Barbara J. Haertlein

ScholarGPS® ID: 13464167029596

Affiliation
Johnson & Johnson, New Brunswick, New Jersey, United States
Affiliation History

Field
Physical Sciences and Mathematics
Discipline
Chemistry
Top Specialties
Medicinal Chemistry | Potassium Channel | Chemical Synthesis
Metrics Summary
Publication Count
22
Predicted Citations
1,032
Predicted h-index
17
Ranking

Publications and Citation History

Publications based on Top Specialties

Types of Publication

  • Publications
  • Books
  • Patents
  • NIH/NSF
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Dual Inhibition of Cathepsin G and Chymase Is Effective in Animal Models of Pulmonary Inflammation (journal article)
Maryanoff, Bruce E. | de Garavilla, Lawrence | Greco, Michael N. | Haertlein, Barbara J. | Wells, Grace I. | Andrade-Gordon, Patricia | Abraham, William M.
American Journal of Respiratory and Critical Care Medicine, volume 181, issue 3, pages 247-253 (2010).
10.1164/rccm.200904-0627OC
Cited by (53) | Cite | Source
Cooperative antithrombotic effect from the simultaneous inhibition of thrombin and factor Xa (journal article)
Giardino, Edward C | Haertlein, Barbara J | de Garavilla, Lawrence | Costanzo, Michael J | Damiano, Bruce P | Andrade-Gordon, Patricia | Maryanoff, Bruce E
Blood Coagulation & Fibrinolysis, volume 21, issue 2, pages 128-134 (2010).
10.1097/MBC.0b013e3283358100
Cited by (24) | Cite | Source
Nonpeptide Urotensin-II Receptor Antagonists: A New Ligand Class Based on Piperazino-Phthalimide and Piperazino-Isoindolinone Subunits (journal article)
Lawson, Edward C. | Luci, Diane K. | Ghosh, Shyamali | Kinney, William A. | Reynolds, Charles H. | Qi, Jenson | Smith, Charles E. | Wang, Yuanping | Minor, Lisa K. | Haertlein, Barbara J. | ... | Maryanoff, Bruce E.
Journal of Medicinal Chemistry, volume 52, issue 23, pages 7432-7445 (2009).
10.1021/jm900683d
Cited by (70) | Cite | Source
Carba‐nucleosides as Potent Antagonists of the Adenosine 5′‐Diphosphate (ADP) Purinergic Receptor (P2Y12 ) on Human Platelets (journal article)
Ye, Hong | Chen, Cailin | Zhang, Han‐Cheng | Haertlein, Barbara | Parry, Tom J. | Damiano, Bruce P. | Maryanoff, Bruce E.
ChemMedChem, volume 3, issue 5, pages 732-736 (2008).
10.1002/cmdc.200700310
Cited by (11) | Cite | Source
Orally efficacious thrombin inhibitors with cyanofluorophenylacetamide as the P2 motif (journal article)
Kreutter, Kevin D. | Lu, Tianbao | Lee, Lily | Giardino, Edward C. | Patel, Sharmila | Huang, Hui | Xu, Guozhang | Fitzgerald, Mark | Haertlein, Barbara J. | Mohan, Venkatraman | ... | Player, Mark R.
Bioorganic & Medicinal Chemistry Letters, volume 18, issue 9, pages 2865-2870 (2008).
10.1016/j.bmcl.2008.03.087
Cited by (29) | Cite | Source
Phenylpiperidine-benzoxazinones as urotensin-II receptor antagonists: Synthesis, SAR, and in vivo assessment (journal article)
Luci, Diane K. | Ghosh, Shyamali | Smith, Charles E. | Qi, Jenson | Wang, Yuanping | Haertlein, Barbara | Parry, Tom J. | Li, Jian | Almond, Harold R. | Minor, Lisa K. | ... | Lawson, Edward C.
Bioorganic & Medicinal Chemistry Letters, volume 17, issue 23, pages 6489-6492 (2007).
10.1016/j.bmcl.2007.09.092
