Xinxin Gao

ScholarGPS® ID: 22321051950566

Affiliation

Genentech, Inc., South San Francisco, United States

Affiliation History

Field

Life Sciences

Discipline

Biochemistry

Top Specialties

Medical Imaging | Peptide

Metrics Summary

Publication Count

Predicted Citations

673

Predicted h-index

Ranking

Publications and Citation History

Publications based on Top Specialties

Types of Publication

Publications
Books
Patents
NIH/NSF

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Cystine-knot peptide inhibitors of HTRA1 bind to a cryptic pocket within the active site region (journal article) Li, Yanjie \| Wei, Yuehua \| Ultsch, Mark \| Li, Wei \| Tang, Wanjian \| Tombling, Benjamin \| Gao, Xinxin \| Dimitrova, Yoana \| Gampe, Christian \| Fuhrmann, Jakob \| ... \| Kirchhofer, Daniel Nature Communications, volume 15, issue 1 (2024). 10.1038/s41467-024-48655-w Cite \| Source
Disulfide-constrained peptide scaffolds enable a robust peptide-therapeutic discovery platform (journal article) Zhou, Lijuan \| Cai, Fei \| Li, Yanjie \| Gao, Xinxin \| Wei, Yuehua \| Fedorova, Anna \| Kirchhofer, Daniel \| Hannoush, Rami N. \| Zhang, Yingnan PLOS ONE, volume 19, issue 3, pages e0300135- (2024). 10.1371/journal.pone.0300135 Cited by (1) \| Cite \| Source
A phage-displayed disulfide constrained peptide discovery platform yields novel human plasma protein binders (journal article) Gao, Xinxin \| Kaluarachchi, Harini \| Zhang, Yingnan \| Hwang, Sunhee \| Hannoush, Rami N. PLOS ONE, volume 19, issue 3, pages e0299804- (2024). 10.1371/journal.pone.0299804 Cited by (2) \| Cite \| Source
Directed evolution identifies high-affinity cystine-knot peptide agonists and antagonists of Wnt/β-catenin signaling (journal article) Hansen, Simon \| Zhang, Yingnan \| Hwang, Sunhee \| Nabhan, Ahmad \| Li, Wanqing \| Fuhrmann, Jakob \| Kschonsak, Yvonne \| Zhou, Lijuan \| Nile, Aaron H. \| Gao, Xinxin \| ... \| Hannoush, Rami N. Proceedings of the National Academy of Sciences, volume 119, issue 46 (2022). 10.1073/pnas.2207327119 Cited by (15) \| Cite \| Source
Fatty acylation enhances the cellular internalization and cytosolic distribution of a cystine-knot peptide (journal article) Gao, Xinxin \| Mazière, Ann De \| Beard, Rhiannon \| Klumperman, Judith \| Hannoush, Rami N. iScience, volume 24, issue 11, pages 103220- (2021). 10.1016/j.isci.2021.103220 Cited by (5) \| Cite \| Source
Nanolipoprotein particles for co-delivery of cystine-knot peptides and Fab–based therapeutics (journal article) Darwish, Martine \| Gao, Xinxin \| Shatz, Whitney \| Li, Hong \| Lin, May \| Franke, Yvonne \| Tam, Christine \| Mortara, Kyle \| Zilberleyb, Inna \| Hannoush, Rami N. \| Blanchette, Craig Nanoscale Advances, volume 3, issue 13, pages 3929-3941 (2021). 10.1039/D1NA00218J Cite \| Source
Cystine knot scaffold platform (patent) Hannoush, Rami \| Kaluarachchi, Harini \| Nile, Aaron \| Noland, Cameron \| Zhang, Yingnan \| Zhou, Lijuan \| Gao, Xinxin Patent Number: 10696721 (2020) Cite \| Source
Cystine knot scaffold platform (patent) Hannoush, Rami \| Kaluarachchi, Harini \| Nile, Aaron \| Noland, Cameron \| Zhang, Yingnan \| Zhou, Lijuan \| Gao, Xinxin Patent Number: 10428125 (2019) Cited by (1) \| Cite \| Source
