Shu-Hui Chen

ScholarGPS® ID: 24221058199182

Affiliation

WuXi AppTec, China

Affiliation History

Field

Medicine

Discipline

Oncology

Top Specialties

Metrics Summary

Publication Count

Predicted Citations

1,770

Predicted h-index

Ranking

Publications and Citation History

Publications based on Top Specialties

Types of Publication

Publications
Books
Patents
NIH/NSF

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Discovery of a Macrocyclic Influenza Cap-Dependent Endonuclease Inhibitor (journal article) Feng, Jiajie \| Guo, Fengying \| Li, Peng \| Zhang, Jing \| Jiang, Kaixuan \| Zhu, Zhenzhen \| Yin, Shanshan \| Lin, Xiaowan \| Lin, Fusen \| Xiao, Fubiao \| ... \| Chen, Shuhui Journal of Medicinal Chemistry, volume 67, issue 4, pages 2570-2583 (2024). 10.1021/acs.jmedchem.3c01715 Cited by (1) \| Cite \| Source
Discovery of novel bicyclic[3.3.0]proline peptidyl α-ketoamides as potent 3CL-protease inhibitors for SARS-CoV-2 (journal article) Chen, Xiaoxin \| Li, Peng \| Huang, Jianzhou \| Yang, Yaxun \| Zhang, Haoyu \| Wang, Zheng \| Zhu, Zhenzhen \| Wang, Jingjing \| Zhang, Jianchen \| Chen, Kevin \| ... \| Chen, Shuhui Bioorganic & Medicinal Chemistry Letters, volume 90 (2023). 10.1016/j.bmcl.2023.129324 Cited by (2) \| Cite \| Source
Synthesis and evaluation of hydrazinyl-containing pyrrolo[2,3-d]pyrimidine series as potent, selective and oral JAK1 inhibitors for the treatment of rheumatoid arthritis (journal article) Mao, Weiwei \| Wu, Hao \| Guo, Qiang \| Zheng, Xuejian \| Wei, Changqing \| Liao, Yonggang \| Shen, Liang \| Mi, Jingyu \| Li, Jian \| Chen, Shuhui \| Qian, Wenyuan Bioorganic & Medicinal Chemistry Letters, volume 74 (2022). 10.1016/j.bmcl.2022.128905 Cited by (2) \| Cite \| Source
Discovery and preclinical evaluations of JBD0131, a novel nitrodihydro-imidazooxazole anti-tuberculosis agent (journal article) Luo, Wei \| Huang, Zhigang \| Xu, Deming \| Yang, Meng \| Zhu, Yusong \| Shen, Liang \| Chen, Shuhui \| Tao, Xin \| Bin, Wang \| Hu, Yinghu \| ... \| Ding, Charles Z. Bioorganic & Medicinal Chemistry Letters, volume 72 (2022). 10.1016/j.bmcl.2022.128871 Cited by (3) \| Cite \| Source
Discovery and preclinical profile of sudapyridine (WX-081), a novel anti-tuberculosis agent (journal article) Huang, Zhigang \| Luo, Wei \| Xu, Deming \| Guo, Fengxun \| Yang, Meng \| Zhu, Yusong \| Shen, Liang \| Chen, Shuhui \| Tang, Dongdong \| Li, Lei \| ... \| Ding, Charles Z. Bioorganic & Medicinal Chemistry Letters, volume 71 (2022). 10.1016/j.bmcl.2022.128824 Cited by (17) \| Cite \| Source
Discovery and preclinical evaluations of WX-0593, a novel ALK inhibitor targeting crizotinib-resistant mutations (journal article) Liu, Xile \| Zhang, Lu \| Wan, Haiwen \| Zhu, Zhenzhen \| Jin, Jing \| Qin, Yuxin \| Mao, Weifeng \| Yan, Kang \| Fang, Douglas \| Jiang, Wen \| ... \| Ding, Charles Z. Bioorganic & Medicinal Chemistry Letters, volume 66 (2022). 10.1016/j.bmcl.2022.128730 Cited by (7) \| Cite \| Source
