Bruno Alicke

ScholarGPS® ID: 15886702211573

Affiliation

Genentech, Inc., South San Francisco, United States

Affiliation History

Field

Medicine

Discipline

Oncology

Top Specialties

Cancer | Neoplasm | Hedgehog Signaling Pathway | Medicinal Chemistry

Metrics Summary

Publication Count

Predicted Citations

3,952

Predicted h-index

Ranking

Publications and Citation History

Publications based on Top Specialties

Types of Publication

Publications
Books
Patents
NIH/NSF

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Retrospective Assessment of Translational Pharmacokinetic–Pharmacodynamic Modeling Performance: A Case Study with Apitolisib, a Dual PI3K/mTOR Inhibitor (journal article) Moein, Anita \| Jin, Jin Y. \| Wright, Matthew R. \| Alicke, Bruno \| Wong, Harvey Drugs in R&D (2024). 10.1007/s40268-024-00459-5 Cite \| Source
Preclinical characterization of the absorption and disposition of the brain penetrant PI3K/mTOR inhibitor paxalisib and prediction of its pharmacokinetics and efficacy in human (journal article) Salphati, Laurent \| Pang, Jodie \| Alicke, Bruno \| Plise, Emile G. \| Cheong, Jonathan \| Jaochico, Allan \| Olivero, Alan G. \| Sampath, Deepak \| Wong, Susan \| Zhang, Xiaolin Xenobiotica, volume 54, issue 2, pages 64-74 (2024). 10.1080/00498254.2024.2303586 Cite \| Source
IAP antagonist GDC-0917 is more potent than Debio1143 in promoting cell death, c-IAP1 degradation and tumor growth inhibition (journal article) Alicke, Bruno \| Varfolomeev, Eugene \| Lee, Shi Hui Kaylee \| Frommlet, Alexandra \| Ubhayakar, Savita \| Quinn, John G. \| Fairbrother, Wayne J. \| Jones, Robert \| Gould, Stephen E. \| Vucic, Domagoj Cell Death & Disease, volume 13, issue 9 (2022). 10.1038/s41419-022-05283-w Cited by (2) \| Cite \| Source
Growth‐rate model predicts in vivo tumor response from in vitro data (journal article) Diegmiller, Rocky \| Salphati, Laurent \| Alicke, Bruno \| Wilson, Timothy R. \| Stout, Thomas J. \| Hafner, Marc CPT: Pharmacometrics & Systems Pharmacology, volume 11, issue 9, pages 1183-1193 (2022). 10.1002/psp4.12836 Cited by (5) \| Cite \| Source
Generalized Additive Mixed Modeling of Longitudinal Tumor Growth Reduces Bias and Improves Decision Making in Translational Oncology (journal article) Forrest, William F. \| Alicke, Bruno \| Mayba, Oleg \| Osinska, Magdalena \| Jakubczak, Michal \| Piatkowski, Pawel \| Choniawko, Lech \| Starr, Alice \| Gould, Stephen E. Cancer Research, volume 80, issue 22, pages 5089-5097 (2020). 10.1158/0008-5472.CAN-20-0342 Cited by (11) \| Cite \| Source
Immunization associated with primary tumor growth leads to rejection of commonly used syngeneic tumors upon tumor rechallenge (journal article) Alicke, Bruno \| Totpal, Klara \| Schartner, Jill M \| Berkley, Amy M \| Lehar, Sophie M \| Capietto, Aude-Hélène \| Cubas, Rafael A \| Gould, Stephen E Journal for ImmunoTherapy of Cancer, volume 8, issue 2, pages e000532- (2020). 10.1136/jitc-2020-000532 Cited by (9) \| Cite \| Source
