Jikui Guan

ScholarGPS® ID: 21108039771206

Affiliation

University of Gothenburg, Gothenburg, Sweden

Affiliation History

Field

Life Sciences

Discipline

Molecular and Cell Biology

Top Specialties

Neuroblastoma | Lymphoma | Mutation

Metrics Summary

Publication Count

Predicted Citations

1,000

Predicted h-index

Ranking

Publications and Citation History

Publications based on Top Specialties

Types of Publication

Publications
Books
Patents
NIH/NSF

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ALK F1174S mutation impairs ALK kinase activity in EML4-ALK variant 1 and sensitizes EML4-ALK variant 3 to crizotinib (journal article) Guan, Jikui \| Chuang, Tzu-Po \| Vikström, Anders \| Palmer, Ruth H. \| Hallberg, Bengt Frontiers in Oncology, volume 13 (2024). 10.3389/fonc.2023.1281510 Cite \| Source
ALK signaling primes the DNA damage response sensitizing ALK-driven neuroblastoma to therapeutic ATR inhibition (journal article) Borenäs, Marcus \| Umapathy, Ganesh \| Lind, Dan E. \| Lai, Wei-Yun \| Guan, Jikui \| Johansson, Joel \| Jennische, Eva \| Schmidt, Alexander \| Kurhe, Yeshwant \| Gabre, Jonatan L. \| ... \| Palmer, Ruth H. Proceedings of the National Academy of Sciences, volume 121, issue 1 (2024). 10.1073/pnas.2315242121 Cited by (3) \| Cite \| Source
IGF1R Contributes to Cell Proliferation in ALK-Mutated Neuroblastoma with Preference for Activating the PI3K-AKT Signaling Pathway (journal article) Guan, Jikui \| Borenäs, Marcus \| Xiong, Junfeng \| Lai, Wei-Yun \| Palmer, Ruth H. \| Hallberg, Bengt Cancers, volume 15, issue 17, pages 4252- (2023). 10.3390/cancers15174252 Cited by (3) \| Cite \| Source
Sustained Response to Entrectinib in an Infant With a Germline ALKAL2 Variant and Refractory Metastatic Neuroblastoma With Chromosomal 2p Gain and Anaplastic Lymphoma Kinase and Tropomyosin Receptor Kinase Activation (journal article) Treis, Diana \| Umapathy, Ganesh \| Fransson, Susanne \| Guan, Jikui \| Mendoza-García, Patricia \| Siaw, Joachim T. \| Wessman, Sandra \| Gordon Murkes, Lena \| Stenman, Jakob J. E. \| Djos, Anna \| ... \| Kogner, Per JCO Precision Oncology (2022). 10.1200/PO.21.00271 Cited by (8) \| Cite \| Source
Chromosome Imbalances in Neuroblastoma—Recent Molecular Insight into Chromosome 1p-deletion, 2p-gain, and 11q-deletion Identifies New Friends and Foes for the Future (journal article) Guan, Jikui \| Hallberg, Bengt \| Palmer, Ruth H. Cancers, volume 13, issue 23, pages 5897- (2021). 10.3390/cancers13235897 Cited by (15) \| Cite \| Source
Mapping the Phospho-dependent ALK Interactome to Identify Novel Components in ALK Signaling (journal article) Aboualizadeh, Farzaneh \| Yao, Zhong \| Guan, Jikui \| Drecun, Luka \| Pathmanathan, Shivanthy \| Snider, Jamie \| Umapathy, Ganesh \| Kotlyar, Max \| Jurisica, Igor \| Palmer, Ruth \| Stagljar, Igor Journal of Molecular Biology, volume 433, issue 23, pages 167283- (2021). 10.1016/j.jmb.2021.167283 Cited by (8) \| Cite \| Source
BioID-Screening Identifies PEAK1 and SHP2 as Components of the ALK Proximitome in Neuroblastoma Cells (journal article) Uçkun, Ezgi \| Siaw, Joachim T. \| Guan, Jikui \| Anthonydhason, Vimala \| Fuchs, Johannes \| Wolfstetter, Georg \| Hallberg, Bengt \| Palmer, Ruth H. Journal of Molecular Biology, volume 433, issue 19, pages 167158- (2021). 10.1016/j.jmb.2021.167158 Cited by (9) \| Cite \| Source
Loss of RET Promotes Mesenchymal Identity in Neuroblastoma Cells (journal article) Siaw, Joachim T. \| Gabre, Jonatan L. \| Uçkun, Ezgi \| Vigny, Marc \| Zhang, Wancun \| Van den Eynden, Jimmy \| Hallberg, Bengt \| Palmer, Ruth H. \| Guan, Jikui Cancers, volume 13, issue 8, pages 1909- (2021). 10.3390/cancers13081909 Cited by (7) \| Cite \| Source
ALK ligand ALKAL2 potentiates MYCN‐driven neuroblastoma in the absence of ALK mutation (journal article) Borenäs, Marcus \| Umapathy, Ganesh \| Lai, Wei‐Yun \| Lind, Dan E \| Witek, Barbara \| Guan, Jikui \| Mendoza‐Garcia, Patricia \| Masudi, Tafheem \| Claeys, Arne \| Chuang, Tzu‐Po \| ... \| Palmer, Ruth H The EMBO Journal, volume 40, issue 3 (2021). 10.15252/embj.2020105784 Cited by (30) \| Cite \| Source
