Keith T. Demarest

ScholarGPS® ID: 18851411999203

Affiliation

Johnson & Johnson, New Brunswick, New Jersey, United States

Affiliation History

Field

Medicine

Discipline

Cardiology

Top Specialties

Metrics Summary

Publication Count

192

Predicted Citations

8,365

Predicted h-index

Ranking

Publications and Citation History

Publications based on Top Specialties

Types of Publication

Publications
Books
Patents
NIH/NSF

Add Delete
Discovery of PEGylated 6-Benzhydryl-4-amino-quinazolines as Peripherally Restricted CB1 R Inverse Agonists (journal article) Zhang, Yue-Mei \| Greco, Michael \| Le Blanc, Tonya \| Lang, Wensheng \| Kauffman, Jack \| Masucci, John \| Murray, William V. \| Demarest, Keith \| Macielag, Mark Joseph ACS Medicinal Chemistry Letters, volume 11, issue 12, pages 2504-2509 (2020). 10.1021/acsmedchemlett.0c00495 Cite \| Source
5,5-Difluoro- and 5-Fluoro-5-methyl-hexose-based C-Glucosides as potent and orally bioavailable SGLT1 and SGLT2 dual inhibitors (journal article) Xu, Guozhang \| Du, Fuyong \| Kuo, Gee-Hong \| Xu, June Zhi \| Liang, Yin \| Demarest, Keith \| Gaul, Michael D. Bioorganic & Medicinal Chemistry Letters, volume 30, issue 17, pages 127387- (2020). 10.1016/j.bmcl.2020.127387 Cited by (8) \| Cite \| Source
Discovery of potent and orally bioavailable indazole-based glucagon receptor antagonists for the treatment of type 2 diabetes (journal article) Xu, Guozhang \| Gaul, Michael D. \| Song, Fengbin \| Du, Fuyong \| Liang, Yin \| DesJarlais, Renee L. \| DiLoreto, Karen \| Shook, Brian \| Rentzeperis, Dennis \| Santulli, Rosie \| ... \| Demarest, Keith Bioorganic & Medicinal Chemistry Letters, volume 29, issue 20, pages 126668- (2019). 10.1016/j.bmcl.2019.126668 Cited by (3) \| Cite \| Source
Design, synthesis and structure activity relationships of indazole and indole derivatives as potent glucagon receptor antagonists (journal article) Song, Fengbin \| Xu, Guozhang \| Gaul, Michael D. \| Zhao, Baoping \| Lu, Tianbao \| Zhang, Rui \| DesJarlais, Renee L. \| DiLoreto, Karen \| Huebert, Norman \| Shook, Brian \| ... \| Demarest, Keith Bioorganic & Medicinal Chemistry Letters, volume 29, issue 15, pages 1974-1980 (2019). 10.1016/j.bmcl.2019.05.036 Cited by (15) \| Cite \| Source
GPR40 agonists in anti-diabetic drug combinations (patent) Liang, Yin \| Demarest, Keith T. Patent Number: 10195178 (2019) Cite \| Source
6-Benzhydryl-4-amino-quinolin-2-ones as Potent Cannabinoid Type 1 (CB1 ) Receptor Inverse Agonists and Chemical Modifications for Peripheral Selectivity (journal article) Zhang, Yue-Mei \| Greco, Michael N. \| Macielag, Mark J. \| Teleha, Christopher A. \| DesJarlais, Renee L. \| Tang, Yuting \| Ho, George \| Hou, Cuifen \| Chen, Cailin \| Zhao, Shuyuan \| ... \| Leonard, James Journal of Medicinal Chemistry, volume 61, issue 22, pages 10276-10298 (2018). 10.1021/acs.jmedchem.8b01467 Cited by (13) \| Cite \| Source
