Simon Hansen

ScholarGPS® ID: 10523575623519

Affiliation

Genentech, Inc., South San Francisco, United States

Affiliation History

Field

Life Sciences

Discipline

Biochemistry

Top Specialties

Peptide | Chemical Biology | Structural Biology

Metrics Summary

Publication Count

Predicted Citations

502

Predicted h-index

Ranking

Publications and Citation History

Publications based on Top Specialties

Types of Publication

Publications
Books
Patents
NIH/NSF

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Synthetic Multivalent Disulfide-Constrained Peptide Agonists Potentiate Wnt1/β-Catenin Signaling via LRP6 Coreceptor Clustering (journal article) Thakur, Avinash K. \| Miller, Stephen E. \| Liau, Nicholas P.D. \| Hwang, Sunhee \| Hansen, Simon \| de Sousa e Melo, Felipe \| Sudhamsu, Jawahar \| Hannoush, Rami N. ACS Chemical Biology, volume 18, issue 4, pages 772-784 (2023). 10.1021/acschembio.2c00753 Cited by (3) \| Cite \| Source
Structure of the Wnt–Frizzled–LRP6 initiation complex reveals the basis for coreceptor discrimination (journal article) Tsutsumi, Naotaka \| Hwang, Sunhee \| Waghray, Deepa \| Hansen, Simon \| Jude, Kevin M. \| Wang, Nan \| Miao, Yi \| Glassman, Caleb R. \| Caveney, Nathanael A. \| Janda, Claudia Y. \| ... \| Garcia, K. Christopher Proceedings of the National Academy of Sciences, volume 120, issue 11 (2023). 10.1073/pnas.2218238120 Cited by (9) \| Cite \| Source
Senescent cells perturb intestinal stem cell differentiation through Ptk7 induced noncanonical Wnt and YAP signaling (journal article) Yun, Jina \| Hansen, Simon \| Morris, Otto \| Madden, David T. \| Libeu, Clare Peters \| Kumar, Arjun J. \| Wehrfritz, Cameron \| Nile, Aaron H. \| Zhang, Yingnan \| Zhou, Lijuan \| ... \| Jasper, Heinrich Nature Communications, volume 14, issue 1 (2023). 10.1038/s41467-022-35487-9 Cited by (11) \| Cite \| Source
Directed evolution identifies high-affinity cystine-knot peptide agonists and antagonists of Wnt/β-catenin signaling (journal article) Hansen, Simon \| Zhang, Yingnan \| Hwang, Sunhee \| Nabhan, Ahmad \| Li, Wanqing \| Fuhrmann, Jakob \| Kschonsak, Yvonne \| Zhou, Lijuan \| Nile, Aaron H. \| Gao, Xinxin \| ... \| Hannoush, Rami N. Proceedings of the National Academy of Sciences, volume 119, issue 46 (2022). 10.1073/pnas.2207327119 Cited by (15) \| Cite \| Source
It Takes Two to Regenerate: Optimizing Custom Wnt Surrogates (journal article) Hansen, Simon \| Hannoush, Rami N. Cell Chemical Biology, volume 27, issue 5, pages 473-475 (2020). 10.1016/j.chembiol.2020.05.004 Cited by (1) \| Cite \| Source
Lead Optimization Yields High Affinity Frizzled 7-Targeting Peptides That Modulate Clostridium difficile Toxin B Pathogenicity in Epithelial Cells (journal article) Hansen, Simon \| Nile, Aaron H. \| Mehta, Shrenik C. \| Fuhrmann, Jakob \| Hannoush, Rami N. Journal of Medicinal Chemistry, volume 62, issue 17, pages 7739-7750 (2019). 10.1021/acs.jmedchem.9b00500 Cited by (9) \| Cite \| Source
A selective peptide inhibitor of Frizzled 7 receptors disrupts intestinal stem cells (journal article) Nile, Aaron H. \| de Sousa e Melo, Felipe \| Mukund, Susmith \| Piskol, Robert \| Hansen, Simon \| Zhou, Lijuan \| Zhang, Yingnan \| Fu, Yue \| Gogol, Emily B. \| Kömüves, László G. \| ... \| Hannoush, Rami N. Nature Chemical Biology, volume 14, issue 6, pages 582-590 (2018). 10.1038/s41589-018-0035-2 Cited by (52) \| Cite \| Source
A selective peptide inhibitor of Frizzled 7 receptors disrupts intestinal stem cells (journal article) Nile, Aaron H. \| Melo, F. de Sousa e \| Mukund, Susmith \| Piskol, Robert \| Hansen, Simon \| Zhou, Lijuan \| Zhang, Yingnan \| Fu, Y. \| Gogol, Emily \| Komuves, Laszlo \| ... \| Hannoush, Rami N. Nature Chemical Biology, volume 14, issue 6, pages 582-590 (2018). 10.2210/pdb5wbs/pdb Cited by (3) \| Cite \| Source
Curvature of designed armadillo repeat proteins allows modular peptide binding (journal article) Hansen, Simon \| Ernst, Patrick \| König, Sebastian L.B. \| Reichen, Christian \| Ewald, Christina \| Nettels, Daniel \| Mittl, Peer R.E. \| Schuler, Benjamin \| Plückthun, Andreas Journal of Structural Biology, volume 201, issue 2, pages 108-117 (2018). 10.1016/j.jsb.2017.08.009 Cited by (12) \| Cite \| Source \| Open Access
