Carol O'Brien

ScholarGPS® ID: 10699974116869

Affiliation

Genentech, Inc., South San Francisco, United States

Affiliation History

Field

Life Sciences

Discipline

Biology and Biological Sciences

Top Specialties

Cancer | Breast Cancer

Metrics Summary

Publication Count

Predicted Citations

2,275

Predicted h-index

Ranking

Publications and Citation History

Publications based on Top Specialties

Types of Publication

Publications
Books
Patents
NIH/NSF

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Predictive and Pharmacodynamic Biomarkers of Response to the Phosphatidylinositol 3-Kinase Inhibitor Taselisib in Breast Cancer Preclinical Models (journal article) Moore, Heather M. \| Savage, Heidi M. \| O'Brien, Carol \| Zhou, Wei \| Sokol, Ethan S. \| Goldberg, Michael E. \| Metcalfe, Ciara \| Friedman, Lori S. \| Lackner, Mark R. \| Wilson, Timothy R. Molecular Cancer Therapeutics, volume 19, issue 1, pages 292-303 (2020). 10.1158/1535-7163.MCT-19-0284 Cited by (9) \| Cite \| Source
Genetic variations associated with drug resistance (patent) Lackner, Mark \| Amler, Lukas C. \| Cavet, Guy \| O'Brien, Carol \| Pandita, Ajay Patent Number: 9879267 (2018) Cite \| Source
Activating Mutations in PIK3CB Confer Resistance to PI3K Inhibition and Define a Novel Oncogenic Role for p110β (journal article) Nakanishi, Yoshito \| Walter, Kimberly \| Spoerke, Jill M. \| O'Brien, Carol \| Huw, Ling Y. \| Hampton, Garret M. \| Lackner, Mark R. Cancer Research, volume 76, issue 5, pages 1193-1203 (2016). 10.1158/0008-5472.CAN-15-2201 Cited by (49) \| Cite \| Source
PTEN Loss Is Associated with Worse Outcome in HER2 -Amplified Breast Cancer Patients but Is Not Associated with Trastuzumab Resistance (journal article) Stern, Howard M. \| Gardner, Humphrey \| Burzykowski, Tomasz \| Elatre, Wafaa \| O'Brien, Carol \| Lackner, Mark R. \| Pestano, Gary A. \| Santiago, Angela \| Villalobos, Ivonne \| Eiermann, Wolfgang \| ... \| Press, Michael F. Clinical Cancer Research, volume 21, issue 9, pages 2065-2074 (2015). 10.1158/1078-0432.CCR-14-2993 Cited by (54) \| Cite \| Source \| Open Access
Evaluation of PI3K-pathway–activation status in matched primary (P) and metastatic (M) ER+/HER2- breast cancer (BC) lesions according to PIK3CA-mutation status. (journal article) Fumagalli, Debora \| Jose, Vinu \| Salgado, Roberto \| Michiels, Stefan \| Wilson, Timothy R. \| O'Brien, Carol \| Huw, Ling \| Rouas, Ghizlane \| Criscitiello, Carmen \| Pugliano, Lina \| ... \| Sotiriou, Christos Journal of Clinical Oncology, volume 32, issue 15_suppl, pages 11060-11060 (2014). 10.1200/jco.2014.32.15_suppl.11060 Cite \| Source
Acquired PIK3CA amplification causes resistance to selective phosphoinositide 3-kinase inhibitors in breast cancer (journal article) Huw, L-Y \| O'Brien, C \| Pandita, A \| Mohan, S \| Spoerke, J M \| Lu, S \| Wang, Y \| Hampton, G M \| Wilson, T R \| Lackner, M R Oncogenesis, volume 2, issue 12, pages e83-e83 (2013). 10.1038/oncsis.2013.46 Cited by (71) \| Cite \| Source \| Open Access
Phosphoinositide 3-Kinase (PI3K) Pathway Alterations Are Associated with Histologic Subtypes and Are Predictive of Sensitivity to PI3K Inhibitors in Lung Cancer Preclinical Models (journal article) Spoerke, Jill M. \| O'Brien, Carol \| Huw, Ling \| Koeppen, Hartmut \| Fridlyand, Jane \| Brachmann, Rainer K. \| Haverty, Peter M. \| Pandita, Ajay \| Mohan, Sankar \| Sampath, Deepak \| ... \| Lackner, Mark R. Clinical Cancer Research, volume 18, issue 24, pages 6771-6783 (2012). 10.1158/1078-0432.CCR-12-2347 Cited by (150) \| Cite \| Source \| Open Access
Trastuzamab antibody drug conjugates demonstrate robust in vitro antitumor activity in HER2 amplified breast cancer cell lines (journal article) Mohan, Sankar \| O'Brien, Carol \| Savage, Heidi \| Phillips, Gail \| Stern, Howard \| Lackner, Mark \| Pandita, Ajay Clinical Cancer Research, volume 16, issue 19_Supplement, pages B19-B19 (2010). 10.1158/DIAG-10-B19 Cite \| Source