Design, synthesis and biological evaluation of (2S,3R,4R,5S,6R)-5-fluoro-6-(hydroxymethyl)-2-aryltetrahydro-2H-pyran-3,4-diols as potent and orally active SGLT dual inhibitors (journal article) Xu, Guozhang \| Gaul, Michael D. \| Kuo, Gee-Hong \| Du, Fuyong \| Xu, June Zhi \| Wallace, Nathaniel \| Hinke, Simon \| Kirchner, Thomas \| Silva, Jose \| Huebert, Norman D. \| ... \| Demarest, Keith Bioorganic & Medicinal Chemistry Letters, volume 28, issue 21, pages 3446-3453 (2018). 10.1016/j.bmcl.2018.09.025 Cited by (9) \| Cite \| Source
Potent Sodium/Glucose Cotransporter SGLT1/2 Dual Inhibition Improves Glycemic Control Without Marked Gastrointestinal Adaptation or Colonic Microbiota Changes in Rodents (journal article) Du, Fuyong \| Hinke, Simon A. \| Cavanaugh, Cassandre \| Polidori, David \| Wallace, Nathanial \| Kirchner, Thomas \| Jennis, Matthew \| Lang, Wensheng \| Kuo, Gee-Hong \| Gaul, Micheal D. \| ... \| Hornby, Pamela J. Journal of Pharmacology and Experimental Therapeutics, volume 365, issue 3, pages 676-687 (2018). 10.1124/jpet.118.248575 Cited by (24) \| Cite \| Source
Synthesis and biological evaluation of benzocyclobutane-C-glycosides as potent and orally active SGLT1/SGLT2 dual inhibitors (journal article) Kuo, Gee-Hong \| Gaul, Micheal D. \| Liang, Yin \| Xu, June Z. \| Du, Fuyong \| Hornby, Pamela \| Xu, Guozhang \| Qi, Jenson \| Wallace, Nathaniel \| Lee, Seunghun \| ... \| Demarest, Keith Bioorganic & Medicinal Chemistry Letters, volume 28, issue 7, pages 1182-1187 (2018). 10.1016/j.bmcl.2018.02.057 Cited by (29) \| Cite \| Source
Discovery of Orally Efficacious Tetrahydrobenzimidazoles as TGR5 Agonists for Type 2 Diabetes (journal article) Zhang, Xuqing \| Wall, Mark \| Sui, Zhihua \| Kauffman, Jack \| Hou, Cuifen \| Chen, Cailin \| Du, Fuyong \| Kirchner, Thomas \| Liang, Yin \| Johnson, Dana L. \| ... \| Demarest, Keith ACS Medicinal Chemistry Letters, volume 8, issue 5, pages 560-565 (2017). 10.1021/acsmedchemlett.7b00116 Cited by (8) \| Cite \| Source \| Open Access
Evaluation of anti-diabetic effect and gall bladder function with 2-thio-5-thiomethyl substituted imidazoles as TGR5 receptor agonists (journal article) Zhang, Xuqing \| Sui, Zhihua \| Kauffman, Jack \| Hou, Cuifen \| Chen, Cailin \| Du, Fuyong \| Kirchner, Thomas \| Liang, Yin \| Johnson, Dana \| Murray, William V. \| Demarest, Keith Bioorganic & Medicinal Chemistry Letters, volume 27, issue 8, pages 1760-1764 (2017). 10.1016/j.bmcl.2017.02.069 Cited by (15) \| Cite \| Source
Canagliflozin: a sodium glucose co‐transporter 2 inhibitor for the treatment of type 2 diabetes mellitus (journal article) Rosenthal, Norm \| Meininger, Gary \| Ways, Kirk \| Polidori, David \| Desai, Mehul \| Qiu, Rong \| Alba, Maria \| Vercruysse, Frank \| Balis, Dainius \| Shaw, Wayne \| ... \| Demarest, Keith Annals of the New York Academy of Sciences, volume 1358, issue 1, pages 28-43 (2015). 10.1111/nyas.12852 Cited by (69) \| Cite \| Source \| Open Access