A cell identity switch allows residual BCC to survive Hedgehog pathway inhibition (journal article) Biehs, Brian \| Dijkgraaf, Gerrit J. P. \| Piskol, Robert \| Alicke, Bruno \| Boumahdi, Soufiane \| Peale, Franklin \| Gould, Stephen E. \| de Sauvage, Frederic J. Nature, volume 562, issue 7727, pages 429-433 (2018). 10.1038/s41586-018-0596-y Cited by (100) \| Cite \| Source
PRC2-mediated repression of SMARCA2 predicts EZH2 inhibitor activity in SWI/SNF mutant tumors (journal article) Januario, Thomas \| Ye, Xiaofen \| Bainer, Russell \| Alicke, Bruno \| Smith, Tunde \| Haley, Benjamin \| Modrusan, Zora \| Gould, Stephen \| Yauch, Robert L. Proceedings of the National Academy of Sciences, volume 114, issue 46, pages 12249-12254 (2017). 10.1073/pnas.1703966114 Cited by (60) \| Cite \| Source \| Open Access
Stem cell plasticity enables hair regeneration following Lgr5+ cell loss (journal article) Hoeck, Joerg D. \| Biehs, Brian \| Kurtova, Antonina V. \| Kljavin, Noelyn M. \| de Sousa e Melo, Felipe \| Alicke, Bruno \| Koeppen, Hartmut \| Modrusan, Zora \| Piskol, Robert \| de Sauvage, Frederic J. Nature Cell Biology, volume 19, issue 6, pages 666-676 (2017). 10.1038/ncb3535 Cited by (60) \| Cite \| Source
Brain Distribution and Efficacy of the Brain Penetrant PI3K Inhibitor GDC-0084 in Orthotopic Mouse Models of Human Glioblastoma (journal article) Salphati, Laurent \| Alicke, Bruno \| Heffron, Timothy P. \| Shahidi-Latham, Sheerin \| Nishimura, Merry \| Cao, Tim \| Carano, Richard A. \| Cheong, Jonathan \| Greve, Joan \| Koeppen, Hartmut \| ... \| Olivero, Alan G. Drug Metabolism and Disposition, volume 44, issue 12, pages 1881-1889 (2016). 10.1124/dmd.116.071423 Cited by (40) \| Cite \| Source
Discovery of Clinical Development Candidate GDC-0084, a Brain Penetrant Inhibitor of PI3K and mTOR (journal article) Heffron, Timothy P. \| Ndubaku, Chudi O. \| Salphati, Laurent \| Alicke, Bruno \| Cheong, Jonathan \| Drobnick, Joy \| Edgar, Kyle \| Gould, Stephen E. \| Lee, Leslie B. \| Lesnick, John D. \| ... \| Olivero, Alan G. ACS Medicinal Chemistry Letters, volume 7, issue 4, pages 351-356 (2016). 10.1021/acsmedchemlett.6b00005 Cited by (77) \| Cite \| Source \| Open Access
Distribution of the Phosphatidylinositol 3-Kinase Inhibitors Pictilisib (GDC-0941) and GNE-317 in U87 and GS2 Intracranial Glioblastoma Models—Assessment by Matrix-Assisted Laser Desorption Ionization Imaging (journal article) Salphati, Laurent \| Shahidi-Latham, Sheerin \| Quiason, Cristine \| Barck, Kai \| Nishimura, Merry \| Alicke, Bruno \| Pang, Jodie \| Carano, Richard A. \| Olivero, Alan G. \| Phillips, Heidi S. Drug Metabolism and Disposition, volume 42, issue 7, pages 1110-1116 (2014). 10.1124/dmd.114.057513 Cited by (36) \| Cite \| Source \| Open Access
Learning and Confirming with Preclinical Studies: Modeling and Simulation in the Discovery of GDC-0917, an Inhibitor of Apoptosis Proteins Antagonist (journal article) Wong, H. \| Gould, S. E. \| Budha, N. \| Darbonne, W. C. \| Kadel, E. E. \| La, H. \| Alicke, B. \| Halladay, J. S. \| Erickson, R. \| Portera, C. \| ... \| Fairbrother, W. J. Drug Metabolism and Disposition, volume 41, issue 12, pages 2104-2113 (2013). 10.1124/dmd.113.053926 Cited by (44) \| Cite \| Source \| Open Access
