Renee L. DesJarlais

ScholarGPS® ID: 16086600963026

Affiliation

Johnson & Johnson, New Brunswick, New Jersey, United States

Affiliation History

Field

Physical Sciences and Mathematics

Discipline

Chemistry

Top Specialties

Metrics Summary

Publication Count

105

Predicted Citations

4,950

Predicted h-index

Ranking

Publications and Citation History

Publications based on Top Specialties

Types of Publication

Publications
Books
Patents
NIH/NSF

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Molecular determinants of ASIC1 modulation by divalent cations (journal article) Liu, Yi \| Ma, Jichun \| DesJarlais, Renee L. \| Hagan, Rebecca \| Rech, Jason \| Liu, Changlu \| Miller, Robyn \| Schoellerman, Jeffrey \| Luo, Jinquan \| Letavic, Michael \| ... \| Maher, Michael P. Scientific Reports, volume 14, issue 1 (2024). 10.1038/s41598-024-52845-3 Cite \| Source
Novel Reagent Space: Identifying Unorderable but Readily Synthesizable Building Blocks (journal article) Seierstad, Mark \| Tichenor, Mark S. \| DesJarlais, Renee L. \| Na, Jim \| Bacani, Genesis M. \| Chung, De Michael \| Mercado-Marin, Eduardo V. \| Steffens, Helena C. \| Mirzadegan, Taraneh ACS Medicinal Chemistry Letters, volume 12, issue 11, pages 1853-1860 (2021). 10.1021/acsmedchemlett.1c00340 Cited by (6) \| Cite \| Source
Development and Implementation of an enterprise-wide Predictive Model for Early absorption, distribution, Metabolism and Excretion Properties (journal article) Kumar, Kiran \| Chupakhin, Vladimir \| Vos, Ann \| Morrison, Denise \| Rassokhin, Dmitrii \| Dellwo, Martin J \| McCormick, Keith \| Paternoster, Eric \| Ceulemans, Hugo \| DesJarlais, Renee L Future Medicinal Chemistry, volume 13, issue 19, pages 1639-1654 (2021). 10.4155/fmc-2021-0138 Cited by (11) \| Cite \| Source
Molecular mechanism and structural basis of small-molecule modulation of the gating of acid-sensing ion channel 1 (journal article) Liu, Yi \| Ma, Jichun \| DesJarlais, Renee L. \| Hagan, Rebecca \| Rech, Jason \| Lin, David \| Liu, Changlu \| Miller, Robyn \| Schoellerman, Jeffrey \| Luo, Jinquan \| ... \| Maher, Michael Communications Biology, volume 4, issue 1 (2021). 10.1038/s42003-021-01678-1 Cited by (13) \| Cite \| Source
Hit-to-lead optimization and discovery of a potent, and orally bioavailable G protein coupled receptor kinase 2 (GRK2) inhibitor (journal article) Xu, Guozhang \| Gaul, Michael D. \| Liu, Zhijie \| DesJarlais, Renee L. \| Qi, Jenson \| Wang, Weixue \| Krosky, Daniel \| Petrounia, Ioanna \| Milligan, Cynthia M. \| Hermans, An \| ... \| Spurlino, John C. Bioorganic & Medicinal Chemistry Letters, volume 30, issue 23, pages 127602- (2020). 10.1016/j.bmcl.2020.127602 Cited by (4) \| Cite \| Source
Current and Future Roles of Artificial Intelligence in Medicinal Chemistry Synthesis (journal article) Struble, Thomas J. \| Alvarez, Juan C. \| Brown, Scott P. \| Chytil, Milan \| Cisar, Justin \| DesJarlais, Renee L. \| Engkvist, Ola \| Frank, Scott A. \| Greve, Daniel R. \| Griffin, Daniel J. \| ... \| Jensen, Klavs F. Journal of Medicinal Chemistry, volume 63, issue 16, pages 8667-8682 (2020). 10.1021/acs.jmedchem.9b02120 Cited by (130) \| Cite \| Source
Tandem Suzuki Coupling/Intramolecular Oxetane Ring Opening to Form Polycyclic Ring Systems (journal article) DeRatt, Lindsey G. \| Lawson, Edward C. \| Kumar, Kiran \| Hwang, Soyon S. \| DesJarlais, Renee L. \| Kuduk, Scott D. Organic Letters, volume 22, issue 15, pages 5828-5832 (2020). 10.1021/acs.orglett.0c01899 Cited by (17) \| Cite \| Source
Breaking the Glass Ceiling in Simulation and Modeling: Women in Pharmaceutical Discovery (journal article) Damm-Ganamet, Kelly L. \| DesJarlais, Renee L. \| Marrone, Tami \| Shih, Amy Y. \| Schiffer, Jamie M. \| Perez-Benito, Laura \| Mirzadegan, Taraneh Journal of Medicinal Chemistry, volume 63, issue 5, pages 1929-1936 (2020). 10.1021/acs.jmedchem.9b01512 Cited by (4) \| Cite \| Source
