Gary P. Sims

ScholarGPS® ID: 23499708259478

Affiliation

AstraZeneca plc, Cambridge, United States

Affiliation History

Field

Medicine

Discipline

Immunology

Top Specialties

Antibody | Myasthenia Gravis | Plasma Cell | Arthritis | Inflammation

Metrics Summary

Publication Count

Predicted Citations

7,108

Predicted h-index

Ranking

Publications and Citation History

Publications based on Top Specialties

Types of Publication

Publications
Books
Patents
NIH/NSF

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OP0110 AZD1163 - FIRST-IN-CLASS ANTI-PAD2/4 BI-SPECIFIC ANTIBODY TO INHIBIT AUTOANTIGEN FORMATION IN RHEUMATOID ARTHRITIS (conference) Sims, D. A. \| Andrews, J. \| Kuriakose, T. \| Scaletta, L. \| Rajasinghe, L. \| Sigurdardottir, A. \| Strain, M. \| Jiang, F. \| Boger, E. \| Björsson, L. \| ... \| Sims, G. P. EULAR 2024 European Congress of Rheumatology, 12-15 June. Vienna, Austria (2024) 10.1136/annrheumdis-2024-eular.3510 Cite \| Source
POS0188 TARGETING COMPLEMENT FACTOR B (CFB) VIA A NOVEL SIRNA THERAPY (AZD6912) TO TREAT INFLAMMATORY ARTHRITIS (conference) Sims, G. P. \| Collins, M. \| Pursell, N. \| Kuriakose, T. \| Jiang, F. \| Moore, K. \| Betrand, L. \| Lasaro, M. \| Neisen, J. \| Manetz, S. \| ... \| Close, D. EULAR 2024 European Congress of Rheumatology, 12-15 June. Vienna, Austria (2024) 10.1136/annrheumdis-2024-eular.5200 Cite \| Source
Heavy Chain Constant Region Usage in Antibodies to Peptidylarginine Deiminase 4 as a Marker of Disease Subsets in Rheumatoid Arthritis (journal article) Gómez‐Bañuelos, E. \| Shi, J. \| Wang, H. \| Danila, M. I. \| Bridges, S. L. \| Giles, J. T. \| Sims, G. P. \| Andrade, F. \| Darrah, E. Arthritis & Rheumatology, volume 74, issue 11, pages 1746-1754 (2022). 10.1002/art.42262 Cited by (4) \| Cite \| Source
Oxidised IL-33 signals via RAGE/EGFR to drive a COPD-associated phenotype (conference) Strickson, S \| Houslay, K F \| Negri, V A \| Ohne, Y \| Ottosson, T \| Dodd, R B \| Chaillan Huntington, C \| Li, J \| Killick, H \| Rees, D G \| ... \| Cohen, E S ERS International Congress 2022 abstracts (2022) 10.1183/13993003.congress-2022.2482 Cited by (4) \| Cite \| Source
Characterization of Citrullination Sites in Neutrophils and Mast Cells Activated by Ionomycin via Integration of Mass Spectrometry and Machine Learning (journal article) Chaerkady, Raghothama \| Zhou, Yebin \| Delmar, Jared A. \| Weng, Shao Huan Samuel \| Wang, Junmin \| Awasthi, Shivangi \| Sims, Dorothy \| Bowen, Michael A. \| Yu, Wen \| Cazares, Lisa H. \| ... \| Hess, Sonja Journal of Proteome Research, volume 20, issue 6, pages 3150-3164 (2021). 10.1021/acs.jproteome.1c00028 Cited by (11) \| Cite \| Source
Immune Complex–Driven Generation of Human Macrophages with Anti-Inflammatory and Growth-Promoting Activity (journal article) Dalby, Elizabeth \| Christensen, Stephen M. \| Wang, Jingya \| Hamidzadeh, Kajal \| Chandrasekaran, Prabha \| Hughitt, V. Keith \| Tafuri, Wagner Luiz \| Arantes, Rosa Maria Esteves \| Rodrigues, Ismael Alves \| Herbst, Ronald \| ... \| Mosser, David M. The Journal of Immunology, volume 205, issue 1, pages 102-112 (2020). 10.4049/jimmunol.1901382 Cited by (10) \| Cite \| Source