PTEN Loss Mitigates the Response of Medulloblastoma to Hedgehog Pathway Inhibition (journal article) Metcalfe, Ciara \| Alicke, Bruno \| Crow, Ailey \| Lamoureux, Marlea \| Dijkgraaf, Gerrit J.P. \| Peale, Franklin \| Gould, Stephen E. \| de Sauvage, Frederic J. Cancer Research, volume 73, issue 23, pages 7034-7042 (2013). 10.1158/0008-5472.CAN-13-1222 Cited by (49) \| Cite \| Source \| Open Access
Determination of clinically therapeutic endoxifen concentrations based on efficacy from human MCF7 breast cancer xenografts (journal article) Gong, Inna Y. \| Teft, Wendy A. \| Ly, Justin \| Chen, Yung-Hsiang \| Alicke, Bruno \| Kim, Richard B. \| Choo, Edna F. Breast Cancer Research and Treatment, volume 139, issue 1, pages 61-69 (2013). 10.1007/s10549-013-2530-1 Cited by (28) \| Cite \| Source
Targeting the PI3K Pathway in the Brain—Efficacy of a PI3K Inhibitor Optimized to Cross the Blood–Brain Barrier (journal article) Salphati, Laurent \| Heffron, Timothy P. \| Alicke, Bruno \| Nishimura, Merry \| Barck, Kai \| Carano, Richard A. \| Cheong, Jonathan \| Edgar, Kyle A. \| Greve, Joan \| Kharbanda, Samir \| ... \| Phillips, Heidi S. Clinical Cancer Research, volume 18, issue 22, pages 6239-6248 (2012). 10.1158/1078-0432.CCR-12-0720 Cited by (55) \| Cite \| Source \| Open Access
360 Efficacy of a Brain-penetrant PI3K/mTOR Inhibitor in Orthotopic Models of Glioblastoma (journal article) Salphati, L. \| Heffron, T.P. \| Alicke, B. \| Barck, K. \| Carano, R.A. \| Kharbanda, S. \| Lee, L.B. \| Nishimura, M. \| Olivero, A.G. \| Phillips, H.S. European Journal of Cancer, volume 48 (2012). 10.1016/S0959-8049(12)72158-5 Cite \| Source
The Design and Identification of Brain Penetrant Inhibitors of Phosphoinositide 3-Kinase α (journal article) Heffron, Timothy P. \| Salphati, Laurent \| Alicke, Bruno \| Cheong, Jonathan \| Dotson, Jennafer \| Edgar, Kyle \| Goldsmith, Richard \| Gould, Stephen E. \| Lee, Leslie B. \| Lesnick, John D. \| ... \| Zhang, Xiaolin Journal of Medicinal Chemistry, volume 55, issue 18, pages 8007-8020 (2012). 10.1021/jm300867c Cited by (46) \| Cite \| Source
Antitumor Activity of Targeted and Cytotoxic Agents in Murine Subcutaneous Tumor Models Correlates with Clinical Response (journal article) Wong, Harvey \| Choo, Edna F. \| Alicke, Bruno \| Ding, Xiao \| La, Hank \| McNamara, Erin \| Theil, Frank-Peter \| Tibbitts, Jay \| Friedman, Lori S. \| Hop, Cornelis E.C.A. \| Gould, Stephen E. Clinical Cancer Research, volume 18, issue 14, pages 3846-3855 (2012). 10.1158/1078-0432.CCR-12-0738 Cited by (108) \| Cite \| Source \| Open Access
Potent and Selective Aminopyrimidine-Based B-Raf Inhibitors with Favorable Physicochemical and Pharmacokinetic Properties (journal article) Mathieu, Simon \| Gradl, Stefan N. \| Ren, Li \| Wen, Zhaoyang \| Aliagas, Ignacio \| Gunzner-Toste, Janet \| Lee, Wendy \| Pulk, Rebecca \| Zhao, Guiling \| Alicke, Bruno \| ... \| Rudolph, Joachim Journal of Medicinal Chemistry, volume 55, issue 6, pages 2869-2881 (2012). 10.1021/jm300016v Cited by (44) \| Cite \| Source