Pharmacodynamic Effects of Canagliflozin, a Sodium Glucose Co-Transporter 2 Inhibitor, from a Randomized Study in Patients with Type 2 Diabetes (journal article) Sha, Sue \| Devineni, Damayanthi \| Ghosh, Atalanta \| Polidori, David \| Hompesch, Marcus \| Arnolds, Sabine \| Morrow, Linda \| Spitzer, Heike \| Demarest, Keith \| Rothenberg, Paul PLoS ONE, volume 9, issue 8, pages e105638- (2014). 10.1371/journal.pone.0105638 Cited by (58) \| Cite \| Source \| Open Access
4-Bicyclic heteroaryl-piperidine derivatives as potent, orally bioavailable stearoyl-CoA desaturase-1 (SCD1) inhibitors: Part 2. Pyridazine-based analogs (journal article) Yang, Shyh-Ming \| Tang, Yuting \| Rano, Thomas \| Lu, Huajun \| Kuo, Gee-Hong \| Gaul, Michael D. \| Li, Yaxin \| Ho, George \| Lang, Wensheng \| Conway, James G. \| ... \| Murray, William V. Bioorganic & Medicinal Chemistry Letters, volume 24, issue 5, pages 1437-1441 (2014). 10.1016/j.bmcl.2013.12.075 Cited by (5) \| Cite \| Source
Benzoazepin-oxy-acetic acid derivatives as PPAR-delta agonists used for the increase of HDL-C, lower LDL-C and lower cholesterol (patent) Kuo, Gee-Hong \| Zhang, Yan \| Shen, Lan \| Lu, Songfeng \| Demarest, Keith T. \| Pelton, Patricia Patent Number: 8633184 (2014) Cited by (4) \| Cite \| Source
4-Bicyclic heteroaryl-piperidine derivatives as potent, orally bioavailable Stearoyl-CoA desaturase-1 (SCD1) inhibitors. Part 1: Urea-based analogs (journal article) Yang, Shyh-Ming \| Tang, Yuting \| Zhang, Rui \| Lu, Huajun \| Kuo, Gee-Hong \| Gaul, Michael D. \| Li, Yaxin \| Ho, George \| Conway, James G. \| Liang, Yin \| ... \| Murray, William V. Bioorganic & Medicinal Chemistry Letters, volume 23, issue 24, pages 6773-6776 (2013). 10.1016/j.bmcl.2013.09.096 Cited by (5) \| Cite \| Source
Combination therapy comprising glucose reabsorption inhibitors and PPAR modulators (patent) Bussolari, Jacqueline C. \| Chen, Xiaoli \| Conway, Bruce R. \| Demarest, Keith T. \| Ross, Hamish N. M. \| Severino, Rafael Patent Number: 8278268 (2012) Cite \| Source
4-((phenoxyalkyl)thio)-phenoxyacetic acids and analogs (patent) DeAngelis, Alan \| Demarest, Keith T \| Kuo, Gee-Hong \| Pelton, Patricia \| Wang, Aihua \| Zhang, Rui Patent Number: 8242173 (2012) Cited by (3) \| Cite \| Source
Beneficial Metabolic Effects of CB1R Anti-Sense Oligonucleotide Treatment in Diet-Induced Obese AKR/J Mice (journal article) Tang, Yuting \| Ho, George \| Li, Yaxin \| Hall, Meghan A. \| Hills, Robert L. \| Black, Shawn C. \| Liang, Yin \| Demarest, Keith T. PLoS ONE, volume 7, issue 8, pages e42134- (2012). 10.1371/journal.pone.0042134 Cited by (16) \| Cite \| Source \| Open Access
The use of stable isotope-labeled glycerol and oleic acid to differentiate the hepatic functions of DGAT1 and -2 (journal article) Qi, Jenson \| Lang, Wensheng \| Geisler, John G. \| Wang, Ping \| Petrounia, Ioanna \| Mai, Selyna \| Smith, Charles \| Askari, Hossein \| Struble, Geoffrey T. \| Williams, Robyn \| ... \| Connelly, Margery A. Journal of Lipid Research, volume 53, issue 6, pages 1106-1116 (2012). 10.1194/jlr.M020156 Cited by (93) \| Cite \| Source \| Open Access