Mark Ultsch

ScholarGPS® ID: 22594343819655

Affiliation

Genentech, Inc., South San Francisco, United States

Affiliation History

Field

Life Sciences

Discipline

Biology and Biological Sciences

Top Specialties

Metrics Summary

Publication Count

Predicted Citations

15,793

Predicted h-index

Ranking

Publications and Citation History

Publications based on Top Specialties

Types of Publication

Publications
Books
Patents
NIH/NSF

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Cystine-knot peptide inhibitors of HTRA1 bind to a cryptic pocket within the active site region (journal article) Li, Yanjie \| Wei, Yuehua \| Ultsch, Mark \| Li, Wei \| Tang, Wanjian \| Tombling, Benjamin \| Gao, Xinxin \| Dimitrova, Yoana \| Gampe, Christian \| Fuhrmann, Jakob \| ... \| Kirchhofer, Daniel Nature Communications, volume 15, issue 1 (2024). 10.1038/s41467-024-48655-w Cite \| Source
Allosteric inhibition of HTRA1 activity by a conformational lock mechanism to treat age-related macular degeneration (journal article) Gerhardy, Stefan \| Ultsch, Mark \| Tang, Wanjian \| Green, Evan \| Holden, Jeffrey K. \| Li, Wei \| Estevez, Alberto \| Arthur, Chris \| Tom, Irene \| Rohou, Alexis \| Kirchhofer, Daniel Nature Communications, volume 13, issue 1 (2022). 10.1038/s41467-022-32760-9 Cited by (6) \| Cite \| Source
Structures of the ApoL1 and ApoL2 N-terminal domains reveal a non-classical four-helix bundle motif (journal article) Ultsch, Mark \| Holliday, Michael J. \| Gerhardy, Stefan \| Moran, Paul \| Scales, Suzie J. \| Gupta, Nidhi \| Oltrabella, Francesca \| Chiu, Cecilia \| Fairbrother, Wayne \| Eigenbrot, Charles \| Kirchhofer, Daniel Communications Biology, volume 4, issue 1 (2021). 10.1038/s42003-021-02387-5 Cited by (10) \| Cite \| Source
Compositions and methods for treating cardiovascular disease (patent) Beresini, Maureen \| Burdick, Daniel \| Eigenbrot, Jr., Charles \| Kirchhofer, Daniel \| Lazarus, Robert \| Li, Wei \| Quinn, John \| Skelton, Nicholas \| Ultsch, Mark \| Zhang, Yingnan Patent Number: 10787484 (2020) Cite \| Source
Regions of conformational flexibility in the proprotein convertase PCSK9 and design of antagonists for LDL cholesterol lowering (journal article) Kirchhofer, Daniel \| Burdick, Daniel J. \| Skelton, Nicholas J. \| Zhang, Yingnan \| Ultsch, Mark Biochemical Society Transactions, volume 48, issue 4, pages 1323-1336 (2020). 10.1042/BST20190672 Cited by (7) \| Cite \| Source
Design of Organo-Peptides As Bipartite PCSK9 Antagonists (journal article) Burdick, Daniel J. \| Skelton, Nicholas J. \| Ultsch, Mark \| Beresini, Maureen H. \| Eigenbrot, Charles \| Li, Wei \| Zhang, Yingnan \| Nguyen, Huy \| Kong-Beltran, Monica \| Quinn, John G. \| Kirchhofer, Daniel ACS Chemical Biology, volume 15, issue 2, pages 425-436 (2020). 10.1021/acschembio.9b00899 Cited by (16) \| Cite \| Source
