Deepak Sampath

ScholarGPS® ID: 14613393889740

Affiliation

Genentech, Inc., South San Francisco, United States

Affiliation History

Field

Medicine

Discipline

Oncology

Top Specialties

Metrics Summary

Publication Count

Predicted Citations

7,332

Predicted h-index

Ranking

Publications and Citation History

Publications based on Top Specialties

Types of Publication

Publications
Books
Patents
NIH/NSF

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Preclinical characterization of the absorption and disposition of the brain penetrant PI3K/mTOR inhibitor paxalisib and prediction of its pharmacokinetics and efficacy in human (journal article) Salphati, Laurent \| Pang, Jodie \| Alicke, Bruno \| Plise, Emile G. \| Cheong, Jonathan \| Jaochico, Allan \| Olivero, Alan G. \| Sampath, Deepak \| Wong, Susan \| Zhang, Xiaolin Xenobiotica, volume 54, issue 2, pages 64-74 (2024). 10.1080/00498254.2024.2303586 Cite \| Source
Machine-Learning and Chemicogenomics Approach Defines and Predicts Cross-Talk of Hippo and MAPK Pathways (journal article) Pham, Trang H. \| Hagenbeek, Thijs J. \| Lee, Ho-June \| Li, Jason \| Rose, Christopher M. \| Lin, Eva \| Yu, Mamie \| Martin, Scott E. \| Piskol, Robert \| Lacap, Jennifer A. \| ... \| Dey, Anwesha Cancer Discovery, volume 11, issue 3, pages 778-793 (2021). 10.1158/2159-8290.CD-20-0706 Cited by (22) \| Cite \| Source
Loss of glucocorticoid receptor expression mediates in vivo dexamethasone resistance in T-cell acute lymphoblastic leukemia (journal article) Wandler, Anica M. \| Huang, Benjamin J. \| Craig, Jeffrey W. \| Hayes, Kathryn \| Yan, Hannah \| Meyer, Lauren K. \| Scacchetti, Alessandro \| Monsalve, Gabriela \| Dail, Monique \| Li, Qing \| ... \| Shannon, Kevin Leukemia, volume 34, issue 8, pages 2025-2037 (2020). 10.1038/s41375-020-0748-6 Cited by (29) \| Cite \| Source
Antitumor activity of ipatasertib combined with chemotherapy: results from a phase Ib study in solid tumors (journal article) Isakoff, S.J. \| Tabernero, J. \| Molife, L.R. \| Soria, J.-C. \| Cervantes, A. \| Vogelzang, N.J. \| Patel, M.R. \| Hussain, M. \| Baron, A. \| Argilés, G. \| ... \| Bendell, J. Annals of Oncology, volume 31, issue 5, pages 626-633 (2020). 10.1016/j.annonc.2020.02.007 Cited by (25) \| Cite \| Source
Discovery and Development of Venetoclax, a Selective Antagonist of BCL ‐2 (book chapter) In Successful Drug Discovery Fairbrother, Wayne J. \| Leverson, Joel D. \| Sampath, Deepak \| Souers, Andrew J. Wiley (2019) 10.1002/9783527814695.ch9 Cited by (8) \| Cite \| Source
VCAM-1 Density and Tumor Perfusion Predict T-cell Infiltration and Treatment Response in Preclinical Models (journal article) Riegler, Johannes \| Gill, Herman \| Ogasawara, Annie \| Hedehus, Maj \| Javinal, Vincent \| Oeh, Jason \| Ferl, Gregory Z. \| Marik, Jan \| Williams, Simon \| Sampath, Deepak \| ... \| Carano, Richard A.D. Neoplasia, volume 21, issue 10, pages 1036-1050 (2019). 10.1016/j.neo.2019.08.003 Cited by (15) \| Cite \| Source
