Lindsay C. Spender

ScholarGPS® ID: 18774145771749

Affiliation

University of Dundee, Dundee, United Kingdom

Affiliation History

Field

Life Sciences

Discipline

Molecular and Cell Biology

Top Specialties

Virus | Epstein–Barr Virus | Cancer | Apoptosis

Metrics Summary

Publication Count

Predicted Citations

2,092

Predicted h-index

Ranking

Publications and Citation History

Publications based on Top Specialties

Types of Publication

Publications
Books
Patents
NIH/NSF

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Female Sex but Not Oestrogen Receptor Expression Predicts Survival in Advanced Gastroesophageal Adenocarcinoma—A Post-hoc Analysis of the GO2 Trial (journal article) Baxter, Mark A. \| Spender, Lindsay C. \| Walsh, Shaun \| Bray, Susan \| Skinner, Gemma \| King, Sharon \| Hall, Peter S. \| Seymour, Matthew J. \| Petty, Russell D. Cancers, volume 15, issue 9, pages 2591- (2023). 10.3390/cancers15092591 Cite \| Source
Melanoma secretion of transforming growth factor‐β2 leads to loss of epidermal AMBRA1 threatening epidermal integrity and facilitating tumour ulceration* (journal article) Cosgarea, I. \| McConnell, A.T. \| Ewen, T. \| Tang, D. \| Hill, D.S. \| Anagnostou, M. \| Elias, M. \| Ellis, R.A. \| Murray, A. \| Spender, L.C. \| ... \| Lovat, P.E. British Journal of Dermatology, volume 186, issue 4, pages 694-704 (2022). 10.1111/bjd.20889 Cited by (9) \| Cite \| Source
Interactions between anti-EGFR therapies and cytotoxic chemotherapy in oesophageal squamous cell carcinoma: why clinical trials might have failed and how they could succeed (journal article) Meemanage, Madusha \| Spender, Lindsay C. \| Collinson, Diane \| Iannetta, Joanna \| Challapalli, Pranavi \| Turbitt, Julie \| Clark, Caroline \| Baxter, Mark \| Murray, Graeme \| Walsh, Shaun \| ... \| Petty, Russell D. Cancer Chemotherapy and Pharmacology (2021). 10.1007/s00280-020-04187-w Cited by (3) \| Cite \| Source
Combining precision medicine and prophylaxis in oesophageal squamous cell carcinoma (journal article) Baxter, Mark A. \| Spender, Lindsay C. \| Petty, Russell D. British Journal of Cancer, volume 123, issue 11, pages 1585-1587 (2020). 10.1038/s41416-020-01057-3 Cited by (2) \| Cite \| Source
Multifaceted transforming growth factor-beta (TGFβ) signalling in glioblastoma (journal article) Birch, Joanna L. \| Coull, Barry J. \| Spender, Lindsay C. \| Watt, Courtney \| Willison, Alice \| Syed, Nelofer \| Chalmers, Anthony J. \| Hossain-Ibrahim, M. Kismet \| Inman, Gareth J. Cellular Signalling, volume 72 (2020). 10.1016/j.cellsig.2020.109638 Cited by (22) \| Cite \| Source
Preclinical Evaluation of AZ12601011 and AZ12799734, Inhibitors of Transforming Growth Factor β Superfamily Type 1 Receptors (journal article) Spender, Lindsay C. \| Ferguson, G. John \| Hughes, Gareth D. \| Davies, Barry R. \| Goldberg, Frederick W. \| Herrera, Blanca \| Taylor, Richard G. \| Strathearn, Lauren S. \| Sansom, Owen J. \| Barry, Simon T. \| Inman, Gareth J. Molecular Pharmacology, volume 95, issue 2, pages 222-234 (2019). 10.1124/mol.118.112946 Cited by (22) \| Cite \| Source
The genomic landscape of cutaneous SCC reveals drivers and a novel azathioprine associated mutational signature (journal article) Inman, Gareth J. \| Wang, Jun \| Nagano, Ai \| Alexandrov, Ludmil B. \| Purdie, Karin J. \| Taylor, Richard G. \| Sherwood, Victoria \| Thomson, Jason \| Hogan, Sarah \| Spender, Lindsay C. \| ... \| Leigh, Irene M. Nature Communications, volume 9, issue 1 (2018). 10.1038/s41467-018-06027-1 Cited by (194) \| Cite \| Source \| Open Access
Reduced SMAD2/3 activation independently predicts increased depth of human cutaneous squamous cell carcinoma (journal article) Rose, Aidan M. \| Spender, Lindsay C. \| Stephen, Christopher \| Mitchell, Alastair \| Rickaby, William \| Bray, Susan \| Evans, Alan T. \| Dayal, Jasbani \| Purdie, Karin J. \| Harwood, Catherine A. \| ... \| Inman, Gareth J. Oncotarget, volume 9, issue 18, pages 14552-14566 (2018). 10.18632/oncotarget.24545 Cited by (7) \| Cite \| Source \| Open Access