Visualizing the cellular route of entry of a cystine-knot peptide with Xfect transfection reagent by electron microscopy (journal article) Gao, Xinxin \| De Mazière, Ann \| Iaea, David B. \| Arthur, Christopher P. \| Klumperman, Judith \| Ciferri, Claudio \| Hannoush, Rami N. Scientific Reports, volume 9, issue 1 (2019). 10.1038/s41598-019-43285-5 Cited by (9) \| Cite \| Source
A Decade of Click Chemistry in Protein Palmitoylation: Impact on Discovery and New Biology (journal article) Gao, Xinxin \| Hannoush, Rami N. Cell Chemical Biology, volume 25, issue 3, pages 236-246 (2018). 10.1016/j.chembiol.2017.12.002 Cited by (57) \| Cite \| Source
Cellular uptake of a cystine‐knot peptide and modulation of its intracellular trafficking (journal article) Gao, Xinxin \| Stanger, Karen \| Kaluarachchi, Harini \| Maurer, Till \| Ciepla, Paulina \| Chalouni, Cecile \| Franke, Yvonne \| Hannoush, Rami N The FASEB Journal, volume 31, issue S1 (2017). 10.1096/fasebj.31.1_supplement.lb113 Cite \| Source
Cellular uptake of a cystine-knot peptide and modulation of its intracellular trafficking (journal article) Gao, Xinxin \| Stanger, Karen \| Kaluarachchi, Harini \| Maurer, Till \| Ciepla, Paulina \| Chalouni, Cecile \| Franke, Yvonne \| Hannoush, Rami N. Scientific Reports, volume 6, issue 1 (2016). 10.1038/srep35179 Cited by (27) \| Cite \| Source \| Open Access
Single‐cell Imaging of Wnt Palmitoylation by Porcupine (journal article) Gao, Xinxin \| Hannoush, Rami N The FASEB Journal, volume 30, issue S1 (2016). 10.1096/fasebj.30.1_supplement.lb100 Cite \| Source
Visualizing Wnt Palmitoylation in Single Cells (book chapter) In Wnt Signaling Gao, Xinxin \| Hannoush, Rami N. Springer New York (2016) 10.1007/978-1-4939-6393-5_1 Cited by (5) \| Cite \| Source
Single-cell in situ imaging of palmitoylation in fatty-acylated proteins (journal article) Gao, Xinxin \| Hannoush, Rami N Nature Protocols, volume 9, issue 11, pages 2607-2623 (2014). 10.1038/nprot.2014.179 Cited by (35) \| Cite \| Source
Method for Cellular Imaging of Palmitoylated Proteins with Clickable Probes and Proximity Ligation Applied to Hedgehog, Tubulin, and Ras (journal article) Gao, Xinxin \| Hannoush, Rami N. Journal of the American Chemical Society, volume 136, issue 12, pages 4544-4550 (2014). 10.1021/ja410068g Cited by (57) \| Cite \| Source
Single-cell imaging of Wnt palmitoylation by the acyltransferase porcupine (journal article) Gao, Xinxin \| Hannoush, Rami N Nature Chemical Biology, volume 10, issue 1, pages 61-68 (2014). 10.1038/nchembio.1392 Cited by (130) \| Cite \| Source
Engineering and Structural Characterization of a Linear Polyubiquitin-Specific Antibody (journal article) Matsumoto, Marissa L. \| Dong, Ken C. \| Yu, Christine \| Phu, Lilian \| Gao, Xinxin \| Hannoush, Rami N. \| Hymowitz, Sarah G. \| Kirkpatrick, Donald S. \| Dixit, Vishva M. \| Kelley, Robert F. Journal of Molecular Biology, volume 418, issue 3-4, pages 134-144 (2012). 10.1016/j.jmb.2011.12.053 Cited by (103) \| Cite \| Source \| Open Access
Membrane targeting of palmitoylated Wnt and Hedgehog revealed by chemical probes (journal article) Gao, Xinxin \| Arenas-Ramirez, Natalia \| Scales, Suzie J. \| Hannoush, Rami N. FEBS Letters, volume 585, issue 15, pages 2501-2506 (2011). 10.1016/j.febslet.2011.06.033 Cited by (39) \| Cite \| Source \| Open Access
Imaging the lipidome with chemical probes (journal article) Hannoush, Rami \| Gao, Xinxin \| Arenas-Ramirez, Natalia Chemistry and Physics of Lipids, volume 164 (2011). 10.1016/j.chemphyslip.2011.05.064 Cite \| Source