Ghotas Evindar

ScholarGPS® ID: 15704103624448

Affiliation

GlaxoSmithKline plc, London

Affiliation History

Field

Physical Sciences and Mathematics

Discipline

Chemistry

Top Specialties

Chemical Synthesis | Medicinal Chemistry | Peptide | DNA | Heterocyclic Compound

Metrics Summary

Publication Count

Predicted Citations

2,914

Predicted h-index

Ranking

Publications and Citation History

Publications based on Top Specialties

Types of Publication

Publications
Books
Patents
NIH/NSF

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DNA-Encoded Library Technology-Based Discovery, Lead Optimization, and Prodrug Strategy toward Structurally Unique Indoleamine 2,3-Dioxygenase-1 (IDO1) Inhibitors (journal article) Kazmierski, Wieslaw M. \| Xia, Bing \| Miller, John \| De la Rosa, Martha \| Favre, David \| Dunham, Richard M. \| Washio, Yoshiaki \| Zhu, Zhengrong \| Wang, Feng \| Mebrahtu, Makda \| ... \| Samano, Vicente Journal of Medicinal Chemistry, volume 63, issue 7, pages 3552-3562 (2020). 10.1021/acs.jmedchem.9b01799 Cited by (54) \| Cite \| Source
Development of a Selection Method for Discovering Irreversible (Covalent) Binders from a DNA-Encoded Library (journal article) Zhu, Zhengrong \| Grady, LaShadric C. \| Ding, Yun \| Lind, Kenneth E. \| Davie, Christopher P. \| Phelps, Christopher B. \| Evindar, Ghotas SLAS Discovery, volume 24, issue 2, pages 169-174 (2019). 10.1177/2472555218808454 Cited by (21) \| Cite \| Source
Compounds for affinity chromatography and for extending the half-life of a therapeutic agent (patent) Kumpalume, Peter \| Schon, Oliver \| Donahue, Christine Patricia \| Evindar, Ghotas \| Israel, David I. \| Paolella, David \| Kuai, Letian \| Prabhu, Ninad V. Patent Number: 9938243 (2018) Cite \| Source
Design and Application of a DNA-Encoded Macrocyclic Peptide Library (journal article) Zhu, Zhengrong \| Shaginian, Alex \| Grady, LaShadric C. \| O’Keeffe, Thomas \| Shi, Xiangguo E. \| Davie, Christopher P. \| Simpson, Graham L. \| Messer, Jeffrey A. \| Evindar, Ghotas \| Bream, Robert N. \| ... \| Pal, Sandeep ACS Chemical Biology, volume 13, issue 1, pages 53-59 (2018). 10.1021/acschembio.7b00852 Cited by (81) \| Cite \| Source
Chapter 7. DNA-encoded Library Technology (ELT) (book chapter) In Chemical and Biological Synthesis Yao, Gang \| Lu, Xiaojie \| Phelps, Chris \| Evindar, Ghotas Royal Society of Chemistry (2018) 10.1039/9781788012805-00153 Cited by (1) \| Cite \| Source
Compounds for affinity chromatography and for extending the half-life of a therapeutic agent (patent) Kumpalume, Peter \| Schon, Oliver \| Donahue, Christine Patricia \| Evindar, Ghotas \| Israel, David I. \| Paolella, David \| Kuai, Letian \| Prabhu, Ninad V. Patent Number: 9809558 (2017) Cite \| Source
Discovery and Characterization of a Class of Pyrazole Inhibitors of Bacterial Undecaprenyl Pyrophosphate Synthase (journal article) Concha, Nestor \| Huang, Jianzhong \| Bai, Xiaopeng \| Benowitz, Andrew \| Brady, Pat \| Grady, LaShadric C. \| Kryn, Luz Helena \| Holmes, David \| Ingraham, Karen \| Jin, Qi \| ... \| Stavenger, Robert A. Journal of Medicinal Chemistry, volume 59, issue 15, pages 7299-7304 (2016). 10.1021/acs.jmedchem.6b00746 Cited by (28) \| Cite \| Source