Cited by (17) | Cite | Source
In-Depth Study of Tripeptide-Based α-Ketoheterocycles as Inhibitors of Thrombin. Effective Utilization of the S1 ‘ Subsite and Its Implications to Structure-Based Drug Design. (journal article)
Costanzo, Michael J. | Almond, Harold R. | Hecker, Leonard R. | Schott, Mary R. | Yabut, Stephen C. | Zhang, Han-Cheng | Andrade-Gordon, Patricia | Corcoran, Thomas W. | Giardino, Edward C. | Kauffman, Jack A. | ... | Maryanoff, Bruce E.
Journal of Medicinal Chemistry, volume 50, issue 23, pages 5868-5868 (2007).
10.1021/jm701211q
Cited by (1) | Cite | Source | Open Access
Urotensin‐II Induces Ear Flushing in Rats (journal article)
Qi, J‐S | Schulingkamp, R | Parry, T J | Colburn, R | Stone, D | Haertlein, B | Minor, L K | Andrade‐Gordon, P | Damiano, B P
British Journal of Pharmacology, volume 150, issue 4, pages 415-423 (2007).
10.1038/sj.bjp.0707006
Cited by (8) | Cite | Source | Open Access
A Novel, Potent Dual Inhibitor of the Leukocyte Proteases Cathepsin G and Chymase (journal article)
de Garavilla, Lawrence | Greco, Michael N. | Sukumar, Narayanasami | Chen, Zhi-Wei | Pineda, Agustin O. | Mathews, F. Scott | Di Cera, Enrico | Giardino, Edward C. | Wells, Grace I. | Haertlein, Barbara J. | ... | Maryanoff, Bruce E.
Journal of Biological Chemistry, volume 280, issue 18, pages 18001-18007 (2005).
10.1074/jbc.M501302200
Cited by (77) | Cite | Source | Open Access
In-Depth Study of Tripeptide-Based α-Ketoheterocycles as Inhibitors of Thrombin. Effective Utilization of the S1 ‘ Subsite and Its Implications to Structure-Based Drug Design (journal article)
Costanzo, Michael J. | Almond, Harold R. | Hecker, Leonard R. | Schott, Mary R. | Yabut, Stephen C. | Zhang, Han-Cheng | Andrade-Gordon, Patricia | Corcoran, Thomas W. | Giardino, Edward C. | Kauffman, Jack A. | ... | Maryanoff, Bruce E.
Journal of Medicinal Chemistry, volume 48, issue 6, pages 1984-2008 (2005).
10.1021/jm0303857
Cited by (57) | Cite | Source
Antiplatelet and Antithrombotic Activity of RWJ-53308, A Novel Orally Active Glycoprotein IIb/IIIa Antagonist (journal article)
Damiano, Bruce P | Mitchell, John A | Giardino, Edward | Corcoran, Thomas | Haertlein, Barbara J | de Garavilla, Lawrence | Kauffman, Jack A | Hoekstra, William J | Maryanoff, Bruce E | Andrade-Gordon, Patricia
Thrombosis Research, volume 104, issue 2, pages 113-126 (2001).
10.1016/S0049-3848(01)00353-X
Cited by (29) | Cite | Source
Potent, Orally Active GPIIb/IIIa Antagonists Containing a Nipecotic Acid Subunit. Structure−Activity Studies Leading to the Discovery of RWJ-53308 (journal article)
Hoekstra, William J. | Maryanoff, Bruce E. | Damiano, Bruce P. | Andrade-Gordon, Patricia | Cohen, Judith H. | Costanzo, Michael J. | Haertlein, Barbara J. | Hecker, Leonard R. | Hulshizer, Becky L. | Kauffman, Jack A. | ... | Yabut, Stephen C.
Journal of Medicinal Chemistry, volume 42, issue 25, pages 5254-5265 (1999).
10.1021/jm990418b
Cited by (71) | Cite | Source
Solid-phase parallel synthesis applied to lead optimization: Discovery of potent analogues of the GPIIb/IIIa antagonist RWJ-50042 (journal article)
