Ivan Votruba

ScholarGPS® ID: 28201779248192

Affiliation

Gilead Sciences, Inc., Foster City, United States

Affiliation History

Field

Physical Sciences and Mathematics

Discipline

Chemistry

Top Specialties

Metrics Summary

Publication Count

248

Predicted Citations

5,686

Predicted h-index

Ranking

Publications and Citation History

Publications based on Top Specialties

Types of Publication

Publications
Books
Patents
NIH/NSF

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Structural Basis for Inhibition of Mycobacterial and Human Adenosine Kinase by 7-Substituted 7-(Het)aryl-7-deazaadenine Ribonucleosides (journal article) Snášel, Jan \| Nauš, Petr \| Dostál, Jiří \| Hnízda, Aleš \| Fanfrlík, Jindřich \| Brynda, Jiří \| Bourderioux, Aurelie \| Dušek, Michal \| Dvořáková, Hana \| Stolaříková, Jiřina \| ... \| Pichová, Iva Journal of Medicinal Chemistry, volume 57, issue 20, pages 8268-8279 (2014). 10.1021/jm500497v Cited by (26) \| Cite \| Source
6-Alkyl-, 6-aryl- or 6-hetaryl-7-deazapurine ribonucleosides as inhibitors of human or MTB adenosine kinase and potential antimycobacterial agents (journal article) Perlíková, Pavla \| Konečný, Petr \| Nauš, Petr \| Snášel, Jan \| Votruba, Ivan \| Džubák, Petr \| Pichová, Iva \| Hajdúch, Marián \| Hocek, Michal MedChemComm, volume 4, issue 11, pages 1497- (2013). 10.1039/c3md00232b Cited by (17) \| Cite \| Source \| Open Access
9-Norbornyl-6-chloropurine is a novel antileukemic compound interacting with cellular GSH. (journal article) Placková, Pavla \| Rozumová, Nela \| Hrebabecky, Hubert \| Sála, Michal \| Nencka, Radim \| Elbert, Tomás \| Dvoráková, Alexandra \| Votruba, Ivan \| Mertlíková-Kaiserová, Helena Anticancer research, volume 33, issue 8 (2013). Cited by (2) \| Cite
Mutations in adenosine deaminase-like (ADAL) protein confer resistance to the antiproliferative agents N6-cyclopropyl-PMEDAP and GS-9219. (journal article) Frey, Christian R \| Andrei, Graciela \| Votruba, Ivan \| Cannizzaro, Carina \| Han, Bin \| Fung, Wanchi \| Hung, Magdeleine \| Liu, Xiaohong \| Geleziunas, Romas \| Fiten, Pierre \| ... \| Cihlar, Tomas Anticancer research, volume 33, issue 5 (2013). Cited by (4) \| Cite
ChemInform Abstract: Sphingosine and Clavaminol H Derivatives Bearing Fluorinated Chains and Their Cytotoxic Activity. (journal article) Prchalova, Eva \| Votruba, Ivan \| Kotora, Martin ChemInform, volume 43, issue 48 (2012). 10.1002/chin.201248044 Cite \| Source
Sphingosine and clavaminol H derivatives bearing fluorinated chains and their cytotoxic activity (journal article) Prchalová, Eva \| Votruba, Ivan \| Kotora, Martin Journal of Fluorine Chemistry, volume 141 (2012). 10.1016/j.jfluchem.2012.06.005 Cited by (13) \| Cite \| Source
Sugar-modified derivatives of cytostatic 7-(het)aryl-7-deazaadenosines: 2′-C-methylribonucleosides, 2′-deoxy-2′-fluoroarabinonucleosides, arabinonucleosides and 2′-deoxyribonucleosides (journal article) Nauš, Petr \| Perlíková, Pavla \| Bourderioux, Aurelie \| Pohl, Radek \| Slavětínská, Lenka \| Votruba, Ivan \| Bahador, Gina \| Birkuš, Gabriel \| Cihlář, Tomáš \| Hocek, Michal Bioorganic & Medicinal Chemistry, volume 20, issue 17, pages 5202-5214 (2012). 10.1016/j.bmc.2012.07.003 Cited by (30) \| Cite \| Source
Antiviral activity of acyclic nucleoside phosphonates PMEA, (S)-HPMPC, PMEDAP and ribavirin against Cauliflower mosaic virus in Brassica pekinensis (journal article) Špak, Josef \| Votruba, Ivan \| Pavingerová, Daniela \| Holý, Antonín \| Špaková, Vlastimila \| Petrzik, Karel Plant Cell, Tissue and Organ Culture (PCTOC), volume 110, issue 1, pages 63-68 (2012). 10.1007/s11240-012-0130-0 Cited by (3) \| Cite \| Source
ChemInform Abstract: 6‐Alkynylpurines Bearing Electronacceptor Substituents: Preparation, Reactivity in Cycloaddition Reactions and Cytostatic Activity. (journal article) Krovacek, Martin \| Dvorakova, Hana \| Votruba, Ivan \| Cisarova, Ivana \| Dvorak, Dalimil ChemInform, volume 43, issue 20 (2012). 10.1002/chin.201220169 Cite \| Source
