Hans D. Brightbill

ScholarGPS® ID: 27027394231408

Affiliation

Genentech, Inc., South San Francisco, United States

Affiliation History

Field

Medicine

Discipline

Immunology

Top Specialties

Antibody | Cytokine | Toll-like Receptor | Allergy

Metrics Summary

Publication Count

Predicted Citations

4,878

Predicted h-index

Ranking

Publications and Citation History

Publications based on Top Specialties

Types of Publication

Publications
Books
Patents
NIH/NSF

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Diffusion Tensor MRI is sensitive to fibrotic injury in a mouse model of oxalate induced chronic kidney disease (journal article) Virgincar, Rohan S. \| Wong, Aaron K. \| Barck, Kai H. \| Webster, Joshua D. \| Hung, Jeffrey \| Caplazi, Patrick \| Choy, Man Kin \| Forrest, William F. \| Bell, Laura C. \| de Crespigny, Alex J. \| ... \| Xie, Luke American Journal of Physiology-Renal Physiology (2024). 10.1152/ajprenal.00099.2024 Cite \| Source
LOXL4, but not LOXL2, is the critical determinant of pathological collagen cross-linking and fibrosis in the lung (journal article) Ma, Hsiao-Yen \| Li, Qingling \| Wong, Weng Ruh \| N’Diaye, Elsa-Noah \| Caplazi, Patrick \| Bender, Hannah \| Huang, Zhiyu \| Arlantico, Alexander \| Jeet, Surinder \| Wong, Aaron \| ... \| Ding, Ning Science Advances, volume 9, issue 21 (2023). 10.1126/sciadv.adf0133 Cited by (4) \| Cite \| Source
IL-23 signaling is not an important driver of liver inflammation and fibrosis in murine non-alcoholic steatohepatitis models (journal article) Heredia, Jose E. \| Sorenson, Clara \| Flanagan, Sean \| Nunez, Victor \| Jones, Charles \| Martzall, Angela \| Leong, Laurie \| Martinez, Andres Paler \| Scherl, Alexis \| Brightbill, Hans D. \| ... \| Ding, Ning PLOS ONE, volume 17, issue 9, pages e0274582- (2022). 10.1371/journal.pone.0274582 Cited by (4) \| Cite \| Source
BMP1 is not required for lung fibrosis in mice (journal article) Ma, Hsiao-Yen \| N’Diaye, Elsa-Noah \| Caplazi, Patrick \| Huang, Zhiyu \| Arlantico, Alexander \| Jeet, Surinder \| Wong, Aaron \| Brightbill, Hans D. \| Li, Qingling \| Wong, Weng Ruth \| ... \| Ding, Ning Scientific Reports, volume 12, issue 1 (2022). 10.1038/s41598-022-09557-3 Cited by (5) \| Cite \| Source
NF-κB-inducing kinase maintains T cell metabolic fitness in antitumor immunity (journal article) Gu, Meidi \| Zhou, Xiaofei \| Sohn, Jee Hyung \| Zhu, Lele \| Jie, Zuliang \| Yang, Jin-Young \| Zheng, Xiaofeng \| Xie, Xiaoping \| Yang, Jie \| Shi, Yaoyao \| ... \| Sun, Shao-Cong Nature Immunology, volume 22, issue 2, pages 193-204 (2021). 10.1038/s41590-020-00829-6 Cited by (52) \| Cite \| Source
Discovery of Potent Benzolactam IRAK4 Inhibitors with Robust in Vivo Activity (journal article) Rajapaksa, Naomi S. \| Gobbi, Alberto \| Drobnick, Joy \| Do, Steven \| Kolesnikov, Aleksandr \| Liang, Jun \| Chen, Yongsheng \| Sujatha-Bhaskar, Swathi \| Huang, Zhiyu \| Brightbill, Hans \| ... \| Bryan, Marian C. ACS Medicinal Chemistry Letters, volume 11, issue 3, pages 327-333 (2020). 10.1021/acsmedchemlett.9b00380 Cited by (17) \| Cite \| Source
TAZ is required for lung alveolar epithelial cell differentiation after injury (journal article) Sun, Tianhe \| Huang, Zhiyu \| Zhang, Hua \| Posner, Clara \| Jia, Guiquan \| Ramalingam, Thirumalai R. \| Xu, Min \| Brightbill, Hans \| Egen, Jackson G. \| Dey, Anwesha \| Arron, Joseph R. JCI Insight, volume 4, issue 14 (2019). 10.1172/jci.insight.128674 Cited by (50) \| Cite \| Source
Development of Potent and Selective Pyrazolopyrimidine IRAK4 Inhibitors (journal article) Bryan, Marian C. \| Drobnick, Joy \| Gobbi, Alberto \| Kolesnikov, Aleksandr \| Chen, Yongsheng \| Rajapaksa, Naomi \| Ndubaku, Chudi \| Feng, Jianwen \| Chang, Willy \| Francis, Ross \| ... \| Kiefer, James R. Journal of Medicinal Chemistry, volume 62, issue 13, pages 6223-6240 (2019). 10.1021/acs.jmedchem.9b00439 Cited by (19) \| Cite \| Source
NIK signaling axis regulates dendritic cell function in intestinal immunity and homeostasis (journal article) Jie, Zuliang \| Yang, Jin-Young \| Gu, Meidi \| Wang, Hui \| Xie, Xiaoping \| Li, Yanchuan \| Liu, Ting \| Zhu, Lele \| Shi, Jianhong \| Zhang, Lingyun \| ... \| Sun, Shao-Cong Nature Immunology, volume 19, issue 11, pages 1224-1235 (2018). 10.1038/s41590-018-0206-z Cited by (33) \| Cite \| Source
