Helena I. Boshoff | Scholar Profiles and Rankings

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The Antitubercular Activities of Natural Products with Fused-Nitrogen-Containing Heterocycles (journal article) Boshoff, Helena I. \| Malhotra, Neha \| Barry, Clifton E. \| Oh, Sangmi Pharmaceuticals, volume 17, issue 2, pages 211- (2024). 10.3390/ph17020211 Cite \| Source
Inhibition of DXR in the MEP pathway with lipophilic N -alkoxyaryl FR900098 analogs (journal article) Bague, Darean \| Wang, Ruiqin \| Hodge, Dana \| Mikati, Marwa O. \| Roma, Jose S. \| Boshoff, Helena I. \| Dailey, Allyson L. \| Girma, Misgina \| Couch, Robin D. \| Odom John, Audrey R. \| Dowd, Cynthia S. RSC Medicinal Chemistry (2024). 10.1039/D3MD00642E Cite \| Source
Synthesis and Structure–Activity Relationships of a New Class of Oxadiazoles Targeting DprE1 as Antitubercular Agents (journal article) Yadav, Veena D. \| Boshoff, Helena I. \| Trifonov, Lena \| Roma, Jose Santinni O. \| Ioerger, Thomas R. \| Barry, Clifton E. \| Oh, Sangmi ACS Medicinal Chemistry Letters, volume 14, issue 9, pages 1275-1283 (2023). 10.1021/acsmedchemlett.3c00295 Cited by (1) \| Cite \| Source
MEPicides: α,β-unsaturated Fosmidomycin N -Acyl Analogs as Efficient Inhibitors of Plasmodium falciparum 1-Deoxy- d -xylulose-5-phosphate reductoisomerase (journal article) Wang, Xu \| Edwards, Rachel L. \| Ball, Haley S. \| Heidel, Kenneth M. \| Brothers, Robert C. \| Johnson, Claire \| Haymond, Amanda \| Girma, Misgina \| Dailey, Allyson \| Roma, Jose Santinni \| ... \| Dowd, Cynthia S. ACS Infectious Diseases, volume 9, issue 7, pages 1387-1395 (2023). 10.1021/acsinfecdis.3c00132 Cited by (3) \| Cite \| Source
Structure Based Discovery of Inhibitors of CYP125 and CYP142 from Mycobacterium tuberculosis (journal article) Katariya, Mona M. \| Snee, Matthew \| Tunnicliffe, Richard B. \| Kavanagh, Madeline E. \| Boshoff, Helena I. M. \| Amadi, Cecilia N. \| Levy, Colin W. \| Munro, Andrew W. \| Abell, Chris \| Leys, David \| ... \| McLean, Kirsty J. Chemistry – A European Journal, volume 29, issue 29 (2023). 10.1002/chem.202203868 Cited by (3) \| Cite \| Source
Chemical approaches to unraveling the biology of mycobacteria (journal article) Finin, Peter \| Khan, R. M. Naseer \| Oh, Sangmi \| Boshoff, Helena I.M. \| Barry, Clifton E. Cell Chemical Biology, volume 30, issue 5, pages 420-435 (2023). 10.1016/j.chembiol.2023.04.014 Cite \| Source
Nonhydrolyzable d-phenylalanine-benzoxazole derivatives retain antitubercular activity (journal article) Pepi, Michael J. \| Chacko, Shibin \| Kopetz, Nicole \| Boshoff, Helena I.M. \| Cuny, Gregory D. \| Hedstrom, Lizbeth Bioorganic & Medicinal Chemistry Letters, volume 80 (2023). 10.1016/j.bmcl.2022.129116 Cite \| Source
Molecular insights into Mmpl3 lead to the development of novel indole-2-carboxamides as antitubercular agents (journal article) Ray, Rajdeep \| Birangal, Sumit Raosaheb \| Fathima, Fajeelath \| Boshoff, Helena I. \| Forbes, He Eun \| Hariharapura, Raghu Chandrashekhar \| Shenoy, G. Gautham Molecular Systems Design & Engineering, volume 7, issue 6, pages 592-606 (2022). 10.1039/D1ME00122A Cited by (2) \| Cite \| Source
DNA-Dependent Binding of Nargenicin to DnaE1 Inhibits Replication in Mycobacterium tuberculosis (journal article) Chengalroyen, Melissa D. \| Mason, Mandy K. \| Borsellini, Alessandro \| Tassoni, Raffaella \| Abrahams, Garth L. \| Lynch, Sasha \| Ahn, Yong-Mo \| Ambler, Jon \| Young, Katherine \| Crowley, Brendan M. \| ... \| Mizrahi, Valerie ACS Infectious Diseases, volume 8, issue 3, pages 612-625 (2022). 10.1021/acsinfecdis.1c00643 Cited by (12) \| Cite \| Source
Synthesis and biological evaluation of orally active prodrugs and analogs of para-aminosalicylic acid (PAS) (journal article) Hegde, Pooja V. \| Howe, Michael D. \| Zimmerman, Matthew D. \| Boshoff, Helena I.M. \| Sharma, Sachin \| Remache, Brianna \| Jia, Ziyi \| Pan, Yan \| Baughn, Anthony D. \| Dartois, Veronique \| Aldrich, Courtney C. European Journal of Medicinal Chemistry, volume 232 (2022). 10.1016/j.ejmech.2022.114201 Cited by (5) \| Cite \| Source