ChemInform Abstract: Synthesis and Biological Activity of Desmethoxy Analogues of Coruscanone A. (journal article) Tichotova, Lucie \| Matousova, Eliska \| Spulak, Marcel \| Kunes, Jiri \| Votruba, Ivan \| Buchta, Vladimir \| Pour, Milan ChemInform, volume 43, issue 8 (2012). 10.1002/chin.201208062 Cite \| Source
Involvement of MAP kinases in the cytotoxicity of acyclic nucleoside phosphonates. (journal article) Mertlíková-Kaiserová, Helena \| Nejedlá, Michaela \| Holy, Antonín \| Votruba, Ivan Anticancer research, volume 32, issue 2 (2012). Cited by (1) \| Cite
ChemInform Abstract: Efficient One‐Pot Synthesis of Polysubstituted 6‐[(1H‐1,2,3‐Triazol‐1‐yl)methyl]uracils Through the “Click” Protocol. (journal article) Jansa, Petr \| Spacek, Petr \| Votruba, Ivan \| Brehova, Petra \| Dracinsky, Martin \| Klepetarova, Blanka \| Janeba, Zlatko ChemInform, volume 42, issue 49 (2011). 10.1002/chin.201149161 Cite \| Source
Antiviral activity of tenofovir against Cauliflower mosaic virus and its metabolism in Brassica pekinensis plants (journal article) Špak, Josef \| Votruba, Ivan \| Pavingerová, Daniela \| Holý, Antonín \| Špaková, Vlastimila \| Petrzik, Karel Antiviral Research, volume 92, issue 2, pages 378-381 (2011). 10.1016/j.antiviral.2011.08.014 Cited by (8) \| Cite \| Source
Synthesis and biological activity of desmethoxy analogues of coruscanone A (journal article) Tichotová, Lucie \| Matoušová, Eliška \| Špulák, Marcel \| Kuneš, Jiří \| Votruba, Ivan \| Buchta, Vladimír \| Pour, Milan Bioorganic & Medicinal Chemistry Letters, volume 21, issue 20, pages 6062-6066 (2011). 10.1016/j.bmcl.2011.08.059 Cited by (11) \| Cite \| Source
A novel and efficient one-pot synthesis of symmetrical diamide (bis-amidate) prodrugs of acyclic nucleoside phosphonates and evaluation of their biological activities (journal article) Jansa, Petr \| Baszczyňski, Ondřej \| Dračínský, Martin \| Votruba, Ivan \| Zídek, Zdeněk \| Bahador, Gina \| Stepan, George \| Cihlar, Tomas \| Mackman, Richard \| Holý, Antonín \| Janeba, Zlatko European Journal of Medicinal Chemistry, volume 46, issue 9, pages 3748-3754 (2011). 10.1016/j.ejmech.2011.05.040 Cited by (75) \| Cite \| Source
Synthesis and Significant Cytostatic Activity of 7-Hetaryl-7-deazaadenosines (journal article) Bourderioux, Aurelie \| Nauš, Petr \| Perlíková, Pavla \| Pohl, Radek \| Pichová, Iva \| Votruba, Ivan \| Džubák, Petr \| Konečný, Petr \| Hajdúch, Marián \| Stray, Kirsten M. \| ... \| Hocek, Michal Journal of Medicinal Chemistry, volume 54, issue 15, pages 5498-5507 (2011). 10.1021/jm2005173 Cited by (101) \| Cite \| Source
Point mutations in human guanylate kinase account for acquired resistance to anticancer nucleotide analogue PMEG (journal article) Mertlíková-Kaiserová, Helena \| Rumlová, Michaela \| Tloušťová, Eva \| Procházková, Eliška \| Holý, Antonín \| Votruba, Ivan Biochemical Pharmacology, volume 82, issue 2, pages 131-138 (2011). 10.1016/j.bcp.2011.04.002 Cited by (4) \| Cite \| Source \| Open Access
2´-deoxy-5,6-dihydro-5-azacytidine - a less toxic alternative of 2´-deoxy-5-azacytidine (journal article) Matoušová, Marika \| Votruba, Ivan \| Otmar, Miroslav \| Tloušťová, Eva \| Günterová, Jana \| Mertlíková-Kaiserová, Helena Epigenetics, volume 6, issue 6, pages 769-776 (2011). 10.4161/epi.6.6.16215 Cited by (24) \| Cite \| Source \| Open Access
ChemInform Abstract: [2 + 2 + 2]‐Cocyclotrimerization of 6‐Alkynyl‐7‐benzylpurines with α,ω‐Diynes. (journal article) Opekar, Stanislav \| Turek, Pavel \| Pohl, Radek \| Klepetarova, Blanka \| Votruba, Ivan \| Hocek, Michal \| Kotora, Martin ChemInform, volume 42, issue 16 (2011). 10.1002/chin.201116168 Cite \| Source
Synthesis and antiviral activity of N9-[3-fluoro-2-(phosphonomethoxy)propyl] analogues derived from N6-substituted adenines and 2,6-diaminopurines (journal article) Baszczyňski, Ondřej \| Jansa, Petr \| Dračínský, Martin \| Klepetářová, Blanka \| Holý, Antonín \| Votruba, Ivan \| Clercq, Erik de \| Balzarini, Jan \| Janeba, Zlatko Bioorganic & Medicinal Chemistry, volume 19, issue 7, pages 2114-2124 (2011). 10.1016/j.bmc.2011.02.050 Cited by (27) \| Cite \| Source