Kristi Leonard

ScholarGPS® ID: 21950302771292

Affiliation

Johnson & Johnson, New Brunswick, New Jersey, United States

Affiliation History

Field

Physical Sciences and Mathematics

Discipline

Chemistry

Top Specialties

Medicinal Chemistry | Cancer | Chemical Synthesis | Integrin

Metrics Summary

Publication Count

Predicted Citations

1,305

Predicted h-index

Ranking

Publications and Citation History

Publications based on Top Specialties

Types of Publication

Publications
Books
Patents
NIH/NSF

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Discovery of a Potent and Selective Covalent Inhibitor of Bruton’s Tyrosine Kinase with Oral Anti-Inflammatory Activity (journal article) Tichenor, Mark S. \| Wiener, John J. M. \| Rao, Navin L. \| Pooley Deckhut, Charlotte \| Barbay, J. Kent \| Kreutter, Kevin D. \| Bacani, Genesis M. \| Wei, Jianmei \| Chang, Leon \| Murrey, Heather E. \| ... \| Edwards, James P. ACS Medicinal Chemistry Letters, volume 12, issue 5, pages 782-790 (2021). 10.1021/acsmedchemlett.1c00044 Cited by (8) \| Cite \| Source
Optimization and biological evaluation of thiazole-bis-amide inverse agonists of RORγt (journal article) Gege, Christian \| Albers, Michael \| Kinzel, Olaf \| Kleymann, Gerald \| Schlüter, Thomas \| Steeneck, Christoph \| Hoffmann, Thomas \| Xue, Xiaohua \| Cummings, Maxwell D. \| Spurlino, John \| ... \| Goldberg, Steven D. Bioorganic & Medicinal Chemistry Letters, volume 30, issue 12, pages 127205- (2020). 10.1016/j.bmcl.2020.127205 Cited by (12) \| Cite \| Source
Discovery and optimization of new oxadiazole substituted thiazole RORγt inverse agonists through a bioisosteric amide replacement approach (journal article) Steeneck, Christoph \| Gege, Christian \| Kinzel, Olaf \| Albers, Michael \| Kleymann, Gerald \| Schlüter, Thomas \| Schulz, Andreas \| Xue, Xiaohua \| Cummings, Maxwell D. \| Fourie, Anne M. \| ... \| Goldberg, Steven D. Bioorganic & Medicinal Chemistry Letters, volume 30, issue 12, pages 127174- (2020). 10.1016/j.bmcl.2020.127174 Cited by (11) \| Cite \| Source
Discovery of a Gut-Restricted JAK Inhibitor for the Treatment of Inflammatory Bowel Disease (journal article) Leonard, Kristi A. \| Madge, Lisa A. \| Krawczuk, Paul J. \| Wang, Aihua \| Kreutter, Kevin D. \| Bacani, Genesis M. \| Chai, Wenying \| Smith, Russell C. \| Tichenor, Mark S. \| Harris, Michael C. \| ... \| Koudriakova, Tatiana Journal of Medicinal Chemistry, volume 63, issue 6, pages 2915-2929 (2020). 10.1021/acs.jmedchem.9b01439 Cited by (14) \| Cite \| Source
Identification and biological evaluation of thiazole-based inverse agonists of RORγt (journal article) Gege, Christian \| Cummings, Maxwell D. \| Albers, Michael \| Kinzel, Olaf \| Kleymann, Gerald \| Schlüter, Thomas \| Steeneck, Christoph \| Nelen, Marina I. \| Milligan, Cindy \| Spurlino, John \| ... \| Hoffmann, Thomas Bioorganic & Medicinal Chemistry Letters, volume 28, issue 9, pages 1446-1455 (2018). 10.1016/j.bmcl.2018.03.093 Cited by (19) \| Cite \| Source