Phosphoproteome and gene expression profiling of ALK inhibition in neuroblastoma cell lines reveals conserved oncogenic pathways (journal article) Van den Eynden, Jimmy \| Umapathy, Ganesh \| Ashouri, Arghavan \| Cervantes-Madrid, Diana \| Szydzik, Joanna \| Ruuth, Kristina \| Koster, Jan \| Larsson, Erik \| Guan, Jikui \| Palmer, Ruth H. \| Hallberg, Bengt Science Signaling, volume 11, issue 557 (2018). 10.1126/scisignal.aar5680 Cited by (30) \| Cite \| Source
Clinical response of the novel activating ALK-I1171T mutation in neuroblastoma to the ALK inhibitor ceritinib (journal article) Guan, Jikui \| Fransson, Susanne \| Siaw, Joachim Tetteh \| Treis, Diana \| Van den Eynden, Jimmy \| Chand, Damini \| Umapathy, Ganesh \| Ruuth, Kristina \| Svenberg, Petter \| Wessman, Sandra \| ... \| Hallberg, Bengt Molecular Case Studies, volume 4, issue 4, pages a002550- (2018). 10.1101/mcs.a002550 Cited by (39) \| Cite \| Source \| Open Access
PO-181 Anaplastic lymphoma kinase addictive neuroblastoma cell lines are associated with growth upon treatment with MEK inhibitor trametinib (journal article) Umapathy, G. \| Guan, J. \| Gustafsson, D. \| Palmer, R. \| Hallberg, B. ESMO Open, volume 3 (2018). 10.1136/esmoopen-2018-EACR25.702 Cite \| Source \| Open Access
PO-314 ALK inhibitor, ceritinib, abrogates activation of the novel ALK-I1171T mutation in neuroblastoma (journal article) Siaw, J. \| Guan, J. \| Fransson, S. \| Treis, D. \| Martinsson, T. \| Per, K. \| Palmer, R.H. \| Hallberg, B. ESMO Open, volume 3 (2018). 10.1136/esmoopen-2018-EACR25.344 Cite \| Source \| Open Access
ALKALs are in vivo ligands for ALK family receptor tyrosine kinases in the neural crest and derived cells (journal article) Fadeev, Andrey \| Mendoza-Garcia, Patricia \| Irion, Uwe \| Guan, Jikui \| Pfeifer, Kathrin \| Wiessner, Stephanie \| Serluca, Fabrizio \| Singh, Ajeet Pratap \| Nüsslein-Volhard, Christiane \| Palmer, Ruth H. Proceedings of the National Academy of Sciences, volume 115, issue 4 (2018). 10.1073/pnas.1719137115 Cited by (57) \| Cite \| Source \| Open Access
MEK inhibitor trametinib does not prevent the growth of anaplastic lymphoma kinase (ALK)–addicted neuroblastomas (journal article) Umapathy, Ganesh \| Guan, Jikui \| Gustafsson, Dan E. \| Javanmardi, Niloufar \| Cervantes-Madrid, Diana \| Djos, Anna \| Martinsson, Tommy \| Palmer, Ruth H. \| Hallberg, Bengt Science Signaling, volume 10, issue 507 (2017). 10.1126/scisignal.aam7550 Cited by (40) \| Cite \| Source
Novel Mechanisms of ALK Activation Revealed by Analysis of the Y1278S Neuroblastoma Mutation (journal article) Guan, Jikui \| Yamazaki, Yasuo \| Chand, Damini \| Van Dijk, Jesper \| Ruuth, Kristina \| Palmer, Ruth \| Hallberg, Bengt Cancers, volume 9, issue 11, pages 149- (2017). 10.3390/cancers9110149 Cited by (15) \| Cite \| Source \| Open Access
Anaplastic lymphoma kinase L1198F and G1201E mutations identified in anaplastic thyroid cancer patients are not ligand-independent (journal article) Guan, Jikui \| Wolfstetter, Georg \| Siaw, Joachim \| Chand, Damini \| Hugosson, Fredrik \| Palmer, Ruth H. \| Hallberg, Bengt Oncotarget, volume 8, issue 7, pages 11566-11578 (2017). 10.18632/oncotarget.14141 Cited by (15) \| Cite \| Source \| Open Access
The ALK inhibitor PF-06463922 is effective as a single agent in neuroblastoma driven by expression of ALK and MYCN (journal article) Guan, J. \| Tucker, E. R. \| Wan, H. \| Chand, D. \| Danielson, L. S. \| Ruuth, K. \| El Wakil, A. \| Witek, B. \| Jamin, Y. \| Umapathy, G. \| ... \| Hallberg, B. Disease Models & Mechanisms, volume 9, issue 9, pages 941-952 (2016). 10.1242/dmm.024448 Cited by (50) \| Cite \| Source \| Open Access
Brigatinib, an anaplastic lymphoma kinase inhibitor, abrogates activity and growth in ALK-positive neuroblastoma cells, Drosophila and mice (journal article) Siaw, Joachim T. \| Wan, Haiying \| Pfeifer, Kathrin \| Rivera, Victor M. \| Guan, Jikui \| Palmer, Ruth H. \| Hallberg, Bengt Oncotarget, volume 7, issue 20, pages 29011-29022 (2016). 10.18632/oncotarget.8508 Cited by (46) \| Cite \| Source \| Open Access
FAM150A and FAM150B are activating ligands for anaplastic lymphoma kinase (journal article) Guan, Jikui \| Umapathy, Ganesh \| Yamazaki, Yasuo \| Wolfstetter, Georg \| Mendoza, Patricia \| Pfeifer, Kathrin \| Mohammed, Ateequrrahman \| Hugosson, Fredrik \| Zhang, Hongbing \| Hsu, Amy W \| ... \| Palmer, Ruth H eLife, volume 4 (2015). 10.7554/eLife.09811 Cited by (108) \| Cite \| Source \| Open Access