David W. Kang

ScholarGPS® ID: 20164200342260

Affiliation

Halozyme, Inc., United States

Affiliation History

Field

Life Sciences

Discipline

Biomedical Sciences

Top Specialties

Allergy | Antibody

Metrics Summary

Publication Count

Predicted Citations

216

Predicted h-index

Ranking

Publications and Citation History

Publications based on Top Specialties

Types of Publication

Publications
Books
Patents
NIH/NSF

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Identifying a predictive relationship between maximal flow rate and viscosity for subcutaneous administration of macromolecules with recombinant human hyaluronidase PH20 in a miniature pig model (journal article) Connor, Robert J. \| Clift, Renee \| Kang, David W. Drug Delivery, volume 30, issue 1 (2023). 10.1080/10717544.2023.2252999 Cited by (1) \| Cite \| Source
Investigating the contribution of hyaluronan to the breast tumour microenvironment using multiparametric MRI and MR elastography (journal article) Reeves, Emma L. \| Li, Jin \| Zormpas‐Petridis, Konstantinos \| Boult, Jessica K. R. \| Sullivan, James \| Cummings, Craig \| Blouw, Barbara \| Kang, David \| Sinkus, Ralph \| Bamber, Jeffrey C. \| ... \| Robinson, Simon P. Molecular Oncology, volume 17, issue 6, pages 1076-1092 (2023). 10.1002/1878-0261.13437 Cited by (2) \| Cite \| Source
Risk Factors, Hyaluronidase Expression, and Clinical Immunogenicity of Recombinant Human Hyaluronidase PH20, an Enzyme Enabling Subcutaneous Drug Administration (journal article) Printz, Marie A. \| Sugarman, Barry J. \| Paladini, Rudolph D. \| Jorge, Michael C. \| Wang, Yan \| Kang, David W. \| Maneval, Daniel C. \| LaBarre, Michael J. The AAPS Journal, volume 24, issue 6 (2022). 10.1208/s12248-022-00757-3 Cited by (2) \| Cite \| Source
Investigating the contribution of hyaluronan (HA) to the breast tumour microenvironment using multiparametric MRI and histology (conference) Reeves, Emma \| Li, Jin \| Zormpas-Petridis, Konstantinos \| Sullivan, James \| Cummings, Craig \| Blouw, Barbara \| Kang, David \| Sinkus, Ralph \| Bamber, Jeffrey \| Jamin, Yann \| Robinson, Simon Joint Annual Meeting ISMRM-ESMRMB ISMRT 31st Annual Meeting (2022) London, England, UK 10.58530/2022/0549 Cite \| Source
PEGylated recombinant human hyaluronidase (PEGPH20) pre-treatment improves intra-tumour distribution and efficacy of paclitaxel in preclinical models (journal article) Morosi, Lavinia \| Meroni, Marina \| Ubezio, Paolo \| Fuso Nerini, Ilaria \| Minoli, Lucia \| Porcu, Luca \| Panini, Nicolò \| Colombo, Marika \| Blouw, Barbara \| Kang, David W. \| ... \| Frapolli, Roberta Journal of Experimental & Clinical Cancer Research, volume 40, issue 1 (2021). 10.1186/s13046-021-02070-x Cited by (22) \| Cite \| Source
Safety of recombinant human hyaluronidase PH20 for subcutaneous drug delivery (journal article) Knowles, Stephen P. \| Printz, Marie A. \| Kang, David W. \| LaBarre, Michael J. \| Tannenbaum, Renee P. Expert Opinion on Drug Delivery, volume 18, issue 11, pages 1673-1685 (2021). 10.1080/17425247.2021.1981286 Cited by (15) \| Cite \| Source
Dispersive effects and focused biodistribution of recombinant human hyaluronidase PH20: A locally acting and transiently active permeation enhancer (journal article) Kang, David W. \| Bittner, Beate \| Sugarman, Barry J. \| Zepeda, Monica L. \| Printz, Marie A. PLOS ONE, volume 16, issue 7, pages e0254765- (2021). 10.1371/journal.pone.0254765 Cited by (4) \| Cite \| Source
Depolymerization of Hyaluronan Using PEGylated Human Recombinant Hyaluronidase Promotes Nanoparticle Tumor Penetration (journal article) Brundel, Daniel HS \| Feeney, Orlagh M \| Nowell, Cameron J \| Suys, Estelle JA \| Gracia, Gracia \| Kaminskas, Lisa M \| McIntosh, Michelle M \| Kang, David W \| Porter, Christopher JH Nanomedicine, volume 16, issue 4, pages 275-292 (2021). 10.2217/nnm-2020-0433 Cited by (5) \| Cite \| Source
Subcutaneous Injection Performance in Yucatan Miniature Pigs with and without Human Hyaluronidase and Auto-injector Tolerability in Humans (journal article) Shi, Galen H. \| Connor, Robert J. \| Collins, David S. \| Kang, David W. AAPS PharmSciTech, volume 22, issue 1 (2021). 10.1208/s12249-020-01880-0 Cited by (8) \| Cite \| Source
