Cuifen Hou

ScholarGPS® ID: 16374592594802

Affiliation

Johnson & Johnson, New Brunswick, New Jersey, United States

Affiliation History

Field

Medicine

Discipline

Cardiology

Top Specialties

Medicinal Chemistry | Chemical Synthesis

Metrics Summary

Publication Count

Predicted Citations

454

Predicted h-index

Ranking

Publications and Citation History

Publications based on Top Specialties

Types of Publication

Publications
Books
Patents
NIH/NSF

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6-Benzhydryl-4-amino-quinolin-2-ones as Potent Cannabinoid Type 1 (CB1 ) Receptor Inverse Agonists and Chemical Modifications for Peripheral Selectivity (journal article) Zhang, Yue-Mei \| Greco, Michael N. \| Macielag, Mark J. \| Teleha, Christopher A. \| DesJarlais, Renee L. \| Tang, Yuting \| Ho, George \| Hou, Cuifen \| Chen, Cailin \| Zhao, Shuyuan \| ... \| Leonard, James Journal of Medicinal Chemistry, volume 61, issue 22, pages 10276-10298 (2018). 10.1021/acs.jmedchem.8b01467 Cited by (13) \| Cite \| Source
Discovery of Orally Efficacious Tetrahydrobenzimidazoles as TGR5 Agonists for Type 2 Diabetes (journal article) Zhang, Xuqing \| Wall, Mark \| Sui, Zhihua \| Kauffman, Jack \| Hou, Cuifen \| Chen, Cailin \| Du, Fuyong \| Kirchner, Thomas \| Liang, Yin \| Johnson, Dana L. \| ... \| Demarest, Keith ACS Medicinal Chemistry Letters, volume 8, issue 5, pages 560-565 (2017). 10.1021/acsmedchemlett.7b00116 Cited by (8) \| Cite \| Source \| Open Access
Evaluation of anti-diabetic effect and gall bladder function with 2-thio-5-thiomethyl substituted imidazoles as TGR5 receptor agonists (journal article) Zhang, Xuqing \| Sui, Zhihua \| Kauffman, Jack \| Hou, Cuifen \| Chen, Cailin \| Du, Fuyong \| Kirchner, Thomas \| Liang, Yin \| Johnson, Dana \| Murray, William V. \| Demarest, Keith Bioorganic & Medicinal Chemistry Letters, volume 27, issue 8, pages 1760-1764 (2017). 10.1016/j.bmcl.2017.02.069 Cited by (15) \| Cite \| Source
Tetrahydroindazole derivatives as potent and peripherally selective cannabinoid-1 (CB1) receptor inverse agonists (journal article) Matthews, Jay M. \| McNally, James J. \| Connolly, Peter J. \| Xia, Mingde \| Zhu, Bin \| Black, Shawn \| Chen, Cailin \| Hou, Cuifen \| Liang, Yin \| Tang, Yuting \| Macielag, Mark J. Bioorganic & Medicinal Chemistry Letters, volume 26, issue 21, pages 5346-5349 (2016). 10.1016/j.bmcl.2016.09.025 Cited by (18) \| Cite \| Source
Tetrahydropyrazolo[4,3- c ]pyridine derivatives as potent and peripherally selective cannabinoid-1 (CB1) receptor inverse agonists (journal article) Zhu, Bin \| Matthews, Jay M. \| Xia, Mingde \| Black, Shawn \| Chen, Cailin \| Hou, Cuifen \| Liang, Yin \| Tang, Yuting \| Macielag, Mark J. Bioorganic & Medicinal Chemistry Letters, volume 26, issue 22, pages 5597-5601 (2016). 10.1016/j.bmcl.2016.09.026 Cited by (5) \| Cite \| Source
