Debby P. Chang

ScholarGPS® ID: 15568607435561

Affiliation

Genentech, Inc., South San Francisco, United States

Affiliation History

Field

Physical Sciences and Mathematics

Discipline

Chemistry

Top Specialties

Antibody | Vaccine

Metrics Summary

Publication Count

Predicted Citations

339

Predicted h-index

Ranking

Publications and Citation History

Publications based on Top Specialties

Types of Publication

Publications
Books
Patents
NIH/NSF

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Hydroxypropyl methyl cellulose derivatives stabilize fragment antibody against aggregation in spray dried formulations at elevated temperature and resist pH changes (journal article) Nayak, Purnendu \| Rajagopal, Karthikan \| Chang, Debby European Journal of Pharmaceutics and Biopharmaceutics, volume 178 (2022). 10.1016/j.ejpb.2022.07.011 Cite \| Source
Release Mechanisms and Practical Percolation Threshold for Long-acting Biodegradable Implants: An Image to Simulation Study (journal article) Zhang, Shawn \| Nagapudi, Karthik \| Shen, Mike \| Lomeo, Joshua \| Qin, Yuri \| Zhu, Aiden \| Nayak, Purnendu \| Chang, Debby \| Hannoush, Rami N. Journal of Pharmaceutical Sciences, volume 111, issue 7, pages 1896-1910 (2022). 10.1016/j.xphs.2021.12.009 Cited by (6) \| Cite \| Source
Design of PLGA-Based Drug Delivery Systems Using a Physically-Based Sustained Release Model (journal article) Koshari, Stijn H.S. \| Shi, Xutao \| Jiang, Linda \| Chang, Debby \| Rajagopal, Karthikan \| Lenhoff, Abraham M. \| Wagner, Norman J. Journal of Pharmaceutical Sciences, volume 111, issue 2, pages 345-357 (2022). 10.1016/j.xphs.2021.09.007 Cited by (4) \| Cite \| Source
Microstructure, Quality, and Release Performance Characterization of Long-Acting Polymer Implant Formulations with X-Ray Microscopy and Quantitative AI Analytics (journal article) Nagapudi, Karthik \| Zhu, Aiden \| Chang, Debby P. \| Lomeo, Joshua \| Rajagopal, Karthikan \| Hannoush, Rami N. \| Zhang, Shawn Journal of Pharmaceutical Sciences, volume 110, issue 10, pages 3418-3430 (2021). 10.1016/j.xphs.2021.05.016 Cited by (9) \| Cite \| Source
Accelerated in vitro release testing method for a long-acting peptide-PLGA formulation (journal article) Goel, Meenakshi \| Leung, Dennis \| Famili, Amin \| Chang, Debby \| Nayak, Purnendu \| Al-Sayah, Mohammad European Journal of Pharmaceutics and Biopharmaceutics, volume 165 (2021). 10.1016/j.ejpb.2021.05.008 Cited by (7) \| Cite \| Source
Intravitreal Administration of Acetyl Triethyl Citrate and Benzyl Benzoate Is Retinotoxic in Rabbits but Not in Cynomolgus Monkeys (journal article) Andaya, Roxanne \| Booler, Helen \| Nagata, Denise de Almeida \| Lawson, Chris \| Vogt, Jennifer \| Schuetz, Chris \| Chang, Debby P. \| Bantseev, Vladimir Toxicologic Pathology, volume 49, issue 3, pages 621-633 (2021). 10.1177/0192623320971571 Cited by (2) \| Cite \| Source
Long-Term Stability of Anti-Vascular Endothelial Growth Factor (a-VEGF) Biologics Under Physiologically Relevant Conditions and Its Impact on the Development of Long-Acting Delivery Systems (journal article) Chang, Debby P. \| Burra, Shalini \| Day, Eric S. \| Chan, Joyce \| Comps-Agrar, Laetitia \| Nivaggioli, Thierry \| Rajagopal, Karthikan Journal of Pharmaceutical Sciences, volume 110, issue 2, pages 860-870 (2021). 10.1016/j.xphs.2020.09.043 Cited by (10) \| Cite \| Source