Safety, Tolerability, and Pharmacokinetics of the Novel Hepatitis B Virus Expression Inhibitor GST-HG131 in Healthy Chinese Subjects: a First-in-Human Single- and Multiple-Dose Escalation Trial (journal article) Li, Xiaojiao \| Liu, Yusi \| Yao, Hanxin \| Wang, Meng \| Gao, Lei \| Lou, Jinfeng \| Mao, John \| Wu, Wenqiang \| Zhou, Yixin \| Tang, Yanan \| ... \| Ding, Yanhua Antimicrobial Agents and Chemotherapy, volume 66, issue 5 (2022). 10.1128/aac.00094-22 Cited by (4) \| Cite \| Source
Discovery and optimization of selective RET inhibitors via scaffold hopping (journal article) Luo, Zhibo \| Wang, Lingli \| Fu, Zhifei \| Shuai, Bin \| Luo, Miaorong \| Hu, Guoping \| Chen, Jian \| Sun, Jikui \| Wang, Jiansong \| Li, Jian \| ... \| Zhang, Yang Bioorganic & Medicinal Chemistry Letters, volume 47 (2021). 10.1016/j.bmcl.2021.128149 Cited by (7) \| Cite \| Source
Design, syntheses and evaluations of novel indole derivatives as orally selective estrogen receptor degraders (SERD) (journal article) Dong, Jiaqiang \| Wang, Tie-lin \| Lu, Jianyu \| Ding, Charles Z. \| Hu, Lihong \| Hu, Guoping \| He, Huijun \| Zeng, Xu \| Li, Xiaoting \| Sun, Deheng \| ... \| Chen, Shuhui Bioorganic & Medicinal Chemistry Letters, volume 30, issue 22, pages 127601- (2020). 10.1016/j.bmcl.2020.127601 Cited by (13) \| Cite \| Source
Therapeutic Effect and Mechanisms of the Novel Monosulfactam 0073 (journal article) Sun, Ying \| Liao, Xueyuan \| Huang, Zhigang \| Xie, Yaliu \| Liu, Yanbin \| Ma, Cuicui \| Jiang, Boguang \| Zhang, Li \| Yan, Yuhang \| Li, Guobo \| ... \| Wei, Xiawei Antimicrobial Agents and Chemotherapy, volume 64, issue 10 (2020). 10.1128/AAC.00529-20 Cited by (4) \| Cite \| Source
Discovery of 3-Quinazolin-4(3 H )-on-3-yl-2, N -dimethylpropanamides as Orally Active and Selective PI3Kα Inhibitors (journal article) Dong, Jiaqiang \| Huang, Jingjie \| Zhou, Ji \| Tan, Ye \| Jin, Jing \| Tan, Xi \| Wang, Bei \| Yu, Tao \| Wu, Chengde \| Chen, Shuhui \| Wang, Tie-Lin ACS Medicinal Chemistry Letters, volume 11, issue 7, pages 1463-1469 (2020). 10.1021/acsmedchemlett.0c00239 Cited by (5) \| Cite \| Source
Design, synthesis, and evaluation of a novel macrocyclic anti-EV71 agent (journal article) Li, Peng \| Wu, Siqi \| Xiao, Tianyichen \| Li, Yunlong \| Su, Zhiming \| Wei, Wei \| Hao, Fei \| Hu, Guoping \| Lin, Fusen \| Chen, Xinsheng \| ... \| Chen, Shuhui Bioorganic & Medicinal Chemistry, volume 28, issue 12, pages 115551- (2020). 10.1016/j.bmc.2020.115551 Cited by (4) \| Cite \| Source
Preclinical Evaluation of Amphihevir, a First-in-Class Clinical Hepatitis C Virus NS4B Inhibitor (journal article) Tao, Xin \| Wang, Ningyu \| Wang, Jianfei \| Fu, Zhifei \| Gu, Zhengxian \| Zhang, Yang \| Chen, Shuhui \| Wang, Lichun \| Yu, Luoting Antimicrobial Agents and Chemotherapy, volume 63, issue 12 (2019). 10.1128/AAC.01237-19 Cited by (3) \| Cite \| Source
