Celine Schalk-Hihi

ScholarGPS® ID: 24894319861195

Affiliation

Janssen Pharmaceutica

Affiliation History

Field

Life Sciences

Discipline

Biology and Biological Sciences

Top Specialties

Crystal Structure | Matrix Metallopeptidase | Medicinal Chemistry | Metalloproteinase

Metrics Summary

Publication Count

Predicted Citations

1,768

Predicted h-index

Ranking

Publications and Citation History

Publications based on Top Specialties

Types of Publication

Publications
Books
Patents
NIH/NSF

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6-Substituted quinolines as RORγt inverse agonists (journal article) Barbay, J. Kent \| Cummings, Maxwell D. \| Abad, Marta \| Castro, Glenda \| Kreutter, Kevin D. \| Kummer, David A. \| Maharoof, Umar \| Milligan, Cynthia \| Nishimura, Rachel \| Pierce, Joan \| ... \| Leonard, Kristi Bioorganic & Medicinal Chemistry Letters, volume 27, issue 23, pages 5277-5283 (2017). 10.1016/j.bmcl.2017.10.027 Cited by (23) \| Cite \| Source
Discovery of a highly selective chemical inhibitor of matrix metalloproteinase-9 (MMP-9) that allosterically inhibits zymogen activation (journal article) Scannevin, Robert H. \| Alexander, Richard \| Haarlander, Tara Mezzasalma \| Burke, Sharon L. \| Singer, Monica \| Huo, Cuifen \| Zhang, Yue-Mei \| Maguire, Diane \| Spurlino, John \| Deckman, Ingrid \| ... \| Rhodes, Kenneth J. Journal of Biological Chemistry, volume 292, issue 43, pages 17963-17974 (2017). 10.1074/jbc.M117.806075 Cited by (93) \| Cite \| Source \| Open Access
Identification and structure activity relationships of quinoline tertiary alcohol modulators of RORγt (journal article) Kummer, David A. \| Cummings, Maxwell D. \| Abad, Marta \| Barbay, Joseph \| Castro, Glenda \| Wolin, Ronald \| Kreutter, Kevin D. \| Maharoof, Umar \| Milligan, Cynthia \| Nishimura, Rachel \| ... \| Leonard, Kristi Bioorganic & Medicinal Chemistry Letters, volume 27, issue 9, pages 2047-2057 (2017). 10.1016/j.bmcl.2017.02.044 Cited by (25) \| Cite \| Source
Methods of treatment using allosteric processing inhibitors for matrix metalloproteinases (patent) Leonard, Kristi A. \| Alexander, Richard Scott \| Barbay, Joseph Kent \| Bone, Roger F. \| Crysler, Carl \| Deckman, Ingrid Christa \| Jackson, Paul F. \| Kuo, Lawrence C. \| Lewandowski, Frank A. \| Maguire, Diane M. \| ... \| Wang, Aihua Patent Number: 8883473 (2014) Cited by (3) \| Cite \| Source
Methods for designing, selecting and/or optimizing allosteric processing inhibitors for matrix metalloproteinases (patent) Leonard, Kristi A. \| Alexander, Richard Scott \| Barbay, Joseph Kent \| Bone, Roger F. \| Deckman, Ingrid Christa \| Jackson, Paul F. \| Kuo, Lawrence C. \| Lewandowski, Frank A. \| Maguire, Diane M. \| Milligan, Cynthia M. \| ... \| Wang, Aihua Patent Number: 8798939 (2014) Cite \| Source
Crystal structure of the pro form of a matrix metalloproteinase and an allosteric processing inhibitor (patent) Leonard, Kristi A. \| Alexander, Richard Scott \| Barbay, Joseph Kent \| Bone, Roger F. \| Deckman, Ingrid Christa \| Jackson, Paul F. \| Kuo, Lawrence C. \| Lewandowski, Frank A. \| Maguire, Diane M. \| Milligan, Cynthia M. \| ... \| Wang, Aihua Patent Number: 8753857 (2014) Cited by (2) \| Cite \| Source
A thiocarbamate inhibitor of endothelial lipase raises HDL cholesterol levels in mice (journal article) Greco, M.N. \| Connelly, M.A. \| Leo, G.C. \| Olson, M.W. \| Powell, E. \| Huang, Z. \| Hawkins, M. \| Smith, C. \| Schalk-Hihi, C. \| Darrow, A.L. \| ... \| Hlasta, D.J. Bioorganic & Medicinal Chemistry Letters, volume 23, issue 9, pages 2595-2597 (2013). 10.1016/j.bmcl.2013.02.113 Cited by (8) \| Cite \| Source
Protein engineering of monoacylglycerol lipase (MGLL) (patent) Grasberger, Bruce L. \| Schalk-Hihi, Celine \| Maguire, Diane M. \| Lewandowski, Frank A. \| Milligan, Cynthia M. \| Alexander, Richard S. Patent Number: 8257698 (2012) Cited by (2) \| Cite \| Source
Screening and Characterization of Human Monoglyceride Lipase Active Site Inhibitors Using Orthogonal Binding and Functional Assays (journal article) Clemente, José C. \| Nulton, Erica \| Nelen, Marina \| Todd, Matthew J. \| Maguire, Diane \| Schalk-Hihi, Céline \| Kuo, Lawrence C. \| Zhang, Sui-Po \| Flores, Christopher M. \| Kranz, James K. SLAS Discovery, volume 17, issue 5, pages 629-640 (2012). 10.1177/1087057112441012 Cited by (8) \| Cite \| Source \| Open Access