Discovery of a Potent Class of PI3Kα Inhibitors with Unique Binding Mode via Encoded Library Technology (ELT) (journal article) Yang, Hongfang \| Medeiros, Patricia F. \| Raha, Kaushik \| Elkins, Patricia \| Lind, Kenneth E. \| Lehr, Ruth \| Adams, Nicholas D. \| Burgess, Joelle L. \| Schmidt, Stanley J. \| Knight, Steven D. \| ... \| Evindar, Ghotas ACS Medicinal Chemistry Letters, volume 6, issue 5, pages 531-536 (2015). 10.1021/acsmedchemlett.5b00025 Cited by (61) \| Cite \| Source \| Open Access
Application of encoded library technology (ELT) to a protein–protein interaction target: Discovery of a potent class of integrin lymphocyte function-associated antigen 1 (LFA-1) antagonists (journal article) Kollmann, Christopher S. \| Bai, Xiaopeng \| Tsai, Ching-Hsuan \| Yang, Hongfang \| Lind, Kenneth E. \| Skinner, Steven R. \| Zhu, Zhengrong \| Israel, David I. \| Cuozzo, John W. \| Morgan, Barry A. \| ... \| Evindar, Ghotas Bioorganic & Medicinal Chemistry, volume 22, issue 7, pages 2353-2365 (2014). 10.1016/j.bmc.2014.01.050 Cited by (85) \| Cite \| Source
Encoded Library Technology as a Source of Hits for the Discovery and Lead Optimization of a Potent and Selective Class of Bactericidal Direct Inhibitors of Mycobacterium tuberculosis InhA (journal article) Encinas, Lourdes \| O’Keefe, Heather \| Neu, Margarete \| Remuiñán, Modesto J. \| Patel, Amish M. \| Guardia, Ana \| Davie, Christopher P. \| Pérez-Macías, Natalia \| Yang, Hongfang \| Convery, Maire A. \| ... \| Evindar, Ghotas Journal of Medicinal Chemistry, volume 57, issue 4, pages 1276-1288 (2014). 10.1021/jm401326j Cited by (103) \| Cite \| Source \| Open Access
Discovery of Clinical Candidate GSK1842799 As a Selective S1P1 Receptor Agonist (Prodrug) for Multiple Sclerosis (journal article) Deng, Hongfeng \| Bernier, Sylvie G. \| Doyle, Elisabeth \| Lorusso, Jeanine \| Morgan, Barry A. \| Westlin, William F. \| Evindar, Ghotas ACS Medicinal Chemistry Letters, volume 4, issue 10, pages 942-947 (2013). 10.1021/ml400194r Cited by (18) \| Cite \| Source \| Open Access
Discovery of Thieno[3,2- d ]pyrimidine-6-carboxamides as Potent Inhibitors of SIRT1, SIRT2, and SIRT3 (journal article) Disch, Jeremy S. \| Evindar, Ghotas \| Chiu, Cynthia H. \| Blum, Charles A. \| Dai, Han \| Jin, Lei \| Schuman, Eli \| Lind, Kenneth E. \| Belyanskaya, Svetlana L. \| Deng, Jianghe \| ... \| Perni, Robert B. Journal of Medicinal Chemistry, volume 56, issue 9, pages 3666-3679 (2013). 10.1021/jm400204k Cited by (171) \| Cite \| Source
Exploring amino acids derivatives as potent, selective, and direct agonists of sphingosine-1-phosphate receptor subtype-1 (journal article) Evindar, Ghotas \| Deng, Hongfeng \| Bernier, Sylvie G. \| Doyle, Elisabeth \| Lorusso, Jeanine \| Morgan, Barry A. \| Westlin, William F. Bioorganic & Medicinal Chemistry Letters, volume 23, issue 2, pages 472-475 (2013). 10.1016/j.bmcl.2012.11.053 Cited by (2) \| Cite \| Source