Identification and biological evaluation of thiazole-based inverse agonists of ROR gamma t. (journal article) Gege, Christian \| Cummings, Maxwell D. \| Albers, Michael \| Kinzel, Olaf \| Kleymann, Gerald \| Schlüter, Thomas \| Steeneck, Christoph \| Nelen, Marina I. \| Milligan, Cindy \| Spurlino, John \| ... \| Hoffmann, Thomas Bioorganic & Medicinal Chemistry Letters, volume 28, issue 9, pages 1446-1455 (2018). 10.2210/pdb6cvh/pdb Cite \| Source
6-Substituted quinolines as RORγt inverse agonists (journal article) Barbay, J. Kent \| Cummings, Maxwell D. \| Abad, Marta \| Castro, Glenda \| Kreutter, Kevin D. \| Kummer, David A. \| Maharoof, Umar \| Milligan, Cynthia \| Nishimura, Rachel \| Pierce, Joan \| ... \| Leonard, Kristi Bioorganic & Medicinal Chemistry Letters, volume 27, issue 23, pages 5277-5283 (2017). 10.1016/j.bmcl.2017.10.027 Cited by (23) \| Cite \| Source
Identification and structure activity relationships of quinoline tertiary alcohol modulators of RORγt (journal article) Kummer, David A. \| Cummings, Maxwell D. \| Abad, Marta \| Barbay, Joseph \| Castro, Glenda \| Wolin, Ronald \| Kreutter, Kevin D. \| Maharoof, Umar \| Milligan, Cynthia \| Nishimura, Rachel \| ... \| Leonard, Kristi Bioorganic & Medicinal Chemistry Letters, volume 27, issue 9, pages 2047-2057 (2017). 10.1016/j.bmcl.2017.02.044 Cited by (25) \| Cite \| Source
Substituted thieno[2,3-d]pyrimidines as adenosine A2A receptor antagonists (journal article) Shook, Brian C. \| Chakravarty, Devraj \| Barbay, J. Kent \| Wang, Aihua \| Leonard, Kristi \| Alford, Vernon \| Powell, Mark T. \| Rassnick, Stefanie \| Scannevin, Robert H. \| Carroll, Karen \| ... \| Jackson, Paul F. Bioorganic & Medicinal Chemistry Letters, volume 23, issue 9, pages 2688-2691 (2013). 10.1016/j.bmcl.2013.02.078 Cited by (19) \| Cite \| Source
Design and synthesis of polyethylene glycol-modified biphenylsulfonyl-thiophene-carboxamidine inhibitors of the complement component C1s (journal article) Subasinghe, Nalin L. \| Khalil, Ehab \| Travins, Jeremy M. \| Ali, Farah \| Ballentine, Shelley K. \| Hufnagel, Heather R. \| Pan, Wenxi \| Leonard, Kristi \| Bone, Roger F. \| Soll, Richard M. \| ... \| Gaul, Michael D. Bioorganic & Medicinal Chemistry Letters, volume 22, issue 16, pages 5303-5307 (2012). 10.1016/j.bmcl.2012.06.030 Cited by (12) \| Cite \| Source
METHODS OF INHIBITING PRO MATRIX METALLOPROTEINASE ACTIVATION (patent) Jackson, Paul Francis \| Manthey, Carl \| Rhodes, Kenneth \| Scannevin, Robert \| Leonard, Kristi Anne \| Barbay, Joseph Kent \| Todd, Matthew \| Springer, Barry A. Patent Number: 20120302573 (2012) Cite \| Source
Design and Characterization of Optimized Adenosine A2A /A1 Receptor Antagonists for the Treatment of Parkinson's Disease (journal article) Shook, Brian C. \| Rassnick, Stefanie \| Wallace, Nathaniel \| Crooke, Jeffrey \| Ault, Mark \| Chakravarty, Devraj \| Barbay, J. Kent \| Wang, Aihua \| Powell, Mark T. \| Leonard, Kristi \| ... \| Jackson, Paul F. Journal of Medicinal Chemistry, volume 55, issue 3, pages 1402-1417 (2012). 10.1021/jm201640m Cited by (50) \| Cite \| Source
