Matthias Götte

ScholarGPS® ID: 10385635774582

Affiliation

University of Alberta, Edmonton, Canada

Affiliation History

Field

Life Sciences

Discipline

Microbiology

Top Specialties

Metrics Summary

Publication Count

135

Predicted Citations

8,161

Predicted h-index

Ranking

Publications and Citation History

Publications based on Top Specialties

Types of Publication

Publications
Books
Patents
NIH/NSF

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Binding and Sliding Dynamics of the Hepatitis C Virus Polymerase: Hunting the 3′ Terminus (journal article) Gidi, Yasser \| Robert, Anaïs \| Tordo, Alix \| Lovell, Terri C. \| Ramos-Sanchez, Jorge \| Sakaya, Aya \| Götte, Matthias \| Cosa, Gonzalo ACS Infectious Diseases, volume 9, issue 8, pages 1488-1498 (2023). 10.1021/acsinfecdis.3c00048 Cite \| Source
Structural basis for substrate selection by the SARS-CoV-2 replicase (journal article) Malone, Brandon F. \| Perry, Jason K. \| Olinares, Paul Dominic B. \| Lee, Hery W. \| Chen, James \| Appleby, Todd C. \| Feng, Joy Y. \| Bilello, John P. \| Ng, Honkit \| Sotiris, Johanna \| ... \| Darst, Seth A. Nature, volume 614, issue 7949, pages 781-787 (2023). 10.1038/s41586-022-05664-3 Cited by (19) \| Cite \| Source
Evolution of naturally arising SARS-CoV-2 defective interfering particles (journal article) Girgis, Samer \| Xu, Zaikun \| Oikonomopoulos, Spyros \| Fedorova, Alla D. \| Tchesnokov, Egor P. \| Gordon, Calvin J. \| Schmeing, T. Martin \| Götte, Matthias \| Sonenberg, Nahum \| Baranov, Pavel V. \| ... \| Pelletier, Jerry Communications Biology, volume 5, issue 1 (2022). 10.1038/s42003-022-04058-5 Cited by (12) \| Cite \| Source
Mutations in the SARS-CoV-2 RNA-dependent RNA polymerase confer resistance to remdesivir by distinct mechanisms (journal article) Stevens, Laura J. \| Pruijssers, Andrea J. \| Lee, Hery W. \| Gordon, Calvin J. \| Tchesnokov, Egor P. \| Gribble, Jennifer \| George, Amelia S. \| Hughes, Tia M. \| Lu, Xiaotao \| Li, Jiani \| ... \| Denison, Mark R. Science Translational Medicine, volume 14, issue 656 (2022). 10.1126/scitranslmed.abo0718 Cited by (106) \| Cite \| Source
Human endogenous retrovirus-K (HERV-K) reverse transcriptase (RT) structure and biochemistry reveals remarkable similarities to HIV-1 RT and opportunities for HERV-K–specific inhibition (journal article) Baldwin, Eric T. \| Götte, Matthias \| Tchesnokov, Egor P. \| Arnold, Eddy \| Hagel, Margit \| Nichols, Charles \| Dossang, Pam \| Lamers, Marieke \| Wan, Paul \| Steinbacher, Stefan \| Romero, Donna L. Proceedings of the National Academy of Sciences, volume 119, issue 27 (2022). 10.1073/pnas.2200260119 Cited by (18) \| Cite \| Source
The Nucleoside/Nucleotide Analogs Tenofovir and Emtricitabine Are Inactive against SARS-CoV-2 (journal article) Feng, Joy Y. \| Du Pont, Venice \| Babusis, Darius \| Gordon, Calvin J. \| Tchesnokov, Egor P. \| Perry, Jason K. \| Duong, Vincent \| Vijjapurapu, Arya \| Zhao, Xiaofeng \| Chan, Julie \| ... \| Bilello, John P. Molecules, volume 27, issue 13, pages 4212- (2022). 10.3390/molecules27134212 Cited by (10) \| Cite \| Source
Efficient Incorporation and Template‐Dependent Polymerase Inhibition are Major Determinants for the Broad‐Spectrum Antiviral Activity of Remdesivir (journal article) Gordon, Calvin J. \| Lee, Hery W. \| Tchesnokov, Egor P. \| Perry, Jason K. \| Feng, Joy Y. \| Bilello, John P. \| Porter, Danielle P. \| Gotte, Matthias The FASEB Journal, volume 36, issue S1 (2022). 10.1096/fasebj.2022.36.S1.R4278 Cite \| Source
Sandacrabins – Structurally Unique Antiviral RNA Polymerase Inhibitors from a Rare Myxobacterium** (journal article) Bader, Chantal D. \| Panter, Fabian \| Garcia, Ronald \| Tchesnokov, Egor P. \| Haid, Sibylle \| Walt, Christine \| Spröer, Cathrin \| Kiefer, Alexander F. \| Götte, Matthias \| Overmann, Jörg \| ... \| Müller, Rolf Chemistry – A European Journal, volume 28, issue 10 (2022). 10.1002/chem.202104484 Cited by (9) \| Cite \| Source
Changes in fatigue, barriers, and predictors towards physical activity in advanced cancer patients over a period of 12 months—a comparative study (journal article) Frikkel, J. \| Beckmann, M. \| De Lazzari, N. \| Götte, M. \| Kasper, S. \| Hense, J. \| Schuler, M. \| Teufel, M. \| Tewes, M. Supportive Care in Cancer, volume 29, issue 9, pages 5127-5137 (2021). 10.1007/s00520-021-06020-3 Cited by (3) \| Cite \| Source
