Kyle A. Edgar

ScholarGPS® ID: 28761170702055

Affiliation

Genentech, Inc., South San Francisco, United States

Affiliation History

Field

Medicine

Discipline

Oncology

Top Specialties

Phosphoinositide 3-kinase | Cancer

Metrics Summary

Publication Count

Predicted Citations

877

Predicted h-index

Ranking

Publications and Citation History

Publications based on Top Specialties

Types of Publication

Publications
Books
Patents
NIH/NSF

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Effects of PI3K Inhibition on Afucosylated Antibody–Driven FcγRIIIa Events and Phospho-S6 Activity in NK Cells (journal article) Romeo, Valentina \| Gierke, Sarah \| Edgar, Kyle A. \| Liu, Scot D. The Journal of Immunology, volume 203, issue 1, pages 137-147 (2019). 10.4049/jimmunol.1801418 Cited by (2) \| Cite \| Source
Preclinical development of the PI3K Alpha selective and PIK3CA Mutant selective inhibitor GDC-0077 and prediction of its human pharmacokinetics (journal article) Pang, Jodie \| Baumgardner, Matthew \| Braun, Marie-Gabrielle \| Cheong, Jonathan \| Edgar, Kyle \| Friedman, Lori \| Hanan, Emily \| Jaochico, Allan \| Ma, Shuguang \| Plise, Emile \| ... \| Salphati, Laurent Drug Metabolism and Pharmacokinetics, volume 34, issue 1, pages S37- (2019). 10.1016/j.dmpk.2018.09.137 Cite \| Source
Quantitative phosphoproteomic analysis of the PI3K-regulated signaling network (journal article) Gnad, Florian \| Wallin, Jeffrey \| Edgar, Kyle \| Doll, Sophia \| Arnott, David \| Robillard, Liliane \| Kirkpatrick, Donald S. \| Stokes, Matthew P. \| Vijapurkar, Ulka \| Hatzivassiliou, Georgia \| ... \| Belvin, Marcia PROTEOMICS, volume 16, issue 14, pages 1992-1997 (2016). 10.1002/pmic.201600118 Cited by (4) \| Cite \| Source
METHODS OF TREATMENT WITH TASELISIB (patent) Edgar, Kyle A. \| Friedman, Lori S. \| Sampath, Deepak \| Song, Kyung \| Wertz, Ingrid E. \| Wilson, Timothy R. Patent Number: 20160375033 (2016) Cited by (1) \| Cite \| Source
Discovery of Clinical Development Candidate GDC-0084, a Brain Penetrant Inhibitor of PI3K and mTOR (journal article) Heffron, Timothy P. \| Ndubaku, Chudi O. \| Salphati, Laurent \| Alicke, Bruno \| Cheong, Jonathan \| Drobnick, Joy \| Edgar, Kyle \| Gould, Stephen E. \| Lee, Leslie B. \| Lesnick, John D. \| ... \| Olivero, Alan G. ACS Medicinal Chemistry Letters, volume 7, issue 4, pages 351-356 (2016). 10.1021/acsmedchemlett.6b00005 Cited by (77) \| Cite \| Source \| Open Access
Amphiregulin and PTEN evoke a multimodal mechanism of acquired resistance to PI3K inhibition (journal article) Edgar, Kyle A. \| Crocker, Lisa \| Cheng, Eric \| Wagle, Marie-Claire \| Wongchenko, Matthew \| Yan, Yibing \| Wilson, Timothy R. \| Dompe, Nicholas \| Neve, Richard M. \| Belvin, Marcia \| ... \| Wallin, Jeffrey J. Genes & Cancer, volume 5, issue 3-4, pages 113-126 (2014). 10.18632/genesandcancer.10 Cited by (19) \| Cite \| Source \| Open Access
Discovery of 2-{3-[2-(1-Isopropyl-3-methyl-1 H -1,2–4-triazol-5-yl)-5,6-dihydrobenzo[f]imidazo[1,2- d ][1,4]oxazepin-9-yl]-1 H -pyrazol-1-yl}-2-methylpropanamide (GDC-0032): A β-Sparing Phosphoinositide 3-Kinase Inhibitor with High Unbound Exposure and Ro (journal article) Ndubaku, Chudi O. \| Heffron, Timothy P. \| Staben, Steven T. \| Baumgardner, Matthew \| Blaquiere, Nicole \| Bradley, Erin \| Bull, Richard \| Do, Steven \| Dotson, Jennafer \| Dudley, Danette \| ... \| Olivero, Alan G. Journal of Medicinal Chemistry, volume 56, issue 11, pages 4597-4610 (2013). 10.1021/jm4003632 Cited by (166) \| Cite \| Source
The Design and Identification of Brain Penetrant Inhibitors of Phosphoinositide 3-Kinase α (journal article) Heffron, Timothy P. \| Salphati, Laurent \| Alicke, Bruno \| Cheong, Jonathan \| Dotson, Jennafer \| Edgar, Kyle \| Goldsmith, Richard \| Gould, Stephen E. \| Lee, Leslie B. \| Lesnick, John D. \| ... \| Zhang, Xiaolin Journal of Medicinal Chemistry, volume 55, issue 18, pages 8007-8020 (2012). 10.1021/jm300867c Cited by (46) \| Cite \| Source
Active PI3K Pathway Causes an Invasive Phenotype Which Can Be Reversed or Promoted by Blocking the Pathway at Divergent Nodes (journal article) Wallin, Jeffrey J. \| Guan, Jane \| Edgar, Kyle A. \| Zhou, Wei \| Francis, Ross \| Torres, Anthony C. \| Haverty, Peter M. \| Eastham-Anderson, Jeffrey \| Arena, Sabrina \| Bardelli, Alberto \| ... \| Friedman, Lori S. PLoS ONE, volume 7, issue 5, pages e36402- (2012). 10.1371/journal.pone.0036402 Cited by (41) \| Cite \| Source \| Open Access
Nuclear Phospho-Akt Increase Predicts Synergy of PI3K Inhibition and Doxorubicin in Breast and Ovarian Cancer (journal article) Wallin, Jeffrey J. \| Guan, Jane \| Prior, Wei Wei \| Edgar, Kyle A. \| Kassees, Robert \| Sampath, Deepak \| Belvin, Marcia \| Friedman, Lori S. Science Translational Medicine, volume 2, issue 48 (2010). 10.1126/scitranslmed.3000630 Cited by (58) \| Cite \| Source
Pharmacokinetic-Pharmacodynamic Modeling of Tumor Growth Inhibition and Biomarker Modulation by the Novel Phosphatidylinositol 3-Kinase Inhibitor GDC-0941 (journal article) Salphati, Laurent \| Wong, Harvey \| Belvin, Marcia \| Bradford, Delia \| Edgar, Kyle A. \| Prior, Wei Wei \| Sampath, Deepak \| Wallin, Jeffrey J. Drug Metabolism and Disposition, volume 38, issue 9, pages 1436-1442 (2010). 10.1124/dmd.110.032912 Cited by (73) \| Cite \| Source \| Open Access
Isoform-Specific Phosphoinositide 3-Kinase Inhibitors Exert Distinct Effects in Solid Tumors (journal article) Edgar, Kyle A. \| Wallin, Jeffrey J. \| Berry, Megan \| Lee, Leslie B. \| Prior, Wei Wei \| Sampath, Deepak \| Friedman, Lori S. \| Belvin, Marcia Cancer Research, volume 70, issue 3, pages 1164-1172 (2010). 10.1158/0008-5472.CAN-09-2525 Cited by (119) \| Cite \| Source \| Open Access