Predictive Biomarkers of Sensitivity to the Phosphatidylinositol 3′ Kinase Inhibitor GDC-0941 in Breast Cancer Preclinical Models (journal article) O'Brien, Carol \| Wallin, Jeffrey J. \| Sampath, Deepak \| GuhaThakurta, Debraj \| Savage, Heidi \| Punnoose, Elizabeth A. \| Guan, Jane \| Berry, Leanne \| Prior, Wei Wei \| Amler, Lukas C. \| ... \| Lackner, Mark R. Clinical Cancer Research, volume 16, issue 14, pages 3670-3683 (2010). 10.1158/1078-0432.CCR-09-2828 Cited by (229) \| Cite \| Source \| Open Access
Molecular predictors of response to a humanized anti–insulin-like growth factor-I receptor monoclonal antibody in breast and colorectal cancer (journal article) Zha, Jiping \| O'Brien, Carol \| Savage, Heidi \| Huw, Ling-Yuh \| Zhong, Fiona \| Berry, Leanne \| Lewis Phillips, Gail D. \| Luis, Elizabeth \| Cavet, Guy \| Hu, Xiaolan \| ... \| Lackner, Mark R. Molecular Cancer Therapeutics, volume 8, issue 8, pages 2110-2121 (2009). 10.1158/1535-7163.MCT-09-0381 Cited by (73) \| Cite \| Source \| Open Access
In vivo Antitumor Activity of MEK and Phosphatidylinositol 3-Kinase Inhibitors in Basal-Like Breast Cancer Models (journal article) Hoeflich, Klaus P. \| O'Brien, Carol \| Boyd, Zachary \| Cavet, Guy \| Guerrero, Steve \| Jung, Kenneth \| Januario, Tom \| Savage, Heidi \| Punnoose, Elizabeth \| Truong, Tom \| ... \| Lackner, Mark R. Clinical Cancer Research, volume 15, issue 14, pages 4649-4664 (2009). 10.1158/1078-0432.CCR-09-0317 Cited by (419) \| Cite \| Source \| Open Access
Antitumor Efficacy of the Novel RAF Inhibitor GDC-0879 Is Predicted by BRAFV600E Mutational Status and Sustained Extracellular Signal-Regulated Kinase/Mitogen-Activated Protein Kinase Pathway Suppression (journal article) Hoeflich, Klaus P. \| Herter, Sylvia \| Tien, Janet \| Wong, Leo \| Berry, Leanne \| Chan, Jocelyn \| O'Brien, Carol \| Modrusan, Zora \| Seshagiri, Somasekar \| Lackner, Mark \| ... \| Belvin, Marcia Cancer Research, volume 69, issue 7, pages 3042-3051 (2009). 10.1158/0008-5472.CAN-08-3563 Cited by (155) \| Cite \| Source \| Open Access
Genetic Alterations and Oncogenic Pathways Associated with Breast Cancer Subtypes (journal article) Hu, Xiaolan \| Stern, Howard M. \| Ge, Lin \| O'Brien, Carol \| Haydu, Lauren \| Honchell, Cynthia D. \| Haverty, Peter M. \| Peters, Brock A. \| Wu, Thomas D. \| Amler, Lukas C. \| ... \| Cavet, Guy Molecular Cancer Research, volume 7, issue 4, pages 511-522 (2009). 10.1158/1541-7786.MCR-08-0107 Cited by (194) \| Cite \| Source \| Open Access
Genetic variations associated with drug resistance (patent) Lackner, Mark R. \| Amler, Lukas \| Cavet, Guy \| O'Brien, Carol \| Pandita, Ajay Patent Number: 20110177099 (2009) Cite \| Source
Proteomic analysis of breast cancer molecular subtypes and biomarkers of response to targeted kinase inhibitors using reverse-phase protein microarrays (journal article) Boyd, Zachary S. \| Wu, Qun Jenny \| O'Brien, Carol \| Spoerke, Jill \| Savage, Heidi \| Fielder, Paul J. \| Amler, Lukas \| Yan, Yibing \| Lackner, Mark R. Molecular Cancer Therapeutics, volume 7, issue 12, pages 3695-3706 (2008). 10.1158/1535-7163.MCT-08-0810 Cited by (62) \| Cite \| Source \| Open Access
Functional Genomics Identifies ABCC3 as a Mediator of Taxane Resistance in HER2-Amplified Breast Cancer (journal article) O'Brien, Carol \| Cavet, Guy \| Pandita, Ajay \| Hu, Xiaolan \| Haydu, Lauren \| Mohan, Sankar \| Toy, Karen \| Rivers, Celina Sanchez \| Modrusan, Zora \| Amler, Lukas C. \| Lackner, Mark R. Cancer Research, volume 68, issue 13, pages 5380-5389 (2008). 10.1158/0008-5472.CAN-08-0234 Cited by (89) \| Cite \| Source \| Open Access