Remdesivir for the treatment of Covid-19: the value of biochemical studies (journal article) Götte, Matthias Current Opinion in Virology, volume 49 (2021). 10.1016/j.coviro.2021.04.014 Cited by (19) \| Cite \| Source
Inhibition of viral RNA-dependent RNA polymerases with clinically relevant nucleotide analogs (book chapter) In Viral Replication Enzymes and their Inhibitors Part A Maheden, Kieran \| Todd, Brendan \| Gordon, Calvin J. \| Tchesnokov, Egor P. \| Götte, Matthias Elsevier (2021) 10.1016/bs.enz.2021.07.002 Cited by (7) \| Cite \| Source
The active form of the influenza cap-snatching endonuclease inhibitor baloxavir marboxil is a tight binding inhibitor (journal article) Todd, Brendan \| Tchesnokov, Egor P. \| Götte, Matthias Journal of Biological Chemistry, volume 296 (2021). 10.1016/j.jbc.2021.100486 Cited by (16) \| Cite \| Source
Application of Molecular Dynamics Simulations to the Design of Nucleotide Inhibitors Binding to Norovirus Polymerase (journal article) Freedman, Holly \| Kundu, Juthika \| Tchesnokov, Egor Petrovitch \| Law, John Lok Man \| Nieman, James A. \| Schinazi, Raymond F. \| Tyrrell, D. Lorne \| Gotte, Matthias \| Houghton, Michael Journal of Chemical Information and Modeling, volume 60, issue 12, pages 6566-6578 (2020). 10.1021/acs.jcim.0c00742 Cited by (4) \| Cite \| Source
Fatigue, barriers to physical activity and predictors for motivation to exercise in advanced Cancer patients (journal article) Frikkel, J. \| Götte, M. \| Beckmann, M. \| Kasper, S. \| Hense, J. \| Teufel, M. \| Schuler, M. \| Tewes, M. BMC Palliative Care, volume 19, issue 1 (2020). 10.1186/s12904-020-00542-z Cited by (59) \| Cite \| Source
Template-dependent inhibition of coronavirus RNA-dependent RNA polymerase by remdesivir reveals a second mechanism of action (journal article) Tchesnokov, Egor P. \| Gordon, Calvin J. \| Woolner, Emma \| Kocinkova, Dana \| Perry, Jason K. \| Feng, Joy Y. \| Porter, Danielle P. \| Götte, Matthias Journal of Biological Chemistry, volume 295, issue 47, pages 16156-16165 (2020). 10.1074/jbc.AC120.015720 Cited by (106) \| Cite \| Source
Remdesivir targets a structurally analogous region of the Ebola virus and SARS-CoV-2 polymerases (journal article) Lo, Michael K. \| Albariño, César G. \| Perry, Jason K. \| Chang, Silvia \| Tchesnokov, Egor P. \| Guerrero, Lisa \| Chakrabarti, Ayan \| Shrivastava-Ranjan, Punya \| Chatterjee, Payel \| McMullan, Laura K. \| ... \| Spiropoulou, Christina F. Proceedings of the National Academy of Sciences, volume 117, issue 43, pages 26946-26954 (2020). 10.1073/pnas.2012294117 Cited by (47) \| Cite \| Source
Independent inhibition of the polymerase and deubiquitinase activities of the Crimean-Congo Hemorrhagic Fever Virus full-length L-protein (journal article) Tchesnokov, Egor P. \| Bailey-Elkin, Ben A. \| Mark, Brian L. \| Götte, Matthias PLOS Neglected Tropical Diseases, volume 14, issue 6, pages e0008283- (2020). 10.1371/journal.pntd.0008283 Cited by (14) \| Cite \| Source
Remdesivir is a direct-acting antiviral that inhibits RNA-dependent RNA polymerase from severe acute respiratory syndrome coronavirus 2 with high potency (journal article) Gordon, Calvin J. \| Tchesnokov, Egor P. \| Woolner, Emma \| Perry, Jason K. \| Feng, Joy Y. \| Porter, Danielle P. \| Götte, Matthias Journal of Biological Chemistry, volume 295, issue 20, pages 6785-6797 (2020). 10.1074/jbc.RA120.013679 Cited by (690) \| Cite \| Source
The antiviral compound remdesivir potently inhibits RNA-dependent RNA polymerase from Middle East respiratory syndrome coronavirus (journal article) Gordon, Calvin J. \| Tchesnokov, Egor P. \| Feng, Joy Y. \| Porter, Danielle P. \| Götte, Matthias Journal of Biological Chemistry, volume 295, issue 15, pages 4773-4779 (2020). 10.1074/jbc.AC120.013056 Cited by (586) \| Cite \| Source
Independent Inhibition of the Polymerase and Deubiquitinase Activities of the Crimean–Congo Hemorrhagic Fever Virus Full-Length L-Protein (conference) Tchesnokov, Egor P. \| Bailey-Elkin, Ben A. \| Mark, Brian L. \| Götte, Matthias Viruses (2020) 10.3390/proceedings2020050041 Cite \| Source