Preclinical assessment of the ADME, efficacy and drug-drug interaction potential of a novel NAMPT inhibitor (journal article) Liederer, Bianca M. \| Cheong, Jonathan \| Chou, Kang-Jye \| Dragovich, Peter S. \| Le, Hoa \| Liang, Xiaorong \| Ly, Justin \| Mukadam, Sophie \| Oeh, Jason \| Sampath, Deepak \| ... \| Wong, Susan Xenobiotica, volume 49, issue 9, pages 1063-1077 (2019). 10.1080/00498254.2018.1528407 Cited by (1) \| Cite \| Source
Convergent genetic aberrations in murine and human T lineage acute lymphoblastic leukemias (journal article) Huang, Benjamin J. \| Wandler, Anica M. \| Meyer, Lauren K. \| Dail, Monique \| Daemen, Anneleen \| Sampath, Deepak \| Li, Qing \| Wang, Xinyue \| Wong, Jasmine C. \| Nakitandwe, Joy \| ... \| Shannon, Kevin PLOS Genetics, volume 15, issue 6, pages e1008168- (2019). 10.1371/journal.pgen.1008168 Cited by (4) \| Cite \| Source
Neutralization of BCL-2/XL Enhances the Cytotoxicity of T-DM1 In Vivo (journal article) Zoeller, Jason J. \| Vagodny, Aleksandr \| Taneja, Krishan \| Tan, Benjamin Y. \| O'Brien, Neil \| Slamon, Dennis J. \| Sampath, Deepak \| Leverson, Joel D. \| Bronson, Roderick T. \| Dillon, Deborah A. \| Brugge, Joan S. Molecular Cancer Therapeutics, volume 18, issue 6, pages 1115-1126 (2019). 10.1158/1535-7163.MCT-18-0743 Cited by (20) \| Cite \| Source
Combined MEK and BCL-2/XL Inhibition Is Effective in High-Grade Serous Ovarian Cancer Patient–Derived Xenograft Models and BIM Levels Are Predictive of Responsiveness (journal article) Iavarone, Claudia \| Zervantonakis, Ioannis K. \| Selfors, Laura M. \| Palakurthi, Sangeetha \| Liu, Joyce F. \| Drapkin, Ronny \| Matulonis, Ursula A. \| Hallberg, Dorothy \| Velculescu, Victor E. \| Leverson, Joel D. \| ... \| Brugge, Joan S. Molecular Cancer Therapeutics, volume 18, issue 3, pages 642-655 (2019). 10.1158/1535-7163.MCT-18-0413 Cited by (35) \| Cite \| Source
Combinations of AKT inhibitor compounds and chemotherapeutic agents, and methods of use (patent) Lin, Kui \| Nannini, Michelle \| Punnoose, Elizabeth \| Sampath, Deepak \| Wallin, Jeffrey \| Patel, Premal Patent Number: 10092567 (2018) Cite \| Source
The Kinase Activity of Hematopoietic Progenitor Kinase 1 Is Essential for the Regulation of T Cell Function (journal article) Hernandez, Sairy \| Qing, Jing \| Thibodeau, Rebecca Hong \| Du, Xiangnan \| Park, Summer \| Lee, Hyang-Mi \| Xu, Min \| Oh, Soyoung \| Navarro, Armando \| Roose-Girma, Meron \| ... \| Mellman, Ira Cell Reports, volume 25, issue 1, pages 80-94 (2018). 10.1016/j.celrep.2018.09.012 Cited by (64) \| Cite \| Source
Cotargeting BCL-2 and PI3K Induces BAX-Dependent Mitochondrial Apoptosis in AML Cells (journal article) Rahmani, Mohamed \| Nkwocha, Jewel \| Hawkins, Elisa \| Pei, Xinyan \| Parker, Rebecca E. \| Kmieciak, Maciej \| Leverson, Joel D. \| Sampath, Deepak \| Ferreira-Gonzalez, Andrea \| Grant, Steven Cancer Research, volume 78, issue 11, pages 3075-3086 (2018). 10.1158/0008-5472.CAN-17-3024 Cited by (93) \| Cite \| Source
