William H. Parsons

ScholarGPS® ID: 15332937361672

Affiliation
Oberlin College, Oberlin, United States
Affiliation History

Field
Physical Sciences and Mathematics
Discipline
Chemistry
Top Specialties
Medicinal Chemistry | Sodium Channel | Channel Blocker | Chemokine Receptor | Chemical Synthesis | Enzyme | Enzyme Inhibitor | New Class | Potassium Channel | Chronic Pain | Lymphocyte | Neuropathic Pain | Side Chain | Antibiotic
Metrics Summary
Publication Count
137
Predicted Citations
6,564
Predicted h-index
37
Ranking

Publications and Citation History

Publications based on Top Specialties

Types of Publication

  • Publications
  • Books
  • Patents
  • NIH/NSF
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Discovery of Potent and Selective Inhibitors against Protein-Derived Electrophilic Cofactors (journal article)
Wang, Xie | Lin, Zongtao | Bustin, Katelyn A. | McKnight, Nate R. | Parsons, William H. | Matthews, Megan L.
Journal of the American Chemical Society, volume 144, issue 12, pages 5377-5388 (2022).
10.1021/jacs.1c12748
Cited by (16) | Cite | Source
Development of succinimide-based inhibitors for the mitochondrial rhomboid protease PARL (journal article)
Parsons, William H. | Rutland, Nicholas T. | Crainic, Jennifer A. | Cardozo, Joaquin M. | Chow, Alyssa S. | Andrews, Charlotte L. | Sheehan, Brendan K.
Bioorganic & Medicinal Chemistry Letters, volume 49 (2021).
10.1016/j.bmcl.2021.128290
Cited by (5) | Cite | Source
Activity-Based Hydrazine Probes for Protein Profiling of Electrophilic Functionality in Therapeutic Targets (journal article)
Lin, Zongtao | Wang, Xie | Bustin, Katelyn A. | Shishikura, Kyosuke | McKnight, Nate R. | He, Lin | Suciu, Radu M. | Hu, Kai | Han, Xian | Ahmadi, Mina | ... | Matthews, Megan L.
ACS Central Science, volume 7, issue 9, pages 1524-1534 (2021).
10.1021/acscentsci.1c00616
Cited by (23) | Cite | Source
AIG1 and ADTRP are endogenous hydrolases of fatty acid esters of hydroxy fatty acids (FAHFAs) in mice (journal article)
Erikci Ertunc, Meric | Kok, Bernard P. | Parsons, William H. | Wang, Justin G. | Tan, Dan | Donaldson, Cynthia J. | Pinto, Antonio F.M. | Vaughan, Joan M. | Ngo, Nhi | Lum, Kenneth M. | ... | Saghatelian, Alan
Journal of Biological Chemistry, volume 295, issue 18, pages 5891-5905 (2020).
10.1074/jbc.RA119.012145
Cited by (26) | Cite | Source
Role of AIG1 and ADTRP in Endogenous FAHFA Regulation (journal article)
Ertunc, Meric Erikci | Kok, Bernard P. | Parsons, William H. | Wang, Justin G. | Tan, Dan | Donaldson, Cynthia J. | Pinto, Antonio M. | Vaughan, Joan M. | Ngo, Nhi | Lum, Kenneth M. | ... | Saghatelian, Alan
The FASEB Journal, volume 34, issue S1, pages 1-1 (2020).
10.1096/fasebj.2020.34.s1.04337
Cite | Source
Pharmacological convergence reveals a lipid pathway that regulates C. elegans lifespan (journal article)
Chen, Alice L. | Lum, Kenneth M. | Lara-Gonzalez, Pablo | Ogasawara, Daisuke | Cognetta, Armand B | To, Alan | Parsons, William H. | Simon, Gabriel M. | Desai, Arshad | Petrascheck, Michael | ... | Cravatt, Benjamin F.
Nature Chemical Biology, volume 15, issue 5, pages 453-462 (2019).
10.1038/s41589-019-0243-4
Cited by (33) | Cite | Source
Benzo[ d ]imidazole Transient Receptor Potential Vanilloid 1 Antagonists for the Treatment of Pain: Discovery of trans -2-(2-{2-[2-(4-Trifluoromethyl-phenyl)-vinyl]-1 H -benzimidazol-5-yl}-phenyl)-propan-2-ol (Mavatrep) (journal article)
Parsons, William H. | Calvo, Raul R. | Cheung, Wing | Lee, Yu-Kai | Patel, Sharmila | Liu, Jian | Youngman, Mark A. | Dax, Scott L. | Stone, Dennis | Qin, Ning | ... | Player, Mark R.
Journal of Medicinal Chemistry, volume 58, issue 9, pages 3859-3874 (2015).
10.1021/acs.jmedchem.5b00132
Cited by (50) | Cite | Source
ChemInform Abstract: Saxitoxin (journal article)
Thottumkara, Arun P. | Parsons, William H. | Du Bois, J.
ChemInform, volume 45, issue 35 (2014).
10.1002/chin.201435243
Cite | Source
Saxitoxin (journal article)
Thottumkara, Arun P. | Parsons, William H. | Du Bois, J.
Angewandte Chemie, volume 126, issue 23, pages 5868-5894 (2014).
10.1002/ange.201308235
Cited by (14) | Cite | Source
Saxitoxin (journal article)
Thottumkara, Arun P. | Parsons, William H. | Du Bois, J.
