James A. Roper

ScholarGPS® ID: 18623914155177

Affiliation

GlaxoSmithKline plc, London

Affiliation History

Field

Life Sciences

Discipline

Genetics

Top Specialties

Neuroendocrinology | Integrin

Metrics Summary

Publication Count

Predicted Citations

1,390

Predicted h-index

Ranking

Publications and Citation History

Publications based on Top Specialties

Types of Publication

Publications
Books
Patents
NIH/NSF

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Integrins as a drug target in liver fibrosis (journal article) Rahman, Syedia R. \| Roper, James A. \| Grove, Jane I. \| Aithal, Guruprasad P. \| Pun, K. Tao \| Bennett, Andrew J. Liver International, volume 42, issue 3, pages 507-521 (2022). 10.1111/liv.15157 Cited by (35) \| Cite \| Source
Emerging therapeutic opportunities for integrin inhibitors (journal article) Slack, R. J. \| Macdonald, S. J. F. \| Roper, J. A. \| Jenkins, R. G. \| Hatley, R. J. D. Nature Reviews Drug Discovery, volume 21, issue 1, pages 60-78 (2022). 10.1038/s41573-021-00284-4 Cited by (222) \| Cite \| Source
Downregulation of the α v β 6 Integrin via RGD Engagement Is Affinity and Time Dependent (journal article) Roper, James A. \| Wilkinson, Alex L. \| Gower, Elaine \| Slack, Robert J. Journal of Pharmacology and Experimental Therapeutics, volume 376, issue 2, pages 273-280 (2021). 10.1124/jpet.120.000379 Cited by (3) \| Cite \| Source
Profile of a Highly Selective Quaternized Pyrrolidine Betaine αv β6 Integrin Inhibitor—(3 S )-3-(3-(3,5-Dimethyl-1 H -pyrazol-1-yl)phenyl)-4-((1 S and 1 R ,3 R )-1-methyl-3-(2-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)ethyl)pyrrolidin-1-ium-1-yl)butanoate (journal article) Barrett, Tim N. \| Taylor, Jonathan A. \| Barker, Daniel \| Procopiou, Panayiotis A. \| Thompson, James D. F. \| Barrett, John \| Le, Joelle \| Lynn, Sean M. \| Pogany, Peter \| Pratley, Cassie \| ... \| Kerr, William J. Journal of Medicinal Chemistry, volume 62, issue 16, pages 7543-7556 (2019). 10.1021/acs.jmedchem.9b00819 Cited by (5) \| Cite \| Source
Chlorhexidine Hexametaphosphate As a Wound Care Material Coating: Antimicrobial efficacy, Toxicity and Effect on Healing (journal article) Barbour, Michele E \| Maddocks, Sarah E \| Grady, Helena J \| Roper, James A \| Bass, Mark D \| Collins, Andrew M \| Dommett, Rachel M \| Saunders, Margaret Nanomedicine, volume 11, issue 16, pages 2049-2057 (2016). 10.2217/nnm-2016-0084 Cited by (16) \| Cite \| Source \| Open Access
Neuropeptide Receptors (book chapter) In Molecular Neuroendocrinology Lolait, Stephen J. \| Roper, James A. \| Hazell, Georgina G.J. \| Li, Yunfei \| Thomson, Fiona J. \| O'Carroll, Anne‐Marie Wiley (2016) 10.1002/9781118760369.ch10 Cited by (3) \| Cite \| Source
Ultrasonic Stimulation of Mouse Skin Reverses the Healing Delays in Diabetes and Aging by Activation of Rac1 (journal article) Roper, James A. \| Williamson, Rosalind C. \| Bally, Blandine \| Cowell, Christopher A.M. \| Brooks, Rebecca \| Stephens, Phil \| Harrison, Andrew J. \| Bass, Mark D. Journal of Investigative Dermatology, volume 135, issue 11, pages 2842-2851 (2015). 10.1038/jid.2015.224 Cited by (33) \| Cite \| Source \| Open Access
Coronin-1C Protein and Caveolin Protein Provide Constitutive and Inducible Mechanisms of Rac1 Protein Trafficking (journal article) Williamson, Rosalind C. \| Cowell, Christopher A.M. \| Reville, Thomas \| Roper, James A. \| Rendall, Thomas C.S. \| Bass, Mark D. Journal of Biological Chemistry, volume 290, issue 25, pages 15437-15449 (2015). 10.1074/jbc.M115.640367 Cited by (10) \| Cite \| Source \| Open Access
Coronin-1C and RCC2 guide mesenchymal migration by trafficking Rac1 and controlling GEF exposure (journal article) Williamson, Rosalind C. \| Cowell, Christopher A. M. \| Hammond, Christina L. \| Bergen, Dylan \| Roper, James \| Feng, Yi \| Rendall, Thomas C. S. \| Race, Paul R. \| Bass, Mark D. Journal of Cell Science (2014). 10.1242/jcs.154864 Cited by (25) \| Cite \| Source \| Open Access