The Discovery of VX-745: A Novel and Selective p38α Kinase Inhibitor (journal article) Duffy, John P. \| Harrington, Edmund M. \| Salituro, Francesco G. \| Cochran, John E. \| Green, Jeremy \| Gao, Huai \| Bemis, Guy W. \| Evindar, Ghotas \| Galullo, Vincent P. \| Ford, Pamella J. \| ... \| Su, Michael S.S. ACS Medicinal Chemistry Letters, volume 2, issue 10, pages 758-763 (2011). 10.1021/ml2001455 Cited by (67) \| Cite \| Source \| Open Access
ChemInform Abstract: Exploration of Amino Alcohol Derivatives as Novel, Potent, and Highly Selective Sphingosine‐1‐phosphate Receptor Subtype‐1 Agonists. (journal article) Evindar, Ghotas \| et al., et al. ChemInform, volume 41, issue 40 (2010). 10.1002/chin.201040120 Cite \| Source
Sphingosine-1-phosphate (SIP) receptor agonists (patent) Evindar, Ghotas \| Deng, Hongfeng \| Bernier, Sylvie \| Yao, Gang \| Coffin, Aaron \| Yang, Hongfang Patent Number: 7759370 (2010) Cite \| Source
Exploration of amino alcohol derivatives as novel, potent, and highly selective sphingosine-1-phosphate receptor subtype-1 agonists (journal article) Evindar, Ghotas \| Bernier, Sylvie G. \| Doyle, Elisabeth \| Kavarana, Malcolm J. \| Satz, Alexander L. \| Lorusso, Jeanine \| Blanchette, Heather S. \| Saha, Ashis K. \| Hannig, Gerhard \| Morgan, Barry A. \| Westlin, William F. Bioorganic & Medicinal Chemistry Letters, volume 20, issue 8, pages 2520-2524 (2010). 10.1016/j.bmcl.2010.02.098 Cited by (7) \| Cite \| Source
Synthesis and evaluation of arylalkoxy- and biarylalkoxy-phenylamide and phenylimidazoles as potent and selective sphingosine-1-phosphate receptor subtype-1 agonists (journal article) Evindar, Ghotas \| Satz, Alexander L. \| Bernier, Sylvie G. \| Kavarana, Malcolm J. \| Doyle, Elisabeth \| Lorusso, Jeanine \| Taghizadeh, Nazbeh \| Halley, Keith \| Hutchings, Amy \| Kelley, Michael S. \| ... \| Westlin, William F. Bioorganic & Medicinal Chemistry Letters, volume 19, issue 8, pages 2315-2319 (2009). 10.1016/j.bmcl.2009.02.073 Cited by (7) \| Cite \| Source
Synthesis and evaluation of alkoxy-phenylamides and alkoxy-phenylimidazoles as potent sphingosine-1-phosphate receptor subtype-1 agonists (journal article) Evindar, Ghotas \| Bernier, Sylvie G. \| Kavarana, Malcolm J. \| Doyle, Elisabeth \| Lorusso, Jeanine \| Kelley, Michael S. \| Halley, Keith \| Hutchings, Amy \| Wright, Albion D. \| Saha, Ashis K. \| ... \| Westlin, William F. Bioorganic & Medicinal Chemistry Letters, volume 19, issue 2, pages 369-372 (2009). 10.1016/j.bmcl.2008.11.072 Cited by (13) \| Cite \| Source
ChemInform Abstract: Copper‐Catalyzed Domino Annulation Approaches to the Synthesis of Benzoxazoles under Microwave‐Accelerated and Conventional Thermal Conditions. (journal article) Viirre, Russell D. \| Evindar, Ghotas \| Batey, Robert A. ChemInform, volume 39, issue 33 (2008). 10.1002/chin.200833136 Cite \| Source