An Anti-GDNF Family Receptor Alpha 1 (GFRA1) Antibody–Drug Conjugate for the Treatment of Hormone Receptor–Positive Breast Cancer (journal article) Bhakta, Sunil \| Crocker, Lisa M. \| Chen, Yvonne \| Hazen, Meredith \| Schutten, Melissa M. \| Li, Dongwei \| Kuijl, Coenraad \| Ohri, Rachana \| Zhong, Fiona \| Poon, Kirsten A. \| ... \| Junutula, Jagath R. Molecular Cancer Therapeutics, volume 17, issue 3, pages 638-649 (2018). 10.1158/1535-7163.MCT-17-0813 Cited by (22) \| Cite \| Source \| Open Access
Flavopiridol enhances ABT-199 sensitivity in unfavourable-risk multiple myeloma cells in vitro and in vivo (journal article) Zhou, Liang \| Zhang, Yu \| Sampath, Deepak \| Leverson, Joel \| Dai, Yun \| Kmieciak, Maciej \| Nguyen, Matthew \| Orlowski, Robert Z \| Grant, Steven British Journal of Cancer, volume 118, issue 3, pages 388-397 (2018). 10.1038/bjc.2017.432 Cited by (29) \| Cite \| Source \| Open Access
Methods and compositions for modulating estrogen receptor mutants (patent) Hager, Jeffrey J. \| Joseph, James D. \| Qian, Jing \| Smith, Nicholas D. \| Chow Maneval, Edna \| Roychowdhury, Debasish F. \| Friedman, Lori \| Sampath, Deepak Patent Number: 9855270 (2018) Cited by (2) \| Cite \| Source
Found in Translation: How Preclinical Research Is Guiding the Clinical Development of the BCL2-Selective Inhibitor Venetoclax (journal article) Leverson, Joel D. \| Sampath, Deepak \| Souers, Andrew J. \| Rosenberg, Saul H. \| Fairbrother, Wayne J. \| Amiot, Martine \| Konopleva, Marina \| Letai, Anthony Cancer Discovery, volume 7, issue 12, pages 1376-1393 (2017). 10.1158/2159-8290.CD-17-0797 Cited by (95) \| Cite \| Source \| Open Access
Monitoring and Targeting Anti-VEGF Induced Hypoxia within the Viable Tumor by 19 F–MRI and Multispectral Analysis (journal article) Shi, Yunzhou \| Oeh, Jason \| Hitz, Anna \| Hedehus, Maj \| Eastham-Anderson, Jeffrey \| Peale, Franklin V. \| Hamilton, Patricia \| O'Brien, Thomas \| Sampath, Deepak \| Carano, Richard A.D. Neoplasia, volume 19, issue 11, pages 950-959 (2017). 10.1016/j.neo.2017.07.010 Cited by (15) \| Cite \| Source \| Open Access
Single-Cell Dynamics Determines Response to CDK4/6 Inhibition in Triple-Negative Breast Cancer (journal article) Asghar, Uzma S. \| Barr, Alexis R. \| Cutts, Ros \| Beaney, Matthew \| Babina, Irina \| Sampath, Deepak \| Giltnane, Jennifer \| Lacap, Jennifer Arca \| Crocker, Lisa \| Young, Amy \| ... \| Turner, Nicholas C. Clinical Cancer Research, volume 23, issue 18, pages 5561-5572 (2017). 10.1158/1078-0432.CCR-17-0369 Cited by (188) \| Cite \| Source \| Open Access
Targeting MAPK Signaling Pathway with Cobimetinib (GDC-0973) Enhances Anti-Leukemia Efficacy of Venetoclax (ABT-199/GDC-0199) in Acute Myeloid Leukemia Models (journal article) Han, Lina \| Zhang, Qi \| Shi, Ce \| Cavazos, Antonio \| Ruvolo, Vivian R. \| Leverson, Joel D. \| Dail, Monique \| Phillips, Darren C. \| Chen, Jun \| Jin, Sha S. \| ... \| Konopleva, Marina Clinical Lymphoma Myeloma and Leukemia, volume 17 (2017). 10.1016/j.clml.2017.07.064 Cited by (1) \| Cite \| Source