High throughput screening of IRAK4 small molecule inhibitors in TLR ligand stimulated whole blood (journal article) Sujatha-Bhaskar, Swathi \| Huang, Zhiyu \| Francis, George \| Bryan, Callie \| Zarrin, Ali A. \| Kiefer, James \| Ghilardi, Nico \| Brightbill, Hans D. The Journal of Immunology, volume 200, issue 1_Supplement, pages 174.5-174.5 (2018). 10.4049/jimmunol.200.Supp.174.5 Cited by (1) \| Cite \| Source
Cell intrinsic role of NF-κB-inducing kinase in regulating T cell-mediated immune and autoimmune responses (journal article) Li, Yanchuan \| Wang, Hui \| Zhou, Xiaofei \| Xie, Xiaoping \| Chen, Xiang \| Jie, Zuliang \| Zou, Qiang \| Hu, Hongbo \| Zhu, Lele \| Cheng, Xuhong \| ... \| Sun, Shao-Cong Scientific Reports, volume 6, issue 1 (2016). 10.1038/srep22115 Cited by (52) \| Cite \| Source \| Open Access
Dendritic cells require NIK for CD40-dependent cross-priming of CD8+ T cells (journal article) Katakam, Anand K. \| Brightbill, Hans \| Franci, Christian \| Kung, Chung \| Nunez, Victor \| Jones, Charles \| Peng, Ivan \| Jeet, Surinder \| Wu, Lawren C. \| Mellman, Ira \| ... \| Austin, Cary D. Proceedings of the National Academy of Sciences, volume 112, issue 47, pages 14664-14669 (2015). 10.1073/pnas.1520627112 Cited by (36) \| Cite \| Source \| Open Access
Conditional Deletion of NF-κB–Inducing Kinase (NIK) in Adult Mice Disrupts Mature B Cell Survival and Activation (journal article) Brightbill, Hans D. \| Jackman, Janet K. \| Suto, Eric \| Kennedy, Heather \| Jones, Charles \| Chalasani, Sreedevi \| Lin, Zhonghua \| Tam, Lucinda \| Roose-Girma, Meron \| Balazs, Mercedesz \| ... \| Wu, Lawren C. The Journal of Immunology, volume 195, issue 3, pages 953-964 (2015). 10.4049/jimmunol.1401514 Cited by (48) \| Cite \| Source \| Open Access
Conditional Deletion of NF-κB-Inducing Kinase (NIK) in Adult Mice Disrupts Mature B Cell Survival and Activation. (journal article) Brightbill, Hans D \| Jackman, Janet K \| Suto, Eric \| Kennedy, Heather \| Jones, Charles \| Chalasani, Sreedevi \| Lin, Zhonghua \| Tam, Lucinda \| Roose-Girma, Meron \| Balazs, Mercedesz \| ... \| Wu, Lawren C Journal of immunology (Baltimore, Md. : 1950), volume 195, issue 3 (2015). Cited by (1) \| Cite
A microRNA upregulated in asthma airway T cells promotes TH2 cytokine production (journal article) Simpson, Laura J \| Patel, Sana \| Bhakta, Nirav R \| Choy, David F \| Brightbill, Hans D \| Ren, Xin \| Wang, Yanli \| Pua, Heather H \| Baumjohann, Dirk \| Montoya, Misty M \| ... \| Ansel, K Mark Nature Immunology, volume 15, issue 12, pages 1162-1170 (2014). 10.1038/ni.3026 Cited by (192) \| Cite \| Source \| Open Access
Defective CD40‐dependent antigen cross‐priming of CD8+ T cells in mice with conditional deletion of NF‐κB‐inducing kinase (146.11) (journal article) Katakam, Anand \| Brightbill, Hans \| Franci, Christian \| Wu, Lawren \| Mellman, Ira \| Delamarre, Lelia \| Austin, Cary The FASEB Journal, volume 28, issue S1 (2014). 10.1096/fasebj.28.1_supplement.146.11 Cite \| Source
Quilizumab is an Afucosylated Humanized Anti-M1 Prime Therapeutic Antibody (journal article) Brightbill, Hans \| Lin, Yuwen \| Lin, Zhonghua \| Tan, Martha \| Meng, Y. \| Balazs, Mercedesz \| Chung, Shan \| Wu, Lawren Clinical Anti-Inflammatory & Anti-Allergy Drugs, volume 1, issue 1, pages 24-31 (2014). 10.2174/22127038114019990003 Cited by (20) \| Cite \| Source
Apoptotic anti-IgE antibodies (patent) Wu, Lawren \| Balazs, Mercedesz \| Brightbill, Hans \| Chan, Andrew \| Chen, Yvonne \| Chuntharapai, Anan \| Dennis, Mark \| Wong, Terence Patent Number: 8632775 (2014) Cited by (2) \| Cite \| Source
Nucleic acid encoding apoptotic anti-IgE antibodies (patent) Chuntharapai, Anan \| Chan, Andy \| Brightbill, Hans \| Wu, Lawren \| Dennis, Mark \| Balazs, Mercedesz \| Wong, Terence \| Chen, Yvonne Patent Number: 8618274 (2013) Cited by (3) \| Cite \| Source
Addendum: IgE+ memory B cells and plasma cells generated through a germinal-center pathway (journal article) Talay, Oezcan \| Yan, Donghong \| Brightbill, Hans D \| Straney, Elizabeth E M \| Zhou, Meijuan \| Ladi, Ena \| Lee, Wyne P \| Egen, Jackson G \| Austin, Cary D \| Xu, Min \| Wu, Lawren C Nature Immunology, volume 14, issue 12, pages 1302-1304 (2013). 10.1038/ni.2770 Cited by (19) \| Cite \| Source \| Open Access