Discovery and evaluation of novel nitrodihydroimidazooxazoles as promising anti-tuberculosis agents (journal article) Tao, Xin \| Gao, Chao \| Huang, Zhi-Gang \| Luo, Wei \| Liu, Kun-Lin \| Peng, Cui-Ting \| Ding, Charles Z. \| Li, Jian \| Chen, Shu-Hui \| Yu, Luo-Ting Bioorganic & Medicinal Chemistry Letters, volume 29, issue 17, pages 2511-2515 (2019). 10.1016/j.bmcl.2019.06.055 Cited by (10) \| Cite \| Source
Discovery of a Novel Selective Dual Peroxisome Proliferator-Activated Receptor α/δ Agonist for the Treatment of Primary Biliary Cirrhosis (journal article) Jiang, Zhigan \| Liu, Xing \| Yuan, Zhiliang \| He, Haiying \| Wang, Jing \| Zhang, Xiao \| Gong, Zhen \| Hou, Lijuan \| Shen, Liang \| Guo, Fengxun \| ... \| Chen, Shuhui ACS Medicinal Chemistry Letters, volume 10, issue 7, pages 1068-1073 (2019). 10.1021/acsmedchemlett.9b00189 Cited by (5) \| Cite \| Source
Discovery of dimethyl pent-4-ynoic acid derivatives, as potent and orally bioavailable DGAT1 inhibitors that suppress body weight in diet-induced mouse obesity model (journal article) Yu, Tao \| Wu, Chengde \| Shih, NengYang \| Li, Qi \| Chan, Chichung \| Pan, He \| Yao, Dan \| Pan, Yan \| Liang, Wei \| Shen, Liang \| ... \| Chen, Shuhui Bioorganic & Medicinal Chemistry Letters, volume 28, issue 10, pages 1686-1692 (2018). 10.1016/j.bmcl.2018.04.051 Cited by (5) \| Cite \| Source
One-pot synthesis of 3-triazolyl-quinolin-2-(1 H )-ones via sequential Ugi-“click”-Knoevenagel condensations (journal article) Qian, Wenyuan \| Wang, Dahai \| Wang, Honglin \| Yu, Peng \| Liu, Shilan \| Chen, Shuhui Tetrahedron Letters, volume 59, issue 22, pages 2167-2169 (2018). 10.1016/j.tetlet.2018.04.050 Cited by (12) \| Cite \| Source
Discovery of 3,3′-Spiro[Azetidine]-2-oxo-indoline Derivatives as Fusion Inhibitors for Treatment of RSV Infection (journal article) Shi, Weihua \| Jiang, Zhigan \| He, Haiying \| Xiao, Fubiao \| Lin, Fusen \| Sun, Ya \| Hou, Lijuan \| Shen, Liang \| Han, Lixia \| Zeng, Minggao \| ... \| Chen, Shuhui ACS Medicinal Chemistry Letters, volume 9, issue 2, pages 94-97 (2018). 10.1021/acsmedchemlett.7b00418 Cited by (37) \| Cite \| Source
RAF inhibitor LY3009120 sensitizes RAS or BRAF mutant cancer to CDK4/6 inhibition by abemaciclib via superior inhibition of phospho-RB and suppression of cyclin D1 (journal article) Chen, S-H \| Gong, X \| Zhang, Y \| Van Horn, R D \| Yin, T \| Huber, L \| Burke, T F \| Manro, J \| Iversen, P W \| Wu, W \| ... \| Peng, S-B Oncogene, volume 37, issue 6, pages 821-832 (2018). 10.1038/onc.2017.384 Cited by (57) \| Cite \| Source
An efficient stereoselective synthesis of aminocyclohexenes from 7-azanorbornenes via LiAlH 4 mediated tandem double bond migration-ring opening sequence (journal article) Yang, Guangwen \| Wu, Wentao \| Li, Zhixiang \| Chen, Naiwu \| Qin, Jian \| Hu, Guoping \| Zhang, Yang \| Li, Jian \| Chen, Shuhui Tetrahedron Letters, volume 59, issue 6, pages 532-536 (2018). 10.1016/j.tetlet.2017.12.073 Cited by (1) \| Cite \| Source