Angewandte Chemie International Edition, volume 53, issue 23, pages 5760-5784 (2014).
10.1002/anie.201308235
Cited by (123) | Cite | Source
A18 F-Labeled Saxitoxin Derivative for in Vivo PET-MR Imaging of Voltage-Gated Sodium Channel Expression Following Nerve Injury (journal article)
Hoehne, Aileen | Behera, Deepak | Parsons, William H. | James, Michelle L. | Shen, Bin | Borgohain, Preeti | Bodapati, Deepika | Prabhakar, Archana | Gambhir, Sanjiv S. | Yeomans, David C. | ... | Bois, J. Du
Journal of the American Chemical Society, volume 135, issue 48, pages 18012-18015 (2013).
10.1021/ja408300e
Cited by (37) | Cite | Source
Maleimide Conjugates of Saxitoxin as Covalent Inhibitors of Voltage-Gated Sodium Channels (journal article)
Parsons, William H. | Du Bois, J.
Journal of the American Chemical Society, volume 135, issue 29, pages 10582-10585 (2013).
10.1021/ja4019644
Cited by (28) | Cite | Source
Factors Influencing Patient Completion of Diabetes Self-Management Education (journal article)
Adams, Kenneth F. | Sperl-Hillen, JoAnn M. | Davis, Herbert | Spain, C. Victor | Hanson, Ann M. | Fernandes, Omar D. | Von Worley, Ann | Parker, Emily D. | Lavin-Tompkins, Jodi M. | Parsons, William | Beaton, Sarah
Diabetes Spectrum, volume 26, issue 1, pages 40-45 (2013).
10.2337/diaspect.26.1.40
Cited by (13) | Cite | Source | Open Access
Are benefits from diabetes self-management education sustained? (journal article)
Sperl-Hillen, JoAnn | Beaton, Sarah | Fernandes, Omar | Von Worley, Ann | Vazquez-Benitez, Gabriela | Hanson, Ann | Lavin-Tompkins, Jodi | Parsons, William | Adams, Kenneth | Spain, C Victor
The American journal of managed care, volume 19, issue 2 (2013).
Cited by (18) | Cite
Marked difference in saxitoxin and tetrodotoxin affinity for the human nociceptive voltage-gated sodium channel (Nav 1.7) (journal article)
Walker, James R. | Novick, Paul A. | Parsons, William H. | McGregor, Malcolm | Zablocki, Jeff | Pande, Vijay S. | Du Bois, J.
Proceedings of the National Academy of Sciences, volume 109, issue 44, pages 18102-18107 (2012).
10.1073/pnas.1206952109
Cited by (80) | Cite | Source | Open Access
Fluorescent Saxitoxins for Live Cell Imaging of Single Voltage-Gated Sodium Ion Channels beyond the Optical Diffraction Limit (journal article)
Ondrus, Alison E. | Lee, Hsiao-lu D. | Iwanaga, Shigeki | Parsons, William H. | Andresen, Brian M. | Moerner, W.E. | Du Bois, J.
Chemistry & Biology, volume 19, issue 7, pages 902-912 (2012).
10.1016/j.chembiol.2012.05.021
Cited by (48) | Cite | Source | Open Access
Discovery of vinylcycloalkyl-substituted benzimidazole TRPM8 antagonists effective in the treatment of cold allodynia (journal article)
Calvo, Raul R. | Meegalla, Sanath K. | Parks, Daniel J. | Parsons, William H. | Ballentine, Shelley K. | Lubin, Mary Lou | Schneider, Craig | Colburn, Raymond W. | Flores, Christopher M. | Player, Mark R.
Bioorganic & Medicinal Chemistry Letters, volume 22, issue 5, pages 1903-1907 (2012).
10.1016/j.bmcl.2012.01.060
Cited by (34) | Cite | Source
Benzaepinones as sodium channel blockers (patent)
Hoyt, Scott B. | London, Clare | Ok, Dong | Parsons, William H.
Patent Number: 7888345 (2011)
Cited by (18) | Cite | Source
Design and Optimization of Benzimidazole-Containing Transient Receptor Potential Melastatin 8 (TRPM8) Antagonists (journal article)
Parks, Daniel J. | Parsons, William H. | Colburn, Raymond W. | Meegalla, Sanath K. | Ballentine, Shelley K. | Illig, Carl R. | Qin, Ning | Liu, Yi | Hutchinson, Tasha L. | Lubin, Mary Lou | ... | Player, Mark R.
Journal of Medicinal Chemistry, volume 54, issue 1, pages 233-247 (2011).
10.1021/jm101075v
Cited by (59) | Cite | Source
Discovery of a novel class of biphenyl pyrazole sodium channel blockers for treatment of neuropathic pain (journal article)
Tyagarajan, Sriram | Chakravarty, Prasun K. | Zhou, Bishan | Taylor, Brett | Eid, Ronsar | Fisher, Michael H. | Parsons, William H. | Wyvratt, Mathew J. | Lyons, Kathryn A. | Klatt, Tracy | ... | Duffy, Joseph L.
Bioorganic & Medicinal Chemistry Letters, volume 20, issue 24, pages 7479-7482 (2010).
10.1016/j.bmcl.2010.10.017
Cited by (19) | Cite | Source