Aminomethyl substituted thieno[2,3-d]pyrimidines as adenosine A2A receptor antagonists (journal article) Shook, Brian C. \| Charavarty, Devraj \| Barbay, J. Kent \| Wang, Aihua \| Leonard, Kristi \| Alford, Vernon \| Powell, Mark \| Beauchamp, Derek A. \| Rassnick, Stefanie \| Scannevin, Robert \| ... \| Jackson, Paul F. MedChemComm, volume 2, issue 10, pages 950- (2011). 10.1039/c1md00082a Cited by (10) \| Cite \| Source
Optimization of arylindenopyrimidines as potent adenosine A2A/A1 antagonists (journal article) Shook, Brian C. \| Rassnick, Stefanie \| Chakravarty, Devraj \| Wallace, Nathaniel \| Ault, Mark \| Crooke, Jeffrey \| Barbay, J. Kent \| Wang, Aihua \| Leonard, Kristi \| Powell, Mark T. \| ... \| Jackson, Paul F. Bioorganic & Medicinal Chemistry Letters, volume 20, issue 9, pages 2868-2871 (2010). 10.1016/j.bmcl.2010.03.024 Cited by (12) \| Cite \| Source
Biphenylsulfonyl-thiophene-carboxamidine inhibitors of the complement component C1s (journal article) Travins, Jeremy M. \| Ali, Farah \| Huang, Hui \| Ballentine, Shelley K. \| Khalil, Ehab \| Hufnagel, Heather R. \| Pan, Wenxi \| Gushue, Joan \| Leonard, Kristi \| Bone, Roger F. \| ... \| Subasinghe, Nalin L. Bioorganic & Medicinal Chemistry Letters, volume 18, issue 5, pages 1603-1606 (2008). 10.1016/j.bmcl.2008.01.064 Cited by (16) \| Cite \| Source
Novel Potent and Selective αv β3 /αv β5 Integrin Dual Antagonists with Reduced Binding Affinity for Human Serum Albumin. (journal article) Raboisson, Pierre \| Manthey, Carl L. \| Chaikin, Margery \| Lattanze, Jennifer \| Crysler, Carl \| Leonard, Kristi \| Pan, Wenxi \| Tomczuk, Bruce E. \| Marugan, Juan Jose ChemInform, volume 37, issue 51 (2006). 10.1002/chin.200651140 Cite \| Source
Novel 1,4‐Benzodiazepine‐2,5‐diones as Hdm2 Antagonists with Improved Cellular Activity. (journal article) Leonard, Kristi \| et al., et al. ChemInform, volume 37, issue 39 (2006). 10.1002/chin.200639194 Cite \| Source
Novel 1,4-benzodiazepine-2,5-diones as Hdm2 antagonists with improved cellular activity (journal article) Leonard, Kristi \| Marugan, Juan Jose \| Raboisson, Pierre \| Calvo, Raul \| Gushue, Joan M. \| Koblish, Holly K. \| Lattanze, Jennifer \| Zhao, Shuyuan \| Cummings, Maxwell D. \| Player, Mark R. \| ... \| Lu, Tianbao Bioorganic & Medicinal Chemistry Letters, volume 16, issue 13, pages 3463-3468 (2006). 10.1016/j.bmcl.2006.04.009 Cited by (57) \| Cite \| Source
Novel potent and selective αvβ3/αvβ5 integrin dual antagonists with reduced binding affinity for human serum albumin (journal article) Raboisson, Pierre \| Manthey, Carl L. \| Chaikin, Margery \| Lattanze, Jennifer \| Crysler, Carl \| Leonard, Kristi \| Pan, Wenxi \| Tomczuk, Bruce E. \| Marugán, Juan José European Journal of Medicinal Chemistry, volume 41, issue 7, pages 847-861 (2006). 10.1016/j.ejmech.2006.03.008 Cited by (15) \| Cite \| Source
Enantiomerically pure 1,4-benzodiazepine-2,5-diones as Hdm2 antagonists (journal article) Marugan, Juan Jose \| Leonard, Kristi \| Raboisson, Pierre \| Gushue, Joan M. \| Calvo, Raul \| Koblish, Holly K. \| Lattanze, Jennifer \| Zhao, Shuyuan \| Cummings, Maxwell D. \| Player, Mark R. \| ... \| Lu, Tianbao Bioorganic & Medicinal Chemistry Letters, volume 16, issue 12, pages 3115-3120 (2006). 10.1016/j.bmcl.2006.03.067 Cited by (33) \| Cite \| Source