141 Targeting TGFβ signaling in BRAF mutant melanoma (journal article) Spender, L. \| Liu, S. \| Cui, C. \| Girotti, R. \| Sansom, O. \| Frame, M. \| ten Dijke, P. \| Marais, R. \| Inman, G. Journal of Investigative Dermatology, volume 137, issue 5, pages S24- (2017). 10.1016/j.jid.2017.02.155 Cite \| Source
Targeting BRAF-mutant tumours with TGFBR1 inhibitors (journal article) Spender, Lindsay C. \| Inman, Gareth J. Aging, volume 9, issue 1, pages 5-6 (2017). 10.18632/aging.101169 Cite \| Source \| Open Access
Mutational activation of BRAF confers sensitivity to transforming growth factor beta inhibitors in human cancer cells (journal article) Spender, Lindsay C. \| Ferguson, G. John \| Liu, Sijia \| Cui, Chao \| Girotti, Maria Romina \| Sibbet, Gary \| Higgs, Ellen B. \| Shuttleworth, Morven K. \| Hamilton, Tom \| Lorigan, Paul \| ... \| Inman, Gareth J. Oncotarget, volume 7, issue 50, pages 81995-82012 (2016). 10.18632/oncotarget.13226 Cited by (18) \| Cite \| Source \| Open Access
Fatal attractions? Correlations of CXCL12-CXCR4-CXCR7 expression with disease progression in melanoma and Kaposi sarcoma (journal article) Spender, L.C. \| Inman, G.J. British Journal of Dermatology, volume 175, issue 6, pages 1140-1141 (2016). 10.1111/bjd.15136 Cite \| Source \| Open Access
Inactivation of TGFβ receptors in stem cells drives cutaneous squamous cell carcinoma (journal article) Cammareri, Patrizia \| Rose, Aidan M. \| Vincent, David F. \| Wang, Jun \| Nagano, Ai \| Libertini, Silvana \| Ridgway, Rachel A. \| Athineos, Dimitris \| Coates, Philip J. \| McHugh, Angela \| ... \| Inman, Gareth J. Nature Communications, volume 7, issue 1 (2016). 10.1038/ncomms12493 Cited by (79) \| Cite \| Source \| Open Access
Developments in Burkitt's lymphoma: novel cooperations in oncogenic MYC signaling (journal article) Inman, Gareth \| Spender, Lindsay Cancer Management and Research (2014). 10.2147/CMAR.S37745 Cited by (11) \| Cite \| Source \| Open Access
Transforming Growth Factor-β Directly Induces p53-up-regulated Modulator of Apoptosis (PUMA) during the Rapid Induction of Apoptosis in Myc-driven B-cell Lymphomas (journal article) Spender, Lindsay C. \| Carter, Matthew J. \| O'Brien, Darren I. \| Clark, Louise J. \| Yu, Jian \| Michalak, Ewa M. \| Happo, Lina \| Cragg, Mark S. \| Inman, Gareth J. Journal of Biological Chemistry, volume 288, issue 7, pages 5198-5209 (2013). 10.1074/jbc.M112.410274 Cited by (27) \| Cite \| Source \| Open Access
Phosphoinositide 3-kinase/AKT/mTORC1/2 Signaling Determines Sensitivity of Burkitt's Lymphoma Cells to BH3 mimetics (journal article) Spender, Lindsay C. \| Inman, Gareth J. Molecular Cancer Research, volume 10, issue 3, pages 347-359 (2012). 10.1158/1541-7786.MCR-11-0394 Cited by (40) \| Cite \| Source \| Open Access
Inhibition of Germinal Centre Apoptotic Programmes by Epstein-Barr Virus (journal article) Spender, Lindsay C. \| Inman, Gareth J. Advances in Hematology, volume 2011 (2011). 10.1155/2011/829525 Cited by (11) \| Cite \| Source \| Open Access
Epigenetic downregulation of human disabled homolog 2 switches TGF-β from a tumor suppressor to a tumor promoter (journal article) Hannigan, Adèle \| Smith, Paul \| Kalna, Gabriela \| Lo Nigro, Cristiana \| Orange, Clare \| O’Brien, Darren I. \| Shah, Reshma \| Syed, Nelofer \| Spender, Lindsay C. \| Herrera, Blanca \| ... \| Inman, Gareth J. Journal of Clinical Investigation, volume 120, issue 8, pages 2842-2857 (2010). 10.1172/JCI36125 Cited by (83) \| Cite \| Source \| Open Access
Targeting the BCL-2 family in malignancies of germinal centre origin (journal article) Spender, Lindsay C \| Inman, Gareth J Expert Opinion on Therapeutic Targets, volume 13, issue 12, pages 1459-1472 (2009). 10.1517/14728220903379565 Cited by (3) \| Cite \| Source
Downregulation of RUNX1 by RUNX3 Requires the RUNX3 VWRPY Sequence and Is Essential for Epstein-Barr Virus-Driven B-Cell Proliferation (journal article) Brady, Gareth \| Whiteman, Hannah J. \| Spender, Lindsay C. \| Farrell, Paul J. Journal of Virology, volume 83, issue 13, pages 6909-6916 (2009). 10.1128/JVI.00216-09 Cited by (40) \| Cite \| Source \| Open Access