Crystal structure of monoacylglycerol lipase (MGLL) (patent) Schubert, Carsten \| Grasberger, Bruce L. \| Schalk-Hihi, Celine \| Maguire, Diane M. \| Lewandowski, Frank A. \| Milligan, Cynthia M. \| Alexander, Richard S. Patent Number: 8080400 (2011) Cited by (6) \| Cite \| Source
Alternative crystal form of monoacylglycerol lipase (MGLL) (patent) Schubert, Carsten \| Grasberger, Bruce L. \| Schalk-Hihi, Celine \| Maguire, Diane M. \| Lewandowski, Frank A. \| Milligan, Cynthia M. \| Alexander, Richard S. Patent Number: 8067220 (2011) Cite \| Source
Crystal structure of a soluble form of human monoglyceride lipase in complex with an inhibitor at 1.35 Å resolution (journal article) Schalk‐Hihi, Céline \| Schubert, Carsten \| Alexander, Richard \| Bayoumy, Shariff \| Clemente, Jose C. \| Deckman, Ingrid \| DesJarlais, Renee L. \| Dzordzorme, Keli C. \| Flores, Christopher M. \| Grasberger, Bruce \| ... \| Kuo, Lawrence C. Protein Science, volume 20, issue 4, pages 670-683 (2011). 10.1002/pro.596 Cited by (101) \| Cite \| Source \| Open Access
A novel fluorogenic substrate for the measurement of endothelial lipase activity (journal article) Darrow, Andrew L. \| Olson, Matthew W. \| Xin, Hong \| Burke, Sharon L. \| Smith, Charles \| Schalk-Hihi, Celine \| Williams, Robyn \| Bayoumy, Shariff S. \| Deckman, Ingrid C. \| Todd, Matthew J. \| ... \| Connelly, Margery A. Journal of Lipid Research, volume 52, issue 2, pages 374-382 (2011). 10.1194/jlr.D007971 Cited by (23) \| Cite \| Source \| Open Access
Protein Thermal Shifts to Identify Low Molecular Weight Fragments (book chapter) In Fragment-Based Drug Design - Tools, Practical Approaches, and Examples Kranz, James K. \| Schalk-Hihi, Celine Elsevier (2011) 10.1016/B978-0-12-381274-2.00011-X Cited by (104) \| Cite \| Source
Enhancing Recombinant Protein Quality and Yield by Protein Stability Profiling (journal article) Mezzasalma, Tara M. \| Kranz, James K. \| Chan, Winnie \| Struble, Geoffrey T. \| Schalk-Hihi, Céline \| Deckman, Ingrid C. \| Springer, Barry A. \| Todd, Matthew J. SLAS Discovery, volume 12, issue 3, pages 418-428 (2007). 10.1177/1087057106297984 Cited by (87) \| Cite \| Source \| Open Access
Crystal Structure of the Tyrosine Kinase Domain of Colony-stimulating Factor-1 Receptor (cFMS) in Complex with Two Inhibitors (journal article) Schubert, Carsten \| Schalk-Hihi, Céline \| Struble, Geoffrey T. \| Ma, Hong-Chang \| Petrounia, Ioanna P. \| Brandt, Benjamin \| Deckman, Ingrid C. \| Patch, Raymond J. \| Player, Mark R. \| Spurlino, John C. \| Springer, Barry A. Journal of Biological Chemistry, volume 282, issue 6, pages 4094-4101 (2007). 10.1074/jbc.M608183200 Cited by (57) \| Cite \| Source \| Open Access
Protein Engineering of the Colony-stimulating Factor-1 Receptor Kinase Domain for Structural Studies (journal article) Schalk-Hihi, Céline \| Ma, Hong-Chang \| Struble, Geoffrey T. \| Bayoumy, Shariff \| Williams, Robyn \| Devine, Eric \| Petrounia, Ioanna P. \| Mezzasalma, Tara \| Zeng, Lee \| Schubert, Carsten \| ... \| Deckman, Ingrid C. Journal of Biological Chemistry, volume 282, issue 6, pages 4085-4093 (2007). 10.1074/jbc.M608182200 Cited by (11) \| Cite \| Source \| Open Access
Crystal structure of the c-fms kinase domain: applications and use of heterologous substitutions of kinase insert domains for crystallization (patent) Schubert, Carsten \| Springer, Barry A. \| Deckman, Ingrid C. \| Patch, Raymond J. \| Struble, Geoffrey T. \| Ma, Hongchang \| Schalk-Hihi, Celine \| Brandt, Benjamin M. \| Petrounia, Ioanna Patent Number: 20060094081 (2005) Cite \| Source
2-Hydroxy-4,6-diamino-[1,3,5]triazines: A Novel Class of VEGF-R2 (KDR) Tyrosine Kinase Inhibitors (journal article) Baindur, Nand \| Chadha, Naresh \| Brandt, Benjamin M. \| Asgari, Davoud \| Patch, Raymond J. \| Schalk-HiHi, Celine \| Carver, Theodore E. \| Petrounia, Ioanna P. \| Baumann, Christian A. \| Ott, Heidi \| ... \| Player, Mark R. Journal of Medicinal Chemistry, volume 48, issue 6, pages 1717-1720 (2005). 10.1021/jm049372z Cited by (52) \| Cite \| Source
Identification of a Highly Diverged Class ofS-Adenosylmethionine Synthetases in the Archaea (journal article) Graham, David E. \| Bock, Cindy L. \| Schalk-Hihi, Celine \| Lu, Zichun J. \| Markham, George D. Journal of Biological Chemistry, volume 275, issue 6, pages 4055-4059 (2000). 10.1074/jbc.275.6.4055 Cited by (46) \| Cite \| Source \| Open Access