The discovery and SAR of cyclopenta[b]furans as inhibitors of CCR2 (journal article) Winters, Michael P. \| Teleha, Christopher A. \| Kang, Fu-An \| McComsey, David \| O’Neill, John C. \| Hou, Cuifen \| Kirchner, Thomas \| Wang, Ping \| Johnson, Dana \| Sui, Zhihua Bioorganic & Medicinal Chemistry Letters, volume 24, issue 9, pages 2137-2140 (2014). 10.1016/j.bmcl.2014.03.036 Cited by (5) \| Cite \| Source
Discovery and SAR of 5-aminooctahydrocyclopentapyrrole-3a-carboxamides as potent CCR2 antagonists (journal article) Cai, Chaozhong \| McComsey, Dave F. \| Hou, Cuifen \| O’Neill, John C. \| Opas, Evan \| McKenney, Sandra \| Johnson, Dana \| Sui, Zhihua Bioorganic & Medicinal Chemistry Letters, volume 24, issue 4, pages 1239-1242 (2014). 10.1016/j.bmcl.2013.05.024 Cited by (6) \| Cite \| Source
A novel series of N-(azetidin-3-yl)-2-(heteroarylamino)acetamide CCR2 antagonists (journal article) Subasinghe, Nalin L. \| Lanter, James \| Markotan, Thomas \| Opas, Evan \| McKenney, Sandra \| Crysler, Carl \| Hou, Cuifen \| O’Neill, John \| Johnson, Dana \| Sui, Zhihua Bioorganic & Medicinal Chemistry Letters, volume 23, issue 4, pages 1063-1069 (2013). 10.1016/j.bmcl.2012.12.017 Cited by (19) \| Cite \| Source
Novel 2-aminooctahydrocyclopentalene-3a-carboxamides as potent CCR2 antagonists (journal article) Cai, Chaozhong \| Kang, Fu-An \| Hou, Cuifen \| O’Neill, John C. \| Opas, Evan \| McKenney, Sandra \| Johnson, Dana \| Sui, Zhihua Bioorganic & Medicinal Chemistry Letters, volume 23, issue 1, pages 351-354 (2013). 10.1016/j.bmcl.2012.10.069 Cited by (7) \| Cite \| Source
Discovery of a 4-Azetidinyl-1-thiazoyl-cyclohexane CCR2 Antagonist as a Development Candidate (journal article) Zhang, Xuqing \| Hou, Cuifen \| Hufnagel, Heather \| Singer, Monica \| Opas, Evan \| McKenney, Sandra \| Johnson, Dana \| Sui, Zhihua ACS Medicinal Chemistry Letters, volume 3, issue 12, pages 1039-1044 (2012). 10.1021/ml300260s Cited by (17) \| Cite \| Source \| Open Access
CCR2 Antagonists for the Treatment of Diseases Associated with Inflammation (book chapter) In Anti-Inflammatory Drug Discovery HOU, Cuifen \| SUI, Zhihua The Royal Society of Chemistry (2012) 10.1039/9781849735346-00350 Cited by (6) \| Cite \| Source
The discovery of novel cyclohexylamide CCR2 antagonists (journal article) Lanter, James C. \| Markotan, Thomas P. \| Zhang, Xuqing \| Subasinghe, Nalin \| Kang, Fu-An \| Hou, Cuifen \| Singer, Monica \| Opas, Evan \| McKenney, Sandra \| Crysler, Carl \| ... \| Sui, Zhihua Bioorganic & Medicinal Chemistry Letters, volume 21, issue 24, pages 7496-7501 (2011). 10.1016/j.bmcl.2011.09.113 Cited by (9) \| Cite \| Source
Design, synthesis and SAR of indazole and benzoisoxazole containing 4-azetidinyl-1-aryl-cyclohexanes as CCR2 antagonists (journal article) Zhang, Xuqing \| Hufnagel, Heather \| Hou, Cuifen \| Opas, Evan \| McKenney, Sandra \| Crysler, Carl \| O’Neill, John \| Johnson, Dana \| Sui, Zhihua Bioorganic & Medicinal Chemistry Letters, volume 21, issue 20, pages 6042-6048 (2011). 10.1016/j.bmcl.2011.08.074 Cited by (12) \| Cite \| Source