LOX-1: A potential driver of cardiovascular risk in SLE patients (journal article) Sagar, Divya \| Gaddipati, Ranjitha \| Ongstad, Emily L. \| Bhagroo, Nicholas \| An, Ling-Ling \| Wang, Jingya \| Belkhodja, Mehdi \| Rahman, Saifur \| Manna, Zerai \| Davis, Michael A. \| ... \| Gupta, Ruchi PLOS ONE, volume 15, issue 3, pages e0229184- (2020). 10.1371/journal.pone.0229184 Cited by (22) \| Cite \| Source
Evidence for a direct link between PAD4-mediated citrullination and the oxidative burst in human neutrophils (journal article) Zhou, Yebin \| An, Ling-Ling \| Chaerkady, Raghothama \| Mittereder, Nanette \| Clarke, Lori \| Cohen, Taylor S. \| Chen, Bo \| Hess, Sonja \| Sims, Gary P. \| Mustelin, Tomas Scientific Reports, volume 8, issue 1 (2018). 10.1038/s41598-018-33385-z Cited by (59) \| Cite \| Source
Soluble LOX-1: A Potential biomarker for SLE and Cardiovascular Comorbidity (journal article) Sagar, Divya \| Gaddipati, Ranjitha \| Ongstad, Emily \| Rahman, Saifur \| Belkhodja, Mehdi \| Bhagroo, Nicholas \| An, Ling-Ling \| Hasni, Sarfaraz \| Siegal, Richard \| Sanjuan, Miguel A. \| ... \| Gupta, Ruchi The Journal of Immunology, volume 200, issue 1_Supplement, pages 45.1-45.1 (2018). 10.4049/jimmunol.200.Supp.45.1 Cited by (1) \| Cite \| Source
Characterisation of anifrolumab, a fully human anti-interferon receptor antagonist antibody for the treatment of systemic lupus erythematosus (journal article) Riggs, Jeffrey M \| Hanna, Richard N \| Rajan, Bhargavi \| Zerrouki, Kamelia \| Karnell, Jodi L \| Sagar, Divya \| Vainshtein, Inna \| Farmer, Erika \| Rosenthal, Kimberly \| Morehouse, Chris \| ... \| Kolbeck, Roland Lupus Science & Medicine, volume 5, issue 1, pages e000261- (2018). 10.1136/lupus-2018-000261 Cited by (91) \| Cite \| Source \| Open Access
Perspective on Protein Arginine Deiminase Activity—Bicarbonate Is a pH-Independent Regulator of Citrullination (journal article) Zhou, Yebin \| Mittereder, Nanette \| Sims, Gary P. Frontiers in Immunology, volume 9 (2018). 10.3389/fimmu.2018.00034 Cited by (14) \| Cite \| Source \| Open Access
Affinity maturation shapes the function of agonistic antibodies to peptidylarginine deiminase type 4 in rheumatoid arthritis (journal article) Shi, Jing \| Darrah, Erika \| Sims, Gary P \| Mustelin, Tomas \| Sampson, Kevon \| Konig, Maximilian F \| Bingham, Clifton O \| Rosen, Antony \| Andrade, Felipe Annals of the Rheumatic Diseases, volume 77, issue 1, pages 141-148 (2018). 10.1136/annrheumdis-2017-211489 Cited by (14) \| Cite \| Source
OP0331 A novel humanized effector-deficient fcyriia antibody inhibits immune complex mediated proinflammatory responses (conference) Chen, B \| Vousden, K \| Turman, S \| Sun, H \| Wang, S \| Vinall, L \| Kemp, B \| Kasturiangan, S \| Grant, E \| Hinrichs, MJ \| ... \| Sims, G Annual European Congress of Rheumatology, 14–17 June, 2017 (2017) 10.1136/annrheumdis-2017-eular.1994 Cite \| Source