A d -Phenylalanine-Benzoxazole Derivative Reveals the Role of the Essential Enzyme Rv3603c in the Pantothenate Biosynthetic Pathway of Mycobacterium tuberculosis (journal article) Pepi, Michael J. \| Chacko, Shibin \| Marqus, Gary M. \| Singh, Vinayak \| Wang, Zhe \| Planck, Kyle \| Cullinane, Ryan T. \| Meka, Penchala N. \| Gollapalli, Deviprasad R. \| Ioerger, Thomas R. \| ... \| Hedstrom, Lizbeth ACS Infectious Diseases, volume 8, issue 2, pages 330-342 (2022). 10.1021/acsinfecdis.1c00461 Cited by (1) \| Cite \| Source
Expanding Benzoxazole-Based Inosine 5′-Monophosphate Dehydrogenase (IMPDH) Inhibitor Structure–Activity As Potential Antituberculosis Agents (journal article) Chacko, Shibin \| Boshoff, Helena I. M. \| Singh, Vinayak \| Ferraris, Davide M. \| Gollapalli, Deviprasad R. \| Zhang, Minjia \| Lawson, Ann P. \| Pepi, Michael J. \| Joachimiak, Andrzej \| Rizzi, Menico \| ... \| Hedstrom, Lizbeth Journal of Medicinal Chemistry, volume 64, issue 24, pages 18233-18234 (2021). 10.1021/acs.jmedchem.1c01923 Cite \| Source
6-Fluorophenylbenzohydrazides inhibit Mycobacterium tuberculosis growth through alteration of tryptophan biosynthesis (journal article) Consalvi, Sara \| Venditti, Giulia \| Zhu, Junhao \| Boshoff, Helena I. \| Arora, Kriti \| De Logu, Alessandro \| Ioerger, Thomas R. \| Rubin, Eric J. \| Biava, Mariangela \| Poce, Giovanna European Journal of Medicinal Chemistry, volume 226 (2021). 10.1016/j.ejmech.2021.113843 Cited by (2) \| Cite \| Source
Structure-aided optimization of non-nucleoside M. tuberculosis thymidylate kinase inhibitors (journal article) Song, Lijun \| Merceron, Romain \| Hulpia, Fabian \| Lucía, Ainhoa \| Gracia, Begoña \| Jian, Yanlin \| Risseeuw, Martijn D.P. \| Verstraelen, Toon \| Cos, Paul \| Aínsa, José A. \| ... \| Van Calenbergh, Serge European Journal of Medicinal Chemistry, volume 225 (2021). 10.1016/j.ejmech.2021.113784 Cited by (4) \| Cite \| Source
1,3-Diarylpyrazolyl-acylsulfonamides as Potent Anti-tuberculosis Agents Targeting Cell Wall Biosynthesis in Mycobacterium tuberculosis (journal article) Khonde, Lutete Peguy \| Müller, Rudolf \| Boyle, Grant A. \| Reddy, Virsinha \| Nchinda, Aloysius T. \| Eyermann, Charles J. \| Fienberg, Stephen \| Singh, Vinayak \| Myrick, Alissa \| Abay, Efrem \| ... \| Chibale, Kelly Journal of Medicinal Chemistry, volume 64, issue 17, pages 12790-12807 (2021). 10.1021/acs.jmedchem.1c00837 Cited by (16) \| Cite \| Source
Resistance of Mycobacterium tuberculosis to indole 4-carboxamides occurs through alterations in drug metabolism and tryptophan biosynthesis (journal article) Libardo, M. Daben J. \| Duncombe, Caroline J. \| Green, Simon R. \| Wyatt, Paul G. \| Thompson, Stephen \| Ray, Peter C. \| Ioerger, Thomas R. \| Oh, Sangmi \| Goodwin, Michael B. \| Boshoff, Helena I.M. \| Barry, Clifton E. Cell Chemical Biology, volume 28, issue 8, pages 1180-1191.e20 (2021). 10.1016/j.chembiol.2021.02.023 Cited by (8) \| Cite \| Source
Reinvestigation of the structure-activity relationships of isoniazid (journal article) Hegde, Pooja \| Boshoff, Helena I.M. \| Rusman, Yudi \| Aragaw, Wassihun Wedajo \| Salomon, Christine E. \| Dick, Thomas \| Aldrich, Courtney C. Tuberculosis, volume 129 (2021). 10.1016/j.tube.2021.102100 Cited by (4) \| Cite \| Source
Targeting Mycobacterium tuberculosis CoaBC through Chemical Inhibition of 4′-Phosphopantothenoyl- l -cysteine Synthetase (CoaB) Activity (journal article) Evans, Joanna C. \| Murugesan, Dinakaran \| Post, John M. \| Mendes, Vitor \| Wang, Zhe \| Nahiyaan, Navid \| Lynch, Sasha L. \| Thompson, Stephen \| Green, Simon R. \| Ray, Peter C. \| ... \| Mizrahi, Valerie ACS Infectious Diseases, volume 7, issue 6, pages 1666-1679 (2021). 10.1021/acsinfecdis.0c00904 Cited by (4) \| Cite \| Source
Identification of Antifungal Compounds against Multidrug-Resistant Candida auris Utilizing a High-Throughput Drug-Repurposing Screen (journal article) Cheng, Yu-Shan \| Roma, Jose Santinni \| Shen, Min \| Mota Fernandes, Caroline \| Tsang, Patricia S. \| Forbes, He Eun \| Boshoff, Helena \| Lazzarini, Cristina \| Del Poeta, Maurizio \| Zheng, Wei \| Williamson, Peter R. Antimicrobial Agents and Chemotherapy, volume 65, issue 4 (2021). 10.1128/AAC.01305-20 Cited by (19) \| Cite \| Source
Tuberculosis Drug Discovery: A Decade of Hit Assessment for Defined Targets (journal article) Oh, Sangmi \| Trifonov, Lena \| Yadav, Veena D. \| Barry, Clifton E. \| Boshoff, Helena I. Frontiers in Cellular and Infection Microbiology, volume 11 (2021). 10.3389/fcimb.2021.611304 Cited by (40) \| Cite \| Source