Role of Nociceptin/Orphanin FQ and NOP Receptors in the Response to Acute and Repeated Restraint Stress in Rats (journal article) Delaney, G. \| Dawe, K. L. \| Hogan, R. \| Hunjan, T. \| Roper, J. \| Hazell, G. \| Lolait, S. J. \| Fulford, A. J. Journal of Neuroendocrinology, volume 24, issue 12, pages 1527-1541 (2012). 10.1111/j.1365-2826.2012.02361.x Cited by (33) \| Cite \| Source \| Open Access
Syndecan and integrin interactomes: large complexes in small spaces (journal article) Roper, James A \| Williamson, Rosalind C \| Bass, Mark D Current Opinion in Structural Biology, volume 22, issue 5, pages 583-590 (2012). 10.1016/j.sbi.2012.07.003 Cited by (65) \| Cite \| Source \| Open Access
Induction of Adhesion-dependent Signals Using Low-intensity Ultrasound (journal article) Roper, James \| Harrison, Andrew \| Bass, Mark D. Journal of Visualized Experiments (2012). 10.3791/4024-v Cited by (1) \| Cite \| Source
Induction of Adhesion-dependent Signals Using Low-intensity Ultrasound (journal article) Roper, James \| Harrison, Andrew \| Bass, Mark D. Journal of Visualized Experiments (2012). 10.3791/4024 Cited by (8) \| Cite \| Source \| Open Access
G protein-coupled receptors in the hypothalamic paraventricular and supraoptic nuclei – serpentine gateways to neuroendocrine homeostasis (journal article) Hazell, Georgina G.J. \| Hindmarch, Charles C. \| Pope, George R. \| Roper, James A. \| Lightman, Stafford L. \| Murphy, David \| O’Carroll, Anne-Marie \| Lolait, Stephen J. Frontiers in Neuroendocrinology, volume 33, issue 1, pages 45-66 (2012). 10.1016/j.yfrne.2011.07.002 Cited by (61) \| Cite \| Source \| Open Access
The vasopressin Avpr1b receptor: Molecular and pharmacological studies (journal article) Roper, JA \| O'Carroll, A-M \| Young, WS \| Lolait, SJ Stress, volume 14, issue 1, pages 98-115 (2011). 10.3109/10253890.2010.512376 Cited by (96) \| Cite \| Source \| Open Access
Attenuated Stress Response to Acute Restraint and Forced Swimming Stress in Arginine Vasopressin 1b Receptor Subtype (Avpr1b) Receptor Knockout Mice and Wild‐Type Mice Treated with a Novel Avpr1b Receptor Antagonist (journal article) Roper, J. A. \| Craighead, M. \| O’Carroll, A‐M. \| Lolait, S. J. Journal of Neuroendocrinology, volume 22, issue 11, pages 1173-1180 (2010). 10.1111/j.1365-2826.2010.02070.x Cited by (23) \| Cite \| Source \| Open Access
Localisation of GPR30, a novel G protein-coupled oestrogen receptor, suggests multiple functions in rodent brain and peripheral tissues (journal article) Hazell, Georgina G J \| Yao, Song T \| Roper, James A \| Prossnitz, Eric R \| O'Carroll, Anne-Marie \| Lolait, Stephen J Journal of Endocrinology, volume 202, issue 2, pages 223-236 (2009). 10.1677/JOE-09-0066 Cited by (295) \| Cite \| Source \| Open Access
The role of the arginine vasopressin Avp1b receptor in the acute neuroendocrine action of antidepressants (journal article) Stewart, Lesley Q. \| Roper, James A. \| Scott Young, W. \| O’Carroll, Anne-Marie \| Lolait, Stephen J. Psychoneuroendocrinology, volume 33, issue 4, pages 405-415 (2008). 10.1016/j.psyneuen.2007.12.009 Cited by (32) \| Cite \| Source
Pituitary‐Adrenal Response to Acute and Repeated Mild Restraint, Forced Swim and Change in Environment Stress in Arginine Vasopressin Receptor 1b Knockout Mice (journal article) Stewart, L. Q. \| Roper, J. A. \| Young, W. S. \| O’Carroll, A.‐M. \| Lolait, S. J. Journal of Neuroendocrinology, volume 20, issue 5, pages 597-605 (2008). 10.1111/j.1365-2826.2008.01704.x Cited by (38) \| Cite \| Source
Attenuated Stress Response to Acute Lipopolysaccharide Challenge and Ethanol Administration in Vasopressin V1b Receptor Knockout Mice (journal article) Lolait, S. J. \| Stewart, L. Q. \| Roper, J. A. \| Harrison, G. \| Jessop, D. S. \| Young, W. S. \| O'Carroll, A.‐M. Journal of Neuroendocrinology, volume 19, issue 7, pages 543-551 (2007). 10.1111/j.1365-2826.2007.01560.x Cited by (35) \| Cite \| Source \| Open Access