Use of computed tomography to assess subcutaneous drug dispersion with recombinant human hyaluronidase PH20 in a swine model (journal article) Connor, Robert J. \| Taverna, Darin M. \| Thrall, Karla \| LaBarre, Michael J. \| Kang, David W. Journal of Pharmacological and Toxicological Methods, volume 106 (2020). 10.1016/j.vascn.2020.106936 Cited by (6) \| Cite \| Source
A Preclinical Investigation into the Effects of Aging on Dermal Hyaluronan Properties and Reconstitution Following Recombinant Human Hyaluronidase PH20 Administration (journal article) Connor, Robert J. \| Blouw, Barbara \| Cowell, Jessica \| Chen, Kelly \| Zhao, Chunmei \| Kang, David W. Dermatology and Therapy, volume 10, issue 3, pages 503-513 (2020). 10.1007/s13555-020-00380-0 Cited by (2) \| Cite \| Source
A Phase I Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Recombinant Human Hyaluronidase PH20 Administered Intravenously in Healthy Volunteers (journal article) Printz, Marie A. \| Dychter, Samuel S. \| DeNoia, Emanuel P. \| Harrigan, Rena \| Sugarman, Barry J. \| Zepeda, Monica \| Souratha, Jennifer \| Kang, David W. \| Maneval, Daniel C. Current Therapeutic Research, volume 93 (2020). 10.1016/j.curtheres.2020.100604 Cited by (12) \| Cite \| Source
Removal of interstitial hyaluronan with recombinant human hyaluronidase improves the systemic and lymphatic uptake of cetuximab in rats (journal article) Styles, Ian K. \| Feeney, Orlagh M. \| Nguyen, Tri-Hung \| Brundel, Daniel H.S. \| Kang, David W. \| Clift, Renee \| McIntosh, Michelle P. \| Porter, Christopher J.H. Journal of Controlled Release, volume 315 (2019). 10.1016/j.jconrel.2019.10.040 Cited by (11) \| Cite \| Source
Dynamic Contrast-enhanced MRI Detects Responses to Stroma-directed Therapy in Mouse Models of Pancreatic Ductal Adenocarcinoma (journal article) Cao, Jianbo \| Pickup, Stephen \| Clendenin, Cynthia \| Blouw, Barbara \| Choi, Hoon \| Kang, David \| Rosen, Mark \| O'Dwyer, Peter J. \| Zhou, Rong Clinical Cancer Research, volume 25, issue 7, pages 2314-2322 (2019). 10.1158/1078-0432.CCR-18-2276 Cited by (21) \| Cite \| Source
Single-Molecule Unbinding Forces between the Polysaccharide Hyaluronan and Its Binding Proteins (journal article) Bano, Fouzia \| Tammi, Markku I. \| Kang, David W. \| Harris, Edward N. \| Richter, Ralf P. Biophysical Journal, volume 114, issue 12, pages 2910-2922 (2018). 10.1016/j.bpj.2018.05.014 Cited by (22) \| Cite \| Source
Porcine model to evaluate local tissue tolerability associated with subcutaneous delivery of protein (journal article) Kang, D.W. \| Oh, D.A. \| Fu, G.Y. \| Anderson, J.M. \| Zepeda, M.L. Journal of Pharmacological and Toxicological Methods, volume 67, issue 3, pages 140-147 (2013). 10.1016/j.vascn.2013.01.011 Cited by (23) \| Cite \| Source
Recombinant human hyaluronidase PH20 (rHuPH20) facilitates subcutaneous infusions of large volumes of immunoglobulin in a swine model (journal article) Kang, David W. \| Jadin, Laurence \| Nekoroski, Tara \| Drake, Fred H. \| Zepeda, Monica L. Drug Delivery and Translational Research, volume 2, issue 4, pages 254-264 (2012). 10.1007/s13346-012-0065-3 Cited by (19) \| Cite \| Source
Recombinant Human Hyaluronidase (rHuPH20) Facilitates Subcutaneous Infusion of Immunoglobulin, Increases Local Fluid Dispersion, and Reduces Induration in a Porcine Model (journal article) Kang, D.W. \| Jadin, L.M. \| Nekoroski, T.A. \| Zepeda, M.L. Journal of Allergy and Clinical Immunology, volume 129, issue 2, pages AB85- (2012). 10.1016/j.jaci.2011.12.642 Cited by (2) \| Cite \| Source
Improving Subcutaneous Delivery of IgG via Optimizing Delivery Hardware and the Use of Recombinant Human Hyaluronidase (rHuPH20) (journal article) Zepeda, M.L. \| Fu, G.Y. \| Anderson, J.M. \| Haller, M.F. \| Kang, D.W. Journal of Allergy and Clinical Immunology, volume 127, issue 2, pages AB17-AB17 (2011). 10.1016/j.jaci.2010.12.078 Cite \| Source
Device and Methods for Subcutaneous Delivery of High Viscosity Fluids (patent) Kang, David W. \| Zepeda, Monica L. Patent Number: 20100130958 (2009) Cite \| Source