Spontaneous secretion of peptidyl-arginine deiminase 2 and cell surface exposure of peptidyl-arginine deiminase 4 by neutrophils (journal article) Zhou, Yebin \| Chen, Bo \| Mittereder, Nanette \| Chaerkady, Raghothama \| Strain, Martin \| Rahman, Saifur \| Ma, Wenting \| Low, Choon Pei \| Chan, Denice \| Neal, Frances \| ... \| Mustelin, Tomas Mikael The Journal of Immunology, volume 198, issue 1_Supplement, pages 207.5-207.5 (2017). 10.4049/jimmunol.198.Supp.207.5 Cited by (1) \| Cite \| Source
Aging and Systemic Lupus Erythematosus - Immunosenescence and Beyond (journal article) van den Hoogen, Lucas \| Sims, Gary \| van Roon, Joel \| Fritsch-Stork, Ruth Current Aging Science, volume 8, issue 2, pages 158-177 (2015). 10.2174/1874609808666150727111904 Cited by (23) \| Cite \| Source
S100A9 Induced Inflammatory Responses Are Mediated by Distinct Damage Associated Molecular Patterns (DAMP) Receptors In Vitro and In Vivo (journal article) Chen, Bo \| Miller, Allison L. \| Rebelatto, Marlon \| Brewah, Yambasu \| Rowe, Daniel C. \| Clarke, Lori \| Czapiga, Meggan \| Rosenthal, Kim \| Imamichi, Tomozumi \| Chen, Yan \| ... \| Sims, Gary P. PLOS ONE, volume 10, issue 2, pages e0115828- (2015). 10.1371/journal.pone.0115828 Cited by (90) \| Cite \| Source \| Open Access
Characterization of the Hypercitrullination Reaction in Human Neutrophils and Other Leukocytes (journal article) Zhou, Yebin \| Di Pucchio, Tiziana \| Sims, Gary P. \| Mittereder, Nanette \| Mustelin, Tomas Mediators of Inflammation, volume 2015 (2015). 10.1155/2015/236451 Cited by (20) \| Cite \| Source \| Open Access
RAGE inhibits human respiratory syncytial virus syncytium formation by interfering with F-protein function (journal article) Tian, Jane \| Huang, Kelly \| Krishnan, Subramaniam \| Svabek, Catherine \| Rowe, Daniel C. \| Brewah, Yambasu \| Sanjuan, Miguel \| Patera, Andriani C. \| Kolbeck, Roland \| Herbst, Ronald \| Sims, Gary P. Journal of General Virology , volume 94, issue 8, pages 1691-1700 (2013). 10.1099/vir.0.049254-0 Cited by (15) \| Cite \| Source \| Open Access
Opposing Roles of Membrane and Soluble Forms of the Receptor for Advanced Glycation End Products in Primary Respiratory Syncytial Virus Infection (journal article) Miller, A. L. \| Sims, G. P. \| Brewah, Y. A. \| Rebelatto, M. C. \| Kearley, J. \| Benjamin, E. \| Keller, A. E. \| Brohawn, P. \| Herbst, R. \| Coyle, A. J. \| ... \| Kolbeck, R. Journal of Infectious Diseases, volume 205, issue 8, pages 1311-1320 (2012). 10.1093/infdis/jir826 Cited by (14) \| Cite \| Source \| Open Access
A glycoengineered anti‐CD19 antibody with potent antibody‐dependent cellular cytotoxicity activity in vitro and lymphoma growth inhibition in vivo (journal article) Ward, Elizabeth \| Mittereder, Nanette \| Kuta, Ellen \| Sims, Gary P. \| Bowen, Michael A. \| Dall’Acqua, William \| Tedder, Thomas \| Kiener, Peter \| Coyle, Anthony J. \| Wu, Herren \| ... \| Herbst, Ronald British Journal of Haematology, volume 155, issue 4, pages 426-437 (2011). 10.1111/j.1365-2141.2011.08857.x Cited by (67) \| Cite \| Source \| Open Access