Design and applications of a clamp for Green Fluorescent Protein with picomolar affinity (journal article) Hansen, Simon \| Stüber, Jakob C. \| Ernst, Patrick \| Koch, Alexander \| Bojar, Daniel \| Batyuk, Alexander \| Plückthun, Andreas Scientific Reports, volume 7, issue 1 (2017). 10.1038/s41598-017-15711-z Cited by (47) \| Cite \| Source \| Open Access
Structures of designed armadillo repeat proteins binding to peptides fused to globular domains (journal article) Hansen, Simon \| Kiefer, Jonathan D. \| Madhurantakam, Chaithanya \| Mittl, Peer R. E. \| Plückthun, Andreas Protein Science, volume 26, issue 10, pages 1942-1952 (2017). 10.1002/pro.3229 Cited by (9) \| Cite \| Source
Computationally Designed Armadillo Repeat Proteins for Modular Peptide Recognition (journal article) Reichen, Christian \| Hansen, Simon \| Forzani, Cristina \| Honegger, Annemarie \| Fleishman, Sarel J. \| Zhou, Ting \| Parmeggiani, Fabio \| Ernst, Patrick \| Madhurantakam, Chaithanya \| Ewald, Christina \| ... \| Plückthun, Andreas Journal of Molecular Biology, volume 428, issue 22, pages 4467-4489 (2016). 10.1016/j.jmb.2016.09.012 Cited by (17) \| Cite \| Source \| Open Access
Structure and Energetic Contributions of a Designed Modular Peptide-Binding Protein with Picomolar Affinity (journal article) Hansen, Simon \| Tremmel, Dirk \| Madhurantakam, Chaithanya \| Reichen, Christian \| Mittl, Peer R. E. \| Plückthun, Andreas Journal of the American Chemical Society, volume 138, issue 10, pages 3526-3532 (2016). 10.1021/jacs.6b00099 Cited by (26) \| Cite \| Source
Structures of designed armadillo-repeat proteins show propagation of inter-repeat interface effects (journal article) Reichen, Christian \| Madhurantakam, Chaithanya \| Hansen, Simon \| Grütter, Markus G. \| Plückthun, Andreas \| Mittl, Peer R. E. Acta Crystallographica Section D Structural Biology, volume 72, issue 1, pages 168-175 (2016). 10.1107/S2059798315023116 Cited by (10) \| Cite \| Source \| Open Access
Designed Armadillo repeat proteins serve as scaffolds for the rational assembly of peptide binders with picomolar affinities (journal article) Mittl, Peer \| Hansen, Simon \| Ernst, Patrick \| Plückthun, Andreas Acta Crystallographica Section A Foundations and Advances, volume 71, issue a1, pages s267-s267 (2015). 10.1107/S2053273315095923 Cite \| Source \| Open Access
Protein interference applications in cellular and developmental biology using DARPins that recognize GFP and mCherry (journal article) Brauchle, Michael \| Hansen, Simon \| Caussinus, Emmanuel \| Lenard, Anna \| Ochoa-Espinosa, Amanda \| Scholz, Oliver \| Sprecher, Simon G. \| Plückthun, Andreas \| Affolter, Markus Biology Open, volume 3, issue 12, pages 1252-1261 (2014). 10.1242/bio.201410041 Cited by (54) \| Cite \| Source \| Open Access
G-quadruplexes are specifically recognized and distinguished by selected designed ankyrin repeat proteins (journal article) Scholz, Oliver \| Hansen, Simon \| Plückthun, Andreas Nucleic Acids Research, volume 42, issue 14, pages 9182-9194 (2014). 10.1093/nar/gku571 Cited by (16) \| Cite \| Source \| Open Access
Structure-based engineering of designed armadillo repeat proteins. (journal article) Hansen, Simon \| Reichen, Christian \| Madhurantakam, Chaithanya \| Grütter, Markus \| Plückthun, Andreas \| Mittl, Peer Acta Crystallographica Section A Foundations and Advances, volume 70, issue a1, pages C1153-C1153 (2014). 10.1107/S2053273314088469 Cite \| Source \| Open Access
Modular peptide binding: From a comparison of natural binders to designed armadillo repeat proteins (journal article) Reichen, Christian \| Hansen, Simon \| Plückthun, Andreas Journal of Structural Biology, volume 185, issue 2, pages 147-162 (2014). 10.1016/j.jsb.2013.07.012 Cited by (47) \| Cite \| Source
Erratum to “Designed Armadillo Repeat Proteins: Library Generation, Characterization and Selection of Peptide Binders with High Specificity” [J. Mol. Biol. (2012) 424, 68–87] (journal article) Varadamsetty, Gautham \| Tremmel, Dirk \| Hansen, Simon \| Parmeggiani, Fabio \| Plückthun, Andreas Journal of Molecular Biology, volume 425, issue 5, pages 969-970 (2013). 10.1016/j.jmb.2013.01.012 Cited by (1) \| Cite \| Source