Ectoine and Hydroxyectoine Stabilize Antibodies in Spray-Dried Formulations at Elevated Temperature and during a Freeze/Thaw Process (journal article) Nayak, Purnendu K. \| Goode, Meghan \| Chang, Debby P. \| Rajagopal, Karthikan Molecular Pharmaceutics, volume 17, issue 9, pages 3291-3297 (2020). 10.1021/acs.molpharmaceut.0c00395 Cited by (11) \| Cite \| Source
Optimizing the Formulation and Lyophilization Process for a Fragment Antigen Binding (Fab) Protein Using Solid-State Hydrogen–Deuterium Exchange Mass Spectrometry (ssHDX-MS) (journal article) Kumar, Lokesh \| Chandrababu, Karthik Balakrishna \| Balakrishnan, Shenbaga Moorthy \| Allmendinger, Andrea \| Walters, Benjamin \| Zarraga, Isidro E. \| Chang, Debby P. \| Nayak, Purnendu \| Topp, Elizabeth M. Molecular Pharmaceutics, volume 16, issue 11, pages 4485-4495 (2019). 10.1021/acs.molpharmaceut.9b00614 Cited by (8) \| Cite \| Source
Data-Driven Development of Predictive Models for Sustained Drug Release (journal article) Koshari, Stijn H.S. \| Chang, Debby P. \| Wang, Nathan B. \| Zarraga, Isidro E. \| Rajagopal, Karthikan \| Lenhoff, Abraham M. \| Wagner, Norman J. Journal of Pharmaceutical Sciences, volume 108, issue 11, pages 3582-3591 (2019). 10.1016/j.xphs.2019.06.027 Cited by (4) \| Cite \| Source
Hydrogels for sustained delivery of biologics to the back of the eye (journal article) Chang, Debby \| Park, Kinam \| Famili, Amin Drug Discovery Today, volume 24, issue 8, pages 1470-1482 (2019). 10.1016/j.drudis.2019.05.037 Cited by (48) \| Cite \| Source
Trehalose Limits Fragment Antibody Aggregation and Influences Charge Variant Formation in Spray-Dried Formulations at Elevated Temperatures (journal article) Rajagopal, Karthikan \| Chang, Debby \| Nayak, Purnendu \| Izadi, Saeed \| Patapoff, Thomas \| Zhang, Jennifer \| Kelley, Robert \| Sreedhara, Alavattam Molecular Pharmaceutics, volume 16, issue 1, pages 349-358 (2019). 10.1021/acs.molpharmaceut.8b01002 Cited by (10) \| Cite \| Source
Evaluation of the Toxicity of Intravitreally Injected PLGA Microspheres and Rods in Monkeys and Rabbits: Effects of Depot Size on Inflammatory Response (journal article) Thackaberry, Evan A. \| Farman, Cindy \| Zhong, Fiona \| Lorget, Florence \| Staflin, Karin \| Cercillieux, Angelique \| Miller, Paul E. \| Schuetz, Chris \| Chang, Debby \| Famili, Amin \| ... \| Bantseev, Vladimir Investigative Opthalmology & Visual Science, volume 58, issue 10, pages 4274- (2017). 10.1167/iovs.16-21334 Cited by (49) \| Cite \| Source \| Open Access
Contribution of Antibody Hydrodynamic Size to Vitreal Clearance Revealed through Rabbit Studies Using a Species-Matched Fab (journal article) Shatz, Whitney \| Hass, Philip E. \| Mathieu, Mary \| Kim, Hok Seon \| Leach, Kim \| Zhou, Michelle \| Crawford, Yongping \| Shen, Amy \| Wang, Kathryn \| Chang, Debby P. \| ... \| Kelley, Robert F. Molecular Pharmaceutics, volume 13, issue 9, pages 2996-3003 (2016). 10.1021/acs.molpharmaceut.6b00345 Cited by (63) \| Cite \| Source
Investigation of Fragment Antibody Stability and Its Release Mechanism from Poly(Lactide-co-Glycolide)-Triacetin Depots for Sustained-Release Applications (journal article) Chang, Debby P. \| Garripelli, Vivek Kumar \| Rea, Jennifer \| Kelley, Robert \| Rajagopal, Karthikan Journal of Pharmaceutical Sciences, volume 104, issue 10, pages 3404-3417 (2015). 10.1002/jps.24546 Cited by (22) \| Cite \| Source