Overcoming hERG activity in the discovery of a series of 4-azetidinyl-1-aryl-cyclohexanes as CCR2 antagonists (journal article) Zhang, Xuqing \| Hufnagel, Heather \| Markotan, Thomas \| Lanter, James \| Cai, Chaozhong \| Hou, Cuifen \| Singer, Monica \| Opas, Evan \| McKenney, Sandra \| Crysler, Carl \| ... \| Sui, Zhihua Bioorganic & Medicinal Chemistry Letters, volume 21, issue 18, pages 5577-5582 (2011). 10.1016/j.bmcl.2011.06.080 Cited by (19) \| Cite \| Source
Synthesis and structure–activity relationship of 7-azaindole piperidine derivatives as CCR2 antagonists (journal article) Xia, Mingde \| Hou, Cuifen \| DeMong, Duane \| Pollack, Scott \| Pan, Meng \| Singer, Monica \| Matheis, Michele \| Murray, William \| Cavender, Druie \| Wachter, Michael Bioorganic & Medicinal Chemistry Letters, volume 18, issue 24, pages 6468-6470 (2008). 10.1016/j.bmcl.2008.10.061 Cited by (15) \| Cite \| Source
Substituted dipiperidine alcohols as potent CCR2 antagonists (journal article) Xia, Mingde \| Hou, Cuifen \| DeMong, Duane \| Pollack, Scott \| Pan, Meng \| Brackley, James \| Singer, Monica \| Matheis, Michele \| Cavender, Druie \| Wachter, Michael Bioorganic & Medicinal Chemistry Letters, volume 18, issue 12, pages 3562-3564 (2008). 10.1016/j.bmcl.2008.05.010 Cited by (13) \| Cite \| Source
Synthesis and biological evaluation of phenyl piperidine derivatives as CCR2 antagonists (journal article) Xia, Mingde \| Hou, Cuifen \| Pollack, Scott \| Brackley, James \| DeMong, Duane \| Pan, Meng \| Singer, Monica \| Matheis, Michele \| Olini, Gil \| Cavender, Druie \| Wachter, Michael Bioorganic & Medicinal Chemistry Letters, volume 17, issue 21, pages 5964-5968 (2007). 10.1016/j.bmcl.2007.07.065 Cited by (10) \| Cite \| Source
Synthesis, Structure−Activity Relationship and in Vivo Antiinflammatory Efficacy of Substituted Dipiperidines as CCR2 Antagonists (journal article) Xia, Mingde \| Hou, Cuifen \| DeMong, Duane E. \| Pollack, Scott R. \| Pan, Meng \| Brackley, James A. \| Jain, Nareshkumar \| Gerchak, Chrissy \| Singer, Monica \| Malaviya, Ravi \| ... \| Wachter, Michael Journal of Medicinal Chemistry, volume 50, issue 23, pages 5561-5563 (2007). 10.1021/jm070902b Cited by (27) \| Cite \| Source
Potent and selective CC-chemokine receptor-2 (CCR2) antagonists as a potential treatment for asthma (journal article) Lagu, Bharat \| Gerchak, Chrissy \| Pan, Meng \| Hou, Cuifen \| Singer, Monica \| Malaviya, Ravi \| Matheis, Michele \| Olini, Gil \| Cavender, Druie \| Wachter, Michael Bioorganic & Medicinal Chemistry Letters, volume 17, issue 15, pages 4382-4386 (2007). 10.1016/j.bmcl.2007.01.115 Cited by (31) \| Cite \| Source
In Vivo Activity of a Phospholipase C Inhibitor, 1-(6-((17β-3-Methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1 H -pyrrole-2,5-dione (U73122), in Acute and Chronic Inflammatory Reactions (journal article) Hou, Cuifen \| Kirchner, Thomas \| Singer, Monica \| Matheis, Michele \| Argentieri, Dennis \| Cavender, Druie Journal of Pharmacology and Experimental Therapeutics, volume 309, issue 2, pages 697-704 (2004). 10.1124/jpet.103.060574 Cited by (53) \| Cite \| Source \| Open Access