Hoekstra, William J. | Maryanoff, Bruce E. | Andrade-Gordon, Patricia | Cohen, Judith H. | Costanzo, Michael J. | Damiano, Bruce P. | Haertlein, Barbara J. | Harris, Bruce D. | Kauffman, Jack A. | Keane, Patricia M. | ... | Yabut, Stephen C.
Bioorganic & Medicinal Chemistry Letters, volume 6, issue 20, pages 2371-2376 (1996).
10.1016/0960-894X(96)00438-6
Cited by (30) | Cite | Source
Species differences in platelet responses to thrombin and SFLLRN. Receptor-mediated calcium mobilization and aggregation, and regulation by protein kinases (journal article)
Derian, Claudia K. | Santulli, Rosemary J. | Tomko, Karen A. | Haertlein, Barbara J. | Andrade-Gordon, Patricia
Thrombosis Research, volume 78, issue 6, pages 505-519 (1995).
10.1016/0049-3848(95)00084-5
Cited by (62) | Cite | Source
Cardiovascular Profile of RWJ 29009, a New Potassium Channel Activator, in Anesthetized and Conscious Dogs (journal article)
Damiano, Bruce P. | Giardino, Edward C. | Haertlein, Barbara J. | Stump, Gary L. | Mitchell, John A. | Falotico, Robert
Journal of Cardiovascular Pharmacology, volume 2, issue 2, pages 300-310 (1994).
10.1097/00005344-199411000-00018
Cite | Source
Cardiovascular Profile of RWJ 29009, a New Potassium Channel Activator, in Anesthetized and Conscious Dogs (journal article)
Damiano, Bruce P. | Giardino, Edward C. | Haertlein, Barbara J. | Stump, Gary L. | Mitchell, John A. | Falotico, Robert
Journal of Cardiovascular Pharmacology, volume 23, issue 2, pages 300-310 (1994).
10.1097/00005344-199402000-00018
Cited by (7) | Cite | Source | Open Access
Novel thieno[2,3-b]- and [3,4-b]pyrans as potassium channel openers. Thiophene systems—XVII (journal article)
Press, Jeffery B. | McNally, James J. | Sanfilippo, Pauline J. | Addo, Michael F. | Loughney, Deborah | Giardino, Edward | Katz, Laurence B. | Falotico, Robert | Haertlein, Barbara J.
Bioorganic & Medicinal Chemistry, volume 1, issue 6, pages 423-435 (1993).
10.1016/S0968-0896(00)82153-7
Cited by (5) | Cite | Source
Synthesis and structure-activity relationship of 6-substituted purine derivatives as novel selective positive inotropes (journal article)
Press, Jeffery B. | Falotico, Robert | Hajos, Zoltan G. | Sawyers, Rebecca Anne | Kanojia, Ramesh M. | Williams, Louella | Haertlein, Barbara | Kauffman, Jack A. | Lakas-Weiss, Constance | Salata, Joseph J.
Journal of Medicinal Chemistry, volume 35, issue 24, pages 4509-4515 (1992).
10.1021/jm00102a001
Cited by (16) | Cite | Source
Simultaneous monitoring of bemoradan pharmacokinetics and hemodynamics in mongrel dogs (journal article)
Huang, Shiew‐Mei | Falotico, Robert | Haertlein, Barbara | Smith, Ian L.
Biopharmaceutics & Drug Disposition, volume 13, issue 7, pages 539-547 (1992).
10.1002/bdd.2510130707
Cited by (1) | Cite | Source
6-Benzoxazinylpyridazin-3-ones: potent, long-acting positive inotrope and peripheral vasodilator agents (journal article)
Combs, Donald W. | Rampulla, Marianne S. | Bell, Stanley C. | Klaubert, Dieter H. | Tobia, Alfonso J. | Falotico, Robert | Haertlein, Barbara | Lakas-Weiss, Constance | Moore, John B.
Journal of Medicinal Chemistry, volume 33, issue 1, pages 380-386 (1990).
10.1021/jm00163a061
Cited by (92) | Cite | Source