Tetravalent biepitopic targeting enables intrinsic antibody agonism of tumor necrosis factor receptor superfamily members (journal article) Yang, Yanli \| Yeh, Sherry H. \| Madireddi, Shravan \| Matochko, Wadim L. \| Gu, Chen \| Pacheco Sanchez, Patricia \| Ultsch, Mark \| De Leon Boenig, Gladys \| Harris, Seth F. \| Leonard, Brandon \| ... \| Lazar, Greg A. mAbs, volume 11, issue 6, pages 996-1011 (2019). 10.1080/19420862.2019.1625662 Cited by (27) \| Cite \| Source
Identification of a Helical Segment within the Intrinsically Disordered Region of the PCSK9 Prodomain (journal article) Ultsch, M. \| Li, W. \| Eigenbrot, C. \| Di Lello, P. \| Lipari, M.T. \| Gerhardy, S. \| AhYoung, A.P. \| Quinn, J. \| Franke, Y. \| Chen, Y. \| ... \| Kirchhofer, D. Journal of Molecular Biology, volume 431, issue 5, pages 885-903 (2019). 10.1016/j.jmb.2018.11.025 Cited by (8) \| Cite \| Source
Development, Optimization, and Structural Characterization of an Efficient Peptide-Based Photoaffinity Cross-Linking Reaction for Generation of Homogeneous Conjugates from Wild-Type Antibodies (journal article) Vance, Nicholas \| Zacharias, Neelie \| Ultsch, Mark \| Li, Guangmin \| Fourie, Aimee \| Liu, Peter \| LaFrance-Vanasse, Julien \| Ernst, James A. \| Sandoval, Wendy \| Kozak, Katherine R. \| ... \| Sadowsky, Jack Bioconjugate Chemistry, volume 30, issue 1, pages 148-160 (2019). 10.1021/acs.bioconjchem.8b00809 Cited by (19) \| Cite \| Source
Discovery of a cryptic peptide-binding site on PCSK9 and design of antagonists (journal article) Zhang, Yingnan \| Ultsch, Mark \| Skelton, Nicholas J \| Burdick, Daniel J \| Beresini, Maureen H \| Li, Wei \| Kong-Beltran, Monica \| Peterson, Andrew \| Quinn, John \| Chiu, Cecilia \| ... \| Kirchhofer, Daniel Nature Structural & Molecular Biology, volume 24, issue 10, pages 848-856 (2017). 10.1038/nsmb.3453 Cited by (58) \| Cite \| Source
Design of Selective Benzoxazepin PI3Kδ Inhibitors Through Control of Dihedral Angles (journal article) Safina, Brian S. \| Elliott, Richard L. \| Forrest, Andrew K. \| Heald, Robert A. \| Murray, Jeremy M. \| Nonomiya, Jim \| Pang, Jodie \| Salphati, Laurent \| Seward, Eileen M. \| Staben, Steven T. \| ... \| Sutherlin, Daniel P. ACS Medicinal Chemistry Letters, volume 8, issue 9, pages 936-940 (2017). 10.1021/acsmedchemlett.7b00170 Cited by (20) \| Cite \| Source
3-2-1: Structural insights from stepwise shrinkage of a three-helix Fc-binding domain to a single helix (journal article) Ultsch, M \| Braisted, A \| Maun, H R \| Eigenbrot, C Protein Engineering, Design and Selection, volume 30, issue 9, pages 619-625 (2017). 10.1093/protein/gzx029 Cited by (25) \| Cite \| Source
Crenezumab’s Preferential Binding Of Oligomeric Amyloid-Beta Species Underlies Its Unique Mechanism Of Action (S7.005) (journal article) Atwal, Jasvinder \| Meilandt, William \| Wetzel-Smith, Monica \| Li, Bing \| Bainbridge, Travis \| Reichelt, Mike \| Ultsch, Mark \| Ernst, James \| Wang, Weiru \| Crowell, Susan \| ... \| Ferl, Greg Neurology, volume 88, issue 16_supplement (2017). 10.1212/WNL.88.16_supplement.S7.005 Cited by (1) \| Cite \| Source
