplement 1, pages 1247-1247 (2023).
10.1182/blood-2023-191140
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A Nonsynonymous-Single-Nucleotide Polymorphism (ns-SNP) in TFPI , the Gene Encoding Tissue Factor Pathway Inhibitor (TFPI), is Pleiotropically Associated with Increased Plasma TFPI Levels and a Decreased Risk of Type 2 Diabetes (T2D) in Mexican Americans (journal article)
Lopez, Alberto D. | Diego, Vincent P. | Patel, Kanisha | Almeida, Marcio A. | Curran, Joanne E. | Escobar, Miguel | Powell, Jerry S. | Lehman, Donna M. | DeFronzo, Ralph A | Williams-Blangero, Sarah | ... | Howard, Tom E.
Blood, volume 140, issue Supplement 1, pages 8536-8537 (2022).
10.1182/blood-2022-171201
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The Nonsynonymous-Single-Nucleotide Polymorphism (ns-SNP) 353 R>q in the Coagulation Factor VII (FVII) Gene, F7 , is Associated with Decreased Plasma FVII Levels and a Decreased Risk of Coronary Heart Disease (CHD) in Mexican Americans of South Texas (journal article)
Patel, Kanisha | Diego, Vincent P. | Lopez, Alberto D. | Almeida, Marcio A. | Curran, Joanne E. | Escobar, Miguel | Powell, Jerry S. | Lehman, Donna M. | DeFronzo, Ralph A | Williams-Blangero, Sarah | ... | Howard, Tom E.
Blood, volume 140, issue Supplement 1, pages 2799-2800 (2022).
10.1182/blood-2022-168478
Cited by (1) | Cite | Source
The G505A Nonsynonymous Single-Nucleotide Polymorphism (SNP) in TAFI , the Gene Encoding Thrombin-Activatable Fibrinolysis Inhibitor (TAFI) Is Pleiotropically Associated with TAFI Antigen Levels and Coronary Heart Disease (CHD) in Mexican Americans of Sou (journal article)
Jhaveri, Shuchita | Diego, Vincent P. | Nguyen, Hoang Anh Thi | Kumar, Satish | Almeida, Marcio A. | Peralta, Juan M | Curran, Joanne E. | Luu, Bernadette W. | Lehman, Donna M. | DeFronzo, Ralph A | ... | Howard, Tom E.
Blood, volume 138, issue Supplement 1, pages 3217-3217 (2021).
10.1182/blood-2021-151968
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The Factor II (FII) Expression Quantitative Trait Locus (eQTL) Prothrombin G20210A Is Pleiotropically Associated with Plasma Fibrinogen Levels and Has a Profound Effect on Obesity in Mexican Americans of South Texas (journal article)
Nguyen, Hoang Anh Thi | Diego, Vincent P. | Jhaveri, Shuchita | Almeida, Marcio A. | Kumar, Satish | Peralta, Juan M | Curran, Joanne E. | Luu, Bernadette W. | Lehman, Donna M. | DeFronzo, Ralph A | ... | Howard, Tom E.
Blood, volume 138, issue Supplement 1, pages 1059-1059 (2021).
10.1182/blood-2021-154338
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On the Role of Hemostasis Variables in Cardiometabolic Outcomes (journal article)
Lopez, Alberto D. | Patel, Kanisha | Diego, Vincent P. | Almeida, Marcio A. | Blangero, John | Powell, Jerry S. | Howard, Tom E.
Blood, volume 138, issue Supplement 1, pages 4266-4266 (2021).
10.1182/blood-2021-154441
Cited by (1) | Cite | Source
Genomic variations in patients with myelodysplastic syndrome and karyotypes without numerical or structural changes (journal article)
Ribeiro, Cristiano Luiz | Pinto, Irene P. | Pereira, Samara S. S. | Minasi, Lysa B. | de S. M. Kluthcouski, Fernanda | de M. Arantes, Adriano | da Cruz, Aparecido D. | de Almeida, Marcio A. A. | Howard, Tom E. | da Silva, Cláudio C.
Scientific Reports, volume 11, issue 1 (2021).
10.1038/s41598-021-81467-2
Cited by (3) | Cite | Source
N-Linked Glycans on Therapeutic Factor VIII (FVIII) Proteins Attenuate Immunogenicity Potential: Evidence from Independent HLA-Class-II/FVIII (HLAcII/FVIII) Peptidomes (journal article)
Diego, Vincent P. | Luu, Bernadette W. | Movva, Hari | Hofmann, Marco | Almeida, Marcio A. | Dinh, Long V. | Powell, Jerry S. | Rajalingam, Raja | Peralta, Juan M | Mead, Henry | ... | Howard, Tom E.
Blood, volume 136, issue Supplement 1, pages 29-30 (2020).
10.1182/blood-2020-142493
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Quantitative HLA‐class‐II/factor VIII (FVIII) peptidomic variation in dendritic cells correlates with the immunogenic potential of therapeutic FVIII proteins in hemophilia A (journal article)
Diego, Vincent P. | Luu, Bernadette W. | Hofmann, Marco | Dinh, Long V. | Almeida, Marcio | Powell, Jerry S. | Rajalingam, Raja | Peralta, Juan M. | Kumar, Satish | Curran, Joanne E. | ... | Howard, Tom E.
Journal of Thrombosis and Haemostasis, volume 18, issue 1, pages 201-216 (2020).