Discovery of potent and orally bioavailable indazole-based glucagon receptor antagonists for the treatment of type 2 diabetes (journal article) Xu, Guozhang \| Gaul, Michael D. \| Song, Fengbin \| Du, Fuyong \| Liang, Yin \| DesJarlais, Renee L. \| DiLoreto, Karen \| Shook, Brian \| Rentzeperis, Dennis \| Santulli, Rosie \| ... \| Demarest, Keith Bioorganic & Medicinal Chemistry Letters, volume 29, issue 20, pages 126668- (2019). 10.1016/j.bmcl.2019.126668 Cited by (3) \| Cite \| Source
Design, synthesis and structure activity relationships of indazole and indole derivatives as potent glucagon receptor antagonists (journal article) Song, Fengbin \| Xu, Guozhang \| Gaul, Michael D. \| Zhao, Baoping \| Lu, Tianbao \| Zhang, Rui \| DesJarlais, Renee L. \| DiLoreto, Karen \| Huebert, Norman \| Shook, Brian \| ... \| Demarest, Keith Bioorganic & Medicinal Chemistry Letters, volume 29, issue 15, pages 1974-1980 (2019). 10.1016/j.bmcl.2019.05.036 Cited by (15) \| Cite \| Source
6-Benzhydryl-4-amino-quinolin-2-ones as Potent Cannabinoid Type 1 (CB1 ) Receptor Inverse Agonists and Chemical Modifications for Peripheral Selectivity (journal article) Zhang, Yue-Mei \| Greco, Michael N. \| Macielag, Mark J. \| Teleha, Christopher A. \| DesJarlais, Renee L. \| Tang, Yuting \| Ho, George \| Hou, Cuifen \| Chen, Cailin \| Zhao, Shuyuan \| ... \| Leonard, James Journal of Medicinal Chemistry, volume 61, issue 22, pages 10276-10298 (2018). 10.1021/acs.jmedchem.8b01467 Cited by (13) \| Cite \| Source
Computational chemistry at Janssen (journal article) van Vlijmen, Herman \| Desjarlais, Renee L. \| Mirzadegan, Tara Journal of Computer-Aided Molecular Design, volume 31, issue 3, pages 267-273 (2017). 10.1007/s10822-016-9998-9 Cited by (14) \| Cite \| Source
Method of inhibiting C-KIT kinase (patent) Illig, Carl R. \| Ballentine, Shelley K. \| Chen, Jinsheng \| Meegalla, Sanath K. \| Rudolph, M. Jonathan \| Wall, Mark J. \| Wilson, Kenneth J. \| Desjarlais, Renee Louise \| Manthey, Carl M. \| Molloy, Christopher J. Patent Number: 9526731 (2016) Cite \| Source
Collaborating to improve the use of free-energy and other quantitative methods in drug discovery (journal article) Sherborne, Bradley \| Shanmugasundaram, Veerabahu \| Cheng, Alan C. \| Christ, Clara D. \| DesJarlais, Renee L. \| Duca, Jose S. \| Lewis, Richard A. \| Loughney, Deborah A. \| Manas, Eric S. \| McGaughey, Georgia B. \| ... \| van Vlijmen, Herman Journal of Computer-Aided Molecular Design, volume 30, issue 12, pages 1139-1141 (2016). 10.1007/s10822-016-9996-y Cited by (42) \| Cite \| Source
Inhibitors of c-fms kinase (patent) Illig, Carl R. \| Ballentine, Shelley K. \| Chen, Jinsheng \| Desjarlais, Renee Louise \| Meegalla, Sanath K. \| Wall, Mark \| Wilson, Kenneth Patent Number: 9452996 (2016) Cite \| Source
Inhibitors of c-fms kinase (patent) Illig, Carl R. \| Ballentine, Shelley K. \| Chen, Jinsheng \| Desjarlais, Renee Louise \| Meegalla, Sanath K. \| Wall, Mark \| Wilson, Kenneth Patent Number: 9403804 (2016) Cite \| Source
Inhibitors of c-fms kinase (patent) Illig, Carl R. \| Ballentine, Shelley K. \| Chen, Jinsheng \| Desjarlais, Renee Louise \| Meegalla, Sanath K. \| Wall, Mark \| Wilson, Kenneth \| Tomczuk, Bruce E. Patent Number: 9394289 (2016) Cite \| Source
Inhibitors of c-fms kinase (patent) Illig, Carl R. \| Ballentine, Shelley K. \| Chen, Jinsheng \| Desjarlais, Renee Louise \| Meegalla, Sanath K. \| Wall, Mark \| Wilson, Kenneth J. Patent Number: 9296726 (2016) Cited by (1) \| Cite \| Source
Role of Histone-Modifying Enzymes and Their Complexes in Regulation of Chromatin Biology (journal article) DesJarlais, Renee \| Tummino, Peter J. Biochemistry, volume 55, issue 11, pages 1584-1599 (2016). 10.1021/acs.biochem.5b01210 Cited by (74) \| Cite \| Source
Inhibitors of C-FMS kinase (patent) Illig, Carl R. \| Chen, Jinsheng \| Desjarlais, Renee Louise \| Wilson, Kenneth Patent Number: 9266866 (2016) Cited by (2) \| Cite \| Source