Structure of Crenezumab Complex with Aβ Shows Loss of β-Hairpin (journal article) Ultsch, Mark \| Li, Bing \| Maurer, Till \| Mathieu, Mary \| Adolfsson, Oskar \| Muhs, Andreas \| Pfeifer, Andrea \| Pihlgren, Maria \| Bainbridge, Travis W. \| Reichelt, Mike \| ... \| Wang, Weiru Scientific Reports, volume 6, issue 1 (2016). 10.1038/srep39374 Cited by (84) \| Cite \| Source \| Open Access
Resolving TYK2 locus genotype-to-phenotype differences in autoimmunity (journal article) Dendrou, Calliope A. \| Cortes, Adrian \| Shipman, Lydia \| Evans, Hayley G. \| Attfield, Kathrine E. \| Jostins, Luke \| Barber, Thomas \| Kaur, Gurman \| Kuttikkatte, Subita Balaram \| Leach, Oliver A. \| ... \| Fugger, Lars Science Translational Medicine, volume 8, issue 363 (2016). 10.1126/scitranslmed.aag1974 Cited by (179) \| Cite \| Source \| Open Access
Developments in the Implementation of Acoustic Droplet Ejection for Protein Crystallography (journal article) Wu, Ping \| Noland, Cameron \| Ultsch, Mark \| Edwards, Bonnie \| Harris, David \| Mayer, Robert \| Harris, Seth F. SLAS Technology, volume 21, issue 1, pages 97-106 (2016). 10.1177/2211068215598938 Cited by (16) \| Cite \| Source \| Open Access
Structure of Crenezumab Complex with A beta Shows Loss of beta-Hairpin (journal article) Ultsch, Mark \| Li, Bing \| Maurer, Till \| Mathieu, Mary \| Adolfsson, Oskar \| Muhs, Andreas \| Pfeifer, Andrea \| Pihlgren, Maria \| Bainbridge, Travis W. \| Reichelt, Mike \| ... \| Wang, Weiru Scientific Reports, volume 6 (2016). 10.2210/pdb5vzx/pdb Cited by (8) \| Cite \| Source
Optimization of 5-(2,6-dichlorophenyl)-3-hydroxy-2-mercaptocyclohex-2-enones as potent inhibitors of human lactate dehydrogenase (journal article) Labadie, Sharada \| Dragovich, Peter S. \| Chen, Jinhua \| Fauber, Benjamin P. \| Boggs, Jason \| Corson, Laura B. \| Ding, Charles Z. \| Eigenbrot, Charles \| Ge, HongXiu \| Ho, Qunh \| ... \| Zhou, Aihe Bioorganic & Medicinal Chemistry Letters, volume 25, issue 1, pages 75-82 (2015). 10.1016/j.bmcl.2014.11.008 Cited by (19) \| Cite \| Source \| Open Access
Identification of 3,6-disubstituted dihydropyrones as inhibitors of human lactate dehydrogenase (journal article) Fauber, Benjamin P. \| Dragovich, Peter S. \| Chen, Jinhua \| Corson, Laura B. \| Ding, Charles Z. \| Eigenbrot, Charles \| Labadie, Sharada \| Malek, Shiva \| Peterson, David \| Purkey, Hans E. \| ... \| Zhou, Aihe Bioorganic & Medicinal Chemistry Letters, volume 24, issue 24, pages 5683-5687 (2014). 10.1016/j.bmcl.2014.10.067 Cited by (18) \| Cite \| Source
Structure based design of novel 6,5 heterobicyclic mitogen-activated protein kinase kinase (MEK) inhibitors leading to the discovery of imidazo[1,5-a] pyrazine G-479 (journal article) Robarge, Kirk D. \| Lee, Wendy \| Eigenbrot, Charles \| Ultsch, Mark \| Wiesmann, Christian \| Heald, Robert \| Price, Steve \| Hewitt, Joanne \| Jackson, Philip \| Savy, Pascal \| ... \| Baumgardner, Matthew Bioorganic & Medicinal Chemistry Letters, volume 24, issue 19, pages 4714-4723 (2014). 10.1016/j.bmcl.2014.08.008 Cited by (30) \| Cite \| Source