10.1111/jth.14647
Cited by (4) | Cite | Source
On the Role of F8 Sequence Mismatch and Class-II Human Leukocyte Antigen Binding in the Development of Neutralizing Antibodies ("Inhibitors") Directed Against Therapeutic Factor VIII Proteins (tFVIIIs): Evidence from the PATH Study (journal article)
Diego, Vincent P. | Luu, Bernadette W. | Ameri, Afshin | Chitlur, Meera B. | Almeida, Marcio A. | Haack, Karin | Kumar, Satish | Dinh, Long V. | Mead, Henry | Powell, Jerry S. | ... | Howard, Tom E.
Blood, volume 134, issue Supplement_1, pages 2393-2393 (2019).
10.1182/blood-2019-132218
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Peptides identified on monocyte-derived dendritic cells: a marker for clinical immunogenicity to FVIII products (journal article)
Jankowski, Wojciech | Park, Yara | McGill, Joseph | Maraskovsky, Eugene | Hofmann, Marco | Diego, Vincent P. | Luu, Bernadette W. | Howard, Tom E. | Kellerman, Roberta | Key, Nigel S. | Sauna, Zuben E.
Blood Advances, volume 3, issue 9, pages 1429-1440 (2019).
10.1182/bloodadvances.2018030452
Cited by (20) | Cite | Source
P059 Analysis of HLAcII peptidomes presented by dendritic cells (DCs) from healthy donors and hemophilia-A (HA) patients with or without factor VIII (FVIII) inhibitors after ex vivo administration of different therapeutic FVIII proteins (tFVIIIs) (journal article)
Howard, Tom E. | Diego, Vincent P. | Hofmann, Marco | Almeida, Marcio | Luu, Bernadette W. | Dinh, Long V. | Rajalingam, Raja | Escobar, Miguel | Curran, Joanne | Williams-Blangero, Sarah | ... | Sauna, Zuben E.
Human Immunology, volume 79 (2018).
10.1016/j.humimm.2018.07.117
Cited by (1) | Cite | Source
A Novel Biomarker for Inhibitor Risk Prediction-the HLA-II Bound and Unbound Components of FVIII Derived Peptides-Reveals a Protective Influence for N-Linked Glycosylation (journal article)
Viel, Kevin R. | Hofmann, Marco | Zollner, Sabine | Luu, Bernadette W. | Raja, Rajalingam | Powell, Jerry Sherman | Maraskovsky, Eugene | Howard, Tom E.
Blood, volume 126, issue 23, pages 2292-2292 (2015).
10.1182/blood.V126.23.2292.2292
Cited by (1) | Cite | Source
FACTOR VIII MUTATION REPAIR AND TOLERANCE INDUCTION AND RELATED CDNAs, COMPOSITIONS, METHODS AND SYSTEMS (patent)
Howard, Tom E.
Patent Number: 20160045575 (2015)
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The intron-22–inverted F8 locus permits factor VIII synthesis: explanation for low inhibitor risk and a role for pharmacogenomics (journal article)
Sauna, Zuben E. | Lozier, Jay N. | Kasper, Carol K. | Yanover, Chen | Nichols, Timothy | Howard, Tom E.
Blood, volume 125, issue 2, pages 223-228 (2015).
10.1182/blood-2013-12-530113
Cited by (21) | Cite | Source | Open Access
The Spectrum of Amino Acid Substitutions Resulting from Single Nucleotide Substitutions in the Coagulation Biosystem: Impact on Identification By Mass Spectrometry (journal article)
Viel, Kevin R. | Kim, Benjamin | Tejero, Maria Elizabeth | Cole, Shelley S. | Howard, Tom E. | Ortiz, Amparo Santamaría
Blood, volume 124, issue 21, pages 4221-4221 (2014).
10.1182/blood.V124.21.4221.4221
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Single-nucleotide variations defining previously unreported ADAMTS13 haplotypes are associated with differential expression and activity of the VWF-cleaving protease in a Salvadoran congenital thrombotic thrombocytopenic purpura family (journal article)
Kim, Benjamin | Hing, Zachary A. | Wu, Andrew | Schiller, Tal | Struble, Evi B. | Liuwantara, David | Kempert, Pamela H. | Broxham, Eric J. | Edwards, Nathan C. | Marder, Victor J. | ... | Kimchi-Sarfaty, Chava
British Journal of Haematology, volume 165, issue 1, pages 154-158 (2014).
10.1111/bjh.12713
Cited by (4) | Cite | Source | Open Access
Single-Nucleotide Variations Defining Previously Unreported ADAMTS13 Haplotypes Are Associated With Differential Expression and Activity Of The VWF-Cleaving Protease In a Salvadoran Congenital Thrombotic Thrombocytopenic Purpura Family (journal article)
Kim, Benjamin | Hing, Zachary A. | Wu, Andrew | Schiller, Tal | Struble, Evi B. | Liuwantara, David | Kempert, Pamela H. | Broxham, Eric J. | Edwards, Nathan C. | Marder, Victor J. | ... | Kimchi-Sarfaty, Chava
Blood, volume 122, issue 21, pages 2319-2319 (2013).
10.1182/blood.V122.21.2319.2319
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Endogenous factor VIII synthesis from the intron 22–inverted F8 locus may modulate the immunogenicity of replacement therapy for hemophilia A (journal article)
Pandey, Gouri Shankar | Yanover, Chen | Miller-Jenkins, Lisa M | Garfield, Susan | Cole, Shelley A | Curran, Joanne E | Moses, Eric K | Rydz, Natalia | Simhadri, Vijaya | Kimchi-Sarfaty, Chava | ... | Sauna, Zuben E
Nature Medicine, volume 19, issue 10, pages 1318-1324 (2013).
10.1038/nm.3270
Cited by (59) | Cite | Source | Open Access